Ginseng + Extract Ingredients & Drug Interactions
by Paradise
What is this page for?
First and foremost: checking Ginseng + Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ginseng + Extract is a dietary supplement by Paradise with 4 active ingredients. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and stress, digestive support.Based on those ingredients, 1,210 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chinese Licorice Root Extract, Tangerine Rind Extract, Dried, Jujube Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ginseng + Extract by Paradise
Ask about any prescription or over-the-counter medication and we check it for interactions with Ginseng + Extract by Paradise — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ginseng + Extract by Paradise
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product has four active ingredients. The Proprietary Blend of Synergistic Herbal Extracts is the first, but its specific components are listed separately: Jujube Extract (from the zizyphus fruit), Tangerine Rind Extract (dried), Chinese Licorice Root Extract, and Panax Red Ginseng Root Extract.
The only inactive ingredient listed is cellulose, a common capsule binder.
Does it work?
Moderate evidence
The evidence for what this product does is sparse in our data. Jujube Extract shows insufficient evidence for aging skin, anemia, anxiety, and asthma.
Tangerine Rind Extract shows insufficient evidence for cancer. Chinese Licorice Root Extract is rated possibly effective for atopic dermatitis (eczema) and canker sores, though most other uses also lack reliable evidence.
We hold no effectiveness data for Panax Red Ginseng Root Extract.
How safe is it?
Well-documented data
Jujube Extract is widely eaten as food, but concentrated medicinal supplements haven't been well studied, so it's best to avoid them unless you've talked with your doctor. It was linked to headache and mild diarrhea in small studies.
Chinese Licorice Root Extract is fine in small food amounts but can cause serious problems at high doses or with long-term use — headache, nausea, and vomiting are most common, with rare cases of more severe effects. Tangerine Rind Extract is safe as a fruit but concentrated extracts should be used cautiously; topical forms can occasionally cause contact dermatitis.
For Jujube, pregnancy is rated Likely Safe, but licorice is rated Unsafe in pregnancy — glycyrrhizin has been linked to harmful effects. Breastfeeding safety data isn't available for Jujube or Tangerine, so avoid medicinal doses of licorice while nursing.
We hold no pregnancy or breastfeeding data for the Red Ginseng.
Meds to double-check
Moderate interaction found
Check with your pharmacist if you take digoxin (heart medication), warfarin or other blood thinners, diabetes drugs, loop diuretics (water pills), cancer drugs like cisplatin or paclitaxel, CNS depressants (sleep aids, anxiety meds), or any drug your liver metabolizes via CYP1A2, CYP2B6, CYP2C19, or CYP3A4 pathways. We could not check the Red Ginseng ingredient, so it's especially important to run your full medication list through the search tool.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This blend combines ingredients with some traditional use and mixed evidence. If you take digoxin, blood thinners, diabetes drugs, or CNS depressants, you need to check with your pharmacist before starting — the licorice and jujube pose real interaction risks.
Pregnant or breastfeeding? Talk to your doctor first, especially because of the licorice.
Most otherwise healthy adults might tolerate it, but concentrated herbal supplements always warrant a quick conversation with your pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ginseng + Extract, straight from the product label.
| Brand | Paradise |
|---|---|
| Barcode (UPC) | 601944777128 |
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2025 |
| DSLD ID | 336862 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ginseng + Extract by Paradise, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend of Synergistic Herbal extracts | 50 mg | -- |
| Jujube Extract | 0 NP | -- |
| Tangerine Rind Extract, Dried | 0 NP | -- |
| Chinese Licorice Root Extract | 0 NP | -- |
| Panax Red ginseng Root Extract | 200 mg | -- |
Other ingredients: Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Quality - purity - potency We are dedicated to sourcing premium ultra pure ingredients that meet the highest standards of excellence.
We never add unnecessary fillers, binders, preservatives or flow agents to our encapsulation process. Our active whole spectrum extracts contain a full profile of naturally occurring constituents and are extracted without the use of toxic solvents and/or harsh chemicals.
Vegan
Non-GMO Gluten free
Contains no common allergens. Made without fillers.
Manufactured in the USA. GMP quality assured & FDA registered.
General Statements
Paradise products have won over a decade of Best of Supplements Awards.
Formula
Active whole spectrum difference Our active whole spectrum extracts contain a full profile of naturally occurring constituents and are extracted without the use of toxic solvents and/or harsh chemicals. This unique method captures the true essence of the whole herb while still retaining a highly active and bioavailable concentration of phyto nutrients.
Ginseng + Extract With energy balancing Tangerine & Jujube
Storage
Warning: Keep in a cool dry place, out of the reach of children.
Precautions
Warning: Keep in a cool dry place, out of the reach of children.
If pregnant, nursing, or using any prescription medication consult your health care professional before using this product.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Paradise Enhancing Nature's Miracles Since 1994 Paradise Since 1994
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Take 1 vegetarian capsule 1-2 times daily or as directed by a qualified health care professional.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ginseng + Extract by Paradise label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ginseng + Extract by Paradise
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend of Synergistic Herbal extracts
Panax Red ginseng Root Extract
Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.
Ginseng + Extract by Paradise Drug Interactions
HelloPharmacist Interaction Report
Paradise Ginseng + Extract contains four active ingredients, three of which have documented interactions with medications.
The most serious concern is Chinese Licorice Root Extract, which interacts with digoxin (a heart medication) at Moderate severity — theoretically increasing the risk of heart toxicity, especially if licorice causes potassium loss.
Read the full breakdown — every affected drug type, severity by severity
Jujube Extract and Tangerine Rind Extract also carry Moderate interactions: Jujube may add to the sedative effects of CNS depressants (like sleep aids or anxiety medications), may reduce how your liver clears certain medications (CYP1A2 substrates), and could theoretically increase the risk of low blood sugar (hypoglycemia) if you take diabetes drugs. Tangerine Rind Extract has only Minor interactions with midazolam (Versed, a sedative), though human studies suggest the real-world effect is small.
Chinese Licorice Root Extract also interacts Moderately with blood thinners (warfarin), certain cancer drugs (cisplatin, paclitaxel), loop diuretics (water pills), and several other drug classes metabolized by your liver. We could not check Panax Red Ginseng Root Extract — we hold no interaction data for it.
Altogether, these interactions span 1,193 individual medications.
Run your exact prescriptions through the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ginseng + Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ginseng + Extract interact with 1,210 drugs. Click any drug to see the details.
3 of the 4 ingredients in Ginseng + Extract interact with drugs. Each result below shows which ingredient is responsible. Chinese Licorice Root Extract Tangerine Rind Extract, Dried Jujube Extract
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Ado-trastuzumab Emtansine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Abemaciclib interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Abiraterone interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Abiraterone Acetate interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Ginseng + Extract — through 1 ingredient. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
Read the full Chinese Licorice Root Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Acalabrutinib interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Ginseng + Extract — through 1 ingredient. Tap an ingredient for the detail:
Jujube ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Jujube Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Ginseng + Extract — through 1 ingredient. Tap an ingredient for the detail:
Chinese Licorice Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, licorice might reduce the effects of antihypertensive drugs.
Read the full Chinese Licorice Root Extract + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with Ginseng + Extract — through 1 ingredient. Tap an ingredient for the detail:
Jujube ExtractCns Depressants Moderate
Interaction Summary
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Read the full Jujube Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen interactionChinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Aspirin interactionChinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Aspirin, Caffeine interactionJujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Aspirin, Caffeine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionChinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Butalbital interactionChinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Butalbital, Caffeine interactionChinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Butalbital, Caffeine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionJujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Butalbital, Codeine interactionChinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Ginseng + Extract — through 2 ingredients. Tap an ingredient for the detail:
Jujube ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Read the full Jujube Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionChinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionJujube ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Read the full Jujube Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Caffeine, Codeine interactionChinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Caffeine, Codeine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionJujube ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Read the full Jujube Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionChinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Caffeine, Isometheptene interactionJujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Caffeine, Isometheptene interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Caffeine, Pyrilamine interactionChinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Diuretic Drugs +1 Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Acetaminophen, Caffeine, Pyrilamine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionJujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionJujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionJujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionChinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Jujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionChinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Ginseng + Extract — through 3 ingredients. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Chinese Licorice Root Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionJujube ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionTangerine Rind Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine Rind Extract, Dried + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ginseng + Extract with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Chinese Licorice Root Extract
Antihypertensive Drugs
Theoretically, licorice might reduce the effects of antihypertensive drugs.
In human research, licorice increases blood pressure in a dose-dependent manner.
Cisplatin (Platinol-Aq)
Theoretically, licorice might reduce the effects of cisplatin.
In animal research, licorice diminished the therapeutic efficacy of cisplatin.
Corticosteroids
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Case reports suggest that concomitant use of licorice and oral corticosteroids, such as hydrocortisone, can potentiate the duration of activity and increase blood levels of corticosteroids. Additionally, in one case report, a patient with neurogenic orthostatic hypertension stabilized on fludrocortisone 0.1 mg twice daily developed pseudohyperaldosteronism after recent consumption of large amounts of black licorice.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.
In vitro research shows that licorice extract and glabridin, a licorice constituent, inhibit CYP2B6 isoenzymes. Licorice extract from the species G. uralensis seems to inhibit CYP2B6 isoenzymes to a greater degree than G. glabra extract in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2B6; however, these interactions have not yet been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
In vitro, licorice extracts from the species G. glabra and G. uralensis inhibit CYP2C19 isoenzymes in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C19; however, this interaction has not yet been reported in humans.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
In vitro, licorice extract from the species G. glabra and G. uralensis inhibits CYP2C8 isoenzymes. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C8; however, this interaction has not yet been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
There is conflicting evidence about the effect of licorice on CYP2C9 enzyme activity. In vitro research shows that extracts from the licorice species G. glabra and G. uralensis moderately inhibit CYP2C9 isoenzymes. However, evidence from an animal model shows that licorice extract from the species G. uralensis can induce hepatic CYP2C9 activity. Until more is known, licorice should be used cautiously in people taking CYP2C9 substrates.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Pharmacokinetic research shows that the licorice constituent glycyrrhizin, taken in a dosage of 150 mg orally twice daily for 14 days, modestly decreases the area under the concentration-time curve of midazolam by about 20%. Midazolam is a substrate of CYP3A4, suggesting that glycyrrhizin modestly induces CYP3A4 activity. Animal research also shows that licorice extract from the species G. uralensis induces CYP3A4 activity. However, licorice extract from G. glabra species appear to inhibit CYP3A4-induced metabolism of testosterone in vitro. It is thought that the G. glabra inhibits CYP3A4 due to its constituent glabridin, which is a moderate CYP3A4 inhibitor in vitro and not present in other licorice species. Until more is known, licorice should be used cautiously in people taking CYP3A4 substrates.
Digoxin (Lanoxin)
Theoretically, concomitant use of licorice with digoxin might increase the risk of cardiac toxicity.
Overuse or misuse of licorice with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.
Diuretic Drugs
Theoretically, concomitant use of licorice with diuretic drugs might increase the risk of hypokalemia.
Overuse of licorice might compound diuretic-induced potassium loss. In one case report, a 72-year-old male with a past medical history of hypertension, type 2 diabetes, hyperlipidemia, arrhythmia, stroke, and hepatic dysfunction was hospitalized with severe hypokalemia and uncontrolled hypertension due to pseudohyperaldosteronism. This was thought to be provoked by concomitant daily consumption of a product containing 225 mg of glycyrrhizin, a constituent of licorice, and hydrochlorothiazide 12.5 mg for 1 month.
Estrogens
Theoretically, licorice might increase or decrease the effects of estrogen therapy.
Theoretically, licorice might interfere with estrogen therapy due to estrogenic and anti-estrogenic effects.
Loop Diuretics
Theoretically, loop diuretics might increase the mineralocorticoid effects of licorice.
Theoretically, loop diuretics might enhance the mineralocorticoid effects of licorice by inhibiting the enzyme that converts cortisol to cortisone; however, bumetanide (Bumex) does not appear to have this effect.
Midazolam (Versed)
Theoretically, licorice might decrease levels of midazolam.
In humans, the licorice constituent glycyrrhizin appears to moderately induce the metabolism of midazolam. This is likely due to induction of cytochrome P450 3A4 by licorice. Until more is known, licorice should be used cautiously in people taking midazolam.
P-Glycoprotein Substrates
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
In vitro research shows that licorice can increase P-glycoprotein activity.
Paclitaxel (Abraxane, Onxol)
Theoretically, licorice might decrease plasma levels and clinical effects of paclitaxel.
Multiple doses of licorice taken concomitantly with paclitaxel might reduce the effectiveness of paclitaxel. Animal research shows that licorice 3 grams/kg given orally for 14 days before intravenous administration of paclitaxel decreases the exposure to paclitaxel and increases its clearance. Theoretically, this occurs because licorice induces cytochrome P450 3A4 enzymes, which metabolize paclitaxel. Notably, a single dose of licorice did not affect exposure or clearance of paclitaxel.
Warfarin (Coumadin)
Theoretically, licorice might decrease plasma levels and clinical effects of warfarin.
Licorice seems to increase metabolism and decrease levels of warfarin in animal models. This is likely due to induction of cytochrome P450 2C9 (CYP2C9) metabolism by licorice. Advise patients taking warfarin to avoid taking licorice.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that licorice induces CYP1A2 enzymes.
Methotrexate (Trexall, Others)
Theoretically, licorice might increase levels of methotrexate.
Animal research suggests that intravenous administration of glycyrrhizin, a licorice constituent, and high-dose methotrexate may delay methotrexate excretion and increase systemic exposure, leading to transient elevations in liver enzymes and total bilirubin. This interaction has not yet been reported in humans.
Tangerine Rind Extract, Dried
Cytochrome P450 3A4 (Cyp3A4) Substrates
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4). This suggests that tangeretin may stimulate CYP3A4 activity. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam, a CYP3A4 substrate. Theoretically, tangerine juice might increase CYP3A4 activity and decrease levels of drugs metabolized by this enzyme. However, this effect is unlikely.
Some drugs metabolized by CYP3A4 include amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), felodipine (Plendil), lansoprazole (Prevacid), ondansetron (Zofran), prednisone (Deltasone, Orasone), sertraline (Zoloft), sibutramine (Meridia), and many others.
Midazolam (Versed)
In vitro, tangeretin, a constituent of tangerine, appears to increase the metabolism of midazolam in human liver microsomes by up to 52%. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam. Theoretically, tangerine juice might increase the metabolism and reduce the effects of midazolam. However, this effect is unlikely.
Jujube Extract
Antidiabetes Drugs
Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that zizyphus has hypoglycemic activity. However, a small clinical study shows that zizyphus fruit powder does not reduce fasting blood glucose levels in patients with type 2 diabetes.
Cns Depressants
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Some animal research has found that various parts of zizyphus have sedative effects. However, other animal research shows that zizyphus plant extract does not alter sleep parameters when used in combination with pentobarbital.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Animal research shows that zizyphus induces CYP1A2 enzymes. However, this effect has not been reported in humans.
Brand information
Manufacturer and brand details for Ginseng + Extract, from the product label.
Paradise
See all Paradise products- Name
- Paradise Herbs & Essentials, Inc.
- Street Address
- 19051 Goldenwest St. #106-304
- City
- Huntington Beach
- State
- CA
- ZipCode
- 92648
- Web Address
- www.paradiseherbs.com
Ginseng + Extract by Paradise: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Ginseng + Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Zizyphus
Interacts with 469 drugsZizyphus (jujube) is an edible fruit and traditional remedy used mainly for sleep, anxiety, and digestion. The fruit is a nutritious food, but human evidence for its medicinal benefits is li...
Read the full Zizyphus monograph → Herb & supplement monographTangerine
Interacts with 643 drugsTangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food. While the peel and essential oil are used in traditional medicine and...
Read the full Tangerine monograph → Herb & supplement monographLicorice
Interacts with 1,040 drugsLicorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regular licorice contains glycyrrhizin, whic...
Read the full Licorice monograph →Sources & How We Checked
Ginseng + Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 110 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Zizyphus 15 references
- Adzu, B., Amos, S., Dzarma, S., Wambebe, C., and Gamaniel, K. Effect of Zizyphus spina-christi Willd aqueous extract on the central nervous system in mice. J Ethnopharmacol. 2002;79(1):13-16.
- Cisse, A., Ndiaye, A., Lopez-Sall, P., Seck, F., Faye, B., and Faye, B. [Antidiabetic activity of Zizyphus mauritiana Lam (Rhamnaceae)]. Dakar Med 2000;45(2):105-107.
- Abdel-Zaher, A. O., Salim, S. Y., Assaf, M. H., and Abdel-Hady, R. H. Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. J Ethnopharmacol. 10-3-2005;101(1-3):129-138. PubMed
- Nesseem, D. I., Michel, C. G., Sleem, A. A., and El-Alfy, T. S. Formulation and evaluation of antihyperglycemic leaf extracts of Zizyphus spina-christi (L.) Willd. Pharmazie 2009;64(2):104-109. DOI
- Anand, K. K., Singh, B., Chand, D., Chandan, B. K., and Gupta, V. N. Effect of Zizyphus sativa leaves on blood glucose levels in normal and alloxan-diabetic rats. J Ethnopharmacol. 1989;27(1-2):121-127. PubMed
- Morishita, S., Mishima, Y., Hirai, Y., Saito, T., and Shoji, M. Pharmacological studies of water extract of the Zizyphus seed and the Zizyphus seed containing drug. Gen Pharmacol 1987;18(6):637-641. PubMed
- Watanabe, I., Saito, H., and Takagi, K. Pharmacological studies of Zizyphus seeds. Jpn J Pharmacol 1973;23(4):563-571. DOI
- Wu, S. X., Zhang, J. X., Xu, T., Li, L. F., Zhao, S. Y., and Lan, M. Y. [Effects of seeds, leaves and fruits of Ziziphus spinosa and jujuboside A on central nervous system function]. Zhongguo Zhong Yao Za Zhi 1993;18(11):685-4.
- Glombitza, K. W., Mahran, G. H., Mirhom, Y. W., Michel, K. G., and Motawi, T. K. Hypoglycemic and antihyperglycemic effects of Zizyphus spina-christi in rats. Planta Med 1994;60(3):244-247.
- Jarald, E. E., Joshi, S. B., and Jain, D. C. Antidiabetic activity of extracts and fraction of <it>Zizyphus mauritiana. Pharmaceutical Biology 2009;47:328-334.
- Ebrahimimd S, Ashkani-Esfahani S, Poormahmudibs A. Investigating the efficacy of zizyphus jujuba on neonatal jaundice. Iran J Pediatr. 2011 Sep;21(3):320-4.
- Hajhashemi V, Safaei A. Hypnotic effect of Coriandrum sativum, Ziziphus jujuba, Lavandula angustifolia and Melissa officinalis extracts in mice. Res Pharm Sci. 2015 Nov-Dec;10(6):477-84.
- Jing XY, Peng YR, Wang XM, Duan JA. Effects of Ziziphus jujuba fruit extracts on cytochrome P450 (CYP1A2) activity in rats. Chin J Nat Med. 2015 Aug;13(8):588-94. PubMed
- Irannejad Niri Z, Shidfar F, Jabbari M, et al. The effect of dried Ziziphus vulgaris on glycemic control, lipid profile, apo-proteins and hs-CRP in patients with type 2 diabetes mellitus: a randomized controlled clinical trial. J Food Biochem 2020; Mar 30
- Shergis JL, Hyde A, Meaklim H, Varma P, Da Costa C, Jackson ML. Medicinal seeds Ziziphus spinosa for insomnia: a randomized, placebo-controlled, cross-over, feasibility clinical trial. Complement Ther Med 2021;57:102657. PubMed
Tangerine 3 references
- Yuan, J. M., Wang, X. L., Xiang, Y. B., Gao, Y. T., Ross, R. K., and Yu, M. C. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85(3):358-363. DOI
- Backman, J. T., Maenpaa, J., Belle, D. J., Wrighton, S. A., Kivisto, K. T., and Neuvonen, P. J. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. Clin Pharmacol Ther 2000; PubMed
- Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed
Licorice 92 references
- Farese RV Jr, Biglieri EG, Shackleton CH, et al. Licorice-induced hypermineralocorticoidism. N Engl J Med 1991;325:1223-7. PubMed
- Sigurjonsdottir HA, Ragnarsson J, Franzson L, Sigurdsson G. Is blood pressure commonly raised by moderate consumption of liquorice? J Hum Hypertens 1995;9:345-8.
- Armanini D, Lewicka S, Pratesi C, et al. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. J Endocrinol Invest 1996;19:624-9. PubMed
- Zhang YD, Lorenzo B, Reidenberg MM. Inhibition of 11 beta hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. J Steroid Biochem Mol Biol 1994;49:81-5.
- Strandberg TE, Jarvenpaa AL, Vanhanen H, McKeigue PM. Birth outcome in relation to licorice consumption during pregnancy. Am J Epidemiol 2001;153:1085-8. PubMed
- Sigurjonsdottir HA, Franzson L, Manhem K, et al. Liquorice-induced rise in blood pressure: a linear dose-response relationship. J Hum Hypertens 2001;15:549-52. PubMed
- Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50. PubMed
- Kent UM, Aviram M, Rosenblat M, Hollenberg PF. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Drug Metab Dispos 2002;30:709-15.. PubMed
- Yoshida S, Takayama Y. Licorice-induced hypokalemia as a treatable cause of dropped head syndrome. Clin Neurol Neurosurg 2003;105:286-7.. PubMed
- Strandberg TE, Andersson S, Jarvenpaa AL, et al. Preterm birth and licorice consumption during pregnancy. Am J Epidemiol 2002;156:803-5.. PubMed
- Hussain RM. The sweet cake that reaches parts other cakes can't! Postgrad Med J 2003;79:115-6.. PubMed
- Morris DJ, Davis E, Latif SA. Licorice, tobacco chewing, and hypertension. N Engl J Med 1990;322:849-50. PubMed
- Quinkler M, Stewart PM. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 2003;88:2384-92. PubMed
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