Interactions on record — worth a quick check against your medications. Based on 1 of 6 ingredients. Check your meds →
Dietary supplement

Pepti-Plex Ingredients & Drug Interactions

by SNS Serious Nutrition Solutions

Pepti-Plex label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pepti-Plex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pepti-Plex is a dietary supplement by SNS Serious Nutrition Solutions with 6 active ingredients. Its ingredients are commonly taken for flavoring and culinary use, digestive complaints like bloating and indigestion, boosting absorption of other supplements.Based on those ingredients, 1,019 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BioPerine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pepti-Plex by SNS Serious Nutrition Solutions

Ask about any prescription or over-the-counter medication and we check it for interactions with Pepti-Plex by SNS Serious Nutrition Solutions — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pepti-Plex by SNS Serious Nutrition Solutions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Pepti-Plex contains six active ingredients. BioPerine is black pepper extract, included to boost how your body absorbs other nutrients.

The other five actives — AstraGin, PeptiStrong, VasoFlo+, ApiPure, and Senactiv — are branded ingredients we cannot fully verify. The capsules also contain inactive ingredients: cellulose, rice flour, and magnesium stearate (a binder).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Black Pepper's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: natural anabolic muscle builder and strength.
  • We looked for evidence on: Athletic performance, Fatigue, muscle growth, lean mass, exercise recovery.
  • The closest evidence on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Fatigue.

We hold no effectiveness ratings for any of the six active ingredients in this product. The evidence supporting Pepti-Plex for specific health outcomes isn't established in our data.

Talk with your pharmacist or doctor about whether this supplement is right for what you're trying to achieve.

The evidence, ingredient by ingredient Black Pepper

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black pepper (BioPerine) is generally well tolerated when used in food amounts or as a single medicinal dose. The most common side effects are a burning aftertaste, indigestion, and reduced taste perception.

When inhaled, it can cause cough. Rare serious reactions — allergic responses including hives, facial swelling, and severe cough — have been reported in sensitive people.

Because concentrated piperine supplements aren't as well studied as dietary amounts, use caution and avoid them without talking to your doctor first. We have no pregnancy or breastfeeding safety data on file for any of these ingredients, so if you're pregnant, planning pregnancy, or breastfeeding, check with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Black Pepper

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Black Pepper.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,020 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before using if you take seizure medications like phenytoin (Dilantin), heart or blood pressure drugs like propranolol (Inderal), cholesterol medications like atorvastatin (Lipitor), breathing medications like theophylline, HIV drugs like nevirapine (Viramune), tuberculosis treatments like rifampin (Rifadin), sedatives like pentobarbital (Nembutal), or the immunosuppressant cyclosporine (Neoral, Sandimmune). Altogether, these interactions span 1,005 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Pepti-Plex is designed to support nutrient absorption, but we have no effectiveness data for it in our records. If you take any seizure, heart, blood pressure, cholesterol, breathing, HIV, tuberculosis, or sleep medications, you need to check with your pharmacist first — BioPerine can significantly affect how your body handles these drugs.

Ask about your specific prescriptions before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pepti-Plex, straight from the product label.

Brand SNS Serious Nutrition Solutions
Net contents 120 Veg Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 318428
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pepti-Plex by SNS Serious Nutrition Solutions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Veg Capsule(s)
Maximum serving Sizes:
4 Veg Capsule(s)
Servings per container
30
IngredientAmount% DV
BioPerine10 mg--
AstraGin50 mg--
PeptiStrong2400 mg--
VasoFlo+300 mg--
ApiPure50 mg--
Senactiv50 mg--

Other ingredients: Cellulose, Rice Flour, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Next generation natural anabolic muscle builder Powered by A.I. discovered natural anabolic peptides The future of natural anabolic supplementation has arrived Pepti-Plex is next generation natural anabolic muscle building supplement that is designed to help you gain and maintain lean muscle and strength. Pepti-Plex highlights/supports: Lean muscle & strength Fat loss & improved body-composition Improved endurance, stamina & recovery Lean muscle retention while dieting & aging Powerful anabolic & anti-catabolic properties MTOR activation & improved protein synthesis Increased ribosomal biogenesis & cell signaling Muscle growth & retention thru gene targeting Muscle health, longevity, & anti-aging properties Senolytic properties - Promotes senescent cell clearance Powered by multiple novel muscle building ingredients

GMP Good Manufacturing Practice Product

Supports: Lean muscle & strength Improved endurance & recovery Powerful anabolic & anti-catabolic properties Cell signaling & gene targeting natural anabolic Next generation natural anabolic muscle builder

Allergen information: Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish, or tree nuts ingredients.

Suggested/Recommended/Usage/Directions

SNS Pepti-Plex can be stacked with Anabolic XT, Phosphatidic Acid XT, Optimize-T, VasoForce XT, Focus XT, Recomp20, or a variety of other SNS products for improved synergistic results.

Suggested use: As a dietary supplement, take 4 capsules per day. You may take 4 capsules in the morning or 2 capsules twice per day, with or without food.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

To report a serious adverse event, or obtain product information, contact SNS at [email protected]

Formula

A.I. discovered natural anabolic peptides

Powered by Nutitas Cell-Signaling Technology by Natura 2400mg PeptiStrong 300mg VasoFlo+ 50mg ApiPure 50mg Senactiv

FDA Statement of Identity

Dietary Supplement

Precautions

Allergen information: Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish, or tree nuts ingredients. Produced in a GMP facility that may process other ingredients containing these allergens.

Warning: This product is intended for healthy adults over 18 years of age. Keep stored in a cool, dry place away from children and animals.

Do not use this product if you are pregnant or nursing. Consult your physician before using this or any dietary supplement, especially if you are taking any medication or suffer from any health condition(s).

Storage

Keep stored in a cool, dry place away from children and animals.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pepti-Plex by SNS Serious Nutrition Solutions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pepti-Plex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pepti-Plex by SNS Serious Nutrition Solutions

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Veg Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

BioPerine

Interacts with
1,019 drugs
10 mg per serving Form: Black Pepper Fruit Extract

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

BioPerine monograph & interactions

AstraGin

50 mg per serving Form: Astragalus membranaceus root extract, Panax notoginseng root extract

PeptiStrong

2400 mg per serving Form: Fava Bean, Hydrolysate

VasoFlo+

300 mg per serving Form: Green Tea Leaf Extract, Black Tea leaf extract

ApiPure

50 mg per serving Form: Apigenin

Senactiv

50 mg per serving Form: Panax notoginseng, Rosa roxburghii

Other (inactive) ingredients: Cellulose, Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pepti-Plex by SNS Serious Nutrition Solutions Drug Interactions

Want to check YOUR meds against Pepti-Plex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,019Drugs
976 Moderate 43 Minor

Ingredients driving the most interactions

BioPerine 1,019

Individual Drug Interactions

The ingredients in Pepti-Plex interact with 1,019 drugs. Click any drug to see the details.

1 of the 6 ingredients in Pepti-Plex interact with drugs. Each result below shows which ingredient is responsible. BioPerine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pepti-Plex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

BioPerine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
BioPerine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pepti-Plex, from the product label.

SNS Serious Nutrition Solutions

See all SNS Serious Nutrition Solutions products
Name
Serious Nutrition Solutions, LLC
City
Danville
State
VA
ZipCode
24540
Web Address
www.SeriousNutritionSolutions.com
Pharmacist Counseling Corner

Pepti-Plex by SNS Serious Nutrition Solutions: Common Questions

Does Pepti-Plex by SNS Serious Nutrition Solutions interact with any medications?
Yes. Based on its ingredients, Pepti-Plex has a known interaction with 1,019 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pepti-Plex contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does BioPerine do in this product?
BioPerine is black pepper extract. It's included to help your body absorb the other ingredients more efficiently. It works by affecting how your body processes certain compounds.
What side effects can black pepper cause?
Most people tolerate black pepper well. The common side effects are a burning aftertaste, indigestion, and sometimes a change in taste. Inhaling black pepper can trigger cough. Rare allergic reactions (hives, swelling, severe cough) have happened in sensitive individuals.
Is Pepti-Plex safe during pregnancy?
We don't have pregnancy safety data on file for any of the six active ingredients in this product. Talk with your doctor or pharmacist before using it if you're pregnant, planning pregnancy, or breastfeeding.
What are the other five ingredients besides BioPerine?
The product contains AstraGin, PeptiStrong, VasoFlo+, ApiPure, and Senactiv — all branded ingredients meant to support digestion and absorption. We don't hold monograph data on these, so we can't tell you much more about them.
Does this product have fillers?
Yes, it contains three inactive ingredients: cellulose, rice flour, and magnesium stearate. These are standard binders and fillers used in capsule supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pepti-Plex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pepti-Plex label
Go deeper

The Full Monographs Behind Pepti-Plex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph →
Sources

Sources & How We Checked

Pepti-Plex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Pepper 29 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
  4. Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
  5. Cohle SD, Trestrail JD III, Graham MA, et al. Fatal pepper aspiration. Am J Dis Child 1988;142:633-6. PubMed
  6. Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. PubMed
  7. Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. PubMed
  8. Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
  9. Munakata, M., Kobayashi, K., Niisato-Nezu, J., Tanaka, S., Kakisaka, Y., Ebihara, T., Ebihara, S., Haginoya, K., Tsuchiya, S., and Onuma, A. Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term en
  10. Myers, B. M., Smith, J. L., and Graham, D. Y. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 1987;82(3):211-214.
  11. Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81(1):73-78. PubMed
  12. Subehan, Usia, T., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. Planta Med 2006;72(6):527-532.
  13. Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391. PubMed
  14. Usia, T., Iwata, H., Hiratsuka, A., Watabe, T., Kadota, S., and Tezuka, Y. CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Phytomedicine. 2006;13(1-2):67-73. PubMed
  15. Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487.
  16. Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526. PubMed
  17. Lawless, H. and Stevens, D. A. Effects of oral chemical irritation on taste. Physiol Behav. 1984;32(6):995-998. PubMed
  18. Hiwale, A. R., Dhuley, J. N., and Naik, S. R. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp.Biol. 2002;40(3):277-281.
  19. Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289. PubMed
  20. Sharma, P., Varma, M. V., Chawla, H. P., and Panchagnula, R. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Farmaco 2005;60(11-12):874-883. PubMed
  21. Aher, S., Biradar, S., Gopu, C. L., and Paradkar, A. Novel pepper extract for enhanced P-glycoprotein inhibition. J Pharm.Pharmacol. 2009;61(9):1179-1186. PubMed
  22. Zutshi, R. K., Singh, R., Zutshi, U., Johri, R. K., and Atal, C. K. Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc.Physicians India 1985;33(3):223-224.
  23. Marotta, R. B. and Floch, M. H. Diet and nutrition in ulcer disease. Med Clin North Am 1991;75(4):967-979. PubMed
  24. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
  25. Gimenez L, Zacharisen M. Severe pepper allergy in a young child. WMJ. 2011 Jun;110(3):138-9.
  26. Ren T, Yang M, Xiao M, Zhu J, Xie W, Zuo Z. Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment. Life Sci. 2019;218:314-323. PubMed
  27. Thomas AB, Choudhary DC, Raje A, Nagrik SS. Pharmacokinetics and pharmacodynamic herb-drug interaction of piperine with atorvastatin in rats. J Chromatogr Sci 2021;59(4):371-80. PubMed
  28. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  29. Lin F, Hu Y, Zhang Y, Zhao L, Zhong D, Liu J. Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling. Int J Mol Sci 2024;25(20):10955. PubMed

See these in context on the Black Pepper monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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