Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Probiotic 40 Billion Ingredients & Drug Interactions

by Longevity Premier Nutraceuticals

Probiotic 40 Billion label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic 40 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic 40 Billion is a dietary supplement by Longevity Premier Nutraceuticals with 6 active ingredients. Its ingredients are commonly taken for digestive and gut health, prebiotic to support good bacteria, constipation relief.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus (La-14). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic 40 Billion by Longevity Premier Nutraceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic 40 Billion by Longevity Premier Nutraceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic 40 Billion by Longevity Premier Nutraceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Blend of Probiotic Bacteria” is a proprietary blend — the label doesn't break down how much of each component you get.

Probiotic 40 Billion contains 6 active ingredients: several strains of live beneficial bacteria (Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, and Bifidobacterium lactis), plus a proprietary blend of additional probiotic bacteria, a marine polysaccharide complex, and fructooligosaccharide. The FOS acts as a prebiotic — food for the beneficial bacteria — while the live cultures themselves are meant to support your gut flora.

The inactive ingredients are cellulose, rice maltodextrin, and L-leucine, which serve as fillers and capsule binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Bacterial vaginosis — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).

Evidence exists for some of what these probiotics may do. Lactobacillus acidophilus is rated possibly effective for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, bacterial vaginosis, and H. pylori infection.

For the other bacterial strains and the fructooligosaccharide in this product, the data we hold doesn't establish effectiveness — the evidence is either insufficient or not yet rated. If you're considering this supplement for a specific condition, talk it over with your doctor or pharmacist to see whether the research supports its use for your situation.

The evidence, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. The most common side effects from probiotics are mild gastrointestinal ones — bloating, gas, abdominal discomfort, and diarrhea — but these are uncommon.

FOS can cause gas and bloating, especially at higher doses, though studies suggest doses under 10 grams daily don't increase these problems more than a placebo does. One small concern: live Lactobacillus acidophilus has rarely caused serious infection in people with weakened immune systems or certain medical conditions, so check with your doctor before starting if you have compromised immunity or are hospitalized.

For pregnancy, L. acidophilus is rated possibly safe, but we hold no specific data on the other ingredients' use during pregnancy or breastfeeding — talk with your doctor about whether it's right for you.

Side effects, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Probiotic 40 Billion, double-check any antibiotic drugs you're on — the live bacteria can be killed if you take them together, making the probiotic less effective. Timing them a few hours apart helps.

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with certain gut and digestive issues if the science pans out for you — especially if you've got IBS or are dealing with antibiotic-related diarrhea. The main thing to watch: space it apart from antibiotics, since they'll kill the live cultures.

If you have a weakened immune system or serious health concerns, check with your own doctor first. Most people tolerate it well, but some gas and bloating at the start is normal.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic 40 Billion, straight from the product label.

Brand Longevity Premier Nutraceuticals
Barcode (UPC) 724131646639
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 277532
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic 40 Billion by Longevity Premier Nutraceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
724131646639
IngredientAmount% DV
Fructooligosaccharide0 NP--
Bifidobacterium lactis (BI-04)0 NP--
Lactobacillus plantarum (Lp-115)0 NP--
Marine Polysaccharide Complex0 NP--
Proprietary Blend of Probiotic Bacteria0 NP--
Lactobacillus acidophilus (La-14)0 NP--
Lactobacillus paracasei (LPC-37)0 NP--

Other ingredients: Cellulose, Rice Maltodextrin, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take two (2) capsules once daily. For best results, take one capsule during the day and one capsule in the evening.

Precautions

Cautions: Do not exceed recommended dose.

Pregnant and nursing mothers, children under the age of 18 and individuals with a health condition should consult a physician before using this or any dietary supplement.

Pregnant and nursing mothers, children under the age of 18 and individuals with a health condition should consult a physician before using this or any dietary supplement.

Do not use if the safety seal is damaged or missing. If you have gastritis, gastric ulcer, duodenal ulcer or any allergy, do not use this product or consult your physician prior to use.

Keep out of reach of children.

Storage

Store in a cool & dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in the USA GMP Good Manufacturing Practice

General Statements

Satisfaction 100% Guaranteed

Bi-pass technology

Discounts at: www.LongevityPremier.com

Formulation

GMO free

Healthy digestive system Supports strong immunity

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic 40 Billion by Longevity Premier Nutraceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic 40 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic 40 Billion by Longevity Premier Nutraceuticals

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend of Probiotic Bacteria

0 NP per serving

Other (inactive) ingredients: Cellulose, Rice Maltodextrin, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic 40 Billion by Longevity Premier Nutraceuticals Drug Interactions

Want to check YOUR meds against Probiotic 40 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus (La-14) 182

Individual Drug Interactions

The ingredients in Probiotic 40 Billion interact with 182 drugs. Click any drug to see the details.

1 of the 6 ingredients in Probiotic 40 Billion interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus (La-14)

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic 40 Billion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus (La-14)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus (La-14) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic 40 Billion, from the product label.

Longevity Premier Nutraceuticals

See all Longevity Premier Nutraceuticals products
Name
Longevity Premier Nutraceuticals, Inc.
City
Philadelpia
State
PA
ZipCode
19106
Phone Number
1-877-529-1118
Web Address
www.LongevityPremier.com
Pharmacist Counseling Corner

Probiotic 40 Billion by Longevity Premier Nutraceuticals: Common Questions

Does Probiotic 40 Billion by Longevity Premier Nutraceuticals interact with any medications?
Yes. Based on its ingredients, Probiotic 40 Billion has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic 40 Billion contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotic?
Not at the same time. The antibiotic will kill the live bacteria in the probiotic, so you won't get the full benefit. Ask your doctor or pharmacist how far apart to space them — typically a few hours is enough.
Will this give me gas and bloating?
Some people notice mild bloating or gas when starting a probiotic, especially from the FOS fiber in this formula. The research suggests these effects are usually mild and don't get worse than a placebo at normal doses, so it often settles down as your gut adjusts.
Is this safe if I have a weakened immune system?
Live Lactobacillus acidophilus has rarely caused serious infections in people with very weak immunity. If you're immunocompromised or hospitalized, talk with your doctor before starting — it's not automatically off-limits, but your doctor needs to weigh the pros and cons for you personally.
Can I take this while pregnant or breastfeeding?
Lactobacillus acidophilus is rated possibly safe in pregnancy, but we don't have specific safety data on file for the other bacteria strains or the other ingredients in this formula during pregnancy or lactation. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
Does this actually work for IBS or diarrhea?
The Lactobacillus acidophilus in here is possibly effective for IBS, antibiotic-associated diarrhea, and some other digestive issues. That means there's some decent research, but it's not proven for everyone. Your own experience may differ, so give it a reasonable trial and see how you respond.
What does the FOS do?
FOS is a type of fiber that acts as food for the beneficial bacteria — it's called a prebiotic. We don't have strong evidence yet that it reliably improves bone health, cholesterol, or blood sugar on its own, but it helps feed the live cultures in the probiotic.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic 40 Billion is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic 40 Billion label
Go deeper

The Full Monographs Behind Probiotic 40 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Probiotic 40 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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