HerHeart Ingredients & Drug Interactions
What is this page for?
First and foremost: checking HerHeart against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
HerHeart is a dietary supplement by BergaMet North America with 6 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 547 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Citrus Bergamot extract, Bulgarian Tribulus, Damiana. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against HerHeart by BergaMet North America
Ask about any prescription or over-the-counter medication and we check it for interactions with HerHeart by BergaMet North America — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of HerHeart by BergaMet North America
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
HerHeart contains 6 active ingredients: zinc, citrus bergamot extract, Bulgarian tribulus, damiana, maca, and bergamot polyphenolic fraction. Zinc is a mineral used to treat or prevent deficiency and has been studied for acne and age-related eye health.
Bergamot extract and its polyphenolic fraction—both derived from citrus—are included for their effects on cholesterol levels. Tribulus is a plant traditionally used for sexual function.
Damiana and maca are herbal ingredients also associated with sexual health and general vitality, though the evidence for many of their uses remains limited. The tablet also contains inactive ingredients: cellulose, silicon dioxide, cellulose gum, magnesium stearate, and carnauba wax.
These are standard fillers and binders used to hold the tablet together.
Does it work?
Moderate evidence
The evidence for HerHeart's ingredients is mixed. Zinc is effective for zinc deficiency and likely effective for Wilson disease (a rare copper-storage disorder), and possibly effective for acne and age-related macular degeneration.
The bergamot ingredients are possibly effective for lowering cholesterol but appear possibly ineffective for mental alertness. For nonalcoholic fatty liver disease and autism spectrum disorder, the data isn't strong enough yet to rate.
Tribulus and damiana are both possibly effective for sexual dysfunction, though the evidence is incomplete. Maca's uses—from anemia to athletic performance—have insufficient evidence to say whether it works.
Overall, zinc has the strongest evidence base, while several ingredients lack the research needed to be confident in their benefits.
How safe is it?
Well-documented data
Zinc is generally well tolerated in recommended amounts (below 40 mg daily for adults), but high doses can harm you—they raise the risk of copper deficiency, which may cause anemia and low white blood cell counts. Common side effects from oral zinc include nausea, vomiting, diarrhea, metallic taste, and abdominal cramps, mostly at higher doses.
Bergamot extract is generally well tolerated when taken by mouth short-term, but the data advise against it in pregnancy and breastfeeding because there isn't enough safety information. Tribulus is often well tolerated short-term but should be avoided in pregnancy and while breastfeeding due to hormonal concerns and limited safety data.
Damiana and maca also lack enough safety data for pregnancy and breastfeeding, so they should be avoided during those times. Damiana at very high doses (200 grams) has caused severe muscle spasms resembling poisoning in rare cases.
Fresh, uncooked maca may cause stomach pain.
Meds to double-check
Moderate interaction found
Before you start HerHeart, double-check with your doctor or pharmacist if you take any antibiotics (especially quinolones like ciprofloxacin, tetracyclines like doxycycline, or cephalexin), blood pressure medications, blood sugar medications, lithium, HIV drugs (ritonavir, integrase inhibitors, or biktarvy), penicillamine, cisplatin, or photosensitizing drugs. Many of these interactions can be managed with careful timing, but some combinations may not be right for you.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
HerHeart may appeal to someone looking to support cholesterol levels, sexual function, or micronutrient needs with a multi-ingredient approach. However, if you take blood pressure meds, blood sugar medications, lithium, antibiotics (especially quinolones, tetracyclines, or cephalexin), or HIV drugs, you need to check with your own pharmacist or doctor before starting this product—the spacing or timing of doses may matter, or the combination may not be safe for you.
Avoid it if you're pregnant or breastfeeding. Talk it over with your healthcare provider to make sure it fits your health picture.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about HerHeart, straight from the product label.
| Brand | BergaMet North America |
|---|---|
| Barcode (UPC) | 0799439133983 |
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Dec 18, 2021 |
| DSLD ID | 257120 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Women (not pregnant or lactating), Adult Female (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for HerHeart by BergaMet North America, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Zinc | 3 mg | 30% |
| Proprietary Blend | 1000 mg | -- |
| Citrus Bergamot extract | 0 NP | -- |
| Bulgarian Tribulus | 0 NP | -- |
| Damiana | 0 NP | -- |
| Maca | 0 NP | -- |
| Bergamot Polyphenolic Fraction | 0 NP | -- |
Other ingredients: Cellulose, Silicon Dioxide, Cellulose Gum, Magnesium Stearate, Carnauba Wax
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Multiple clinical studies Clinically proven BergaMet HerHeart has shown to deliver impressive results in managing women's cholesterol levels.
All-natural antioxidant HerHeart contains the world's strongest bergamot SuperFruit which provides an effective way to support healthy cholesterol and glucose levels.
500 mg Citrus Bergamot Superfruit
Maximum strength 47% BPF
Formulation
In addition, HerHeart's patented formulation may help you with energy levels, hot flashes, weight management, and balancing hormones.
Cholesterol Libido Hot flashes Energy Mood
Patented extraction process
No colors, flavors or preservatives. Free of wheat, gluten, fish, egg, dairy and lactose.
Vegan friendly
Non GMO Gluten free
Levels already within normal limits
Precautions
Do not use if seal is broken.
Caution: Do not take during pregnancy or when lactating.
Supplements should not replace a balanced diet.
Storage
Store in a dry, cool place.
Seals/Symbols
Made in U.S.A.
Vegan friendly
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Take 1 tablet twice daily.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
HerHeart by BergaMet North America label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in HerHeart by BergaMet North America
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Zinc
Interacts with67 drugs
Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...
Zinc monograph & interactionsProprietary Blend
Other (inactive) ingredients: Cellulose, Silicon Dioxide, Cellulose Gum, Magnesium Stearate, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.
HerHeart by BergaMet North America Drug Interactions
HelloPharmacist Interaction Report
HerHeart by BergaMet North America interacts with medications through its zinc, bergamot extract, and tribulus content.
The most serious interactions are Moderate in severity. Zinc can reduce levels of several antibiotic types—quinolones, tetracyclines, and cephalexin—as well as penicillamine, ritonavir, integrase inhibitors (including bictegravir/emtricitabine/tenofovir alafenamide), and theoretically may interfere with cisplatin therapy.
These interactions happen because zinc forms complexes in your digestive tract that block absorption of the medication. Both bergamot ingredients in this product carry Moderate risk with antidiabetes drugs (raising the chance of low blood sugar) and photosensitizing medications (raising sun-related skin reactions if bergamot is applied topically).
Tribulus adds Moderate interactions with blood pressure medications, antidiabetes drugs, and lithium—it may lower blood pressure or blood sugar levels, or increase lithium in your bloodstream.
Read the full breakdown — every affected drug type, severity by severity
Additionally, damiana in this blend carries a Moderate interaction with antidiabetes drugs, again raising low blood sugar risk. Maca has no interactions documented in our data.
We could not check the proprietary blend's component ingredients beyond those listed separately.
Altogether, these interactions span 547 individual medications. Most of the risk comes from timing: many of the antibiotic interactions with zinc can be managed by spacing doses at least 2 hours before or 4–6 hours after the supplement.
Before you take HerHeart, run your exact medications through the search tool on this page or check with your own pharmacist or doctor.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against HerHeart?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in HerHeart interact with 547 drugs. Click any drug to see the details.
4 of the 6 ingredients in HerHeart interact with drugs. Each result below shows which ingredient is responsible. Citrus Bergamot extract Bulgarian Tribulus Damiana Zinc
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with HerHeart — through 3 ingredients. Tap an ingredient for the detail:
DamianaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Damiana + Acarbose interactionBergamot Polyphenolic FractionAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking bergamot with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bergamot Polyphenolic Fraction + Acarbose interactionBulgarian TribulusAntidiabetes Drugs Moderate
Interaction Summary
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bulgarian Tribulus + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bulgarian TribulusAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Bulgarian Tribulus + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acepromazine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Ibuprofen interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with HerHeart — through 2 ingredients. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetazolamide interactionBulgarian TribulusAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Bulgarian Tribulus + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with HerHeart — through 3 ingredients. Tap an ingredient for the detail:
Bulgarian TribulusAntidiabetes Drugs Moderate
Interaction Summary
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bulgarian Tribulus + Acetohexamide interactionBergamot Polyphenolic FractionPhotosensitizing Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acetohexamide interactionDamianaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Damiana + Acetohexamide interactionAcitretinSoriatane
How Acitretin interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Acitretin interactionAlbiglutideTanzeum
How Albiglutide interacts with HerHeart — through 3 ingredients. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking bergamot with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bergamot Polyphenolic Fraction + Albiglutide interactionBulgarian TribulusAntidiabetes Drugs Moderate
Interaction Summary
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bulgarian Tribulus + Albiglutide interactionDamianaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Damiana + Albiglutide interactionAlectinib HydrochlorideAlecensa
How Alectinib Hydrochloride interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Alectinib Hydrochloride interactionAliskirenTekturna
How Aliskiren interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bulgarian TribulusAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Bulgarian Tribulus + Aliskiren interactionAlitretinoinPanretin
How Alitretinoin interacts with HerHeart — through 1 ingredient. Tap an ingredient for the detail:
Bergamot Polyphenolic FractionPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot Polyphenolic Fraction + Alitretinoin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in HerHeart with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Citrus Bergamot extract
Antidiabetes Drugs
Theoretically, taking bergamot with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that bergamot juice has hypoglycemic effects.
Photosensitizing Drugs
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Bergamot contains bergapten, which has photosensitizing effects.
Bulgarian Tribulus
Antidiabetes Drugs
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.
Antihypertensive Drugs
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.
Lithium
Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Damiana
Antidiabetes Drugs
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that taking damiana lowers blood glucose level.
Zinc
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.
Cephalexin (Keflex)
Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.
Cisplatin (Platinol-Aq)
Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.
Integrase Inhibitors
Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.
Penicillamine (Cuprimine, Depen)
Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.
Quinolone Antibiotics
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.
Ritonavir (Norvir)
Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.
Tetracycline Antibiotics
Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.
Amiloride (Midamor)
Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.
Atazanavir (Reyataz)
Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.
Brand information
Manufacturer and brand details for HerHeart, from the product label.
BergaMet North America
See all BergaMet North America products- Name
- BergaMet North America LLC
- Street Address
- 6445 S Tenaya Way, Suite B110
- City
- Las Vegas
- State
- NV
- ZipCode
- 89113
- Phone Number
- 1 855 556 2131
- Web Address
- www.bergametna.com
HerHeart by BergaMet North America: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind HerHeart’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Zinc
Interacts with 67 drugsZinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...
Read the full Zinc monograph → Herb & supplement monographBergamot
Interacts with 410 drugsBergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but promising research. The essential oil i...
Read the full Bergamot monograph → Herb & supplement monographTribulus
Interacts with 259 drugsTribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...
Read the full Tribulus monograph → Herb & supplement monographDamiana
Interacts with 86 drugsDamiana is a traditional herb most famous as an aphrodisiac and mild mood-lifter, but solid human evidence for any of its uses is very limited. It is generally well tolerated in the small am...
Read the full Damiana monograph → Herb & supplement monographMaca
Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...
Read the full Maca monograph →Sources & How We Checked
HerHeart's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 118 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Zinc 88 references
- Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
- Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
- Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
- Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
- Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
- Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
- Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
- Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
- Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, et al. Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents. J Am Coll Nutr 1993;12:26-30. PubMed
- Fosmire GJ. Zinc toxicity. Am J Clin Nutr 1990;51:225-7.
- Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. 1995 update. Drug Saf 1995;12:314-33. PubMed
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Seelig MS. Auto-immune complications of D-penicillamine - A possible result of zinc and magnesium depletion and of pyridoxine inactivation. J Am Coll Nutr 1982;1:207-14. PubMed
- Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 1976;11:45-54.. PubMed
- Hirt M, Nobel S, Barron E. Zinc nasal gel for the treatment of common cold symptoms: A double-blind, placebo-controlled trial. Ear Nose Throat J 2000;79:778-82.. DOI
- Simkin PA. Oral zinc sulphate in rheumatoid arthritis. Lancet 1976;2:539-42. PubMed
- Wray D. A double-blind trial of systemic zinc sulfate in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1982;53:469-72. PubMed
- Douglas RM, Miles HB, Moore BW, et al. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother 1987;31:1263-5. PubMed
- Lagiou P, Wuu J, Trichopoulou A, et al. Diet and benign prostatic hyperplasia: a study in Greece. Urology 1999;54:284-90. PubMed
- Ewing CI, Gibbs AC, Ashcroft C, David TJ. Failure of oral zinc supplementation in atopic eczema. Eur J Clin Nutr 1991;45:507-10.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS report no. 8. Arch Oph
- Greenberg JE, Lynn M, Kirsner RS, et al. Mucocutaneous pigmented macule as a result of zinc deposition. J Cutan Pathol 2002;29:613-5. PubMed
- Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7:49-56.
- Turner RB. Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds. Clin Infect Dis 2001;33:1865-70. PubMed
- Belongia EA, Berg R, Liu K. A randomized trial of zinc nasal spray for the treatment of upper respiratory illness in adults. Am J Med 2001;111:103-8. PubMed
- Mossad SB. Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. QJM 2003;96:35-43. DOI
- Leitzmann MF, Stampfer MJ, Wu K, et al. Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst 2003;95:1004-7.. PubMed
- Jafek BW, Linschoten M, Murrow BW. Zicam Induced Anosmia. American Rhinologic Society 49th Annual Fall Scientific Meeting abstract. Orlando, Florida. September 20, 2003. http://app.american-rhinologic.org/programs/2003ARSFallProgram071503.pdf (Accessed 24
- Uebayashi H, Hatanaka T, Kanemura F, Tonosaki K. Acute anosmia in the mouse: behavioral discrimination among the four basic taste substances. Physiol Behav 2001;72:291-6.. PubMed
- Barrett S. Zicam Marketers Sued. United States District Court Western District of Michigan Southern Division, Filed October 14, 2003, Case No. 4:03CV0146.
- Bilici M, Yildirim F, Kandil S, et al. Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:181-90.. PubMed
- Polk RE, Healy DP, Sahai J, et al. Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers. Antimicrob Agents Chemother 1989;33:1841-4. PubMed
- Mery C, Delrieu F, Ghozlan R, et al. Controlled trial of D-penicillamine in rheumatoid arthritis. Dose effect and the role of zinc. Scand J Rheumatol 1976;5:241-7. PubMed
- Penttila O, Hurme H, Neuvonen PJ. Effect of zinc sulfate on the absorption of tetracycline and doxycycline in man. Eur J Clin Pharmacol 1975;9:131-4.
- Kondo Y, Yamagata K, Satoh M, et al. Optimal administration schedule of cisplatin for bladder tumor with minimal induction of metallothionein. J Urol 2003;170:2467-70. PubMed
- Doz F, Berens ME, Deschepper CF, et al. Experimental basis for increasing the therapeutic index of cis-diamminedicarboxylatocyclobutaneplatinum(II) in brain tumor therapy by a high-zinc diet. Cancer Chemother Pharmacol 1992;29:219-26.
- Wester PO. Urinary zinc excretion during treatment with different diuretics. Acta Med Scand 1980;208:209-12. PubMed
- Golik A, Modai D, Weissgarten J, et al. Hydrochlorothiazide-amiloride causes excessive urinary zinc excretion. Clin Pharmacol Ther 1987;42:42-4. PubMed
- Leary WP, Reyes AJ, Van der Byl K. Urinary magnesium and zinc excretion after two different single doses of amiloride in healthy adults. Curr Ther Res 1983;34:205-16.
- McBride K, Slotnick B, Margolis FL. Does intranasal application of zinc sulfate produce anosmia in the mouse? An olfactometric and anatomical study. Chem Senses 2003;28:659-70. PubMed
- Burd GD. Morphological study of the effects of intranasal zinc sulfate irrigation on the mouse olfactory epithelium and olfactory bulb. Microsc Res Tech 1993;24:195-213. PubMed
- Ducray A, Bondier JR, Michel G, et al. Recovery following peripheral destruction of olfactory neurons in young and adult mice. Eur J Neurosci 2002;15:1907-17. PubMed
- Mayer AD, Rosenblatt JS. Peripheral olfactory deafferentation of the primary olfactory system in rats using ZnSO4 nasal spray with special reference to maternal behavior. Physiol Behav 1993;53:587-92. PubMed
- DeCook CA, Hirsch AR. Anosmia due to inhalational zinc: a case report (abstract). Chem Senses 2000;25:659.
- Tisdall FF, Brown A, Defries RD. Persistent anosmia following zinc sulfate nasal spraying. JPed 1938;18:60-2. DOI
- Lawson KA, Wright ME, Subar A, et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst 2007;99:754-64. PubMed
- Public Health Advisory. Loss of sense of smell with intranasal cold remedies containing zinc. U.S. Food and Drug Administration, June 16, 2009. Available at: http://www.fda.gov/Drugs/DrugSafety/PublicHealthAdvisories/ucm166059.htm (Accessed 16 June 2009)
- Dooren JC. FDA warns against use of Zicam. The Wall Street Journal, June 16, 2009. Available at: http://online.wsj.com/article/SB124516778692319231.html#mod=djemHL?mg=com-wsj (Accessed 16 June 2009).
- Alexander TH, Davidson TM. Intranasal zinc and anosmia: the zinc-induced anosmia syndrome. Laryngoscope 2006;116:217-20.
- Health Canada / GlaxoSmithKline Consumer Healthcare. Association of long-term, excessive use of zinc-containing Poli-Grip products with myeloneuropathy and blood dyscrasias. February 18, 2010. Available at: http://hc-sc.gc.ca/dhp-mps/alt_formats/pdf/medef
- GlaxoSmithKline Consumer Advisory. GlaxoSmithKline (GSK) warns about a potential health risk associated with long-term, excessive use of GSK's zinc-containing denture adhesives Super Polygrip Original, Ultra Fresh and Extra Care. February 18, 2010. Availa
- Science M, Johnstone J, Roth DE, et al. Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. CMAJ 2012;184:E551-61. PubMed
- Castilla-Higuero, L., Romero-Gomez, M., Suarez, E., and Castro, M. Acute hepatitis after starting zinc therapy in a patient with presymptomatic Wilson's disease. Hepatology 2000;32(4 Pt 1):877. PubMed
- Sharquie, K. E., Najim, R. A., Farjou, I. B., and Al Timimi, D. J. Oral zinc sulphate in the treatment of acute cutaneous leishmaniasis. Clin.Exp.Dermatol. 2001;26(1):21-26. PubMed
- Dreno, B., Moyse, D., Alirezai, M., Amblard, P., Auffret, N., Beylot, C., Bodokh, I., Chivot, M., Daniel, F., Humbert, P., Meynadier, J., and Poli, F. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of
- Moore, R. Bleeding gastric erosion after oral zinc sulphate. Br.Med J 3-25-1978;1(6115):754. PubMed
- Jafek, B. W., Linschoten, M. R., and Murrow, B. W. Anosmia after intranasal zinc gluconate use. Am J Rhinol. 2004;18(3):137-141. DOI
- Simonart, T. and de, Maertelaer, V. Systemic treatments for cutaneous warts: a systematic review. J Dermatolog.Treat. 2012;23(1):72-77. PubMed
- Cochran, R. J., Tucker, S. B., and Flannigan, S. A. Topical zinc therapy for acne vulgaris. Int.J Dermatol. 1985;24(3):188-190. DOI
- Morgan, A. A. Bleeding gastric erosion after oral zinc sulphate. Br.Med.J. 5-13-1978;1(6122):1283-1284. PubMed
- Murphy, J. V. Intoxication following ingestion of elemental zinc. JAMA 6-22-1970;212(12):2119-2120.
- Lang, C. J., Rabas-Kolominsky, P., Engelhardt, A., Kobras, G., and Konig, H. J. Fatal deterioration of Wilson's disease after institution of oral zinc therapy. Arch Neurol. 1993;50(10):1007-1008. PubMed
- Fjellner, B. Drug-induced lupus erythematosus aggravated by oral zinc therapy. Acta Derm.Venereol. 1979;59(4):368-370. DOI
- Varas Lorenzo, M. J. Zinc acexamate and ranitidine in the short- and mid-term management of gastroduodenal ulcers. Curr Ther Res 21986;39:19-29.
- Bosch, F. and Jimenez, E. Post-marketing surveillance of zinc acexamate in peptic ulcer treatment. Clin Trials J 1990;27:301-312.
- DeCook, C. A. and Hirsch, A. R. Anosmia due to inhalational zinc: a case report (abstract). Chem Senses 2000;25:659.
- Crown LA, May JA. Zinc toxicity: denture adhesives, bone marrow failure and polyneuropathy. Tenn Med. 2012 Feb;105(2):39-40, 42.
- Dadamio J, Van Tournout M, Teughels W, Dekeyser C, Coucke W, Quirynen M. Efficacy of different mouthrinse formulations in reducing oral malodour: a randomized clinical trial. J Clin Periodontol. 2013 May;40(5):505-13. PubMed
- Moyle G, Else L, Jackson A, Back D, Yapa MH, Seymour N, Ringner-Nackter L, Karolia Z, Gazzard B, Boffito M. Coadministration of atazanavir-ritonavir and zinc sulfate: impact on hyperbilirubinemia and pharmacokinetics. Antimicrob Agents Chemother. 2013 Aug PubMed
- Zittel S, Ufer F, Gerloff C, Münchau A, Rosenkranz M. Severe myelopathy after denture cream use--is copper deficiency or excess zinc the cause? Clin Neurol Neurosurg. 2014 Jun;121:17-8. PubMed
- Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
- Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents: Drug Interactions between Integrase Inhibitors and Other Drugs. AIDSinfo. July 14, 2016. Available at: https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescen
- Ding Y, Jia YY, Li F, et al. The effect of staggered administration of zinc sulfate on the pharmacokinetics of oral cephalexin. Br J Clin Pharmacol. 2012 Mar;73(3):422-7. PubMed
- Fallah R, Sabbaghzadegan S, Karbasi SA, Binesh F. Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial. Nutrition. 2015;31(11-12):1358-61. PubMed
- Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev. 2016;12:CD005436. PubMed
- Mahmoud AM, Al-Alem U, Dabbous F, et al. Zinc intake and risk of prostate cancer: Case-control study and meta-analysis. PLoS One. 2016;11(11):e0165956. PubMed
- Nagraj SK, George RP, Shetty N, Levenson D, Ferraiolo DM, Shrestha A. Interventions for managing taste disturbances. Cochrane Database Syst Rev. 2017 Dec 20;12(12):CD010470. PubMed
- Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020:e14252. PubMed
- Janyajirawong R, Vilaichone RK, Sethasine S. Efficacy of zinc supplement in minimal hepatic encephalopathy: A prospective, randomized controlled study (Zinc-MHE Trial). Asian Pac J Cancer Prev 2021;22(9):2879-2887. PubMed
- Nakano M, Nakamura Y, Miyazaki A, Takahashi J. Zinc pharmacotherapy for elderly osteoporotic patients with zinc deficiency in a clinical setting. Nutrients 2021;13(6):1814. PubMed
- Tolino E, Skroza N, Mambrin A, et al. An open-label study comparing oral zinc to lymecycline in the treatment of acne vulgaris. J Clin Aesthet Dermatol 2021;14(5):56-58.
- Hunter J, Arentz S, Goldenberg J, et al. Zinc for the prevention or treatment of acute viral respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials. BMJ Open. 2021;11(11):e047474. PubMed
- Yamazaki K, Kageyama H, Fujiyama T, Ito T, Urano S, Honda T. A case of systemic contact dermatitis due to zinc supplements. Int J Dermatol 2022. PubMed
- Magham K, Han J, Eilbert W, Bunney EB. Severe copper deficiency anemia caused by zinc supplement use. Am J Emerg Med 2023;72:222. PubMed
- Sivakumar RR, Chinnaiah Govindareddy D, Sahoo J, Bobby Z, Chinnakali P. Effect of daily zinc supplementation for 12 weeks on serum thyroid auto-antibody levels in children and adolescents with autoimmune thyroiditis - a randomized controlled trial. J Pedi PubMed
- AlDhasee O, AlMalki H, AlKharashi N, AlJeraisy N, Al Deeb M. Acute zinc sulfate overdose: clinical presentation and management. BMJ Case Rep 2025;18(1):e263899. PubMed
- US Food and Drug Administration (FDA). Biktarvy Prescribing Information. October 2024. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/210251Orig1s020lbl.pdf. Accessed July 16, 2025.
Bergamot 17 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
- Kaddu, S., Kerl, H., and Wolf, P. Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J.Am.Acad.Dermatol. 2001;45(3):458-461. PubMed
- Finsterer, J. Earl Grey tea intoxication. Lancet 4-27-2002;359(9316):1484. PubMed
- Gruson, L. M. and Chang, M. W. Berloque dermatitis mimicking child abuse. Arch.Pediatr.Adolesc.Med. 2002;156(11):1091-1093. PubMed
- Weisenseel, P. and Woitalla, S. [Toxic mustard plaster dematitis and phototoxic dematitis after application of bergamot oil]. MMW.Fortschr.Med. 12-15-2005;147(51-52):53, 55.
- Placzek, M., Fromel, W., Eberlein, B., Gilbertz, K. P., and Przybilla, B. Evaluation of phototoxic properties of fragrances. Acta Derm.Venereol. 2007;87(4):312-316. PubMed
- Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., and Romeo, F. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. F PubMed
- Morliere, P., Huppe, G., Averbeck, D., Young, A. R., Santus, R., and Dubertret, L. In vitro photostability and photosensitizing properties of bergamot oil. Effects of a cinnamate sunscreen. J.Photochem.Photobiol.B 1990;7(2-4):199-208. PubMed
- Young, A. R., Walker, S. L., Kinley, J. S., Plastow, S. R., Averbeck, D., Morliere, P., and Dubertret, L. Phototumorigenesis studies of 5-methoxypsoralen in bergamot oil: evaluation and modification of risk of human use in an albino mouse skin model. J.P PubMed
- Girard, J., Unkovic, J., Delahayes, J., and Lafille, C. [Phototoxicity of Bergamot oil. Comparison between humans and guinea pigs]. Dermatologica 1979;158(4):229-243.
- Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. II. Factors which affect the phototoxic reaction induced by bergamot oil and psoralen derivatives. Contact Dermatitis 1977;3(5):225-23 PubMed
- Zacher, K. D. and Ippen, H. [Contact dermatitis caused by bergamot oil]. Derm.Beruf.Umwelt. 1984;32(3):95-97.
- Yasui, Y. and Hirone, T. Action spectrum for bergamot-oil phototoxicity measured by sunburn cell counting. J.Dermatol. 1994;21(5):319-322. PubMed
- Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. I. Characterization and quantification of the photoactive component. Br.J.Dermatol. 1977;96(5):475-482. PubMed
- Bruno A, Pandolfo G, Crucitti M, Cedro C, Zoccali RA, Muscatello MRA. Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia: Data From an 8-Week, Open-Label Pilot Study. J Clin Psychopharmacol 2017;37(4):468-71. PubMed
Tribulus 10 references
- Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
- Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
- Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
- Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
- Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
- Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
- Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
- Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
- Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
- Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.
Damiana 2 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Alarcon-Aquilar FJ, Roman-Ramos R, Perez-Gutierrez S, et al. Study of the anti-hyperglycemic effect of plants used as antidiabetics. J Ethnopharmacol 1998;61:101-10. PubMed
Maca 1 reference
- Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed
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