Percepta Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Percepta against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Percepta is a dietary supplement by Cognitive Clarity with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis and rheumatoid arthritis, inflammation, immune support.Based on those ingredients, 1,248 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are PTI-703, MemorTea. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Percepta by Cognitive Clarity
Ask about any prescription or over-the-counter medication and we check it for interactions with Percepta by Cognitive Clarity — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Percepta by Cognitive Clarity
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Percepta contains 2 active ingredients. The first is cat's claw (PTI-703), a rainforest vine traditionally used to support immune and joint health.
The second is oolong tea (MemorTea), a lightly oxidized tea leaf known for its caffeine content and polyphenols. The capsule also holds inactive ingredients — microcrystalline cellulose, hypromellose, magnesium stearate, and silica — which are binders, coatings, and flow agents typical of capsule products.
Does it work?
Strong evidence
Oolong tea is likely effective for mental alertness, which fits its caffeine content. For cat's claw, the evidence we hold rates it as insufficient to prove it works for the conditions listed on the label — allergic rhinitis, Alzheimer disease, asthma, osteoporosis, and cancer all lack reliable evidence.
Similarly, oolong tea's evidence is insufficient for autism spectrum disorder, osteoporosis, oral cancer, and COPD.
How safe is it?
Well-documented data
Oolong tea is generally well tolerated in moderate amounts as a beverage. Cat's claw is generally well tolerated short-term in healthy adults, but long-term safety isn't well studied.
The adverse effects reported with cat's claw in one clinical trial included anemia (12% of patients), along with much smaller rates of low white blood cells, low platelets, headache, fatigue, insomnia, and nerve damage — though all patients in that trial had advanced cancer, so it's unclear what was caused by the product itself. Several case reports link cat's claw to kidney injury, ranging from acute kidney failure to inflammation of the kidney tissue.
Oolong tea's most common side effects from its caffeine are insomnia, nervousness, restlessness, rapid heartbeat, and tremors. Rare serious caffeine-related effects include irregular heartbeat, chest pain, and seizures.
Meds to double-check
Major interaction found
Check with your pharmacist before combining Percepta with ephedrine (Major severity risk). Also double-check if you take blood pressure medications, blood thinners, liver-metabolized drugs, immunosuppressants, Paxlovid, acid reflux drugs, antipsychotics, seizure medications, sleeping pills, disulfiram, or dipyridamole — all carry Moderate severity interactions with one or both ingredients.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Percepta combines two herbal ingredients with real medication interactions, especially with blood pressure drugs, blood thinners, and seizure medications. If you take ephedrine or any prescription medication, you need to check it against this product before you start.
Talk with your pharmacist to review your specific medications — the interaction list is long, and some are serious.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Percepta, straight from the product label.
| Brand | Cognitive Clarity |
|---|---|
| Net contents | 0 Not Present |
| Market status | On market |
| Date entered into DSLD | Dec 18, 2021 |
| DSLD ID | 262338 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Percepta by Cognitive Clarity, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 775 mg | -- |
| PTI-703 | 0 NP | -- |
| MemorTea | 0 NP | -- |
Other ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Natural plant-based memory support The first nootropic to target the real reason we lose memory as we age
15 years of scientific studies and exclusive patented ingredients
Studies show our brains begin accumulating plaques & tangles in early adulthood that leads to normal age-related loss of memory and focus. Percepta is believed to be the world's first nootropic to potentially prevent and reduce plaques & tangles in the normal aging brain.
Cat's claw (Uncaria tomentosa) is a woody vine found in the Amazon rain forest. PTI-00703 is our proprietary source of cat's claw identified for plaque & tangle reducing activity. MemorTea is our proprietary source of Oolong tea (Camellia sinensis) identified for plaque & tangle reducing activity. Percepta is our proprietary blend of PTI-00703 cat's claw and MemorTea to produce the world's first nootropic to target plaques & tangles.
Percepta: a natural plant-based nootropic Proprietary blend of patented PTI-00703 cat's claw and MemorTea Targets brain plaques & tangles associated with normal age-related memory loss
Suitable for vegetarians and vegans.
Gluten and gelatin free.
Formula
Contains exclusive patented PTI-00703 cat's claw and MemorTea
Brand IP Statement(s)
Patented PTI-00703 cat's claw and MemorTea for memory support
Backed by US and International Issued Patents PTI-00703 and MemorTea are registered trademarks of Cognitive Clarity Inc.
Precautions
Warning: If you are taking a prescription drug for anti-coagulation (thinning of the blood) or other medications, consult with your health care professional before using this product.
Made without food allergens.
General Statements
Developed by renowned brain researchers, Dr. Alan Snow and Dr. Rudolph Tanzi
Dr. Alan Snow is Founder & CEO of Cognitive Clarity Inc. and former Research Associate Professor of Pathology at University of Washington in Seattle, where he was an Alzheimer's Disease Research Center project team leader. He has published extensively and is an inventor on over 340 issued patents, and is a recipient of 18 National Institute of Health grant awards. Dr. Rudolph Tanzi is co-founder and Chief Scientific Advisor of Cognitive Clarity Inc. and serves as Professor of Neurology at Harvard University. Dr. Tanzi co-discovered all three familial Alzheimer's genes and published over 500 articles. In 2015, he was named "TIME Magazine Most Influential People in the World" and has co-authorized the best sellers "Super Brain", "Super Genes" and "The Healing Self."
Suggested/Recommended/Usage/Directions
Directions: Take 2 capsules once a day with a light meal. For best results take regularly for at least 90 days.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Percepta by Cognitive Clarity label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Percepta by Cognitive Clarity
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Percepta by Cognitive Clarity Drug Interactions
HelloPharmacist Interaction Report
Percepta by Cognitive Clarity contains cat's claw (PTI-703) and oolong tea (MemorTea), both of which interact with medications.
The most serious concern is oolong tea with ephedrine — a Major severity interaction that can cause dangerous stimulant side effects including heart attack, stroke, seizure, or death, so these two must never be combined.
Read the full breakdown — every affected drug type, severity by severity
Cat's claw carries Moderate interactions with blood pressure drugs (antihypertensives and calcium channel blockers), which may lower your blood pressure further. It also interacts with blood thinners (anticoagulants and antiplatelet drugs), potentially raising bleeding risk, and with drugs broken down by your liver's CYP3A4 enzyme — a broad category that includes many common medications.
If you take an immunosuppressant, cat's claw may interfere with it. There's also a Moderate concern with nirmatrelvir/ritonavir (Paxlovid), where cat's claw may reduce its effectiveness.
Oolong tea's caffeine content interacts with several other medications at Moderate severity: acid reflux drugs like cimetidine, disulfiram (used for alcohol addiction), the heart drug dipyridamole, the antipsychotic clozapine, seizure drugs (valproate and phenobarbital), and the sleeping pill pentobarbital. Each of these interactions can reduce drug effectiveness or raise side effect risk.
Altogether, these interactions span 1,233 individual medications. Run your complete medication list through the interaction checker on this page before starting Percepta.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Percepta?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Percepta interact with 1,248 drugs. Click any drug to see the details.
2 of the 2 ingredients in Percepta interact with drugs. Each result below shows which ingredient is responsible. PTI-703 MemorTea
Aminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
MemorteaStimulant Drugs, Ephedrine Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Aminophylline, Amobarbital, Ephedrine interactionCarbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine TannateQuadratuss, Ry Tuss, Rynatuss, Tri Tannate Plus
How Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
MemorteaStimulant Drugs, Ephedrine Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionPti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionDyphylline, Ephedrine, Guaifenesin, PhenobarbitalLufyllin-EPG
How Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
MemorteaStimulant Drugs, Phenobarbital (luminal) +1 Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interactionEphedrine, Guaifenesin (otc Drug)Ephedrine Formula 400, Ephedrine Plus Tabs
How Ephedrine, Guaifenesin (otc Drug) interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
MemorteaStimulant Drugs, Ephedrine Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Ephedrine, Guaifenesin (otc Drug) interactionEphedrine, Guaifenesin, Phenobarbital, TheophyllineMudrane GG
How Ephedrine, Guaifenesin, Phenobarbital, Theophylline interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
MemorteaEphedrine, Theophylline +2 Major
Interaction Summary
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Read the full Memortea + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionEphedrine, Hydroxyzine, TheophyllineAmi Rax, Marax
How Ephedrine, Hydroxyzine, Theophylline interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
MemorteaStimulant Drugs, Theophylline +1 Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Ephedrine, Hydroxyzine, Theophylline interactionEphedrine, Phenobarbital, Potassium Iodide, TheophyllineMudrane, Quadrinal
How Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
MemorteaPhenobarbital (luminal), Ephedrine +2 Major
Interaction Summary
Theoretically, oolong tea might reduce the effects of phenobarbital and increase the risk for convulsions.
Read the full Memortea + Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interactionEphedrine, Phenobarbital, TheophyllineTedral
How Ephedrine, Phenobarbital, Theophylline interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
MemorteaStimulant Drugs, Theophylline +2 Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Ephedrine, Phenobarbital, Theophylline interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
Pti-703Immunosuppressants Moderate
Interaction Summary
Theoretically, cat's claw might interfere with immunosuppressive therapy.
Read the full Pti-703 + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
Pti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Ado-trastuzumab Emtansine interactionAbametapirXeglyze
How Abametapir interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
MemorteaCytochrome P450 1a2 (cyp1a2) Inhibitors Moderate
Interaction Summary
Theoretically, concomitant use might increase the levels and adverse effects of the caffeine in oolong tea.
Read the full Memortea + Abametapir interactionAbciximabReoPro
How Abciximab interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
Pti-703Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Pti-703 + Abciximab interactionMemorteaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oolong tea might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Memortea + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
Pti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
MemorteaCytochrome P450 1a2 (cyp1a2) Inhibitors Moderate
Interaction Summary
Theoretically, concomitant use might increase the levels and adverse effects of the caffeine in oolong tea.
Read the full Memortea + Abiraterone interactionPti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
Pti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
Pti-703Anticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Pti-703 + Abrocitinib interactionMemorteaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oolong tea might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Memortea + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
Pti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Acalabrutinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
Pti-703Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Read the full Pti-703 + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
Pti-703Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Pti-703 + Acenocoumarol interactionMemorteaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oolong tea might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Memortea + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
MemorteaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oolong tea might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Memortea + Acetaminophen, Aspirin interactionPti-703Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Pti-703 + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
Pti-703Anticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Pti-703 + Acetaminophen, Aspirin, Caffeine interactionMemorteaAnticoagulant/antiplatelet Drugs, Stimulant Drugs Moderate
Interaction Summary
Theoretically, oolong tea might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Memortea + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Percepta — through 1 ingredient. Tap an ingredient for the detail:
MemorteaStimulant Drugs, Phenylpropanolamine Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
MemorteaStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Acetaminophen, Butalbital, Caffeine interactionPti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
MemorteaStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Acetaminophen, Butalbital, Caffeine, Codeine interactionPti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
Pti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionMemorteaStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
MemorteaStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Acetaminophen, Caffeine, Codeine interactionPti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
Pti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Acetaminophen, Caffeine, Codeine, Salicylamide interactionMemorteaStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
Pti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Acetaminophen, Caffeine, Dihydrocodeine interactionMemorteaStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
MemorteaStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Memortea + Acetaminophen, Caffeine, Isometheptene interactionPti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Percepta — through 2 ingredients. Tap an ingredient for the detail:
Pti-703Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Pti-703 + Acetaminophen, Caffeine, Pyrilamine interactionMemorteaDiuretic Drugs, Stimulant Drugs Moderate
Interaction Summary
Theoretically, using oolong tea with diuretic drugs might increase the risk of hypokalemia.
Read the full Memortea + Acetaminophen, Caffeine, Pyrilamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Percepta with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
PTI-703
Anticoagulant/Antiplatelet Drugs
Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Cat's claw contains rhynchophylline and isorhynchophylline. Animal research suggests that these alkaloids can inhibit platelet aggregation. This interaction has not been reported in humans.
Antihypertensive Drugs
Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Cat's claw contains rhynchophylline. In vitro and animal research suggests that rhynchophylline can lower blood pressure. This interaction has not been reported in humans.
Calcium Channel Blockers
Theoretically, taking cat's claw with calcium channel blockers might increase the risk of hypotension.
Cat's claw contains various alkaloids, including rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxiene. Animal research suggests that these alkaloids can lower blood pressure by acting as calcium channel blockers. This interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Cat's claw may affect the clearance of drugs metabolized by CYP3A4. In vitro research shows that cat's claw can inhibit CYP3A4 enzymes. In one case report, a patient taking cat's claw (at an unspecified dose) experienced increased serum levels of atazanavir, ritonavir, and saquinavir, all of which are CYP3A4 substrates. Levels returned to normal 15 days after discontinuation of the cat's claw supplement, suggesting inhibition of CYP3A4 by cat's claw. In contrast, animal research suggests that rhynchophylline, an alkaloid contained in cat's claw, induces CYP3A expression and accelerates the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product.
Immunosuppressants
Theoretically, cat's claw might interfere with immunosuppressive therapy.
In human and laboratory research, cat's claw has been shown to have immunostimulating activity. It stimulates phagocytosis and increases respiratory cellular activity and the mobility of leukocytes. Theoretically, this could interfere with the activity of immunosuppressant medications.
Nirmatrelvir/Ritonavir (Paxlovid)
Theoretically, cat's claw may decrease the levels of nirmatrelvir.
Cat's claw contains rhynchophylline. Animal research suggests that this alkaloid induces CYP3A expression, thereby accelerating the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product. This interaction has not been reported in humans.
MemorTea
Ephedrine
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Oolong tea contains caffeine. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death. Tell patients to avoid taking caffeine with ephedrine and other stimulants.
Adenosine (Adenocard)
Theoretically, oolong tea might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Oolong tea contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines such as caffeine, as well as methylxanthine-containing products, be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.
Anticoagulant/Antiplatelet Drugs
Theoretically, oolong tea might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Oolong tea contains caffeine. Caffeine is reported to have antiplatelet activity. Theoretically, the caffeine in oolong tea might increase the risk of bleeding when used concomitantly with these agents. However, this interaction has not been reported in humans.
Beta-Adrenergic Agonists
Theoretically, large amounts of oolong tea might increase the cardiac inotropic effects of beta-agonists.
Oolong tea contains caffeine. Caffeine can increase cardiac inotropic effects of beta-agonists.
Cimetidine (Tagamet)
Theoretically, concomitant use might increase the effects and adverse effects of caffeine in oolong tea.
Oolong tea contains caffeine. Cimetidine can reduce the rate of caffeine clearance by 30% to 50%.
Clozapine (Clozaril)
Theoretically, oolong tea might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Oolong tea contains caffeine. Caffeine can increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Researchers speculate that caffeine might inhibit CYP1A2. However, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients be more sensitive to the interaction between clozapine and caffeine.
Cytochrome P450 1A2 (Cyp1A2) Inhibitors
Theoretically, concomitant use might increase the levels and adverse effects of the caffeine in oolong tea.
Oolong tea contains caffeine. Caffeine is metabolized by cytochrome P450 1A2 (CYP1A2),. Theoretically, drugs that inhibit CYP1A2 may decrease the clearance rate of caffeine from oolong tea and increase caffeine levels.
Dipyridamole (Persantine)
Theoretically, oolong tea might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Oolong tea contains caffeine. Caffeine is a methylxanthine that may inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines such as caffeine, as well as methylxanthine-containing products such as oolong tea, be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.
Disulfiram (Antabuse)
Theoretically, disulfiram might increase the risk of adverse effects from caffeine in oolong tea.
Oolong tea contains caffeine. Disulfiram decreases the clearance and increases the half-life of caffeine.
Diuretic Drugs
Theoretically, using oolong tea with diuretic drugs might increase the risk of hypokalemia.
Oolong tea contains caffeine. In excessive amounts, caffeine can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.
Estrogens
Theoretically, estrogens might increase the levels and adverse effects of caffeine in oolong tea.
Oolong tea contains caffeine. Estrogen inhibits caffeine metabolism.
Flutamide (Eulexin)
Theoretically, oolong tea might increase the levels and adverse effects of flutamide.
Oolong tea contains caffeine. In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide.
Fluvoxamine (Luvox)
Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine in oolong tea.
Oolong tea contains caffeine. Fluvoxamine reduces caffeine metabolism.
Lithium
Theoretically, abrupt oolong tea withdrawal might increase the levels and adverse effects of lithium.
Oolong tea contains caffeine. Abrupt caffeine withdrawal can increase serum lithium levels, worsening lithium tremor.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Oolong tea contains caffeine. Caffeine has been shown to inhibit MAO A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis.
Nicotine
Theoretically, concomitant use might increase the risk of hypertension.
Oolong tea contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.
Pentobarbital (Nembutal)
Theoretically, caffeine in oolong tea might decrease the effects of pentobarbital.
Oolong tea contains caffeine. The caffeine in oolong tea might negate the hypnotic effects of pentobarbital.
Phenobarbital (Luminal)
Theoretically, oolong tea might reduce the effects of phenobarbital and increase the risk for convulsions.
Oolong tea contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. The exact mechanism of this interaction is unclear.
Phenylpropanolamine
Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine in oolong tea.
Oolong tea contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.
Phenytoin (Dilantin)
Theoretically, oolong tea might reduce the effects of phenytoin and increase the risk for convulsions.
Oolong tea contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.
Pioglitazone (Actos)
Theoretically, oolong tea might increase the levels and clinical effects of pioglitazone.
Oolong tea contains caffeine. Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.
Riluzole (Rilutek)
Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Oolong tea contains caffeine. Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce metabolism of one or both agents.
Stimulant Drugs
Theoretically, concomitant use might increase stimulant adverse effects.
Oolong tea contains caffeine. Due to the CNS stimulant effects of the caffeine constituent of oolong tea, concomitant use with stimulant drugs can increase the risk of adverse effects.
Theophylline
Theoretically, oolong tea might increase the levels and adverse effects of theophylline.
Oolong tea contains caffeine. Caffeine decreases theophylline clearance 23% to 29%.
Valproate
Theoretically, oolong tea might reduce the effects of valproate and increase the risk for convulsions.
Oolong tea contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of valproate. However, the exact mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Percepta, from the product label.
Cognitive Clarity
See all Cognitive Clarity products- Name
- Cognitive Clarity Inc.
- City
- Edmonds
- State
- WA
- ZipCode
- 98026
- Phone Number
- (866) 545-5276
Percepta by Cognitive Clarity: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Percepta’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Cat's Claw
Interacts with 962 drugsCat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arthritis symptoms, but the overall evidence...
Read the full Cat's Claw monograph → Herb & supplement monographOolong Tea
Interacts with 652 drugsOolong tea is a traditional partially oxidized tea made from the same plant as green and black tea, and it provides caffeine and plant antioxidants. As a beverage it is generally considered...
Read the full Oolong Tea monograph →Sources & How We Checked
Percepta's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 128 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cat's Claw 16 references
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- Sheng, Y., Li, L., Holmgren, K., and Pero, R. W. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001;8(4):275-282.
- Chen, C. X., Jin, R. M., Li, Y. K., Zhong, J., Yue, L., Chen, S. C., and Zhou, J. Y. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1992;13(2):126-130.
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- Hilepo, J. N., Bellucci, A. G., and Mossey, R. T. Acute renal failure caused by 'cat's claw' herbal remedy in a patient with systemic lupus erythematosus. Nephron 1997;77(3):361. PubMed
- De Paula LCL, Fonseca F, Perazzo F, et al. Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. J Altern Complement Med. 2015;21(1):22-30.
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