Interactions on record — worth a quick check against your medications. Based on 5 of 17 ingredients. Check your meds →
Dietary supplement

ProbioZyme Ingredients & Drug Interactions

by MD Prescriptives

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

ProbioZyme is a dietary supplement by MD Prescriptives with 17 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are B. coagulans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of ProbioZyme by MD Prescriptives

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 17 active ingredients.

ProbioZyme contains 17 active ingredients: digestive enzymes and a probiotic strain. The enzymes—lactase, lipase, cellulase, phytase, xylanase, amylase, glucoamylase, invertase, peptidase, pectinase, protease (three forms), alpha galactosidase, beta glucanase, and hemicellulase—are meant to help break down different types of food.

Bacillus coagulans is a probiotic bacteria (live microorganism) included to support digestive health. The capsule also contains inactive ingredients: rice flour, bamboo extract, vegetarian capsule material, and water.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Lactose intolerance — rated "Effective" (Lactase) (Natural Medicines).
  • On file: Constipation — rated "Possibly Effective" (Bacillus Coagulans) (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Bacillus Coagulans) (Natural Medicines).

Lactase is effective for lactose intolerance—it helps digest the milk sugar lactose. For B. coagulans, the evidence suggests it may help with constipation and irritable bowel syndrome (IBS).

For everything else in the formula—lipase, phytase, the other enzymes, and B. coagulans for other conditions—the evidence we hold is not yet established or is insufficient to rate. That doesn't mean these ingredients don't work; it means the research data available to us isn't solid enough to say either way.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated, though rare cases of allergic reactions have been reported in people handling powdered lactase. Lipase is generally well tolerated in supplement form, but people with serious digestive conditions should use it only under medical guidance.

Phytase is generally considered low-risk in foods, but human supplement data are limited. The protease enzymes are generally well tolerated for most adults, though digestive upset or allergic reactions are possible; rare occupational allergic reactions to airborne protease have been reported.

B. coagulans is generally well tolerated in healthy adults, but live organisms in probiotic products carry a theoretical risk of serious infection (bacteremia, sepsis) in people who are severely ill, immunocompromised, have central venous catheters, or are premature infants. Lipase has shown rare serious gastrointestinal effects when given to premature infants.

For pregnancy, lactase is likely safe; phytase, the proteases, and B. coagulans have insufficient data to know either way—talk with your doctor or pharmacist. For breastfeeding, similar gaps exist for most ingredients; lipase and B. coagulans have not been well studied.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 5 matched ingredients can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take ProbioZyme, check with your doctor or pharmacist if you take antibiotics. B. coagulans may reduce antibiotic effectiveness if taken at the same time; spacing them apart is recommended.

No other medication interactions are documented for the ingredients we were able to check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This is a broad-spectrum enzyme and probiotic blend. Lactase works for lactose intolerance; B. coagulans may help constipation and IBS.

If you take antibiotics, space them apart from this supplement and confirm the timing with your doctor or pharmacist. If you have a serious digestive condition, are severely ill, immunocompromised, or are pregnant or breastfeeding, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ProbioZyme, straight from the product label.

Brand MD Prescriptives
Barcode (UPC) 850009270016
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 261602
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ProbioZyme by MD Prescriptives, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
850009270016
IngredientAmount% DV
Lactase0 NP--
Lipase0 NP--
Cellulase0 NP--
Phytase0 NP--
Xylanase0 NP--
Amylase0 NP--
Glucoamylase0 NP--
Invertase0 NP--
Peptidase0 NP--
Pectinase0 NP--
Protease 3.00 NP--
Protease 6.00 NP--
Alpha Galactosidase0 NP--
Beta Glucanase0 NP--
Hemicelllase0 NP--
Protease 8000 NP--
B. coagulans0 NP--

Other ingredients: Vegetarian Capsule, Rice Flour, Bamboo extract, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

For more information please visit: www.mdprescriptives.com

Formulation

"Our products are uniquely formulated to be highly bioavailable and are hypoallergenic with no hidden fillers, artificial colors, fragrance or harsh chemicals. This product contains no milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, wheat, yeast, gluten or artificial sweeteners. This product is also third party verified GMO-free, and is manufactured at a good manufacturing practices (cGMP) compliant facility. Made with love in the USA."

"Our products are uniquely formulated to be highly bioavailable and are hypoallergenic with no hidden fillers, artificial colors, fragrance or harsh chemicals. This product is also third party verified GMO-free, and is manufactured at a good manufacturing practices (cGMP) compliant facility. Made with love in the USA."

3rd party non-GMO verified

Promotes superior digestion

Brand IP Statement(s)

Here's To Your Best Life Ever! -- The MD Prescriptives Family

Precautions

Warning: Keep out of reach of children

Do not use if seal is broken

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take one capsule at beginning of each meal, or as directed by your healthcare practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

ProbioZyme by MD Prescriptives label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in ProbioZyme by MD Prescriptives

These are the 17 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactase

No known
interactions
0 NP per serving

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Lactase monograph & interactions

Lipase

No known
interactions
0 NP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Cellulase

0 NP per serving

Phytase

No known
interactions
0 NP per serving

Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and c...

Phytase monograph & interactions

Xylanase

0 NP per serving

Amylase

0 NP per serving

Glucoamylase

0 NP per serving

Invertase

0 NP per serving

Peptidase

0 NP per serving

Pectinase

0 NP per serving

Protease 3.0

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease 3.0 monograph & interactions

Protease 6.0

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease 6.0 monograph & interactions

Alpha Galactosidase

0 NP per serving

Beta Glucanase

0 NP per serving

Hemicelllase

0 NP per serving

Protease 800

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease 800 monograph & interactions

B. coagulans

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

B. coagulans monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Rice Flour, Bamboo extract, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

ProbioZyme by MD Prescriptives Drug Interactions

Want to check YOUR meds against ProbioZyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in ProbioZyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

B. coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for ProbioZyme, from the product label.

MD Prescriptives

See all MD Prescriptives products
Name
MD Prescriptives, LLC
Street Address
3025 Silver Star Road, Ste 117
City
Orlando
State
FL
ZipCode
32808
Phone Number
877-963-7737
Web Address
www.mdprescriptives.com
Pharmacist Counseling Corner

ProbioZyme by MD Prescriptives: Common Questions

Does ProbioZyme by MD Prescriptives interact with any medications?
Yes. Based on its ingredients, ProbioZyme has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ProbioZyme contains 17 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this work for lactose intolerance?
Lactase in this formula is effective for lactose intolerance. It breaks down the milk sugar lactose so you can digest dairy products more comfortably. Effectiveness depends on getting enough of the enzyme and taking it with dairy-containing foods.
Is this safe if I have IBS or constipation?
B. coagulans in this formula may help with both IBS and constipation—the evidence suggests it's possibly effective for these. However, if you have a serious digestive condition, talk with your doctor or pharmacist before starting, because lipase and other digestive aids aren't advised without medical guidance in those cases.
Can I take this if I'm pregnant?
Lactase is likely safe in pregnancy. For the other ingredients—lipase, phytase, the proteases, and B. coagulans—there isn't enough data to know either way. Talk with your doctor or pharmacist about whether it's right for you during pregnancy.
What are these enzymes actually for?
Each enzyme breaks down a different type of food: lactase handles milk sugar, lipase breaks down fats, amylase breaks down starches, and proteases break down proteins. The mix is meant to support overall digestion. Phytase and the others target specific carbohydrates and plant compounds.
Can I take this with antibiotics?
B. coagulans—the probiotic in this formula—may be less effective if you take antibiotics at the same time, because antibiotics can kill the live organisms. Space them apart, and ask your doctor or pharmacist how many hours should go between doses.
Are there any fillers or extra ingredients?
The inactive ingredients are vegetarian capsule material, rice flour, bamboo extract, and water. The formula contains no artificial additives beyond these.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ProbioZyme is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ProbioZyme label
Go deeper

The Full Monographs Behind ProbioZyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

ProbioZyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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