Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Premium Gold Energy Manuka Honey Blend Ingredients & Drug Interactions

by ManukaGuard

Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Premium Gold Energy Manuka Honey Blend is a dietary supplement by ManukaGuard with 2 active ingredients. Its ingredients are commonly taken for cough and sore throat, wound and burn care, soothing minor skin irritation.Based on those ingredients, 736 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Manuka Honey Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Premium Gold Energy Manuka Honey Blend by ManukaGuard

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: a manuka honey blend. Manuka honey is a special type of honey from New Zealand known for higher levels of certain compounds than regular honey.

There are no inactive fillers or other ingredients listed.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: sustained energy and physical performance support.
  • We looked for evidence on: Athletic performance, Chemotherapy-related fatigue, Energy metabolism, Endurance, Physical stamina.
  • The closest evidence on file: Honey is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Honey is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-related fatigue.

The evidence shows manuka honey is possibly effective for several uses: cold sores, cough, mouth sores (oral mucositis), burns, and dry eye. That means there's some promising research, but we don't yet have enough data to call it proven.

If you're thinking about using it for one of these purposes, talk with your doctor or pharmacist about what the research actually supports and whether it makes sense for your situation.

The evidence, ingredient by ingredient Honey

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Honey is generally well tolerated as a food for adults and children over 1 year of age. When used as a medicine, the most common side effects from taking it by mouth are nausea, stomach pain, and vomiting; topically you might notice burning, pain, or stinging.

Rare serious reactions can occur if honey contains grayanotoxins — a toxin from rhododendrons found in some honey from the Black Sea coast of Turkey — which can cause heart rhythm problems and low blood pressure. Allergic reactions including anaphylaxis are possible, as are local allergic reactions when applied to skin.

Honey is likely safe in pregnancy and lactation as a food; if you want to use it medicinally, check with your doctor or pharmacist first.

Side effects, ingredient by ingredient Honey

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Honey.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 737 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take phenytoin (Dilantin) for seizures — honey may theoretically increase its levels. Also double-check if you're on blood thinners (anticoagulants) or anti-platelet drugs, or if you take medications broken down by your liver through the CYP3A4 pathway, since the effects are unclear and vary by honey type.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to soothe a cough, cold sore, or burn, manuka honey has some evidence on its side — though the research isn't definitive yet. Just check your medications first, especially if you take seizure drugs, blood thinners, or medications processed by your liver.

Talk with your doctor or pharmacist before using it as a medicine rather than just as food, and avoid honey from the Black Sea region of Turkey.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Premium Gold Energy Manuka Honey Blend, straight from the product label.

Brand ManukaGuard
Barcode (UPC) 858631002203
Net contents 500 Gram(s); 17.6 oz.
Market status On market
Date entered into DSLD Feb 23, 2016
DSLD ID 56396
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Premium Gold Energy Manuka Honey Blend by ManukaGuard, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 tsp
Maximum serving Sizes:
5 tsp
Servings per container
100
UPC/BARCODE
858631002203
IngredientAmount% DV
Calories50 {Calories}--
Total Carbohydrates4 Gram(s)2%
Sugar4 Gram(s)--
Manuka Honey Blend5 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

ManukaGuard proprietary ENERGY BLEND of wild harvested New Zealand Manuka Honey USA harvested, USDA GRADE A Buckwheat & Orange Blossom Honey: Delivers sustained energy, supporting physical performance without the side effects of caffeine commonly found in energy products. Supports healthy gut flora and nourishes the digestive system.

Best Before: Batch:

WHOLE food

-Natural sugars convert to stored energy for sustained energy throughout the day -Supports body weight management -Supports overall gastric and digestive health

SUSTAINED ENERGY PLUS

MANUKA HONEY BLEND

Bottled in the USA with ingredients produced in USA & New Zealand. WILD HARVESTED GENUINE MANUKA HONEY.

Formula

Methylglyoxal 40 mg/kg MGO 40

ENERGY Energy content: -Contains about 7.5 times more energy than a high caffeine energy drink

MGO 40

Wild Harvested Genuine Manuka Honey.

Precautions

IF THIS HONEY CRYSTALIZES PLACE JAR IN HOT WATER UNTIL CRYSTALS DISSOLVE.

Not suitable for children under the age of 1 year.

Seals/Symbols

U

CAFEINE FREE DAILY SUSTAINABLE ENERGY

Formulation

HAS NO GENETICALLY-ENGINEERED INGREDIENTS

Suggested/Recommended/Usage/Directions

Directions: one to five teaspoons daily or as needed. Use with your favorite drinks.

FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

See for yourself

Premium Gold Energy Manuka Honey Blend by ManukaGuard label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Premium Gold Energy Manuka Honey Blend by ManukaGuard

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 tsp Dosage formLiquid Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

4 Gram(s) per serving

Manuka Honey Blend

Interacts with
736 drugs
5 Gram(s) per serving

Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade or Manuka...

Manuka Honey Blend monograph & interactions
Interaction report

Premium Gold Energy Manuka Honey Blend by ManukaGuard Drug Interactions

Want to check YOUR meds against Premium Gold Energy Manuka Honey Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
736Drugs
5 Moderate 731 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Premium Gold Energy Manuka Honey Blend with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Manuka Honey Blend3 drug types · 736 drugs

Phenytoin (Dilantin)

Theoretically, honey might increase levels of phenytoin.
In an animal model, the rate and extent of absorption of phenytoin was increased by honey. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro, honey inhibits platelet aggregation and increases the time to clotting. Furthermore, animal research suggests that feeding mice large doses of honey for 12 days increases bleeding time when compared with no intervention. However, these effects have not been reported in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Some clinical research shows that honey induces CYP3A4. However, other clinical studies found no effect on CYP3A4 activity. Different honey preparations may have different effects on CYP3A4.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Premium Gold Energy Manuka Honey Blend, from the product label.

ManukaGuard

See all ManukaGuard products
Name
Ndal Laboratories Ltd.
Street Address
P.O Box 590,
City
Monterey
State
CA
ZipCode
93942
Phone Number
1-800-916-1220
Web Address
www.ManukaGuard.com
Pharmacist Counseling Corner

Premium Gold Energy Manuka Honey Blend by ManukaGuard: Common Questions

Does Premium Gold Energy Manuka Honey Blend by ManukaGuard interact with any medications?
Yes. Based on its ingredients, Premium Gold Energy Manuka Honey Blend has a known interaction with 736 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Premium Gold Energy Manuka Honey Blend contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe for children?
Honey is generally safe for children over 1 year old. Do not give honey to babies under 1 year of age. If you want to use it medicinally in a child, talk with your child's doctor first.
Can I take this while breastfeeding?
Honey eaten as food by a breastfeeding mother is considered fine. If you want to use manuka honey as medicine while breastfeeding, check with your doctor or pharmacist for personalized advice.
What side effects might I experience?
Most people tolerate it well. The most common side effects from swallowing it are nausea, stomach pain, and vomiting. Applied to skin, you might feel burning, pain, or stinging. Allergic reactions are possible but uncommon.
Does this actually work for colds and coughs?
The research shows honey is possibly effective for cough and cold sores — meaning there's some promise, but we don't have enough data yet to say it's proven. It may be worth trying, but don't count on it to replace other treatments your doctor recommends.
Is this the same as regular honey?
No. Manuka honey is a special type from New Zealand with higher levels of certain compounds than regular honey, which is why it's been studied more closely. Different honey preparations can have different effects on your body.
Where does this honey come from?
The product facts don't specify the source. Since some honey from the Black Sea coast of Turkey can be unsafe due to toxins, you may want to contact the manufacturer to confirm the origin.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Premium Gold Energy Manuka Honey Blend is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Premium Gold Energy Manuka Honey Blend label
Go deeper

The Full Monographs Behind Premium Gold Energy Manuka Honey Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Premium Gold Energy Manuka Honey Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 40 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Honey 40 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Bose B. Honey or sugar in treatment of infected wounds? Lancet 1982;1:963. PubMed
  4. Ozhan H, Akdemir R, Yazici M, et al. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4. PubMed
  5. Centers for Disease Control. Botulism in the Unites Sates, 1899-1996. Handbook for epidemiologists, clinicians, and laboratory workers, 1998. Available online: http://www.cdc.gov/ncidod/dbmd/diseaseinfo/botulism.PDF.
  6. Simon A, Traynor K, Santos K, et al. Medical honey for wound care - still the 'latest resort'? Evid Based Complement Alternat Med 2009;6:165-73. PubMed
  7. Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Int Wound J 2005;2:10-15. PubMed
  8. Ingle R, Levin J, Polinder K. Wound healing with honey - a randomised controlled trial. S Afr Med J 2006;96:831-5.
  9. Johnson DW, van Eps C, Mudge DW, et al. Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients. J Am Soc Nephrol 2005;16:1456-62. PubMed
  10. Sukriti and Garg, S. K. Influence of honey on the pharmacokinetics of phenytoin in rabbits. Ind J Pharmacol 2002;34(147).
  11. Jung, A. and Ottosson, J. [Infantile botulism caused by honey]. Ugeskr Laeger 2001;163(2):169.
  12. Gunduz, A., Turedi, S., Uzun, H., and Topbas, M. Mad honey poisoning. Am J Emerg.Med 2006;24(5):595-598.
  13. van der Vorst, M. M., Jamal, W., Rotimi, V. O., and Moosa, A. Infant botulism due to consumption of contaminated commercially prepared honey. First report from the Arabian Gulf States. Med Princ.Pract. 2006;15(6):456-458. PubMed
  14. Tushar, T., Vinod, T., Rajan, S., Shashindran, C., and Adithan, C. Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. Basic Clin Pharmacol Toxicol 2007;100(4):269-272. PubMed
  15. Nilforoushzadeh, M. A., Jaffary, F., Moradi, S., Derakhshan, R., and Haftbaradaran, E. Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis. BMC Complement Altern Med 2007;7:13. PubMed
  16. Koca, I. and Koca, A. F. Poisoning by mad honey: a brief review. Food Chem Toxicol 2007;45(8):1315-1318. PubMed
  17. Akinci, S., Arslan, U., Karakurt, K., and Cengel, A. An unusual presentation of mad honey poisoning: acute myocardial infarction. Int J Cardiol 2008;129(2):e56-e58. PubMed
  18. Yildirim, N., Aydin, M., Cam, F., and Celik, O. Clinical presentation of non-ST-segment elevation myocardial infarction in the course of intoxication with mad honey. Am J Emerg Med 2008;26(1):108.e-2. PubMed
  19. Shrestha, P., Vaidya, R., and Sherpa, K. Mad honey poisoning: a rare case report of seven cases. Nepal Med Coll J 2009;11(3):212-213.
  20. Fetzner, L., Burhenne, J., Weiss, J., Völker, M., Unger, M., Mikus, G., and Haefeli, W. E. Daily honey consumption does not change CYP3A activity in humans. J Clin Pharmacol 2011;51(8):1223-1232. PubMed
  21. Thamboo, A., Thamboo, A., Philpott, C., Javer, A., and Clark, A. Single-blind study of manuka honey in allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg 2011;40(3):238-243.
  22. Ahmed, A., Khan, R. A., Azim, M. K., Saeed, S. A., Mesaik, M. A., Ahmed, S., and Imran, I. Effect of natural honey on human platelets and blood coagulation proteins. Pak.J Pharm Sci 2011;24(3):389-397.
  23. Yarlioglues, M., Akpek, M., Ardic, I., Elcik, D., Sahin, O., and Kaya, M. G. Mad-honey sexual activity and acute inferior myocardial infarctions in a married couple. Tex.Heart Inst.J 2011;38(5):577-580.
  24. Biberoglu, S., Biberoglu, K., and Komsuoglu, B. Mad honey. JAMA 4-1-1988;259(13):1943.
  25. Biberoglu, K., Biberoglu, S., and Komsuoglu, B. Transient Wolff-Parkinson-White syndrome during honey intoxication. Isr.J.Med.Sci. 1988;24(4-5):253-254.
  26. Gössinger, H., Hruby, K., Pohl, A., Davogg, S., Sutterlütti, G., and Mathis, G. [Poisoning with andromedotoxin-containing honey]. Dtsch Med Wochenschr 1983;108(41):1555-1558.
  27. Fenicia, L., Ferrini, A. M., Aureli, P., and Pocecco, M. A case of infant botulism associated with honey feeding in Italy. Eur J Epidemiol 1993;9(6):671-673. PubMed
  28. Sutlupinar, N., Mat, A., and Satganoglu, Y. Poisoning by toxic honey in Turkey. Arch.Toxicol. 1993;67(2):148-150. PubMed
  29. von Malottki, K. and Wiechmann, H. W. [Acute life-threatening bradycardia: food poisoning by Turkish wild honey]. Dtsch.Med.Wochenschr. 7-26-1996;121(30):936-938.
  30. Abdulla CO, Ayubi A, Zulfiquer F, Santhanam G, Ahmed MA, Deeb J. Infant botulism following honey ingestion. BMJ Case Rep. 2012 Sep 7;2012.
  31. Johnson DW, Badve SV, Pascoe EM, Beller E, Cass A, Clark C, de Zoysa J, Isbel NM, McTaggart S, Morrish AT, Playford EG, Scaria A, Snelling P, Vergara LA, Hawley CM; HONEYPOT Study Collaborative Group. Antibacterial honey for the prevention of peritoneal-d
  32. Matos D, Serrano P, Menezes Brandão F. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis. 2015 Jan;72(1):59-60. PubMed
  33. Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE. Honey for acute cough in children. Cochrane Database Syst Rev. 2014 Dec 23;12:CD007094. PubMed
  34. Vezir E, Kaya A, Toyran M, Azkur D, Dibek Misirlioglu E, Kocabas CN. Anaphylaxis/angioedema caused by honey ingestion. Allergy Asthma Proc. 2014 Jan-Feb;35(1):71-4. PubMed
  35. Wang YT, Qi Y, Tang FY, et al. The effect of cupping therapy for low back pain: A meta-analysis based on existing randomized controlled trials. J Back Musculoskelet Rehabil. 2017;30(6):1187-1195. PubMed
  36. Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM. Honey for acute cough in children. Cochrane Database Syst Rev. 2018;4:CD007094. PubMed
  37. Wong D, Albietz JM, Tran H, et al. Treatment of contact lens related dry eye with antibacterial honey. Cont Lens Anterior Eye. 2017;40(6):389-393. PubMed
  38. Martina SJ, Ramar LAP, Silaban MRI, Luthfi M, Govindan PAP. Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice. Open Access Maced J Med Sci. 2019 Oct 14;7(20):3416-3420. PubMed
  39. Jhawar N, Gonzalez-Estrada A. Honey-induced anaphylaxis in an adult. QJM 2022;115(5):325-326. PubMed
  40. Di Costanzo M, De Paulis N, Peveri S, Montagni M, Berni Canani R, Biasucci G. Anaphylaxis caused by artisanal honey in a child: a case report. J Med Case Rep 2021;15(1):235. PubMed

See these in context on the Honey monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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