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Dietary supplement

Passion Flower 350 mg Ingredients & Drug Interactions

by NOW

Passion Flower 350 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Passion Flower 350 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Passion Flower 350 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, restlessness.Based on those ingredients, 836 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Passion Flower Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Passion Flower 350 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Passion Flower 350 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Passion Flower 350 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: passion flower aerial parts extract at 350 mg per capsule. The extract is made from the above-ground parts of the passion flower plant and is intended to support relaxation and sleep.

The capsule also contains inactive ingredients — maltodextrin, hypromellose, stearic acid, magnesium stearate, and silicon dioxide — which are fillers, binders, and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Calm mood and stress relief.
  • We looked for evidence on: Stress, Pre-procedural anxiety, Insomnia, Benzodiazepine withdrawal, Opioid withdrawal, Anxiety — and 2 related terms.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Passion Flower is rated "Possibly Effective" for Insomnia.
  • Also on file: Passion Flower is rated "Insufficient Reliable Evidence To Rate" for Benzodiazepine withdrawal, Stress, Opioid withdrawal.

Passion flower is rated possibly effective for insomnia and pre-procedural anxiety (nervousness before a medical procedure). For alcohol use disorder and benzoidazepine withdrawal, the evidence isn't established enough to rate how well it works.

If you're considering this for one of those other uses, there's not enough data in our files to say whether it'll help.

The evidence, ingredient by ingredient Passion Flower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Passion flower is generally well tolerated in the short term, but it does commonly cause drowsiness, dizziness, confusion, and occasionally hypersensitivity reactions. The safety data advises against use during pregnancy because of a lack of safety information and possible effects on the uterus.

There isn't enough safety data to recommend it while breastfeeding either. A rare case of severe nausea, vomiting, and heart rhythm changes has been reported with very high doses, though symptoms resolved after stopping the supplement.

Side effects, ingredient by ingredient Passion Flower

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Passion Flower.
  • The most serious interaction on file is rated Moderate.
  • For scale: 837 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check any sedative or anti-anxiety medications you're on — passion flower can add to their drowsy effects and that's a moderate concern. Also run through the checker for medications transported by OATP proteins and drugs metabolized by CYP3A4 enzymes, though those interactions are minor.

If you're unsure whether any of your prescriptions fall into these categories, your pharmacist can help you look them up.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Passion flower may help if you're dealing with insomnia or pre-procedure jitters, but drowsiness is common. If you take sedative medications or any regular prescriptions, check them against the interaction tool first.

Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or taking medications that your liver processes.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Passion Flower 350 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739047632
Net contents 90 Veg Capsule(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 313898
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Passion Flower 350 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
2 Veg Capsule(s)
Servings per container
45
UPC/BARCODE
733739047632
IngredientAmount% DV
Passion Flower Aerial Parts Extract700 mg--

Other ingredients: Maltodextrin, Hypromellose, Stearic Acid, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1-2 capsules daily as needed.

Formula

Passion Flower (Passiflora incarnata) has been used for centuries by Native North and South Americans to promote a calm mood. More recent scientific studies have indicated that certain constituents of Passion Flower may offer temporary relief from nervousness and feelings of stress. Passion Flower extracts have been shown to aid in relaxation, and to alleviate occasional, but minor tenseness and restlessness.

Triangle K (Kosher)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: This product may cause drowsiness.

For adults only. Keep out of reach of children.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish. tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product. Stress relief Standardized 3.5% extract Supports a calm mood

Non-GMO

Vegetarian/vegan

Made and quality tested in the USA with globally sourced ingredients.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish. tree nut or sesame ingredients.

FDA Statement of Identity

A Dietary Supplement

Seals/Symbols

Triangle K (Kosher)

GMP Quality Assured

General Statements

Botanicals/herbs Family owned since 1968.

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Passion Flower 350 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Passion Flower 350 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Passion Flower 350 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Passion Flower Aerial Parts Extract

Interacts with
836 drugs
700 mg per serving Form: Total Flavonoids

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Passion Flower Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Maltodextrin, Hypromellose, Stearic Acid, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Passion Flower 350 mg by NOW Drug Interactions

Want to check YOUR meds against Passion Flower 350 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
836Drugs
248 Moderate 588 Minor

Ingredients driving the most interactions

Passion Flower Aerial Parts Extract 836

Individual Drug Interactions

The ingredients in Passion Flower 350 mg interact with 836 drugs. Click any drug to see the details.

1 of the 1 ingredient in Passion Flower 350 mg interact with drugs. Each result below shows which ingredient is responsible. Passion Flower Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Passion Flower 350 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Passion Flower Aerial Parts Extract3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passion Flower Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Passion Flower 350 mg, from the product label.

NOW

See all NOW products
Name
NOW FOODS
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Passion Flower 350 mg by NOW: Common Questions

Does Passion Flower 350 mg by NOW interact with any medications?
Yes. Based on its ingredients, Passion Flower 350 mg has a known interaction with 836 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Passion Flower 350 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Yes, drowsiness is one of the most common side effects. That's actually why it may help with insomnia, but it also means you shouldn't drive or operate machinery after taking it. If you're sensitive to sedation, start with a lower dose and see how you feel.
Can I take this if I'm pregnant or breastfeeding?
No, the safety data advises against it during pregnancy because of potential effects on the uterus and lack of safety information. There's also not enough data to recommend it while breastfeeding. Talk with your doctor or pharmacist about what might be safer for you right now.
What is 'passion flower aerial parts extract'?
It's an extract made from the above-ground parts of the passion flower plant — the stems, leaves, and flowers. These parts contain the active compounds that give passion flower its calming properties.
Does this product actually help with sleep?
Passion flower is rated possibly effective for insomnia, meaning some evidence supports it, but it's not a sure thing. Results vary from person to person, and it's not as well-studied as some other sleep aids.
Can I take this with my anxiety medication?
It depends on what medication you take. If it's a sedative (like lorazepam or similar drugs), passion flower can add to its effects and cause extra drowsiness, which is a moderate concern. Check your exact medications with the tool on this page before combining them.
What are the inactive ingredients for?
Maltodextrin, hypromellose, stearic acid, magnesium stearate, and silicon dioxide are fillers and binders that help form and stabilize the capsule. They're not active ingredients and have no therapeutic role.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Passion Flower 350 mg label
Go deeper

The Full Monographs Behind Passion Flower 350 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph →
Sources

Sources & How We Checked

Passion Flower 350 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Passion Flower 19 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
  4. Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
  5. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
  6. Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
  7. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
  8. Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
  9. Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
  10. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
  11. Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
  12. Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
  13. Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
  14. Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
  15. Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
  16. Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018 Feb;36:30-32. PubMed
  17. da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
  18. Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
  19. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Passion Flower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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