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Dietary supplement

Pennyroyal Ingredients & Drug Interactions

by TerraVita

Pennyroyal label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pennyroyal against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pennyroyal is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for digestive upset, menstrual cramps, inducing menstruation or abortion (dangerous).Based on those ingredients, 69 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pennyroyal Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pennyroyal by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Pennyroyal by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pennyroyal by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pennyroyal glycerite liquid extract. The only other ingredient is glycerin, which is an inactive ingredient used to hold the extract in liquid form.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pennyroyal product and its label doesn't state a use — see Pennyroyal's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence isn't established in our data for any of pennyroyal's traditional uses — gallbladder disease, gout, insect repellent, cold symptoms, pneumonia, and canker sores all fall into insufficient evidence territory. That means we don't have reliable studies backing its use for these purposes.

The evidence, ingredient by ingredient Pennyroyal

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pennyroyal carries serious safety concerns. The essential oil form is highly toxic and has caused liver failure and death — the active compounds in it, particularly pulegone and its metabolite menthofuran, damage the liver.

Even the leaf tea can cause dizziness, nausea, and stomach cramping. Pregnancy and breastfeeding: the safety data advises against pennyroyal in both.

It's rated likely unsafe because it can cause abortion and severe poisoning. Do not use if you're pregnant, trying to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Pennyroyal

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pennyroyal.
  • The most serious interaction on file is rated Moderate.
  • For scale: 69 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check acetaminophen (Tylenol and products containing it) before you take this product — the combination raises your risk of liver damage. This is the only medication type with documented interaction data in our records for pennyroyal.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pennyroyal isn't recommended as a supplement. Its traditional uses aren't backed by solid evidence, and the safety risks — especially liver damage — outweigh any potential benefit.

If you're considering it, talk with your pharmacist or doctor first, and absolutely avoid it if you're pregnant, breastfeeding, or regularly taking acetaminophen.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pennyroyal, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435228224
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279522
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pennyroyal by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435228224
IngredientAmount% DV
Pennyroyal Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free No flavor

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pennyroyal by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pennyroyal label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pennyroyal by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Pennyroyal Glycerite Liquid Extract

Interacts with
69 drugs
0.13 mL per serving

Pennyroyal is a mint-family plant whose essential oil is highly toxic and has caused serious poisonings and deaths, especially when used to try to bri...

Pennyroyal Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pennyroyal by TerraVita Drug Interactions

Want to check YOUR meds against Pennyroyal?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
69Drugs
69 Moderate

Ingredients driving the most interactions

Pennyroyal Glycerite Liquid Extract 69

Individual Drug Interactions

The ingredients in Pennyroyal interact with 69 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pennyroyal interact with drugs. Each result below shows which ingredient is responsible. Pennyroyal Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pennyroyal with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pennyroyal Glycerite Liquid Extract1 drug type · 69 drugs

Acetaminophen (Tylenol, Others)

Concomitant use of pennyroyal essential oil and acetaminophen might increase the risk of acetaminophen-induced hepatotoxicity.
Pennyroyal is hepatotoxic and depletes hepatic glutathione levels in a similar manner to acetaminophen. A case report describes hepatic failure in a female who took pennyroyal and acetaminophen concurrently.

Likelihood Possible Evidence D
Pennyroyal Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pennyroyal, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Pennyroyal by TerraVita: Common Questions

Does Pennyroyal by TerraVita interact with any medications?
Yes. Based on its ingredients, Pennyroyal has a known interaction with 69 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pennyroyal contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is pennyroyal safe to use while I'm pregnant or breastfeeding?
No. Pennyroyal is rated likely unsafe in both pregnancy and breastfeeding. It can cause abortion and severe poisoning, so it should never be used during these times.
What are the most common side effects if I take pennyroyal leaf tea?
Pennyroyal leaf tea typically causes mild side effects: dizziness, nausea, and abdominal cramping. The essential oil form carries much more serious risks.
Why is pennyroyal dangerous?
The active compounds in pennyroyal — especially pulegone and menthofuran — are directly toxic to your liver. These same compounds can also cause abortion. In severe cases, pennyroyal has caused liver failure and death.
Can I take pennyroyal if I use Tylenol or other pain relievers?
You should not. Pennyroyal and acetaminophen (Tylenol) both stress your liver in similar ways, and using them together increases your risk of liver damage. A case report documented liver failure from this combination.
Does pennyroyal actually work for colds, gout, or other conditions?
We don't have reliable evidence that it works for any of these uses — gallbladder disease, gout, insect repellent, colds, pneumonia, or canker sores all have insufficient evidence. You'd be taking a serious safety risk without proven benefit.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pennyroyal label
Go deeper

The Full Monographs Behind Pennyroyal’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pennyroyal

Interacts with 69 drugs

Pennyroyal is a mint-family plant whose essential oil is highly toxic and has caused serious poisonings and deaths, especially when used to try to bring on a period or end a pregnancy. There...

Read the full Pennyroyal monograph →
Sources

Sources & How We Checked

Pennyroyal's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pennyroyal 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Bakerink JA, Gospe SM Jr, Dimand RJ, Eldridge MW. Multiple organ failure after ingestion of pennyroyal oil from herbal tea in two infants. Pediatrics 1996;98:944-7. DOI
  5. Sudekum M, Poppenga RH, Raju N, Braselton WE Jr. Pennyroyal oil toxicosis in a dog. J Am Vet Med Assoc 1992;200:817-8.. DOI
  6. Anderson IB, Mullen WH, Meeker JE, et al. Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature. Ann Intern Med 1996;124:726-34. PubMed
  7. Sullivan JB Jr, Rumack BH, Thomas H Jr, et al. Pennyroyal oil poisoning and hepatotoxicity. JAMA 1979;242:2873-4. DOI
  8. Fozard J, Hieger M. Hepatic failure from pennyroyal tea interaction with medications metabolized by the cytochrome P450 enzymes. Am J Ther 2019 Aug 13. doi: 10.1097/MJT.0000000000001052. [Epub ahead of print]. PubMed

See these in context on the Pennyroyal monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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