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Dietary supplement

PharmaGABA-100 Ingredients & Drug Interactions

by Thorne

PharmaGABA-100 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PharmaGABA-100 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PharmaGABA-100 is a dietary supplement by Thorne with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gamma-Aminobutyric Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PharmaGABA-100 by Thorne

Ask about any prescription or over-the-counter medication and we check it for interactions with PharmaGABA-100 by Thorne — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of PharmaGABA-100 by Thorne

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

PharmaGABA-100 is a single-ingredient supplement. It contains gamma-aminobutyric acid (GABA), a chemical messenger your brain naturally produces to promote calm and relaxation.

The capsule also includes some inactive ingredients — microcrystalline cellulose, hypromellose, magnesium citrate, and calcium laurate — which help hold the supplement together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gamma-aminobutyric Acid (gaba)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Sleep, stress, and sports performance.
  • We looked for evidence on: Anxiety, Athletic performance, Insomnia, Post-traumatic stress disorder (PTSD), Psychological well-being, Relaxation — and 1 related terms.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Insomnia, Post-traumatic stress disorder (PTSD), Psychological well-being.

The evidence for GABA supplements is still thin. For the conditions most commonly marketed — anxiety, ADHD, athletic performance, and chronic bronchitis — the data we have rates effectiveness as insufficient.

That means research hasn't yet established whether the supplement actually works for these purposes. If you're thinking about taking it, talk with your pharmacist or doctor about what the current science supports.

The evidence, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

GABA appears generally well tolerated when taken by mouth over the short term, though long-term safety hasn't been well studied. The most common side effects in trials were drowsiness, upset stomach, minor throat burning, muscle weakness, and nausea.

One patient reported a temporary loss of menstrual periods. Because safety data in pregnancy and breastfeeding is not adequate, the data advises against use during breastfeeding unless your doctor advises otherwise.

For pregnancy, there isn't enough information to know either way — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gamma-aminobutyric Acid (gaba).
  • The most serious interaction on file is rated Moderate.
  • For scale: 419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this product if you take blood pressure medication (antihypertensives) — GABA may lower your pressure further. Also flag any CNS depressants, like sleep aids, anxiety medications, or opioids, since GABA might intensify drowsiness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

PharmaGABA-100 might interest someone looking to support relaxation, but the evidence for its effectiveness isn't established yet. If you take blood pressure medication or any sedating drugs, check with your pharmacist before starting — GABA could amplify their effects.

It's generally well tolerated short-term, but long-term safety data is limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PharmaGABA-100, straight from the product label.

Brand Thorne
Barcode (UPC) 693749652014
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328836
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PharmaGABA-100 by Thorne, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
693749652014
IngredientAmount% DV
Gamma-Aminobutyric Acid100 mg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Citrate, Calcium Laurate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Sleep Sports performance Stress

Gluten free

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule one to three times daily or as recommended by your health-care practitioner.

Precautions

Tamper evident: Use only if bottle is sealed.

Warning: If pregnant, nursing, or trying to conceive, do not use this product.

Storage

Store tightly sealed in a cool, dry place.

Seals/Symbols

Manufactured in the USA using US & Imported Ingredients NSF Contents Certified

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

This product uses Pharma Foods International’s Gamma- Aminobutyric Acid (PharmaGABA). PharmaGABA is a registered trademark of Pharma Foods International.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PharmaGABA-100 by Thorne label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PharmaGABA-100 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PharmaGABA-100 by Thorne

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Gamma-Aminobutyric Acid

Interacts with
419 drugs
100 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

Gamma-Aminobutyric Acid monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Citrate, Calcium Laurate. These complete the product’s ingredient list but are not active constituents.

Interaction report

PharmaGABA-100 by Thorne Drug Interactions

Want to check YOUR meds against PharmaGABA-100?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
419Drugs
172 Moderate 247 Minor

Ingredients driving the most interactions

Gamma-Aminobutyric Acid 419

Individual Drug Interactions

The ingredients in PharmaGABA-100 interact with 419 drugs. Click any drug to see the details.

1 of the 1 ingredient in PharmaGABA-100 interact with drugs. Each result below shows which ingredient is responsible. Gamma-Aminobutyric Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in PharmaGABA-100 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gamma-Aminobutyric Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma-Aminobutyric Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PharmaGABA-100, from the product label.

Thorne

See all Thorne products
Name
Thorne Research, Inc.
Phone Number
1-800-228-1966
Pharmacist Counseling Corner

PharmaGABA-100 by Thorne: Common Questions

Does PharmaGABA-100 by Thorne interact with any medications?
Yes. Based on its ingredients, PharmaGABA-100 has a known interaction with 419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PharmaGABA-100 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is GABA and what does it do in my body?
GABA is a chemical messenger your brain naturally makes to help you relax and stay calm. It's one of your nervous system's main calming signals. This supplement is a synthetic version meant to support that relaxation effect, though research on whether the pill version works the same way as your body's natural GABA is still limited.
Will PharmaGABA help with anxiety?
The evidence we have rates GABA's effectiveness for anxiety as insufficient — meaning research hasn't yet proven whether it actually works for this. If you're interested in trying it, talk with your doctor or pharmacist first, especially since anxiety often needs professional evaluation and treatment.
What are the most common side effects?
Most side effects reported in trials were mild: drowsiness, upset stomach, minor throat burning, muscle weakness, and nausea. A thorough safety study hasn't been completed, though, so there may be effects we don't yet know about. If you notice anything unusual, stop and talk with your pharmacist.
Is it safe to take while breastfeeding?
No — the safety data advises against using this supplement while breastfeeding because there isn't enough information to know it's safe. Talk with your doctor or pharmacist if you're considering it.
Can I take this long-term?
The data shows GABA is generally well tolerated short-term, but long-term safety hasn't been well studied. If you're thinking about taking it regularly, discuss that with your pharmacist or doctor to decide whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PharmaGABA-100 label
Go deeper

The Full Monographs Behind PharmaGABA-100’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

PharmaGABA-100's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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