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Dietary supplement

Organic Spearmint Ingredients & Drug Interactions

by Zongle Therapeutics

Organic Spearmint label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Spearmint against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Spearmint is a dietary supplement by Zongle Therapeutics with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, nausea, hormonal acne and unwanted hair (pcos-related).Based on those ingredients, 579 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Spearmint. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Spearmint by Zongle Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Spearmint by Zongle Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Spearmint by Zongle Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: spearmint. The liquid also includes spearmint oil that's been steam-distilled.

Spearmint is the herb itself — the plant used in teas and culinary applications — and here it's delivered as a concentrated liquid form rather than a dried leaf or whole plant.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Spearmint's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promotes digestion, breath freshness, focus and mood.
  • We looked for evidence on: Flatulence, Irritable bowel syndrome (IBS), Postoperative nausea and vomiting (PONV), Cognitive function, indigestion, nausea — and 1 related terms.
  • The closest evidence on file: Spearmint is rated "Insufficient Reliable Evidence To Rate" for Cognitive function (Natural Medicines).
  • Also on file: Spearmint is rated "Insufficient Reliable Evidence To Rate" for Flatulence, Irritable bowel syndrome (IBS), Postoperative nausea and vomiting (PONV).

The evidence on spearmint for cognitive decline, memory, flatulence, irritable bowel syndrome, nausea after surgery, and osteoarthritis hasn't been established well enough in the data we hold to rate it one way or the other. That doesn't mean it doesn't work for any of these — it means the research so far is too thin or inconsistent to draw a solid conclusion.

The evidence, ingredient by ingredient Spearmint

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, spearmint is generally well tolerated. Because this is a concentrated supplement liquid rather than food or tea amounts, the safety data is thinner.

Some people have had allergic reactions — contact dermatitis, cheilitis (lip irritation), and in rare cases, swelling of the soft palate from oral use. One person in a trial reported anxiety after taking spearmint extract, though it's unclear whether spearmint caused it.

For pregnancy: the data suggests it's likely safe, though one rating notes possibly unsafe — there isn't enough solid information to know for certain. For breastfeeding: likely safe based on available data.

Because this is a concentrated supplement rather than food amounts, talk with your doctor or pharmacist about whether it's right for you during pregnancy or while nursing.

Side effects, ingredient by ingredient Spearmint

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Spearmint.
  • The most serious interaction on file is rated Moderate.
  • For scale: 580 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on any drugs that damage the liver (hepatotoxic medications) or CNS depressants — sedatives, sleep aids, anti-anxiety drugs, opioids, and similar medications that slow your nervous system. Both are Moderate severity interactions with spearmint.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This Zongle spearmint liquid is a single-ingredient product that's generally well tolerated by mouth, though concentrated supplements carry more uncertainty than food or tea. It interacts with liver-damaging drugs and CNS depressants — two serious medication categories — so check your exact prescriptions before starting.

If you're pregnant, nursing, or taking any regular medications, run this by your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Spearmint, straight from the product label.

Brand Zongle Therapeutics
Barcode (UPC) 856426006405
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 276645
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Spearmint by Zongle Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
1 Drop(s)
Servings per container
500
UPC/BARCODE
856426006405
IngredientAmount% DV
Spearmint60 mg--

Other ingredients: Spearmint Oil, Steam-Distilled

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

For aromatic, topical or internal use.

For internal use dilute one drop in 4 fl. oz. of liquid. Dilute for kids or sensitive skin.

Formulation

USDA Certified Organic

Promotes healthy digestion Promotes fresh breath and cleanses mouth Focusing and uplifting Helps reduce stomach upset

Therapeutic Grade

GMO free Artificial ingredients free Paraben free Pesticide free Preservatives free Gluten free

Vegan

Certified Organic by GCIAOCP

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution: Possible skin sensitivity.

Keep out of reach of children.

If you are pregnant, nursing, or under a doctor's care, consult your physician.

Avoid contact with eyes, inner ears, and sensitive areas.

Formula

Mentha spicata

FDA Statement of Identity

Essential Oil Supplement

Seals/Symbols

USDA Organic

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Spearmint by Zongle Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Spearmint label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Spearmint by Zongle Therapeutics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container500 Amounts shown are per serving.

Spearmint

Interacts with
579 drugs
60 mg per serving

Spearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild horm...

Spearmint monograph & interactions

Other (inactive) ingredients: Spearmint Oil, Steam-Distilled. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Spearmint by Zongle Therapeutics Drug Interactions

Want to check YOUR meds against Organic Spearmint?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
579Drugs
579 Moderate

Ingredients driving the most interactions

Spearmint 579

Individual Drug Interactions

The ingredients in Organic Spearmint interact with 579 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Spearmint interact with drugs. Each result below shows which ingredient is responsible. Spearmint

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Spearmint with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Spearmint2 drug types · 579 drugs

Cns Depressants

Theoretically, spearmint might alter the sedative effects of CNS depressants.
Animal research suggests that (-)-carvone, a major constituent of spearmint, has sedative effects. However, in humans, chewing spearmint-flavored gum induced arousal effects.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Animal research suggests that drinking spearmint tea for 30 days can increase markers of liver damage, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and cause liver degeneration and necrosis, in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Spearmint full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Spearmint, from the product label.

Zongle Therapeutics

See all Zongle Therapeutics products
Name
Zongle Therapeutics LLC
City
Norcross
State
GA
ZipCode
30093
Web Address
www.zongletherapeutics.com
Pharmacist Counseling Corner

Organic Spearmint by Zongle Therapeutics: Common Questions

Does Organic Spearmint by Zongle Therapeutics interact with any medications?
Yes. Based on its ingredients, Organic Spearmint has a known interaction with 579 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Spearmint contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The data suggests spearmint is likely safe during breastfeeding. For pregnancy, the evidence is mixed — one rating says likely safe, another says possibly unsafe. Because this is a concentrated supplement and not just food or tea, talk with your doctor or pharmacist about whether it's right for your situation.
What are the side effects I should watch for?
Most people tolerate spearmint well by mouth. Some folks have had allergic reactions — skin rashes, lip irritation, or rarely swelling in the mouth. One person reported anxiety in a trial, though it's not certain spearmint caused it. Stop and tell your doctor if you notice any rash or swelling.
What is spearmint supposed to do?
The research on spearmint for memory, thinking, bloating, IBS, nausea, or joint pain isn't solid enough yet to say it works. That doesn't mean it won't help you — it means we don't have strong evidence either way.
Is this product safe to use with my liver or sedative medications?
Animal studies suggest spearmint may increase liver damage risk with hepatotoxic drugs and could alter how sedatives work — both Moderate concerns. Check your exact medications with your doctor or pharmacist before starting.
Is this just spearmint, or are there other ingredients?
The active ingredient is spearmint. The product also contains spearmint oil that's been steam-distilled as an inactive ingredient — it's part of the spearmint delivery, not a separate additive.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Spearmint label
Go deeper

The Full Monographs Behind Organic Spearmint’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Spearmint

Interacts with 579 drugs

Spearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild hormone-related issues (such as excess facia...

Read the full Spearmint monograph →
Sources

Sources & How We Checked

Organic Spearmint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Spearmint 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Akdogan M, Ozguner M, Aydin G, Gokalp O. Investigation of biochemical and histopathological effects of Mentha piperita Labiatae and Mentha spicata Labiatae on liver tissue in rats. Hum Exp Toxicol 2004;23:21-8.
  3. Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. PubMed
  4. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  5. de Sousa, D. P., Farias Nobrega, F. F., and de Almeida, R. N. Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality 5-5-2007;19(4):264-268.
  6. Larsen, W., Nakayama, H., Fischer, T., Elsner, P., Frosch, P., Burrows, D., Jordan, W., Shaw, S., Wilkinson, J., Marks, J., Jr., Sugawara, M., Nethercott, M., and Nethercott, J. Fragrance contact dermatitis: a worldwide multicenter investigation (Part II PubMed
  7. Guney, M., Oral, B., Karahanli, N., Mungan, T., and Akdogan, M. The effect of Mentha spicata Labiatae on uterine tissue in rats. Toxicol.Ind.Health 2006;22(8):343-348.
  8. Masumoto, Y., Morinushi, T., Kawasaki, H., Ogura, T., and Takigawa, M. Effects of three principal constituents in chewing gum on electroencephalographic activity. Psychiatry Clin.Neurosci. 1999;53(1):17-23. PubMed
  9. Bulat, R., Fachnie, E., Chauhan, U., Chen, Y., and Tougas, G. Lack of effect of spearmint on lower oesophageal sphincter function and acid reflux in healthy volunteers. Aliment.Pharmacol Ther. 1999;13(6):805-812. PubMed
  10. Francalanci, S., Sertoli, A., Giorgini, S., Pigatto, P., Santucci, B., and Valsecchi, R. Multicentre study of allergic contact cheilitis from toothpastes. Contact Dermatitis 2000;43(4):216-222. PubMed
  11. Bonamonte, D., Mundo, L., Daddabbo, M., and Foti, C. Allergic contact dermatitis from Mentha spicata (spearmint). Contact Dermatitis 2001;45(5):298.
  12. Tomson, N., Murdoch, S., and Finch, T. M. The dangers of making mint sauce. Contact Dermatitis 2004;51(2):92-93. PubMed
  13. Clayton, R. and Orton, D. Contact allergy to spearmint oil in a patient with oral lichen planus. Contact Dermatitis 2004;51(5-6):314-315. PubMed
  14. Dal Sacco, D., Gibelli, D., and Gallo, R. Contact allergy in the burning mouth syndrome: a retrospective study on 38 patients. Acta Derm.Venereol. 2005;85(1):63-64. PubMed
  15. Goncalves, J. C., Oliveira, Fde S., Benedito, R. B., de Sousa, D. P., de Almeida, R. N., and de Araujo, D. A. Antinociceptive activity of (-)-carvone: evidence of association with decreased peripheral nerve excitability. Biol Pharm Bull. 2008;31(5):1017- PubMed
  16. Ormerod, A. D. and Main, R. A. Sensitisation to "sensitive teeth" toothpaste. Contact Dermatitis 1985;13(3):192-193. PubMed
  17. Skrebova, N., Brocks, K., and Karlsmark, T. Allergic contact cheilitis from spearmint oil. Contact Dermatitis 1998;39(1):35. PubMed
  18. Damiani E, Aloia AM, Priore MG, et al. Allergy to mint (Mentha spicata). J Investig Allergol Clin Immunol 2012;22:309-10.
  19. Connelly AE, Tucker AJ, Tulk H, et al. High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. J Med Food 2014;17:1361-7. PubMed
  20. Lasrado JA, Nieman KM, Fonseca BA, et al. Safety and tolerability of a dried aqueous spearmint extract. Regul Toxicol Pharmacol 2017;86:167-176. PubMed

See these in context on the Spearmint monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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