Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Percepta Ingredients & Drug Interactions

by Cognitive Clarity

Capsule Category: Botanical
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

Percepta is a dietary supplement by Cognitive Clarity with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis and rheumatoid arthritis, inflammation, immune support.Based on those ingredients, 1,248 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are PTI-703, MemorTea. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Percepta by Cognitive Clarity

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (775 mg) without saying how much of each component you get.

Percepta contains 2 active ingredients. The first is cat's claw (PTI-703), a rainforest vine traditionally used to support immune and joint health.

The second is oolong tea (MemorTea), a lightly oxidized tea leaf known for its caffeine content and polyphenols. The capsule also holds inactive ingredients — microcrystalline cellulose, hypromellose, magnesium stearate, and silica — which are binders, coatings, and flow agents typical of capsule products.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Memory support and age-related cognitive decline.
  • We looked for evidence on: Alzheimer disease, Mental alertness, Age-related memory loss, Cognitive function, Brain health.
  • The strongest evidence on file: Oolong Tea is rated "Likely Effective" for Mental alertness (Natural Medicines).
  • Also on file: Cat's Claw is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease.

Oolong tea is likely effective for mental alertness, which fits its caffeine content. For cat's claw, the evidence we hold rates it as insufficient to prove it works for the conditions listed on the label — allergic rhinitis, Alzheimer disease, asthma, osteoporosis, and cancer all lack reliable evidence.

Similarly, oolong tea's evidence is insufficient for autism spectrum disorder, osteoporosis, oral cancer, and COPD.

The evidence, ingredient by ingredient Cat's Claw Oolong Tea

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oolong tea is generally well tolerated in moderate amounts as a beverage. Cat's claw is generally well tolerated short-term in healthy adults, but long-term safety isn't well studied.

The adverse effects reported with cat's claw in one clinical trial included anemia (12% of patients), along with much smaller rates of low white blood cells, low platelets, headache, fatigue, insomnia, and nerve damage — though all patients in that trial had advanced cancer, so it's unclear what was caused by the product itself. Several case reports link cat's claw to kidney injury, ranging from acute kidney failure to inflammation of the kidney tissue.

Oolong tea's most common side effects from its caffeine are insomnia, nervousness, restlessness, rapid heartbeat, and tremors. Rare serious caffeine-related effects include irregular heartbeat, chest pain, and seizures.

Side effects, ingredient by ingredient Cat's Claw Oolong Tea

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Cat's Claw, Oolong Tea.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,249 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before combining Percepta with ephedrine (Major severity risk). Also double-check if you take blood pressure medications, blood thinners, liver-metabolized drugs, immunosuppressants, Paxlovid, acid reflux drugs, antipsychotics, seizure medications, sleeping pills, disulfiram, or dipyridamole — all carry Moderate severity interactions with one or both ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Percepta combines two herbal ingredients with real medication interactions, especially with blood pressure drugs, blood thinners, and seizure medications. If you take ephedrine or any prescription medication, you need to check it against this product before you start.

Talk with your pharmacist to review your specific medications — the interaction list is long, and some are serious.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Percepta, straight from the product label.

Brand Cognitive Clarity
Net contents 0 Not Present
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 262338
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Percepta by Cognitive Clarity, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Proprietary Blend775 mg--
PTI-7030 NP--
MemorTea0 NP--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Natural plant-based memory support The first nootropic to target the real reason we lose memory as we age

15 years of scientific studies and exclusive patented ingredients

Studies show our brains begin accumulating plaques & tangles in early adulthood that leads to normal age-related loss of memory and focus. Percepta is believed to be the world's first nootropic to potentially prevent and reduce plaques & tangles in the normal aging brain.

Cat's claw (Uncaria tomentosa) is a woody vine found in the Amazon rain forest. PTI-00703 is our proprietary source of cat's claw identified for plaque & tangle reducing activity. MemorTea is our proprietary source of Oolong tea (Camellia sinensis) identified for plaque & tangle reducing activity. Percepta is our proprietary blend of PTI-00703 cat's claw and MemorTea to produce the world's first nootropic to target plaques & tangles.

Percepta: a natural plant-based nootropic Proprietary blend of patented PTI-00703 cat's claw and MemorTea Targets brain plaques & tangles associated with normal age-related memory loss

Suitable for vegetarians and vegans.

Gluten and gelatin free.

Formula

Contains exclusive patented PTI-00703 cat's claw and MemorTea

Brand IP Statement(s)

Patented PTI-00703 cat's claw and MemorTea for memory support

Backed by US and International Issued Patents PTI-00703 and MemorTea are registered trademarks of Cognitive Clarity Inc.

Precautions

Warning: If you are taking a prescription drug for anti-coagulation (thinning of the blood) or other medications, consult with your health care professional before using this product.

Made without food allergens.

General Statements

Developed by renowned brain researchers, Dr. Alan Snow and Dr. Rudolph Tanzi

Dr. Alan Snow is Founder & CEO of Cognitive Clarity Inc. and former Research Associate Professor of Pathology at University of Washington in Seattle, where he was an Alzheimer's Disease Research Center project team leader. He has published extensively and is an inventor on over 340 issued patents, and is a recipient of 18 National Institute of Health grant awards. Dr. Rudolph Tanzi is co-founder and Chief Scientific Advisor of Cognitive Clarity Inc. and serves as Professor of Neurology at Harvard University. Dr. Tanzi co-discovered all three familial Alzheimer's genes and published over 500 articles. In 2015, he was named "TIME Magazine Most Influential People in the World" and has co-authorized the best sellers "Super Brain", "Super Genes" and "The Healing Self."

Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules once a day with a light meal. For best results take regularly for at least 90 days.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Percepta by Cognitive Clarity label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Percepta by Cognitive Clarity

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

775 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Percepta by Cognitive Clarity Drug Interactions

Want to check YOUR meds against Percepta?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,248Drugs
8 Major 1,121 Moderate 119 Minor

Ingredients driving the most interactions

PTI-703 962
MemorTea 652

Each ingredient & the kinds of drugs it affects

For each ingredient in Percepta with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

PTI-7036 drug types · 962 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Cat's claw contains rhynchophylline and isorhynchophylline. Animal research suggests that these alkaloids can inhibit platelet aggregation. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Cat's claw contains rhynchophylline. In vitro and animal research suggests that rhynchophylline can lower blood pressure. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Calcium Channel Blockers

Theoretically, taking cat's claw with calcium channel blockers might increase the risk of hypotension.
Cat's claw contains various alkaloids, including rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxiene. Animal research suggests that these alkaloids can lower blood pressure by acting as calcium channel blockers. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Cat's claw may affect the clearance of drugs metabolized by CYP3A4. In vitro research shows that cat's claw can inhibit CYP3A4 enzymes. In one case report, a patient taking cat's claw (at an unspecified dose) experienced increased serum levels of atazanavir, ritonavir, and saquinavir, all of which are CYP3A4 substrates. Levels returned to normal 15 days after discontinuation of the cat's claw supplement, suggesting inhibition of CYP3A4 by cat's claw. In contrast, animal research suggests that rhynchophylline, an alkaloid contained in cat's claw, induces CYP3A expression and accelerates the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, cat's claw might interfere with immunosuppressive therapy.
In human and laboratory research, cat's claw has been shown to have immunostimulating activity. It stimulates phagocytosis and increases respiratory cellular activity and the mobility of leukocytes. Theoretically, this could interfere with the activity of immunosuppressant medications.

Likelihood Possible Evidence D
Nirmatrelvir/Ritonavir (Paxlovid)

Theoretically, cat's claw may decrease the levels of nirmatrelvir.
Cat's claw contains rhynchophylline. Animal research suggests that this alkaloid induces CYP3A expression, thereby accelerating the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product. This interaction has not been reported in humans.

Likelihood Possible Evidence D

MemorTea37 drug types · 652 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Oolong tea contains caffeine. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death. Tell patients to avoid taking caffeine with ephedrine and other stimulants.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, oolong tea might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Oolong tea contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines such as caffeine, as well as methylxanthine-containing products, be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, oolong tea might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Oolong tea contains caffeine. Caffeine is reported to have antiplatelet activity. Theoretically, the caffeine in oolong tea might increase the risk of bleeding when used concomitantly with these agents. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of oolong tea might increase the cardiac inotropic effects of beta-agonists.
Oolong tea contains caffeine. Caffeine can increase cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Cimetidine (Tagamet)

Theoretically, concomitant use might increase the effects and adverse effects of caffeine in oolong tea.
Oolong tea contains caffeine. Cimetidine can reduce the rate of caffeine clearance by 30% to 50%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Theoretically, oolong tea might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Oolong tea contains caffeine. Caffeine can increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Researchers speculate that caffeine might inhibit CYP1A2. However, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients be more sensitive to the interaction between clozapine and caffeine.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Inhibitors

Theoretically, concomitant use might increase the levels and adverse effects of the caffeine in oolong tea.
Oolong tea contains caffeine. Caffeine is metabolized by cytochrome P450 1A2 (CYP1A2),. Theoretically, drugs that inhibit CYP1A2 may decrease the clearance rate of caffeine from oolong tea and increase caffeine levels.

Likelihood Possible Evidence D
Dipyridamole (Persantine)

Theoretically, oolong tea might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Oolong tea contains caffeine. Caffeine is a methylxanthine that may inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines such as caffeine, as well as methylxanthine-containing products such as oolong tea, be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram might increase the risk of adverse effects from caffeine in oolong tea.
Oolong tea contains caffeine. Disulfiram decreases the clearance and increases the half-life of caffeine.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, using oolong tea with diuretic drugs might increase the risk of hypokalemia.
Oolong tea contains caffeine. In excessive amounts, caffeine can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine in oolong tea.
Oolong tea contains caffeine. Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Flutamide (Eulexin)

Theoretically, oolong tea might increase the levels and adverse effects of flutamide.
Oolong tea contains caffeine. In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide.

Likelihood Possible Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine in oolong tea.
Oolong tea contains caffeine. Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Theoretically, abrupt oolong tea withdrawal might increase the levels and adverse effects of lithium.
Oolong tea contains caffeine. Abrupt caffeine withdrawal can increase serum lithium levels, worsening lithium tremor.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Oolong tea contains caffeine. Caffeine has been shown to inhibit MAO A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Oolong tea contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence D
Pentobarbital (Nembutal)

Theoretically, caffeine in oolong tea might decrease the effects of pentobarbital.
Oolong tea contains caffeine. The caffeine in oolong tea might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, oolong tea might reduce the effects of phenobarbital and increase the risk for convulsions.
Oolong tea contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. The exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine in oolong tea.
Oolong tea contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, oolong tea might reduce the effects of phenytoin and increase the risk for convulsions.
Oolong tea contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, oolong tea might increase the levels and clinical effects of pioglitazone.
Oolong tea contains caffeine. Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Oolong tea contains caffeine. Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce metabolism of one or both agents.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, concomitant use might increase stimulant adverse effects.
Oolong tea contains caffeine. Due to the CNS stimulant effects of the caffeine constituent of oolong tea, concomitant use with stimulant drugs can increase the risk of adverse effects.

Likelihood Probable Evidence C
Theophylline

Theoretically, oolong tea might increase the levels and adverse effects of theophylline.
Oolong tea contains caffeine. Caffeine decreases theophylline clearance 23% to 29%.

Likelihood Probable Evidence D
Valproate

Theoretically, oolong tea might reduce the effects of valproate and increase the risk for convulsions.
Oolong tea contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of valproate. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Percepta, from the product label.

Cognitive Clarity

See all Cognitive Clarity products
Name
Cognitive Clarity Inc.
City
Edmonds
State
WA
ZipCode
98026
Phone Number
(866) 545-5276
Pharmacist Counseling Corner

Percepta by Cognitive Clarity: Common Questions

Does Percepta by Cognitive Clarity interact with any medications?
Yes. Based on its ingredients, Percepta has a known interaction with 1,248 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Percepta contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Percepta if I'm pregnant?
Cat's claw is rated possibly unsafe in pregnancy because of its traditional use as an abortifacient and lack of safety data — avoid it. Oolong tea is rated possibly safe or possibly unsafe depending on the source, so the picture isn't clear either. Talk with your doctor or pharmacist for personalized advice before using this product during pregnancy.
Is Percepta safe while breastfeeding?
Cat's claw should be avoided while breastfeeding due to insufficient safety information. Oolong tea is rated possibly safe, though caffeine does pass into breast milk — if you use it, keep intake low and watch your baby for fussiness. Check with your pharmacist about your individual situation.
What is cat's claw used for in this product?
Cat's claw is listed for allergic rhinitis, Alzheimer disease, asthma, osteoporosis, and cancer, but the evidence we hold doesn't confirm it works for any of these conditions — the rating is insufficient for all of them.
What does the oolong tea in Percepta do?
Oolong tea is likely effective for mental alertness, mainly because of its caffeine content. The evidence for its other listed uses — autism, osteoporosis, oral cancer, and COPD — is insufficient.
Will Percepta make me jittery or keep me awake?
Yes, possibly. Oolong tea contains caffeine, which commonly causes insomnia, nervousness, restlessness, rapid heartbeat, and tremors. If you're sensitive to caffeine or take it late in the day, these side effects are a real risk.
How long is it safe to take Percepta?
Cat's claw is generally well tolerated short-term in healthy adults, but long-term safety isn't well studied. There's no clear data on how long you should use this product, so talk with your pharmacist about duration.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Percepta label
Sources

Sources & How We Checked

Percepta's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 128 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cat's Claw 16 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  3. Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
  4. Müller AC, Kanfer I. Potential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and African traditional medicines. Biopharm Drug Dispos. 2011;32(8):458-70. PubMed
  5. Sheng, Y., Bryngelsson, C., and Pero, R. W. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000;69(2):115-126. PubMed
  6. Lamm, S., Sheng, Y., and Pero, R. W. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine 2001;8(4):267-274.
  7. Sheng, Y., Li, L., Holmgren, K., and Pero, R. W. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001;8(4):275-282.
  8. Chen, C. X., Jin, R. M., Li, Y. K., Zhong, J., Yue, L., Chen, S. C., and Zhou, J. Y. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1992;13(2):126-130.
  9. Flythe, J. E., Rueda, J. F., Riscoe, M. K., and Watnick, S. Silicate nephrolithiasis after ingestion of supplements containing silica dioxide. Am.J.Kidney Dis. 2009;54(1):127-130. PubMed
  10. Zhou, J. and Zhou, S. Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. J.Ethnopharmacol. 10-28-2010;132(1):15-27. PubMed
  11. Zhou, J. Y. and Zhou, S. W. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia 2012;83(4):617-626. PubMed
  12. Hemingway, S. R. and Phillipson, J. D. Proceedings: Alkaloids from S. American species of Uncaria (Rubiaceae). J.Pharm.Pharmacol. 1974;26 Suppl:113P.
  13. Hilepo, J. N., Bellucci, A. G., and Mossey, R. T. Acute renal failure caused by 'cat's claw' herbal remedy in a patient with systemic lupus erythematosus. Nephron 1997;77(3):361. PubMed
  14. De Paula LCL, Fonseca F, Perazzo F, et al. Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. J Altern Complement Med. 2015;21(1):22-30.
  15. Portalatin G, Shettigar S, Carrion-Rodriguez A, et al. Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis. Case Rep Nephrol Dial 2022;12(3):219-225.
  16. Lei S, Guo A, Lu J, et al. Activation of PXR causes drug interactions with Paxlovid in transgenic mice. Acta Pharm Sin B 2023;13(11):4502-4510. PubMed

See these in context on the Cat's Claw monograph →

Oolong Tea 112 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
  3. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
  4. Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
  5. Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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