Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Pro+ Ingredients & Drug Interactions

by BergaMet North America

Pro+ label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pro+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pro+ is a dietary supplement by BergaMet North America with 5 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 684 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Citrus Bergamot extract, Alpha Lipoic Acid, Vitamin C. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pro+ by BergaMet North America

Ask about any prescription or over-the-counter medication and we check it for interactions with Pro+ by BergaMet North America — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pro+ by BergaMet North America

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Pro+ contains five active ingredients. Vitamin C is included for immune support and as an antioxidant.

Alpha-lipoic acid is a compound with antioxidant properties studied for metabolic health. Olive leaf extract comes from the olive plant and is used in traditional practice.

Chromium is a mineral that plays a role in blood sugar regulation. Citrus Bergamot extract is derived from a variety of citrus fruit.

The product also contains inactive ingredients—cellulose, silicon dioxide, cellulose gum, magnesium stearate, and carnauba wax—which serve as fillers, flow agents, and tablet coating.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Heart health, cholesterol, and blood sugar support.
  • We looked for evidence on: Atherosclerosis, Cardiovascular disease (CVD), Chromium deficiency, Diabetes, Diabetic nephropathy, Diabetic neuropathy — and 4 related terms.
  • The strongest evidence on file: Chromium is rated "Likely Effective" for Chromium deficiency (Natural Medicines).
  • Also on file: Alpha-lipoic Acid is rated "Possibly Effective" for Diabetic neuropathy.
  • Also on file: Chromium is rated "Possibly Effective" for Diabetes.

The evidence for this product's ingredients is mixed. Vitamin C is effective for preventing vitamin C deficiency and is possibly effective for anemia of chronic disease, atrial fibrillation, cataracts, and exercise-induced respiratory infections.

Alpha-lipoic acid is possibly effective for diabetic nerve damage and elevated cholesterol and triglycerides, and possibly effective for weight management. Chromium is likely effective for chromium deficiency and possibly effective for diabetes, though it is possibly ineffective for prediabetes, schizophrenia, and high blood pressure.

Citrus Bergamot extract is possibly effective for high cholesterol but possibly ineffective for mental alertness. Olive leaf extract has insufficient evidence to rate its effectiveness for any of the conditions studied—there isn't enough reliable data on file.

No single ingredient is proven to address a specific condition that this product claims to treat overall.

The evidence, ingredient by ingredient Vitamin C Alpha-lipoic Acid Olive Chromium Bergamot

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin C is generally well tolerated at normal dietary and supplement doses, but very high doses can cause side effects—abdominal cramps, diarrhea, heartburn, nausea, vomiting, and kidney stones (especially in those prone to them) are more likely above 2 grams daily. Alpha-lipoic acid appears generally well tolerated orally and may cause headache, heartburn, nausea, vomiting, dizziness, or skin rash.

It can lower blood sugar and is best used under medical guidance. Chromium is usually well tolerated at typical supplement doses, though high or long-term doses may carry risks; common side effects include gastrointestinal irritation, headaches, insomnia, and mood changes.

Olive leaf extract seems well tolerated and may cause headache or mild stomach discomfort. Citrus Bergamot extract is well tolerated when taken orally short-term; one person reported heartburn in a trial.

Regarding pregnancy: vitamin C at normal dietary amounts is likely safe, but avoid high-dose supplements; alpha-lipoic acid should be avoided because there isn't enough safety information; chromium data isn't on file, so talk with your doctor; olive leaf extract data isn't on file; citrus bergamot extract is possibly unsafe and should be avoided. For breastfeeding, avoid alpha-lipoic acid and citrus bergamot extract due to insufficient safety information, and discuss chromium and olive leaf extract with your healthcare provider since data isn't available.

Side effects, ingredient by ingredient Vitamin C Alpha-lipoic Acid Olive Chromium Bergamot

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Bergamot, Alpha-lipoic Acid, Chromium, Vitamin C.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 684 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Pro+, check with your pharmacist if you take estrogens (oral contraceptives or hormone replacement therapy)—vitamin C may raise estrogen levels. Blood thinners like warfarin and antiplatelet drugs need attention too, as vitamin C and alpha-lipoic acid both interact.

Diabetes medications and insulin carry a Moderate risk of low blood sugar from chromium, alpha-lipoic acid, and bergamot. Thyroid medication (levothyroxine) interacts with both vitamin C and chromium.

If you're on chemotherapy, photosensitizing drugs, or psychiatric or HIV medications, run this product through the checker below with your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pro+ combines several ingredients studied for metabolic and antioxidant support, but if you take blood thinners, diabetes medications, thyroid medication, chemotherapy, or oral contraceptives or hormone replacement therapy, you'll want to check this product with your pharmacist first. The interactions with estrogens and blood thinners are the most serious concerns documented here.

Talk to your pharmacist or doctor before adding this to your routine, especially if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pro+, straight from the product label.

Brand BergaMet North America
Barcode (UPC) 0609722864589
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 257136
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pro+ by BergaMet North America, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
0609722864589
IngredientAmount% DV
Vitamin C25 mg42%
Alpha Lipoic Acid50 mg--
Olive leaf extract100 mg--
Chromium200 mcg170%
Citrus Bergamot extract675 mg--

Other ingredients: Cellulose, Silicon Dioxide, Cellulose Gum, Magnesium Stearate, Carnauba wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Multiple clinical studies BergaMet Pro+ has shown to deliver impressive cardiovascular benefits.

Heart health Cholesterol Blood sugar

Patented extraction process

No colors, flavors or preservatives. Free of wheat, gluten, fish, egg, dairy and lactose.

Vegan friendly

Non GMO Gluten free

Formula

Powerful antioxidant BergaMet Pro+ from the world's strongest Superfruit, citrus bergamia risso (Bergamot) plant, indeed represents an effective approach in supporting a healthy cardiovascular system. It contains 5 powerful antioxidant flavonoids that may help support healthy cholesterol and blood glucose levels. Also, it may help support weight management in conjunction with a healthy diet and exercise. Levels already within normal limits

675 mg citrus bergamot superfruit

Maximum strength 47% BPF

Precautions

Do not use if seal is broken.

Caution: Do not take during pregnancy or when lactating.

Supplements should not replace a balanced diet.

Storage

Store in a dry, cool place.

Seals/Symbols

Made in U.S.A.

Vegan friendly

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 1 tablet with breakfast and 1 tablet with dinner, per day.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pro+ by BergaMet North America label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pro+ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pro+ by BergaMet North America

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin C

Interacts with
207 drugs
25 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Alpha Lipoic Acid

Interacts with
263 drugs
50 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha Lipoic Acid monograph & interactions

Olive leaf extract

No known
interactions
100 mg per serving Form: Oleuropein

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Olive leaf extract monograph & interactions

Chromium

Interacts with
178 drugs
200 mcg per serving Form: ChromeMate Chromium Polynicotinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Citrus Bergamot extract

Interacts with
410 drugs
675 mg per serving

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but...

Citrus Bergamot extract monograph & interactions

Other (inactive) ingredients: Cellulose, Silicon Dioxide, Cellulose Gum, Magnesium Stearate, Carnauba wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pro+ by BergaMet North America Drug Interactions

Want to check YOUR meds against Pro+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
684Drugs
614 Moderate 70 Minor

Ingredients driving the most interactions

Citrus Bergamot extract 410
Alpha Lipoic Acid 263
Vitamin C 207
Chromium 178

Individual Drug Interactions

The ingredients in Pro+ interact with 684 drugs. Click any drug to see the details.

4 of the 5 ingredients in Pro+ interact with drugs. Each result below shows which ingredient is responsible. Citrus Bergamot extract Alpha Lipoic Acid Vitamin C Chromium

Each ingredient & the kinds of drugs it affects

For each ingredient in Pro+ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Citrus Bergamot extract2 drug types · 410 drugs

Antidiabetes Drugs

Theoretically, taking bergamot with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that bergamot juice has hypoglycemic effects.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Bergamot contains bergapten, which has photosensitizing effects.

Likelihood Probable Evidence D
Citrus Bergamot extract full monograph & interactions

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pro+, from the product label.

BergaMet North America

See all BergaMet North America products
Name
BergaMet North America LLC
Street Address
6445 S Tenaya Way, Suite B110
City
Las Vegas
State
NV
ZipCode
89113
Phone Number
1 855 556 2131
Web Address
www.bergametna.com
Pharmacist Counseling Corner

Pro+ by BergaMet North America: Common Questions

Does Pro+ by BergaMet North America interact with any medications?
Yes. Based on its ingredients, Pro+ has a known interaction with 684 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pro+ contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Pro+ if I'm on birth control or hormone replacement therapy?
You should check with your pharmacist first. Vitamin C in this product may raise estrogen blood levels significantly—up to 55% in some cases—which could affect how your hormones work. Your pharmacist can review your specific dose and medication to advise you.
Can I take Pro+ if I'm on a blood thinner like warfarin?
Not without checking with your pharmacist. Vitamin C and alpha-lipoic acid both interact with blood thinners and antiplatelet drugs, and the interaction is rated Moderate severity. Your pharmacist needs to review your exact dose and medication to see if it's safe for you.
What are the common side effects of Pro+?
The most likely side effects come from vitamin C at higher doses—abdominal cramps, diarrhea, heartburn, and nausea. Alpha-lipoic acid may cause headache, heartburn, or dizziness. Chromium can cause gastrointestinal irritation, headaches, or mood changes. Most people tolerate the ingredients without problems at typical doses.
Is Pro+ safe to take during pregnancy?
There isn't enough safety information for all the ingredients. Vitamin C at normal dietary amounts is likely safe, but avoid high-dose supplements. Alpha-lipoic acid and citrus bergamot extract should be avoided because data is insufficient or indicates possible risk. Talk with your doctor about what's safe for your pregnancy.
Can I take Pro+ if I have diabetes or take diabetes medication?
Not without checking with your doctor or pharmacist first. Chromium, alpha-lipoic acid, and bergamot may lower blood sugar, and taking them with diabetes medications carries a Moderate risk of dangerously low blood sugar. Your healthcare provider needs to review your specific medication and dose.
What is alpha-lipoic acid in this product supposed to do?
Alpha-lipoic acid is an antioxidant compound that is possibly effective for diabetic nerve damage and possibly effective for high cholesterol and weight management. The evidence is promising but not conclusive for these uses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pro+ is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pro+ label
Go deeper

The Full Monographs Behind Pro+’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Bergamot

Interacts with 410 drugs

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but promising research. The essential oil i...

Read the full Bergamot monograph →
Sources

Sources & How We Checked

Pro+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 171 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin C 51 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
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Bergamot 17 references
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See these in context on the Bergamot monograph →

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