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Dietary supplement

Probiotic 15 Billion Microflora Ingredients & Drug Interactions

by Inside

Probiotic 15 Billion Microflora label
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Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic 15 Billion Microflora against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic 15 Billion Microflora is a dietary supplement by Inside with 2 active ingredients. Its ingredients are commonly taken for digestive and gut health, prebiotic to support good bacteria, constipation relief.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Unique IS-2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic 15 Billion Microflora by Inside

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic 15 Billion Microflora by Inside — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic 15 Billion Microflora by Inside

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Fructooligosaccharides (FOS) is a prebiotic fiber that feeds beneficial bacteria in your gut.

Bacillus coagulans (branded as Unique IS-2) is a live probiotic microorganism designed to support digestive health. The capsule also contains inactive ingredients: magnesium stearate, rice flour, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive and gut health support.
  • We looked for evidence on: Constipation, Diarrhea, Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), Antibiotic-associated diarrhea — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Fructo-oligosaccharides (fos) is rated "Insufficient Reliable Evidence To Rate" for Constipation, Travelers' diarrhea.

The evidence for what this product can do varies by ingredient. Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome (IBS), meaning some research supports its use for these.

For antibiotic-associated diarrhea, athletic performance, and other uses listed, the evidence isn't established in our data. Fructooligosaccharides has insufficient evidence to rate for osteoporosis, constipation, diabetes, travelers' diarrhea, and high cholesterol, so we don't yet know if it helps with these.

The evidence, ingredient by ingredient Fructo-oligosaccharides (fos) Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients are generally well tolerated in healthy adults, but there are a few things to know. Fructooligosaccharides can cause gas, bloating, abdominal pain, and constipation — especially at higher doses — though studies suggest these happen less often than you'd expect.

Bacillus coagulans is generally well tolerated, but safety data is limited, and there's a theoretical concern that live probiotics could cause serious infection in people with severely weakened immune systems, central lines, or who are very ill; healthy people with intact immune systems appear to be at very low risk. The product label notes limited data for supplement use, so talk with your doctor before starting.

Side effects, ingredient by ingredient Fructo-oligosaccharides (fos) Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, let your pharmacist know — timing matters. Separate your antibiotic dose from this probiotic by a few hours so the antibiotic doesn't kill the live organisms.

For all other medications, no interactions are documented in our data for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may be worth considering if you have constipation or IBS and want to try a Bacillus coagulans strain. If you're on antibiotics, space them apart from this product.

Talk with your doctor or pharmacist first if you're pregnant, nursing, immunocompromised, or very ill.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic 15 Billion Microflora, straight from the product label.

Brand Inside
Barcode (UPC) 891923001522
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336606
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic 15 Billion Microflora by Inside, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
891923001522
IngredientAmount% DV
Fructooligosaccharides500 mg--
Unique IS-275 mg--

Other ingredients: Magnesium Stearate, Rice Flour, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: For adults only. Take one (1) capsule per day on an empty stomach, or as directed by your doctor.

Precautions

Warning: If you are pregnant, breastfeeding, or taking any medications, consult your doctor before use.

Discontinue use and consult a doctor if any adverse reactions occur. Do not use if safety seal under cap is broken or missing.

Keep out of reach of children.

Storage

Store at room temperature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Questions or Comments? Call 1800.213.9370 insidevitamins.online

Formula

Bacillus coagulans

FDA Statement of Identity

Dietary Supplement

Formulation

Benefits: Supports a healthy immune system Promotes digestion and nutrient absorption. Combats pathogenic bacteria; improves metabolism.

Free of : Artificial Color, Artificial Flavor, No GMO'S. Gluten FREE, Soy FREE, No Starch, No Yeast.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic 15 Billion Microflora by Inside label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic 15 Billion Microflora label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic 15 Billion Microflora by Inside

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fructooligosaccharides

No known
interactions
500 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructooligosaccharides monograph & interactions

Unique IS-2

Interacts with
182 drugs
75 mg per serving Form: Bacillus coagulans

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Unique IS-2 monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Rice Flour, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic 15 Billion Microflora by Inside Drug Interactions

Want to check YOUR meds against Probiotic 15 Billion Microflora?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Unique IS-2 182

Individual Drug Interactions

The ingredients in Probiotic 15 Billion Microflora interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Probiotic 15 Billion Microflora interact with drugs. Each result below shows which ingredient is responsible. Unique IS-2

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic 15 Billion Microflora with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Unique IS-21 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Unique IS-2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic 15 Billion Microflora, from the product label.

Inside

See all Inside products
Name
Inside Vitamins & Supplements
City
Pembroke Pines
State
FL
ZipCode
33332
Phone Number
1800.213.9370
Web Address
insidevitamins.online
Pharmacist Counseling Corner

Probiotic 15 Billion Microflora by Inside: Common Questions

Does Probiotic 15 Billion Microflora by Inside interact with any medications?
Yes. Based on its ingredients, Probiotic 15 Billion Microflora has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic 15 Billion Microflora contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my constipation?
Bacillus coagulans in this product is possibly effective for constipation based on available research, so it may help — but results vary from person to person. Fructooligosaccharides doesn't have enough evidence yet to know if it helps with constipation.
Can I take this while on antibiotics?
You can take both, but don't take them at the same time. Antibiotics kill the live bacteria in this probiotic, so separate them by a few hours. Ask your pharmacist about the best timing for your specific antibiotic.
What are the side effects?
The most common are gas, bloating, abdominal pain, and constipation — mostly from the FOS — but these tend to be mild, especially at lower doses. Studies show these happen less often than you'd expect. If you're severely ill or have a very weak immune system, talk to your doctor first because live probiotics carry a small theoretical risk.
Is this safe during pregnancy or breastfeeding?
The product label doesn't include pregnancy or lactation data for either ingredient, so we don't have enough information to say either way. Talk with your doctor or pharmacist about whether this is right for you during pregnancy or nursing.
What's the difference between the two ingredients in this product?
Fructooligosaccharides (FOS) is a prebiotic — it's a type of fiber that feeds the good bacteria already in your gut. Bacillus coagulans is a live probiotic — it's a beneficial microorganism itself. Together, they're meant to support your digestive health in two ways.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic 15 Billion Microflora is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic 15 Billion Microflora label
Go deeper

The Full Monographs Behind Probiotic 15 Billion Microflora’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Probiotic 15 Billion Microflora's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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