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Dietary supplement

Pau D'Arco Ingredients & Drug Interactions

by Nature's Sunshine

Pau D'Arco label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco is a dietary supplement by Nature's Sunshine with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau D'Arco by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco by Nature's Sunshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pau D'Arco by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pau d'arco, a botanical extract from the pau d'arco tree. Pau d'arco has been used traditionally for various purposes, though modern evidence for those uses remains limited.

There are no inactive fillers or other ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: detoxification and immune and circulatory support.
  • We looked for evidence on: immune function, circulation, detoxification.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for pau d'arco's effectiveness is not established in the data we hold. The product's label indicates insufficient reliable evidence to rate its use for cancer, peptic ulcers, wound healing, and dysmenorrhea.

If you're considering it for a specific health concern, talk with your doctor or pharmacist about what the current science actually supports.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at standard doses, but caution is warranted at higher doses—human safety data is limited. The lapachol constituent, in doses above 1.5 grams daily, may cause anemia, increased bleeding risk, severe nausea, vomiting, and diarrhea.

Occupational exposure to pau d'arco sawdust can cause asthma and dermatitis, though this is mainly a concern for those handling the wood directly. The safety data advises against pau d'arco during pregnancy due to possible harm to the developing baby and lack of safety data.

There isn't enough information to know whether it's safe while breastfeeding, so talk with your doctor or pharmacist for personalized advice if you're nursing.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pau D'Arco, double-check your medications if you take blood thinners or antiplatelet drugs (such as warfarin, clopidogrel, or aspirin). A Moderate interaction is documented in our data, and the risk of increased bleeding is real—especially at higher doses.

Use the search tool on this page to confirm your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'arco is a single-ingredient botanical with limited evidence for any specific use and a Moderate interaction risk with blood thinners and antiplatelet medications. If you take any of those drugs, check with your doctor or pharmacist before starting this product.

Pregnancy and breastfeeding are situations where you'll want personalized guidance from your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco, straight from the product label.

Brand Nature's Sunshine
Net contents 7 Oz(s); 200 Gram(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 278197
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Gram(s)
Maximum serving Sizes:
7 Gram(s)
Servings per container
28
IngredientAmount% DV
Pau d'Arco7 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Natures Sunshine Herbal experts since 1972

Formulation

Traditionally herbal support for detoxification and to help maintain a healthy circulatory system. Immune system support

Nature's sunshine uses natural source materials that are subject to color variation.

Guaranteed pure

FDA Statement of Identity

Dietary Supplement

Formula

Pau D'Arco bark, also known as taheebo, is traditionally used for detoxification as well as support for immune and circulatory systems.

Ko Pareve (Kosher)

General Statements

New look! Same great product We source the world's purest ingredients, no matter where they are grown, to ensure the active nutrients are delivered just as nature intended.

The weight stated on the bag is correct; product settles during shipping.

We are committed to you and our planet. Scan to learn more.

Suggested/Recommended/Usage/Directions

Recommended use: Add 1 tablespoon (7 grams) to 8-12 ounces of boiling water and remove from heat. Steep for 20 minutes and strain before enjoying.

Precautions

This bag has been sealed for your protection. Do not use if the seal is open or damaged.

Seals/Symbols

Ko Pareve (Kosher)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco by Nature's Sunshine

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size7 Gram(s) Dosage formPowder Servings per container28 Amounts shown are per serving.

Pau d'Arco

Interacts with
122 drugs
7 Gram(s) per serving

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco monograph & interactions
Interaction report

Pau D'Arco by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Pau D'Arco?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco 122

Individual Drug Interactions

The ingredients in Pau D'Arco interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau D'Arco interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc.
City
Spanish Fork
State
UT
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Pau D'Arco by Nature's Sunshine: Common Questions

Does Pau D'Arco by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Pau D'Arco has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No. The safety data advises against pau d'arco during pregnancy because of possible harm to the developing baby and lack of safety data. Talk with your doctor or pharmacist about whether this product is right for you.
Is it safe while breastfeeding?
There isn't enough information to know whether it's safe while nursing. Talk with your doctor or pharmacist before taking it if you're breastfeeding.
Does pau d'arco actually work for cancer, ulcers, or wound healing?
The evidence isn't established. We have insufficient reliable evidence to rate pau d'arco for cancer, peptic ulcers, wound healing, or dysmenorrhea. If you're considering it for any of these, discuss your options with your doctor.
What side effects should I watch for?
At standard doses, side effects are uncommon. But at higher doses—especially above 1.5 grams daily of the lapachol constituent—nausea, vomiting, diarrhea, anemia, and increased bleeding risk are possible. If you experience any of these, stop taking it and talk with your pharmacist.
Is this powder safe to breathe in while handling it?
The powder itself from the capsule should be fine, but occupational exposure to pau d'arco sawdust (a concern mainly for woodworkers) can trigger asthma and dermatitis. If you have respiratory sensitivities, handle the product normally and you should be okay.
Does this product have fillers or other ingredients besides pau d'arco?
No. This product contains only the active ingredient pau d'arco—no other fillers or excipients are listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco label
Go deeper

The Full Monographs Behind Pau D'Arco’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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