Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Pankreon Ingredients & Drug Interactions

by GM Germa

Pankreon label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pankreon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pankreon is a dietary supplement by GM Germa with 6 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain, Barley Malt. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pankreon by GM Germa

Ask about any prescription or over-the-counter medication and we check it for interactions with Pankreon by GM Germa — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pankreon by GM Germa

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Pankreon contains six active ingredients: pepsin, pancreatin, barley malt, ox bile extract, betain, and papain. These are digestive enzymes and plant extracts meant to support digestion.

Pepsin breaks down protein; pancreatin is a mix of pancreatic enzymes; barley malt, ox bile, betain, and papain each play a role in the digestive process. The tablet also contains several inactive ingredients — dicalcium phosphate, microcrystalline cellulose, magnesium stearate, stearic acid, silica, and FD&C Brown — which are fillers, binders, and colorants.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Likely Effective" (Barley) (Natural Medicines).
  • On file: Hypercholesterolemia — rated "Likely Effective" (Barley) (Natural Medicines).

The data shows barley malt as likely effective for high cholesterol and coronary heart disease. For papain's uses — cancer, dental cavities, radiation skin damage, muscle soreness, shingles, and intestinal parasites — the evidence is insufficient to rate; we simply don't have reliable data yet.

Pepsin, pancreatin, ox bile extract, and betain don't have effectiveness ratings in our data.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Barley Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pepsin is generally well tolerated in adults but may cause digestive upset or allergic reactions. Barley malt is safe as a food (though it contains gluten), but concentrated barley supplements aren't well studied in pregnancy or breastfeeding.

Papain is tolerated as a food but can irritate the digestive tract and trigger allergies in sensitive people; concentrated papain and unripe papaya are best avoided in pregnancy, and there isn't enough safety data for supplemental papain while breastfeeding. Both pepsin and papain can rarely cause serious allergic reactions in people sensitive to proteolytic enzymes — symptoms may include throat tightness, swelling, breathing difficulty, or rash.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Barley Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Papain, Barley.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pankreon, double-check with your doctor or pharmacist if you take warfarin (a blood thinner) — papain may increase its effect and your bleeding risk. Also mention triclabendazole (an antiparasitic) if you use it, as barley malt might reduce how well it works.

If you take any other medications, run them through the search tool below to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Pankreon is a digestive enzyme blend that may help if you're looking for digestive support. If you take warfarin or triclabendazole, or if you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting — some ingredients have safety or interaction concerns that need individual review.

Check your exact medications with the tool on this page before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pankreon, straight from the product label.

Brand GM Germa
Barcode (UPC) 790933701302
Net contents 30 Tab(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 252960
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pankreon by GM Germa, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
790933701302
IngredientAmount% DV
Pepsin150 mg--
Pancreatin129 mg--
Barley Malt60 mg--
Ox Bile extract129 mg--
Betain60 mg--
Papain30 mg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Stearic Acid, Silica, FD&C Brown

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Use as a Dietary Supplement. Take 1 capsule a day, preferably with food or as directed by your doctor.

Precautions

Warning: Do not use If pregnant or nursing, ask a physician before use If taking any medication or have any medical condition

Warning: Do not use If allergic to any of the ingredients

Warning: Do not use If any adverse reactions occur.

Not intended for use by person under the age of 18.

In case of accidental overdose, get medical help or contact a Poison Control Center immediately. Do not use if either seal is torn, broken or missing

Keep out of the reach of children

Food allergy notice: Do not use this product if prone to allergic reaction from any of the ingredients.

Storage

Store at controlled room temperature between 15 degrees and 30 degrees C (59 degrees-86 degrees F).

Seals/Symbols

Made in USA

General Statements

Please Recycle Questions or Comments: 1-305-278-0033, M-F, 9-5 Eastern

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Enzymatic digestant Digestive aid

Promotes digestion health.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pankreon by GM Germa label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pankreon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pankreon by GM Germa

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pepsin

No known
interactions
150 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Pancreatin

129 mg per serving

Barley Malt

Interacts with
1 drug
60 mg per serving

Barley is a nutritious whole grain that is a good source of soluble fiber called beta-glucan, which has solid evidence for modestly lowering LDL ('bad...

Barley Malt monograph & interactions

Ox Bile extract

129 mg per serving

Betain

60 mg per serving

Papain

Interacts with
2 drugs
30 mg per serving Form: Carica papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Stearic Acid, Silica, FD&C Brown. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pankreon by GM Germa Drug Interactions

Want to check YOUR meds against Pankreon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Moderate

Ingredients driving the most interactions

Papain 2
Barley Malt 1

Individual Drug Interactions

The ingredients in Pankreon interact with 3 drugs. Click any drug to see the details.

2 of the 6 ingredients in Pankreon interact with drugs. Each result below shows which ingredient is responsible. Papain Barley Malt

Each ingredient & the kinds of drugs it affects

For each ingredient in Pankreon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions

Barley Malt1 drug type · 1 drug

Triclabendazole (Egaten)

Theoretically, barley might decrease the clinical effects of triclabendazole.
Animal research suggests that a diet supplemented with barley can reduce the bioavailability of triclabendazole when taken concomitantly. This effect has not been shown in humans.

Likelihood Possible Evidence D
Barley Malt full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pankreon, from the product label.

GM Germa

See all GM Germa products
Name
Germa Products, LLC
Street Address
13121 SW 122 Avenue
City
Miami
State
FL
ZipCode
33186
Phone Number
1-305-278-0033
Web Address
www.germa.net
Pharmacist Counseling Corner

Pankreon by GM Germa: Common Questions

Does Pankreon by GM Germa interact with any medications?
Yes. Based on its ingredients, Pankreon has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pankreon contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Pankreon contain gluten?
Yes — barley malt, one of the active ingredients, contains gluten. If you have celiac disease or gluten sensitivity, this product isn't for you.
Is it safe to take Pankreon while I'm pregnant?
The safety data is mixed. Barley malt is likely safe as a food but hasn't been well studied in concentrated supplement form during pregnancy. Pepsin safety hasn't been established in pregnancy, and papain is considered possibly unsafe. Talk with your doctor or pharmacist before taking it.
Can I take Pankreon while breastfeeding?
There isn't enough safety data for barley malt or papain supplements during breastfeeding. Pepsin safety while breastfeeding also isn't well studied. Check with your doctor or pharmacist to decide what's best for you and your baby.
What are the most common side effects?
Digestive upset — bloating, gas, abdominal distension — is most common. Allergic reactions are possible in sensitive people, especially to pepsin and papain. Stop and talk with your pharmacist if you notice symptoms like itching, swelling, rash, or trouble breathing.
Does barley malt in this product actually work for cholesterol?
Barley malt is rated likely effective for high cholesterol and heart disease based on the evidence. But it's one of six ingredients in this blend, so the overall effect depends on the full formula and your individual response.
Why can't you check some of the ingredients for drug interactions?
We don't hold monographs on pancreatin, ox bile extract, or betain, so we can't confirm whether they interact with medications. That doesn't mean they're safe with everything — just that the data isn't available to us. Your pharmacist can help you look those up separately if you're on prescription medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pankreon is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pankreon label
Go deeper

The Full Monographs Behind Pankreon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Barley

Interacts with 1 drug

Barley is a nutritious whole grain that is a good source of soluble fiber called beta-glucan, which has solid evidence for modestly lowering LDL ('bad') cholesterol when eaten regularly. It...

Read the full Barley monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Pankreon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Barley 15 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Fernandez-Anaya S, Crespo JF, Rodriguez JR, et al. Beer anaphylaxis. J Allergy Clin Immunol 1999;103:959-60.
  3. Lembo A, Camilleri M. Chronic constipation. N Engl J Med 2003;349:1360-8. . PubMed
  4. Ferre, I., Giraldez, F. J., Alvarez-Bujidos, M. L., and Mantecon, A. R. Influence of barley supplement on plasma concentration of triclabendazole metabolites in sheep. Vet.Rec. 11-22-1997;141(21):549-551. PubMed
  5. Curioni, A., Santucci, B., Cristaudo, A., Canistraci, C., Pietravalle, M., Simonato, B., and Giannattasio, M. Urticaria from beer: an immediate hypersensitivity reaction due to a 10- kDa protein derived from barley. Clin Exp Allergy 1999;29(3):407-413. PubMed
  6. Fernandez-Anaya, S., Crespo, J. F., Rodriguez, J. R., Daroca, P., Carmona, E., Herraez, L., and Lopez-Rubio, A. Beer anaphylaxis. J Allergy Clin Immunol. 1999;103(5 Pt 1):959-960.
  7. Cronin, E. Contact dermatitis from barley dust. Contact Dermatitis 1979;5(3):196. PubMed
  8. Block, G., Tse, K. S., Kijek, K., Chan, H., and Chan-Yeung, M. Baker's asthma. Studies of the cross-antigenicity between different cereal grains. Clin Allergy 1984;14(2):177-185.
  9. van Ketel, W. G. Immediate type allergy to malt in beer. Contact Dermatitis 1980;6(4):297-298. PubMed
  10. Ellis, H. J., Doyle, A. P., Day, P., Wieser, H., and Ciclitira, P. J. Demonstration of the presence of coeliac-activating gliadin-like epitopes in malted barley. Int Arch Allergy Immunol. 1994;104(3):308-310. PubMed
  11. Vidal, C. and Gonzalez-Quintela, A. Food-induced and occupational asthma due to barley flour. Ann Allergy Asthma Immunol. 1995;75(2):121-124.
  12. Gutgesell, C. and Fuchs, T. Contact urticaria from beer. Contact Dermatitis 1995;33(6):436-437. PubMed
  13. Baker, P. G. and Read, A. E. Oats and barley toxicity in coeliac patients. Postgrad.Med J 1976;52(607):264-268. PubMed
  14. Nakase, M., Usui, Y., Alvarez-Nakase, A. M., Adachi, T., Urisu, A., Nakamura, R., Aoki, N., Kitajima, K., and Matsuda, T. Cereal allergens: rice-seed allergens with structural similarity to wheat and barley allergens. Allergy 1998;53(46 Suppl):55-57. PubMed
  15. Pereira, F., Rafael, M., and Lacerda, M. H. Contact dermatitis from barley. Contact Dermatitis 1998;39(5):261-262. PubMed

See these in context on the Barley monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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