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Dietary supplement

Plan B4 Food Ingredients & Drug Interactions

by HoltraCeuticals

Plan B4 Food label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Plan B4 Food against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Plan B4 Food is a dietary supplement by HoltraCeuticals with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Synetrim(R) CQ. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Plan B4 Food by HoltraCeuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Plan B4 Food by HoltraCeuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Plan B4 Food by HoltraCeuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Plan B4 Food is a single-ingredient capsule built around Synetrim(R) CQ, which is Cissus quadrangularis, a plant extract. The capsule itself is made from vegetable cellulose (a plant-based ingredient) and microcrystalline cellulose as a binding agent.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Cissus Quadrangularis's overall clinical evidence instead.

Moderate

Some clinical evidence supports Cissus Quadrangularis for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Obesity — rated "Possibly Effective" (Natural Medicines).

Cissus quadrangularis is possibly effective for obesity. Small clinical studies suggest it may help reduce fasting blood sugar in people who are overweight or have obesity.

For high cholesterol (hyperlipidemia), bone loss (osteopenia), cancer, and epilepsy, the evidence we hold is insufficient to rate it—we simply don't have enough reliable data to say whether it works.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, though long-term safety hasn't been thoroughly studied. Trial participants reported headache and insomnia at rates similar to placebo, as well as flatulence, diarrhea, gastritis, and dry mouth at similar or lower rates than placebo.

There isn't enough safety data to know whether it's safe in pregnancy or while breastfeeding—talk with your doctor or pharmacist for personalized advice if either applies to you.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes medications (insulin, metformin, sulfonylureas, GLP-1 agonists, or similar), you should confirm with your doctor or pharmacist before starting Plan B4 Food. There's a moderate risk that Cissus quadrangularis may increase low blood sugar (hypoglycemia) when combined with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Plan B4 Food may be worth considering if you're interested in weight management support and don't take diabetes medications. If you're on any blood sugar–lowering drug, check with your doctor or pharmacist first—this product could lower your glucose further.

It's best studied for short-term use, and long-term effects remain unclear.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Plan B4 Food, straight from the product label.

Brand HoltraCeuticals
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 19396
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Plan B4 Food by HoltraCeuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Synetrim(R) CQ150 mg--

Other ingredients: Micro Crystalline Cellulose, Vegetable capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule daily with meals. Can be taken throughout the day or as directed by a health professional.

Storage

Store in a cool, dry place with the lid tightly closed.

Precautions

Keep out of reach of children.

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Freshly Made

General Statements

Made in a GMP Certified Facility in USA

Inhibits the Absorption of Dietary Carbs and Fat

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

HOLTORF MEDICAL GROUP(R) CENTERS FOR HORMONE IMBALANCE, HYPOTHYROIDISM AND FATIGUE

Formulation

No artificial colors, no artificial flavors, no milk or milk derivatives, no preservatives, no sodium.

General

WO-1080-CPN-1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Plan B4 Food by HoltraCeuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Plan B4 Food label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Plan B4 Food by HoltraCeuticals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Synetrim(R) CQ

Interacts with
86 drugs
150 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Synetrim(R) CQ monograph & interactions

Other (inactive) ingredients: Micro Crystalline Cellulose, Vegetable capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Plan B4 Food by HoltraCeuticals Drug Interactions

Want to check YOUR meds against Plan B4 Food?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Synetrim(R) CQ 86

Individual Drug Interactions

The ingredients in Plan B4 Food interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Plan B4 Food interact with drugs. Each result below shows which ingredient is responsible. Synetrim(R) CQ

Each ingredient & the kinds of drugs it affects

For each ingredient in Plan B4 Food with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Synetrim(R) CQ1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Synetrim(R) CQ full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Plan B4 Food, from the product label.

HoltraCeuticals

See all HoltraCeuticals products
Web Address
Holtraceuticals.com
Pharmacist Counseling Corner

Plan B4 Food by HoltraCeuticals: Common Questions

Does Plan B4 Food by HoltraCeuticals interact with any medications?
Yes. Based on its ingredients, Plan B4 Food has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Plan B4 Food contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this work for weight loss?
Cissus quadrangularis is possibly effective for obesity. Small studies suggest it may help reduce fasting blood sugar in people who are overweight or obese, which could be one mechanism. That said, the evidence isn't definitive—your mileage may vary.
What are the side effects I might notice?
Headache and insomnia have been reported, along with flatulence, diarrhea, gastritis, and dry mouth. Importantly, the rates of these effects in trials were similar to or lower than with placebo, so they're not common.
Is it safe to take long-term?
Cissus quadrangularis is generally well tolerated in short-term use, but long-term safety hasn't been well studied. If you're thinking of using it for months or longer, talk it over with your pharmacist or doctor.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data to know either way. The safety data advises against use in pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What's actually in Plan B4 Food?
It's one active ingredient—Synetrim(R) CQ (Cissus quadrangularis)—in a vegetable capsule with microcrystalline cellulose as a binder. No other active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Plan B4 Food is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Plan B4 Food label
Go deeper

The Full Monographs Behind Plan B4 Food’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Plan B4 Food's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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