Interactions on record — worth a quick check against your medications. Based on 7 of 11 ingredients. Check your meds →
Dietary supplement

Premium Mushroom Complex 11 Mushroom Blend 2600 mg Ingredients & Drug Interactions

by Nutrivein

Premium Mushroom Complex 11 Mushroom Blend 2600 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Premium Mushroom Complex 11 Mushroom Blend 2600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Premium Mushroom Complex 11 Mushroom Blend 2600 mg is a dietary supplement by Nutrivein with 11 active ingredients. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 662 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Mushroom, organic Lion's Mane mushroom, Chaga Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Premium Mushroom Complex 11 Mushroom Blend 2600 mg by Nutrivein

Ask about any prescription or over-the-counter medication and we check it for interactions with Premium Mushroom Complex 11 Mushroom Blend 2600 mg by Nutrivein — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Premium Mushroom Complex 11 Mushroom Blend 2600 mg by Nutrivein

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 11 active ingredients.
  • “Advanced Mushroom Complex” is a proprietary blend — the label gives one combined amount (200 mg) without saying how much of each component you get.

This supplement contains 11 active mushroom ingredients totaling 2,600 mg per serving. They include organic lion's mane and turkey tail, agaricus blazei, chaga, white button, cordyceps sinensis, reishi, an advanced mushroom complex blend, maitake, shiitake, and enoki mushrooms.

These are whole-mushroom or extract powders chosen for traditional use in wellness practices. The capsule itself is made from methylcellulose, a plant-based binder.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't yet support these mushrooms for most of their traditional uses. Lion's mane, agaricus, chaga, cordyceps, reishi, maitake, and shiitake all show insufficient reliable evidence for conditions like cognitive function, cancer support, athletic performance, and cardiovascular health.

Cordyceps is rated possibly ineffective for athletic performance, and reishi is rated possibly ineffective for high cholesterol. Shiitake is rated possibly ineffective for dental plaque.

If you're considering this product for a specific health goal, talk with your doctor or pharmacist about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Lion's Mane Mushroom Cordyceps Reishi Mushroom Agaricus Mushroom Chaga Maitake Mushroom Shiitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane, agaricus, chaga, cordyceps, reishi, maitake, and shiitake are all generally well tolerated, though long-term safety in supplement form hasn't been thoroughly studied. Common mild side effects include gastrointestinal discomfort, nausea, diarrhea, and rash.

Agaricus carries rare reports of serious liver injury (hepatotoxicity) and allergic reactions; three cases of severe liver damage were reported in women undergoing chemotherapy. Chaga has been linked to kidney problems from excessive oxalate content.

Shiitake can cause shiitake dermatitis (a rash resembling whiplash marks) if eaten raw, and workers exposed to shiitake spores have developed breathing problems. During pregnancy, the safety data for lion's mane, agaricus, chaga, cordyceps, reishi, maitake, and shiitake are not established.

The same applies during breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Lion's Mane Mushroom Cordyceps Reishi Mushroom Agaricus Mushroom Chaga Maitake Mushroom Shiitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Maitake Mushroom, Cordyceps, Shiitake Mushroom, Reishi Mushroom, Agaricus Mushroom, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 662 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on blood thinners (anticoagulants or antiplatelet drugs), diabetes medications, blood-pressure drugs, immune-suppressing medications, or warfarin specifically. These are the Moderate-severity interactions documented for this blend's ingredients.

Cordyceps also carries a Minor-severity interaction with testosterone supplements.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This blend brings together seven mushroom species with some traditional wellness use, though solid evidence for most health claims remains limited. It's worth considering if you're interested in mushroom supplements — just be aware it may interact with blood thinners, diabetes medications, blood-pressure drugs, and immune-suppressing medications.

If you take any prescription drugs, especially those categories, or if you're pregnant or breastfeeding, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Premium Mushroom Complex 11 Mushroom Blend 2600 mg, straight from the product label.

Brand Nutrivein
Barcode (UPC) B07MWHPLYR
Net contents 90 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 271382
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Premium Mushroom Complex 11 Mushroom Blend 2600 mg by Nutrivein, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
B07MWHPLYR
IngredientAmount% DV
organic Turkey Tail Mushroom0 NP--
organic Lion's Mane mushroom800 mg--
Agaricus blazei0 NP--
Chaga Mushroom0 NP--
White Button Mushroom0 NP--
Cordyceps sinensis Mushroom800 mg--
Reishi Mushroom800 mg--
Advanced Mushroom Complex200 mg--
Maitake Mushroom0 NP--
Shiitake Mushroom0 NP--
Enoki Mushroom0 NP--
Oyster Mushroom0 NP--

Other ingredients: Methylcellulose Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 3 veggie capsules once daily, preferably with a meal and water, or as directed by a healthcare professional.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Storage: Keep tightly closed in a dry place and do not expose to excessive heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Zero: GMOs, fillers, preservatives, stearates, artificial ingredients, binders, dioxides, lactose Does not contain: Corn, gluten, soy, sugar, shellfish, eggs, peanuts

Boosts immunity and defense Supports brain function Enhances memory, focus and clarity

Vegan

Made with non-GMO ingredients

General Statements

Lot # and expiration date printed at bottom of bottle

Formula

2600 mg per serving

FDA Statement of Identity

All Natural Dietary Supplement

Seals/Symbols

Made in USA with global ingredients Made in an FDA registered facility GMP Good Manufacturing Practice Third party tested

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Premium Mushroom Complex 11 Mushroom Blend 2600 mg by Nutrivein label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Premium Mushroom Complex 11 Mushroom Blend 2600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Premium Mushroom Complex 11 Mushroom Blend 2600 mg by Nutrivein

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Lion's Mane mushroom

Interacts with
327 drugs
800 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Organic Lion's Mane mushroom monograph & interactions

Cordyceps sinensis Mushroom

Interacts with
249 drugs
800 mg per serving Form: Cordycepic Acid

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...

Cordyceps sinensis Mushroom monograph & interactions

Reishi Mushroom

Interacts with
375 drugs
800 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom monograph & interactions

Advanced Mushroom Complex

200 mg per serving

Other (inactive) ingredients: Methylcellulose Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Premium Mushroom Complex 11 Mushroom Blend 2600 mg by Nutrivein Drug Interactions

Want to check YOUR meds against Premium Mushroom Complex 11 Mushroom Blend 2600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
662Drugs
654 Moderate 8 Minor

Ingredients driving the most interactions

Reishi Mushroom 375
organic Lion's Mane mushroom 327
Chaga Mushroom 327
Shiitake Mushroom 312
Maitake Mushroom 260

Individual Drug Interactions

The ingredients in Premium Mushroom Complex 11 Mushroom Blend 2600 mg interact with 662 drugs. Click any drug to see the details.

7 of the 11 ingredients in Premium Mushroom Complex 11 Mushroom Blend 2600 mg interact with drugs. Each result below shows which ingredient is responsible. Reishi Mushroom organic Lion's Mane mushroom Chaga Mushroom Shiitake Mushroom Maitake Mushroom Cordyceps sinensis Mushroom Agaricus blazei

Each ingredient & the kinds of drugs it affects

For each ingredient in Premium Mushroom Complex 11 Mushroom Blend 2600 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi Mushroom3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom full monograph & interactions

organic Lion's Mane mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
organic Lion's Mane mushroom full monograph & interactions

Chaga Mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
Chaga Mushroom full monograph & interactions

Shiitake Mushroom2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake Mushroom full monograph & interactions

Maitake Mushroom3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Mushroom full monograph & interactions

Cordyceps sinensis Mushroom3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps sinensis Mushroom full monograph & interactions

Agaricus blazei1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus blazei full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Premium Mushroom Complex 11 Mushroom Blend 2600 mg, from the product label.

Nutrivein

See all Nutrivein products
Name
Nutrivein
Street Address
720 N 10th St A-330
City
Renton
State
WA
ZipCode
98057
Phone Number
888-705-3526
Web Address
www.nutrivein.com
Pharmacist Counseling Corner

Premium Mushroom Complex 11 Mushroom Blend 2600 mg by Nutrivein: Common Questions

Does Premium Mushroom Complex 11 Mushroom Blend 2600 mg by Nutrivein interact with any medications?
Yes. Based on its ingredients, Premium Mushroom Complex 11 Mushroom Blend 2600 mg has a known interaction with 662 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Premium Mushroom Complex 11 Mushroom Blend 2600 mg contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my blood thinner?
Several mushrooms in this blend — lion's mane, chaga, cordyceps, reishi, and maitake — may theoretically increase bleeding risk when combined with blood thinners. Maitake has a documented case where it increased warfarin's effects. Don't start this product without talking to your doctor or pharmacist first.
Can I take this if I'm on diabetes medication?
Yes, but carefully. Five mushrooms here — lion's mane, agaricus, chaga, reishi, and maitake — may lower blood sugar further, raising the risk of low blood sugar (hypoglycemia). Your doctor or pharmacist can assess whether it's safe for your situation and whether your medication dose needs adjusting.
Is it safe during pregnancy?
There isn't enough safety data to know either way for most of these mushrooms when used as supplements. Talk with your doctor or pharmacist to weigh what you know about this blend against your individual situation.
What side effects should I watch for?
The most common are mild: stomach discomfort, nausea, diarrhea, and rash. Rare but serious ones include liver injury (reported with agaricus in a few cases) and kidney problems (from chaga's oxalate content if taken in very large amounts). Stop and contact your healthcare provider if you notice yellowing of the skin, severe abdominal pain, or dark urine.
Does this actually work for cognitive health or cancer?
The evidence we have doesn't yet support these mushrooms for cognitive function, Alzheimer's disease, cancer, or most other health claims. While they're used traditionally, solid clinical proof is lacking. If you're taking this for a specific health goal, ask your doctor whether it makes sense for you.
Will this interfere with my immune-suppressing medication?
Possibly. Lion's mane, cordyceps, and shiitake may theoretically stimulate the immune system and interfere with immunosuppressants. Check with your doctor or pharmacist before adding this product if you're taking immune-suppressing drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Premium Mushroom Complex 11 Mushroom Blend 2600 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Premium Mushroom Complex 11 Mushroom Blend 2600 mg label
Go deeper

The Full Monographs Behind Premium Mushroom Complex 11 Mushroom Blend 2600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph → Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph →
Sources

Sources & How We Checked

Premium Mushroom Complex 11 Mushroom Blend 2600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 126 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Chaga 9 references
  1. Sun JE, Ao ZH, Lu ZM, et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol 2008;118(1):7-13. PubMed
  2. Hyun KW, Jeong SC, Lee DH, et al. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 2006;27(6):1173-8. PubMed
  3. Kim YO, Han SB, Lee HW, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 2005;77(19):2438-56. PubMed
  4. Kikuchi Y, Seta K, Ogawa Y, et al. Chaga mushroom-induced oxalate nephropathy. Clin Nephrol 2014;81(6):440-4. PubMed
  5. Lee S, Lee HY, Park Y, et al. Development of end stage renal disease after long-term ingestion of chaga mushroom: case report and review of literature. J Korean Med Sci. 2020;35(19):e122.
  6. Kwon O, Kim Y, Paek JH, et al. Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report. Medicine (Baltimore) 2022;101(10):e28997. PubMed
  7. Su L, Xin C, Yang J, et al. A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus. Int J Biol Macromol 2022;214:312-323. PubMed
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Cordyceps 14 references
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Reishi Mushroom 17 references
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Maitake Mushroom 8 references
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