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Dietary supplement

Organic Lions Mane Ingredients & Drug Interactions

by PureCo

Organic Lions Mane label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Lions Mane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Lions Mane is a dietary supplement by PureCo with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Fruiting Body Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Organic Lions Mane by PureCo

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Lions Mane by PureCo — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Organic Lions Mane by PureCo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lion's mane mushroom fruiting body extract. It also includes inactive ingredients — pullulan, brown rice protein, erythritol, sunflower lecithin, and medium chain triglyceride — which help form the capsule and blend.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lion's Mane Mushroom product and its label doesn't state a use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for lion's mane mushroom isn't established in our data. The product is marketed for Alzheimer's disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment, but our data rates all of these uses as having insufficient reliable evidence to make a rating.

If you're considering this supplement for one of these reasons, talk with your pharmacist or doctor about whether the current research supports it for your particular situation.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, lion's mane mushroom is generally well tolerated, though some people in trials reported gastrointestinal discomfort, nausea, and skin rash. Long-term safety as a supplement hasn't been studied well, so caution is warranted if you plan to take it regularly.

The safety data doesn't support use during pregnancy or while breastfeeding — if either applies to you, talk with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check it against blood thinners and antiplatelet drugs (moderate risk of bleeding), diabetes medications (moderate risk of low blood sugar), and immunosuppressant drugs (moderate risk of interference with your therapy). Use the search tool on this page to look up your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane mushroom is generally well tolerated as a food and supplement, but it can interact with blood thinners, diabetes medications, and immunosuppressants. If you take any of those or have other prescriptions, check them with the tool on this page before starting.

Pregnant or nursing? Skip it until you've talked with your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Lions Mane, straight from the product label.

Brand PureCo
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 318404
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Lions Mane by PureCo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegan Capsule(s)
Maximum serving Sizes:
2 Vegan Capsule(s)
Servings per container
30
IngredientAmount% DV
Lion's Mane Fruiting Body Extract1000 mg--

Other ingredients: Pullulan, Brown Rice Protein, Erythritol, Sunflower Lecithin, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use For adults: Take two (2) capsules once daily, preferably with a meal, or as directed by a healthcare professional.

Precautions

Discontinue use if side effects appear.

If you are pregnant, nursing, taking medications or have any medical condition please discuss use with your healthcare practitioner.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Formulation

Satisfaction Guarantee We offer a full refund on the purchase price of your order within 90 days of purchase. Restrictions apply. For details please visit: www.mypure.co/refunds

We are committed to using organic and non-GMO ingredients whenever possible, and manufacture our products right here in the USA with global & domestic ingredients.

Certified Organic by Organic Certifiers

This product does not contain: Yeast, wheat, gluten, dairy, corn, soy, eggs, sugar, tree nuts, peanuts, fish, shellfish or hydrogenated oils.

General Statements

PureCo - A company founded on one core principle: to bring you the purest dietary supplements possible.

Natural herbals

Seals/Symbols

USDA Organic Certified Organic by Organic Certifiers USA Made in the USA with domestic & international ingredients

Formula

10:1 extract Powerful 30% polysaccharides

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Lions Mane by PureCo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Lions Mane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Lions Mane by PureCo

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegan Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Lion's Mane Fruiting Body Extract

Interacts with
327 drugs
1000 mg per serving Form: Polysaccharides

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Fruiting Body Extract monograph & interactions

Other (inactive) ingredients: Pullulan, Brown Rice Protein, Erythritol, Sunflower Lecithin, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Lions Mane by PureCo Drug Interactions

Want to check YOUR meds against Organic Lions Mane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Fruiting Body Extract 327

Individual Drug Interactions

The ingredients in Organic Lions Mane interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Lions Mane interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Fruiting Body Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Lions Mane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Fruiting Body Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Fruiting Body Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Lions Mane, from the product label.

PureCo

See all PureCo products
Name
Pure Co USA Supplements, LLC
Street Address
239 2nd Ave. S., 2nd Floor
City
St. Petersburg
State
FL
ZipCode
33701
Pharmacist Counseling Corner

Organic Lions Mane by PureCo: Common Questions

Does Organic Lions Mane by PureCo interact with any medications?
Yes. Based on its ingredients, Organic Lions Mane has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Lions Mane contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data isn't sufficient to recommend lion's mane during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in either situation.
What side effects should I watch for?
Most people tolerate it well. The most common side effects in trials were gastrointestinal discomfort, nausea, and skin rash — all relatively mild. Let your pharmacist know if any bother you.
Does lion's mane actually help with memory or brain health?
The evidence isn't established yet in our data. Lion's mane is often marketed for Alzheimer's disease, cognitive function, and other brain-related concerns, but we don't have reliable evidence to rate how well it works for any of those. Your pharmacist can point you toward the latest research.
Why does this product have so many inactive ingredients?
The inactive ingredients — pullulan, brown rice protein, erythritol, sunflower lecithin, and medium chain triglyceride — help make the capsule stable, hold it together, and improve absorption. None of them are active in the supplement itself.
Is this safe to take long-term?
Lion's mane is generally well tolerated, but long-term safety as a supplement hasn't been studied thoroughly. If you plan to take it regularly, check in with your pharmacist to make sure it's a good fit for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Lions Mane is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Lions Mane label
Go deeper

The Full Monographs Behind Organic Lions Mane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Organic Lions Mane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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