Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Advanced Digestive Enzymes Ingredients & Drug Interactions

by Thorne

Advanced Digestive Enzymes label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Advanced Digestive Enzymes is a dietary supplement by Thorne with 5 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Digestive Enzymes by Thorne

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Digestive Enzymes by Thorne — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Advanced Digestive Enzymes by Thorne

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Thorne's Advanced Digestive Enzymes contains 5 active ingredients designed to aid digestion. Betaine hydrochloride boosts stomach acid to help break down food.

Pepsin is a protease — an enzyme that breaks down proteins. The product also includes pancreatin (which provides multiple digestive enzymes), L-glutamic acid hydrochloride, and ox bile concentrate, all of which support the breakdown and absorption of nutrients.

The capsule itself is made from hypromellose (a plant-derived cellulose), with calcium laurate and leucine as inactive ingredients.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This product is marketed for general wellness, not a specific health condition, so there's no single claim to grade against clinical evidence.

Why this rating?
  • The label markets general wellness (“GI support and digestive health”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence we hold doesn't establish that betaine hydrochloride works for dyspepsia (indigestion), hypothyroidism, diarrhea, rheumatoid arthritis, food allergies, or allergic rhinitis — each is rated insufficient reliable evidence. We don't have effectiveness data on file for pepsin, pancreatin, L-glutamic acid hydrochloride, or ox bile concentrate in this product.

If you're considering this for a specific digestive issue, talk with your pharmacist about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride may irritate your stomach and is not safe if you have ulcers, gastritis, or true acid reflux disease — it can worsen these conditions or slow ulcer healing and may trigger heartburn. Pepsin is generally well tolerated in adults but may cause digestive upset or allergic reactions in some people.

Rarely, airborne exposure to pepsin (mainly in occupational settings) has caused allergic rhinitis or asthma. For pregnancy, betaine hydrochloride safety data advises against use.

Pepsin safety in pregnancy has not been established, so avoid it unless a doctor prescribes it. During breastfeeding, betaine hydrochloride should be avoided, and pepsin is not recommended without medical advice because safety data is limited.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check proton pump inhibitors (like omeprazole), H2-blockers (like famotidine), and antacids with your pharmacist. Betaine hydrochloride may reduce how well these medications work.

We could not check three other ingredients (L-glutamic acid hydrochloride, pancreatin, and ox bile concentrate) for interactions, so mention those when you ask.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product is aimed at people looking to support their digestive function with enzymes and stomach acid. It's not for you if you have ulcers, gastritis, or reflux — it could make those worse.

If you take any acid-reducing medication (PPIs, H2-blockers, or antacids), check with your pharmacist before starting. Pregnant or breastfeeding?

Talk to your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Digestive Enzymes, straight from the product label.

Brand Thorne
Barcode (UPC) 693749405023
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 321966
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Digestive Enzymes by Thorne, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
693749405023
IngredientAmount% DV
Betaine Hydrochloride480 mg--
L-Glutamic Acid Hydrochloride480 mg--
Pancreatin140 mg--
Ox Bile concentrate80 mg--
Pepsin70 mg--

Other ingredients: Hypromellose, Calcium Laurate, Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GI support

Gluten free

Plus gallbladder support

Suggested/Recommended/Usage/Directions

Suggested use: Take 1-2 capsules with each meal or as recommended by your health-care practitioner.

Precautions

Tamper evident: Use only if bottle is sealed.

If pregnant, consult your health-care practitioner before using this product.

Do not take this product out of the capsule. This product is contraindicated in patients with peptic ulcers.

Storage

Store tightly sealed in a cool, dry place.

Seals/Symbols

Manufactured in the USA using US & imported ingredients

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

The Pancreatin in one capsule contains no less than: Amylase 15,750 USP units, Protease 14,000 USP units, Lipase 2,450 USP units.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Advanced Digestive Enzymes by Thorne label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Digestive Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Digestive Enzymes by Thorne

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
480 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

L-Glutamic Acid Hydrochloride

480 mg per serving

Pancreatin

140 mg per serving Form: Porcine

Ox Bile concentrate

80 mg per serving

Pepsin

No known
interactions
70 mg per serving Form: Porcine

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Other (inactive) ingredients: Hypromellose, Calcium Laurate, Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Digestive Enzymes by Thorne Drug Interactions

Want to check YOUR meds against Advanced Digestive Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Advanced Digestive Enzymes interact with 36 drugs. Click any drug to see the details.

1 of the 5 ingredients in Advanced Digestive Enzymes interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Digestive Enzymes with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced Digestive Enzymes, from the product label.

Thorne

See all Thorne products
Name
Thorne Research, Inc.
Phone Number
1-800-228-1966
Pharmacist Counseling Corner

Advanced Digestive Enzymes by Thorne: Common Questions

Does Advanced Digestive Enzymes by Thorne interact with any medications?
Yes. Based on its ingredients, Advanced Digestive Enzymes has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Digestive Enzymes contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have acid reflux or GERD?
No — betaine hydrochloride increases stomach acid and isn't safe if you have true acid reflux disease. It could make your symptoms worse. Talk to your doctor or pharmacist about whether this product is right for you.
Is this safe during pregnancy?
The safety data advises against betaine hydrochloride in pregnancy. Pepsin safety hasn't been established either unless a doctor prescribes it. You should discuss this with your doctor or pharmacist before taking it.
Can I breastfeed while taking this?
The safety data suggests avoiding both betaine hydrochloride and pepsin during breastfeeding. Pepsin has limited safety data and isn't recommended without medical advice. Talk with your pharmacist or doctor for personalized guidance.
What are the side effects?
Betaine hydrochloride may irritate your stomach and can cause heartburn. Pepsin is generally well tolerated but may cause digestive upset or allergic reactions. Rarely, inhaled pepsin (mainly in occupational settings) has triggered allergic rhinitis or asthma, though this is uncommon.
Does it actually work for indigestion or poor digestion?
We don't have reliable evidence that betaine hydrochloride works for indigestion or the other digestive complaints listed. If you're hoping this will help a specific issue, check with your pharmacist about whether it's right for you.
What are the inactive ingredients?
The capsule is made from hypromellose (a plant-based cellulose), and it contains calcium laurate and leucine as inactive ingredients. If you have sensitivities to any of these, let us know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Digestive Enzymes is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Digestive Enzymes label
Go deeper

The Full Monographs Behind Advanced Digestive Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Advanced Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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