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Dietary supplement

Hemp Seed Oil 1000 mg Ingredients & Drug Interactions

by NOW

Hemp Seed Oil 1000 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hemp Seed Oil 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hemp Seed Oil 1000 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 938 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Hemp seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hemp Seed Oil 1000 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Hemp Seed Oil 1000 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hemp Seed Oil 1000 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic hemp seed oil at 1000 mg per softgel capsule. Hemp seed oil is derived from the seeds of the hemp plant and is distinct from cannabis extracts or products containing cannabinoids (the compounds that produce a high).

The inactive ingredients are the softgel capsule itself and D-alpha-tocopherol (vitamin E), which serves as a preservative.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: essential fats and omega fatty acids.
  • We looked for evidence on: cardiovascular health, skin health, inflammation.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold on hemp seed oil doesn't support strong claims about what it does. Effectiveness ratings for constipation, atopic dermatitis (a type of eczema), and familial hypercholesterolemia (an inherited cholesterol condition) are all listed as insufficient reliable evidence to rate.

That means the studies so far aren't robust enough to say whether it works for these purposes. If you're considering it for a specific health goal, talk it over with your doctor or pharmacist.

The evidence, ingredient by ingredient Hemp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hemp seed oil from food amounts is generally well tolerated. In supplement form at the doses typically taken, it also appears to be well tolerated overall.

However, concentrated extracts and supplements are less well studied than hemp seed foods, so caution is warranted. Rare but serious adverse effects reported in isolated cases include anaphylaxis, long QT syndrome (an abnormal heart rhythm), and syncope (fainting).

Allergic reactions to hemp seed — including hives, facial swelling, and shortness of breath — have been documented in uncommon cases, usually on first exposure. There is also a case report of elevated liver enzymes and hepatitis in a young child given very high doses of hemp extract for seizures, though that involved phytocannabinoids at doses far exceeding what's in this product.

Side effects, ingredient by ingredient Hemp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 939 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your own doctor or pharmacist if you're on estrogens (birth control or hormone replacement therapy) — this is a Moderate concern. Also flag it if you take blood pressure medications (ACE inhibitors or other antihypertensives), blood thinners (anticoagulants or antiplatelet drugs), or medications processed through your liver's CYP1A2 or CYP3A4 pathways, as hemp seed oil may reduce their effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

NOW Hemp Seed Oil is generally well tolerated in supplement doses, but it does have documented interactions with estrogens, blood pressure medications, blood thinners, and certain other drugs your liver processes. If you take any prescription medications — especially hormone therapy, blood pressure drugs, or blood thinners — check with your doctor or pharmacist before starting this product.

The evidence on whether it actually works for specific conditions isn't strong yet, so be clear on why you're considering it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hemp Seed Oil 1000 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739017994
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244613
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hemp Seed Oil 1000 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
733739017994
IngredientAmount% DV
Calories10 Calorie(s)--
Total Fat1 Gram(s)1%
organic Hemp seed Oil1 Gram(s)--

Other ingredients: Softgel Capsule, D-Alpha-Tocopherol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 softgel 1 to 3 times daily with food.

Formula

NOW Hemp Seed Oil Softgels are a convenient way to get your essential fats. Hemp seed oil has a unique and impressive fatty acid profile that consists mainly of the omega-6 essential fatty acids, linoleic acid and gamma-linolenic acid (GLA), and the omega-3, alpha-linolenic acid. The omega-6 to omega-3 ratio of hemp oil is approximately 3:1, which is considered to be ideal.

Nutritional oil Essential fatty acids

Each serving may typically have the following naturally occurring amounts of polyunsaturated fats and monounsaturated fats: alpha-linolenic acid (omega-3) 21%; linoleic acid and gamma-linolenic acid (GLA) (omega-6) 57%; oleic acid (omega-9) 13%; other (saturated) 9%

Precautions

Caution: For adults only. May cause mild temporary gastro-intestinal disturbances.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish or shellfish ingredients.

Natural color variation may occur in this product.

Non-GMO

Seals/Symbols

GMP Quality Assured

FDA Statement of Identity

A Dietary Supplement

General Statements

Family owned since 1968.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hemp Seed Oil 1000 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hemp Seed Oil 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hemp Seed Oil 1000 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Organic Hemp seed Oil

Interacts with
938 drugs
1 Gram(s) per serving

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...

Organic Hemp seed Oil monograph & interactions

Other (inactive) ingredients: Softgel Capsule, D-Alpha-Tocopherol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hemp Seed Oil 1000 mg by NOW Drug Interactions

Want to check YOUR meds against Hemp Seed Oil 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
938Drugs
41 Moderate 897 Minor

Ingredients driving the most interactions

organic Hemp seed Oil 938

Individual Drug Interactions

The ingredients in Hemp Seed Oil 1000 mg interact with 938 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hemp Seed Oil 1000 mg interact with drugs. Each result below shows which ingredient is responsible. organic Hemp seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Hemp Seed Oil 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Hemp seed Oil6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
organic Hemp seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hemp Seed Oil 1000 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Hemp Seed Oil 1000 mg by NOW: Common Questions

Does Hemp Seed Oil 1000 mg by NOW interact with any medications?
Yes. Based on its ingredients, Hemp Seed Oil 1000 mg has a known interaction with 938 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hemp Seed Oil 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does hemp seed oil get you high?
No. Hemp seed oil is made from the seeds of the hemp plant and doesn't contain cannabinoids — the compounds that produce a high. You won't experience any psychoactive effects from this product.
What are the side effects?
Most people tolerate hemp seed oil well. Rare serious side effects reported in isolated cases include allergic reactions (hives, facial swelling, shortness of breath), anaphylaxis, and heart rhythm problems. Allergy to hemp seed itself is uncommon but can happen, often on first exposure.
Is this safe to take during pregnancy or while breastfeeding?
We don't have safety data on file for hemp seed oil during pregnancy or lactation. Talk with your doctor or pharmacist about whether it's right for you in these situations — they can weigh the specific risks and benefits for your individual health.
Will this actually help with my eczema (or constipation, or cholesterol)?
The evidence we have isn't strong enough to say. Effectiveness ratings for all three conditions are listed as insufficient reliable evidence to rate, meaning studies to date haven't been robust enough to confirm whether it works.
Why are there so many drug interactions listed?
The 939 interactions mainly stem from hemp's ability to speed up how your liver processes certain drugs through two enzyme systems (CYP1A2 and CYP3A4). That affects a large number of medications. However, many of these interactions are theoretical — based on lab research rather than human studies — so severity varies.
What's the D-alpha-tocopherol in this product?
D-alpha-tocopherol is vitamin E. It's used as a preservative in this softgel to keep the hemp seed oil from going rancid.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hemp Seed Oil 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hemp Seed Oil 1000 mg label
Go deeper

The Full Monographs Behind Hemp Seed Oil 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph →
Sources

Sources & How We Checked

Hemp Seed Oil 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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