Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Power Mushrooms Ingredients & Drug Interactions

by Health Concerns

Power Mushrooms label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Power Mushrooms against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Power Mushrooms is a dietary supplement by Health Concerns with 4 active ingredients. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 771 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Poria sclerotium, Red Ganoderma. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Power Mushrooms by Health Concerns

Ask about any prescription or over-the-counter medication and we check it for interactions with Power Mushrooms by Health Concerns — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Power Mushrooms by Health Concerns

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (650 mg) without saying how much of each component you get.

Power Mushrooms contains four active ingredients: a proprietary blend that houses red ganoderma (reishi mushroom), poria sclerotium (poria mushroom), polyporus sclerotium (also a poria form), and tremella. The mushrooms have been used in traditional medicine for centuries, though how they work in the body is still being studied.

The product also contains inactive ingredients — vegetable gum, silicon dioxide, stearic acid, and cellulose — which are fillers and binders that hold the tablet together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: General wellness and immune support.
  • We looked for evidence on: Chronic fatigue syndrome (CFS), Stress, Insomnia, Psychological well-being, Influenza, Coronavirus disease 2019 (COVID-19) — and 4 related terms.
  • The closest evidence on file: Reishi Mushroom is rated "Possibly Ineffective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Poria Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Influenza, Insomnia, Coronavirus disease 2019 (COVID-19).
  • Also on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Chronic fatigue syndrome (CFS).

The evidence on what Power Mushrooms can actually do is pretty thin. Red Ganoderma has been studied for high cholesterol (hyperlipidemia) and appears possibly ineffective for that use.

For altitude sickness, Alzheimer disease, and athletic performance, there isn't enough reliable evidence yet to say whether it helps. Poria sclerotium has also been tested for cancer, chronic fatigue, dementia, diabetes, diabetic kidney damage (diabetic nephropathy), and diarrhea — but the evidence is insufficient to rate it for any of those.

Since tremella's data isn't on file here, we can't speak to what evidence exists for it.

The evidence, ingredient by ingredient Reishi Mushroom Poria Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Red Ganoderma is generally well tolerated in the short term, though long-term safety hasn't been thoroughly studied. Common side effects include dizziness, dry mouth, itching, nausea, rash, and stomach upset.

Respiratory allergy to reishi spores can happen, along with sore throat and runny nose. Rarely, it causes insomnia and headache.

Poria mushroom is generally well tolerated in traditional use, but human safety data are limited. Allergic reactions have been reported rarely, including allergic rhinitis and allergic asthma.

There isn't enough safety data to recommend either ingredient during pregnancy or while breastfeeding — talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Reishi Mushroom Poria Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Poria Mushroom, Reishi Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 771 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take blood pressure medications, blood thinners (especially at higher doses), diabetes medications, sedatives or other central nervous system depressants, anticholinergic drugs (for overactive bladder or certain movement disorders), or cholinergic drugs. We couldn't check Tremella for interactions, so mention it to your pharmacist if they're reviewing your medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Power Mushrooms is based on mushrooms with a long history in traditional medicine, but solid evidence for what it does is sparse. If you take blood pressure medications, blood thinners, diabetes drugs, sedatives, or medications for bladder or movement issues, run your exact prescriptions through the tool below before starting.

Pregnant or nursing? The safety data aren't there — check with your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Power Mushrooms, straight from the product label.

Brand Health Concerns
Net contents 270 Tablet(s)
Market status On market
Date entered into DSLD Apr 25, 2017
DSLD ID 73230
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Power Mushrooms by Health Concerns, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
135
IngredientAmount% DV
Proprietary Blend650 mg--
Red Ganoderma0 NP--
Poria sclerotium0 NP--
Polyporus sclerotium0 NP--
Tremella0 NP--

Other ingredients: Vegetable Gum, Silicon Dioxide, Stearic Acid, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Two to three tablets 3 times per day between meals.

Precautions

Notice: This product is not intended for use by pregnant women.

General Statements

Made in the U.S.A.

Brand IP Statement(s)

Chinese traditional formulas

Combining modern research and ancient wisdom

Formula

Ganoderma (Reishi)

Pinyin: Ling Zhi, Bai Mu Er, Fu Ling, Zhu Ling.

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Power Mushrooms by Health Concerns label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Power Mushrooms label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Power Mushrooms by Health Concerns

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container135 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

650 mg per serving

Other (inactive) ingredients: Vegetable Gum, Silicon Dioxide, Stearic Acid, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Power Mushrooms by Health Concerns Drug Interactions

Want to check YOUR meds against Power Mushrooms?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
771Drugs
771 Moderate

Ingredients driving the most interactions

Poria sclerotium 417
Red Ganoderma 375

Individual Drug Interactions

The ingredients in Power Mushrooms interact with 771 drugs. Click any drug to see the details.

2 of the 4 ingredients in Power Mushrooms interact with drugs. Each result below shows which ingredient is responsible. Poria sclerotium Red Ganoderma

Each ingredient & the kinds of drugs it affects

For each ingredient in Power Mushrooms with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Poria sclerotium3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Poria sclerotium full monograph & interactions

Red Ganoderma3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Red Ganoderma full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Power Mushrooms, from the product label.

Health Concerns

See all Health Concerns products
Name
Health Concerns
Street Address
8001 Capwell Drive
City
Oakland
State
CA
ZipCode
94621
Phone Number
(800) 233-9355
Web Address
www.healthconcerns.com/pro
Pharmacist Counseling Corner

Power Mushrooms by Health Concerns: Common Questions

Does Power Mushrooms by Health Concerns interact with any medications?
Yes. Based on its ingredients, Power Mushrooms has a known interaction with 771 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Power Mushrooms contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Power Mushrooms if I'm pregnant or breastfeeding?
There isn't enough safety data to know either way for either red ganoderma or poria mushroom during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice before taking this product.
What side effects does reishi mushroom cause?
Most commonly, dizziness, dry mouth, itching, nausea, rash, and stomach upset. Allergic reactions to reishi spores, sore throat, and runny nose have been reported. Rarely, insomnia and headache occur. It's generally well tolerated short-term, but long-term safety isn't well studied.
Can this help with high cholesterol or dementia?
Red Ganoderma appears possibly ineffective for high cholesterol. For dementia, Alzheimer disease, and other conditions like chronic fatigue and diabetes, there isn't enough reliable evidence to say whether the mushrooms in this product help.
I take a sedative — is there an issue with this product?
Yes — poria mushroom might enhance the drowsy or depressant effects of sedatives. Check your exact medication with your pharmacist before starting.
Are there any fillers or additives in this product?
Yes. In addition to the four active mushroom ingredients, the product contains vegetable gum, silicon dioxide, stearic acid, and cellulose as binders and fillers to hold the tablet together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Power Mushrooms is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Power Mushrooms label
Go deeper

The Full Monographs Behind Power Mushrooms’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph →
Sources

Sources & How We Checked

Power Mushrooms's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Poria Mushroom 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
  3. Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

See these in context on the Poria Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team