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Dietary supplement

Organic Tribulus Ingredients & Drug Interactions

by Herbal Secrets

Organic Tribulus label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Tribulus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Tribulus is a dietary supplement by Herbal Secrets with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Puncture Vine powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Tribulus by Herbal Secrets

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Tribulus by Herbal Secrets — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Tribulus by Herbal Secrets

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Organic Tribulus contains one active ingredient: organic Puncture Vine powder. This plant is traditionally used in herbal medicine, though the evidence for its effectiveness varies by use.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: male sexual function and performance support.
  • We looked for evidence on: Erectile dysfunction (ED), Male infertility, Premature ejaculation, Sexual dysfunction, testosterone support, libido.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Premature ejaculation, Male infertility.

Tribulus is possibly effective for sexual dysfunction based on the data we hold. For athletic performance, the evidence suggests it's possibly ineffective.

For benign prostatic hyperplasia (enlarged prostate), there isn't enough reliable evidence in our data to rate it either way.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in the short term for healthy adults, but long-term safety data and quality control information are limited. Serious side effects are rare but have been reported — including liver and kidney injury, seizures, and in one extreme case, lower limb weakness and kidney failure after consuming very large amounts.

More commonly, it may cause abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation, though one study found these complaints occurred at similar rates in people taking tribulus and those on placebo. The safety data advises against taking tribulus during pregnancy because it may affect hormones and safety is not established.

We also don't have enough reliable information to know whether it's safe while breastfeeding — talk with your doctor or pharmacist for personalized guidance on either of these situations.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Organic Tribulus, double-check with your doctor or pharmacist if you take blood pressure medications (antihypertensives), diabetes drugs, or lithium. Moderate interactions are documented for all three categories, and combining them with tribulus could lower your blood pressure, blood sugar, or raise lithium levels in your body.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual dysfunction, though the evidence is still developing. If you take blood pressure medications, diabetes drugs, or lithium, you need to check with your doctor or pharmacist before adding this — the interactions could affect how your medications work.

Long-term safety data are limited, so use this short-term and under guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Tribulus, straight from the product label.

Brand Herbal Secrets
Barcode (UPC) 810180028967
Net contents 16 Ounce(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 251527
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Tribulus by Herbal Secrets, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 Teaspoon(s)
Maximum serving Sizes:
0.5 Teaspoon(s)
Servings per container
227
UPC/BARCODE
810180028967
IngredientAmount% DV
organic Puncture Vine powder2 Gram(s)--

Other ingredients: organic Tribulus powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Herbal Secrets Tribulus is made from the roots and fruits of a plant called Puncture Vine or Tribulus terrestris. Tribulus has a long history of use in traditional Ayurveda practices, however it is best known for its benefits in the male reproductive system. Tribulus supports sexual and athletic performance in men. Tribulus promotes cardiovascular and digestive functions.

Raw

Vegan

Non GMO

100% Natural

Certified Organic powder Traditional Ayurvedic Herb

Supports lean muscle mass & strength gain Promotes men's reproductive health Supports overall health & well-being

Contains No Added: Fillers, gluten, starch, preservatives, artificial colors, flavors, sugar or additives.

Certified Organic by: Baystate Organic Certifiers

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: Not recommended for use by pregnant or nursing women. If you are using a sedative medication, consult a health care professional before using this product.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Formula

Kosher

Kosher Certified by Earth Kosher.

Seals/Symbols

Made in the USA

USDA Organic

GMP Good Manufacturing Produce Quality Produce

FDA Statement of Identity

Natural Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Mix 1/4 to 1/2 teaspoon with warm water, once or twice daily or as directed by a health care professional. Close the container tightly after each use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Tribulus by Herbal Secrets label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Tribulus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Tribulus by Herbal Secrets

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.25 Teaspoon(s) Dosage formPowder Servings per container227 Amounts shown are per serving.

Organic Puncture Vine powder

Interacts with
259 drugs
2 Gram(s) per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Organic Puncture Vine powder monograph & interactions

Other (inactive) ingredients: Organic Tribulus powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Tribulus by Herbal Secrets Drug Interactions

Want to check YOUR meds against Organic Tribulus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

organic Puncture Vine powder 259

Individual Drug Interactions

The ingredients in Organic Tribulus interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Tribulus interact with drugs. Each result below shows which ingredient is responsible. organic Puncture Vine powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Tribulus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Puncture Vine powder3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
organic Puncture Vine powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Tribulus, from the product label.

Herbal Secrets

See all Herbal Secrets products
Name
Herbal Secrets
Street Address
629 Grove Street
City
Jersey City
State
NJ
ZipCode
07310
Web Address
amazingnutrition.com
Pharmacist Counseling Corner

Organic Tribulus by Herbal Secrets: Common Questions

Does Organic Tribulus by Herbal Secrets interact with any medications?
Yes. Based on its ingredients, Organic Tribulus has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Tribulus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Tribulus actually work for sexual function?
The evidence suggests it's possibly effective for sexual dysfunction, meaning there's some research support but it's not definitive. Results vary by person, and more robust studies would help clarify how well it works.
Can I take this if I'm pregnant or breastfeeding?
The safety data advise against tribulus during pregnancy because it may affect hormones and safety hasn't been established. For breastfeeding, we don't have enough reliable safety information either way — talk with your doctor or pharmacist about what's right for your situation.
What side effects might I notice?
Most people tolerate it without problems, but it can cause abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation. Serious side effects like liver or kidney injury are rare but have been reported, particularly with very high intakes over extended periods.
Is this safe to take long-term?
We have good short-term safety data for healthy adults, but long-term safety information is limited. Use this product short-term and under guidance from your healthcare provider if you're considering longer use.
Can tribulus help with athletic performance?
Based on the data we hold, tribulus is possibly ineffective for athletic performance, so the evidence doesn't support using it for that purpose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Tribulus is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Tribulus label
Go deeper

The Full Monographs Behind Organic Tribulus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Organic Tribulus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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