Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Pantethine Ingredients & Drug Interactions

by Allergy Research Group

Pantethine label
See full label image
Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pantethine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pantethine is a dietary supplement by Allergy Research Group with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pantethine by Allergy Research Group

Ask about any prescription or over-the-counter medication and we check it for interactions with Pantethine by Allergy Research Group — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Pantethine by Allergy Research Group

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Pantethine” is listed as a grouped ingredient — the label gives one combined amount (660 mg) without saying how much of each component you get.

This product contains one active ingredient: pantethine (also called pantesin), a form of pantothenic acid (vitamin B5). Pantethine is involved in energy production and fat metabolism in your body.

The capsule also contains two inactive ingredients — hydroxypropyl methylcellulose and L-leucine — which are used as binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support for high cholesterol and triglycerides.
  • We looked for evidence on: Hyperlipidemia, Hyperlipoproteinemia.
  • The strongest evidence on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia (Natural Medicines).
  • Also on file: Pantethine is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

Pantethine is possibly effective for hyperlipoproteinemia (an inherited condition affecting blood fats). For athletic performance, hyperlipidemia (high blood fat levels), and pantothenate kinase-associated neurodegeneration (PKAN), the evidence we hold isn't strong enough to rate whether it works.

The evidence, ingredient by ingredient Pantethine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantethine is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are mild gastrointestinal complaints — nausea, vomiting, diarrhea, bloating, flatulence, and epigastric discomfort (upper stomach discomfort).

Rarely, mild skin itching has been reported. There isn't enough reliable safety data to recommend it during pregnancy, and safety during breastfeeding hasn't been well studied — talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Pantethine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs like warfarin, apixaban, clopidogrel, or aspirin — pantethine may theoretically increase the risk of bleeding.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pantethine may help with certain inherited blood fat conditions, but the evidence for other uses is limited. It's generally well tolerated but can cause mild stomach upset.

If you take blood thinners or antiplatelet drugs, check with your doctor or pharmacist before starting — the combination may raise bleeding risk. Talk it over with your own healthcare provider to see if it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pantethine, straight from the product label.

Brand Allergy Research Group
Barcode (UPC) 713947750005
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 23, 2019
DSLD ID 208295
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pantethine by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
713947750005
IngredientAmount% DV
Pantethine660 mg--
Pantesin1.2 Gram(s)--

Other ingredients: Hydroxypropyl Methylcellulose, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Pantethine is a derivative of pantothenic acid (vitamin B5) and a key constituent of coenzyme A. Contains Pantesin, a high quality, pharmaceutical grade brand of pantethine.

Vitamin B5 Metabolite

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 1 or 2 capsules two times daily with meals, or as directed by a healthcare practitioner.

Storage

Keep in a cool, dry place, tightly capped.

Brand IP Statement(s)

Pantesin is a registered trademark of Kyowa Pharma Chemical Co., Ltd.

FDA Statement of Identity

Dietary Supplement

Formulation

Hypoallergenic

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pantethine by Allergy Research Group label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pantethine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pantethine by Allergy Research Group

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Pantethine

Interacts with
122 drugs
660 mg per serving

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantethine monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pantethine by Allergy Research Group Drug Interactions

Want to check YOUR meds against Pantethine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantethine 122

Individual Drug Interactions

The ingredients in Pantethine interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pantethine interact with drugs. Each result below shows which ingredient is responsible. Pantethine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pantethine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantethine1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantethine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pantethine, from the product label.

Allergy Research Group

See all Allergy Research Group products
Name
Allergy Research Group
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800.545.9960
Web Address
www.allergyresearchgroup.com
Pharmacist Counseling Corner

Pantethine by Allergy Research Group: Common Questions

Does Pantethine by Allergy Research Group interact with any medications?
Yes. Based on its ingredients, Pantethine has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pantethine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pantethine, and what does it do?
Pantethine is a form of pantothenic acid (vitamin B5) that your body uses for energy production and fat metabolism. It's the active ingredient in this supplement.
What are the most common side effects?
Mild gastrointestinal complaints are most common — nausea, diarrhea, bloating, flatulence, and upper stomach discomfort. Rarely, mild skin itching occurs. Most people tolerate it well.
Is pantethine safe if I'm pregnant or breastfeeding?
There isn't enough reliable safety data during pregnancy or breastfeeding to recommend it. Talk with your doctor or pharmacist — they can help you decide whether it's right for your situation.
Does pantethine work for high cholesterol?
Pantethine is possibly effective for hyperlipoproteinemia (an inherited blood fat disorder), but for general high cholesterol (hyperlipidemia), the evidence we hold isn't strong enough to say whether it works.
I take a blood thinner — can I take pantethine?
Pantethine may theoretically increase bleeding risk with blood thinners. Check with your doctor or pharmacist before taking it — they know your medications and can advise you safely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pantethine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pantethine label
Go deeper

The Full Monographs Behind Pantethine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph →
Sources

Sources & How We Checked

Pantethine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team