Drug & supplement interaction

Tribulus + Chlorothiazide

Chlorothiazide brand name: Diuril.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Tribulus has a moderate interaction with Chlorothiazide. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Tribulus and Chlorothiazide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Chlorothiazide

Chlorothiazide falls under ANTIHYPERTENSIVE DRUGS — the group Tribulus interacts with.

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Chlorothiazide (Diuril) is a water pill that lowers blood pressure by helping your kidneys flush out extra salt and fluid. Tribulus, in lab and animal studies, seems to gently lower blood pressure too, possibly by blocking an enzyme called ACE. Put the two together and the worry is simply that your pressure could dip a little lower than expected.

Keep in mind this is theoretical, based mostly on animal data plus a small human study, so it's far from certain. Still, if you stack them, watch for signs of low blood pressure like dizziness, lightheadedness when you stand up, or feeling faint. Before adding Tribulus, it's worth a quick chat with your pharmacist or doctor, especially if your pressure already runs low.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Tribulus Also Interacts With Other Medications

Tribulus has 258 moderate known drug interactions in our database — the Chlorothiazide one above is one of them. If you take anything else, check it against the full list below.

Moderate 258 No known interaction 2,572 (incl. Chlorothiazide)
Taking anything else?

Check Another of Your Medications Against Tribulus

Covers the 2,830 medications we’ve checked against Tribulus. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Chlorothiazide

This page covers Tribulus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorothiazide page lists 227 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 192 moderate · 25 minor.

Open the Chlorothiazide interaction page

One more smart check

Taking Tribulus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,680 real supplement products containing Tribulus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tribulus. Your product may carry other ingredients that interact with Chlorothiazide too, on top of Tribulus — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tribulus and Chlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tribulus
Top 10%

#97 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorothiazide
Top half

#1,000 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Tribulus

What is Tribulus?

Tribulus
  • Low libido and sexual function
  • Athletic performance and muscle building
  • Testosterone support
  • Male and female fertility
  • General 'vitality' or wellness

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is generally well tolerated by healthy adults in the short term, but it should be avoided during pregnancy and breastfeeding and discussed with your pharmacist or doctor before use.

Read the full Tribulus monograph & all interactions
Medication

About Chlorothiazide

What Is Chlorothiazide Used For?

Brand name: Diuril

Chlorothiazide is used to reduce fluid buildup (edema) linked to conditions such as heart failure, liver cirrhosis (hepatic cirrhosis), and certain kidney disorders — including nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. It is also used when edema is caused by corticosteroid or estrogen therapy.

The oral suspension (Diuril) is additionally approved to treat high blood pressure, either on its own or alongside other blood pressure medications. The intravenous forms — including Sodium Diuril, Chlorothiazide Sodium, and Chlorothiazide injection products — are reserved for treating edema in patients who cannot take oral medication or in emergency situations; these intravenous products are not approved for high blood pressure management.

See full Chlorothiazide drug information
Keep checking

Other Drugs & Tribulus

Browse every other medication we’ve checked against Tribulus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
258Moderate
0Minor
2,571No known interaction
258 Moderate 2,571 No interaction
Moderate

258 interactions

Showing 60 of 258 moderate interactions — see all 258 on the Tribulus page.

No interaction 2,571 drugs checked — show the list

We also checked Tribulus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,571 medications checked with no known interaction — see the full Tribulus list.

See the full Tribulus interactions page
See every supplement checked against Chlorothiazide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Tribulus monograph › Uses, safety, and every drug interaction in one place Chlorothiazide supplement interactions › Every supplement checked against Chlorothiazide, ranked by severity Chlorothiazide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Tribulus and Chlorothiazide Together: Common Questions

Can you take Tribulus with Chlorothiazide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Tribulus and Chlorothiazide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Chlorothiazide and Tribulus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.