Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Pau D'Arco Bark Ingredients & Drug Interactions

by Indiana Botanic Gardens

Pau D'Arco Bark label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco Bark against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco Bark is a dietary supplement by Indiana Botanic Gardens with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco (bark) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pau D'Arco Bark by Indiana Botanic Gardens

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco Bark by Indiana Botanic Gardens — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Pau D'Arco Bark by Indiana Botanic Gardens

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pau d'arco bark extract. Pau d'arco is a tree bark traditionally used in herbal practice, and this liquid form also includes glycerin and water as inactive ingredients to deliver it.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pau D'arco product and its label doesn't state a use — see Pau D'arco's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pau d'arco isn't established in the data we hold. The product has been studied for cancer, peptic ulcers, wound healing, and painful menstrual periods, but in each case there's insufficient reliable evidence to say whether it works.

If you're thinking about it for one of these uses, that's worth discussing with your doctor — they can help you weigh what's known and what's not.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at lower doses, but human safety data is limited. At higher doses — particularly when the lapachol compound reaches above 1.5 grams daily — it may cause anemia, nausea, vomiting, diarrhea, and increased bleeding risk.

Occupational exposure to pau d'arco sawdust can trigger asthma and severe skin reactions, though that's less likely from taking the supplement itself. Don't use this product during pregnancy — the safety data advises against it due to possible harm to a developing baby.

There isn't enough data to know if it's safe while breastfeeding, so talk with your doctor or pharmacist before using it then.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs (warfarin, dabigatran, aspirin, clopidogrel, and many others), check with your doctor or pharmacist before adding this product. The Moderate interaction could raise your bleeding risk, particularly at higher doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'arco may be worth considering if you're interested in exploring it for its traditional uses, but the evidence for its effectiveness isn't established yet. The main caution is bleeding risk if you take blood thinners or antiplatelet drugs.

Before you start, clear it with your own doctor or pharmacist — especially if you're on any clot-prevention medication, pregnant, or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco Bark, straight from the product label.

Brand Indiana Botanic Gardens
Barcode (UPC) 703308200041
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Aug 22, 2017
DSLD ID 76987
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco Bark by Indiana Botanic Gardens, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
UPC/BARCODE
703308200041
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Pau d'Arco (bark) extract70 mg--

Other ingredients: Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 mL (approx. 28 drops) three times daily, in a small amount of water.

Best if used by date on bottle.

Shake well.

Precautions

Warning: If you are taking any medications or are pregnant or nursing do not use prior to consulting a physician.

Use only if seal is unbroken

Keep out of reach of children

Storage

Store in a dry, cool place.

Formulation

Alcohol free liquid extract

FDA Statement of Identity

Herbal Supplement

Brand IP Statement(s)

IBG Indiana Botanic Gardens

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco Bark by Indiana Botanic Gardens label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco Bark label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco Bark by Indiana Botanic Gardens

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Amounts shown are per serving.

Pau d'Arco (bark) extract

Interacts with
122 drugs
70 mg per serving

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco (bark) extract monograph & interactions

Other (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau D'Arco Bark by Indiana Botanic Gardens Drug Interactions

Want to check YOUR meds against Pau D'Arco Bark?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco (bark) extract 122

Individual Drug Interactions

The ingredients in Pau D'Arco Bark interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau D'Arco Bark interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco (bark) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco Bark with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco (bark) extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco (bark) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco Bark, from the product label.

Indiana Botanic Gardens

See all Indiana Botanic Gardens products
Name
Indiana Botanic Gardens, Inc.
Street Address
3401 W. 37th Ave.
City
Hobart
State
IN
ZipCode
46342
Phone Number
1-800-644-8327
Web Address
www.botanicchoice.com
Pharmacist Counseling Corner

Pau D'Arco Bark by Indiana Botanic Gardens: Common Questions

Does Pau D'Arco Bark by Indiana Botanic Gardens interact with any medications?
Yes. Based on its ingredients, Pau D'Arco Bark has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco Bark contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take pau d'arco if I'm on aspirin or a blood thinner?
Not without checking first. Pau d'arco may increase bleeding risk when combined with these medications. Talk with your doctor or pharmacist about your specific drugs before starting it.
Is pau d'arco safe during pregnancy or breastfeeding?
No — avoid it during pregnancy due to possible harm to the baby. There isn't enough safety data for breastfeeding either, so talk with your doctor or pharmacist if you're considering it during that time.
Does pau d'arco really work for cancer or ulcers?
The evidence isn't established in the data we hold. It's been studied for both, but so far there isn't reliable evidence to say it does or doesn't. Your doctor can discuss what's known and what alternatives might be better supported.
What are the side effects if I take too much?
At doses above 1.5 grams daily of the lapachol compound, users have reported nausea, vomiting, diarrhea, anemia, and increased bleeding. Stick to the product's label directions and talk with your pharmacist if you're unsure about the dose.
Is this product free of fillers and additives?
This liquid form includes glycerin and water as inactive ingredients alongside the pau d'arco extract itself. These help deliver the active ingredient but aren't the active ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco Bark is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco Bark label
Go deeper

The Full Monographs Behind Pau D'Arco Bark’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco Bark's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team