Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Proglucamune Ingredients & Drug Interactions

by Usana

Proglucamune label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Proglucamune against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Proglucamune is a dietary supplement by Usana with 4 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 765 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Reishi mushroom mycelium powder, Shiitake mushroom mycelium powder, Baker's Yeast extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Proglucamune by Usana

Ask about any prescription or over-the-counter medication and we check it for interactions with Proglucamune by Usana — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Proglucamune by Usana

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “InCelligence Beta-Glucan Complex” is a proprietary blend — the label gives one combined amount (550 mg) without saying how much of each component you get.

Proglucamune contains four active ingredients. Zinc supports immune function and is used for zinc deficiency and other conditions.

The product also includes InCelligence Beta-Glucan Complex (a blend of immune-supporting compounds), baker's yeast extract, reishi mushroom mycelium powder, and shiitake mushroom mycelium powder — all traditionally used for immune and digestive support. The tablet also contains several inactive ingredients: microcrystalline cellulose, modified cellulose, vegetable fatty acid, maltodextrin, croscarmellose sodium, silicon dioxide, vanilla extract, organic sunflower lecithin, organic palm olein, and organic guar gum.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Zinc deficiency — rated "Effective" (Zinc) (Natural Medicines).
  • On file: Wilson disease — rated "Likely Effective" (Zinc) (Natural Medicines).
  • On file: Acne — rated "Possibly Effective" (Zinc) (Natural Medicines).
  • On file: Acrodermatitis enteropathica — rated "Possibly Effective" (Zinc) (Natural Medicines).
  • On file: Age-related macular degeneration (AMD) — rated "Possibly Effective" (Zinc) (Natural Medicines).

For zinc alone, the evidence supports its use for zinc deficiency (it's effective) and Wilson disease (likely effective). Zinc may also help with acne, a rare skin condition called acrodermatitis enteropathica, age-related macular degeneration, and diabetes, though the evidence for these is more limited (possibly effective).

For baker's yeast extract, there's possibly effective evidence for irritable bowel syndrome, but for other uses like colds, high cholesterol, or hay fever, we don't have enough reliable evidence yet. Reishi and shiitake mushrooms show mostly insufficient or possibly ineffective evidence for the conditions studied — the data we hold doesn't support their effectiveness for the purposes listed.

The evidence, ingredient by ingredient Zinc Brewer's Yeast Reishi Mushroom Shiitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zinc is generally well tolerated at recommended doses (the safe upper limit is 40 mg daily for adults), but higher doses can cause stomach upset, nausea, diarrhea, metallic taste, and abdominal cramps. Long-term high-dose zinc also raises the risk of copper deficiency, which can lead to anemia.

Baker's yeast extract is generally well tolerated in food amounts but commonly causes gas and bloating; rarely, it can trigger allergic reactions including anaphylaxis. Reishi mushroom is generally well tolerated short-term, though long-term safety isn't well studied — it can cause dizziness, dry mouth, nausea, rash, and stomach upset.

The safety data advises against reishi during pregnancy and breastfeeding. Shiitake mushroom is safe when cooked and eaten as food but concentrated supplements lack safety data; raw shiitake can cause a distinctive skin rash (shiitake dermatitis) and, rarely, allergic reactions including respiratory symptoms in sensitive people.

Side effects, ingredient by ingredient Zinc Brewer's Yeast Reishi Mushroom Shiitake Mushroom

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Shiitake Mushroom, Brewer's Yeast, Reishi Mushroom, Zinc.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 765 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Proglucamune, double-check with your doctor or pharmacist if you're on any of these: monoamine oxidase inhibitors (MAOIs), antibiotics (especially quinolones, tetracyclines, cephalexin, or penicillamine), blood pressure medications, blood thinners (anticoagulants or antiplatelet drugs), diabetes medications, HIV medications (ritonavir, integrase inhibitors, or bictegravir-containing regimens), immunosuppressant drugs, or medications processed through the liver enzyme CYP2D6. Timing matters for some antibiotics — zinc can block their absorption — so spacing them out is key.

These are not reasons to skip the product, but reasons to confirm the details with your own healthcare provider first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Proglucamune may be worth considering if you're looking to support your immune health or address a zinc deficiency, but the effectiveness for other uses is less clear. This product is not for you if you take an MAOI antidepressant, and you'll need to be careful if you take antibiotics, blood pressure medications, blood thinners, diabetes drugs, or immunosuppressants — the interactions can reduce how well those drugs work or raise your risk of side effects.

Talk with your doctor or pharmacist before starting, especially if you're on any regular medications or planning pregnancy or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Proglucamune, straight from the product label.

Brand Usana
Net contents 56 Tablet(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 211647
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Proglucamune by Usana, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
28
IngredientAmount% DV
Zinc6 mg55%
InCelligence Beta-Glucan Complex550 mg--
Baker's Yeast extract250 mg--
Reishi mushroom mycelium powder250 mg--
Shiitake mushroom mycelium powder50 mg--

Other ingredients: Microcrystalline Cellulose, Modified Cellulose, Vegetable Fatty Acid, Maltodextrin, Croscarmellose Sodium, Silicon Dioxide, Vanilla extract, organic Sunflower Lecithin, organic Palm Olein, organic Guar Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Potency Guaranteed

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take two (2) tablets daily, preferably with food.

Precautions

If you have an autoimmune disease, an immune system disorder, or if you are taking immunosuppressant medication, consult your doctor before using this product.

Keep out of reach of children.

Consult your physician if you are pregnant, nursing, taking a prescription drug, or have a medical condition.

There is a safety seal under the cap. Do not use if seal is broken or missing.

General Statements

Laboratory tested, quality guaranteed. Meets USP specification for uniformity, potency, and disintegration, where applicable.

Made with Usana

Storage

Store below 25 degrees C

Brand IP Statement(s)

InCelligence Technology

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Proglucamune by Usana label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Proglucamune label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Proglucamune by Usana

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zinc

Interacts with
67 drugs
6 mg per serving Form: Zinc Gluconate

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

InCelligence Beta-Glucan Complex

550 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Modified Cellulose, Vegetable Fatty Acid, Maltodextrin, Croscarmellose Sodium, Silicon Dioxide, Vanilla extract, Organic Sunflower Lecithin, Organic Palm Olein, Organic Guar Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Proglucamune by Usana Drug Interactions

Want to check YOUR meds against Proglucamune?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
765Drugs
9 Major 714 Moderate 42 Minor

Ingredients driving the most interactions

Reishi mushroom mycelium powder 375
Shiitake mushroom mycelium powder 312
Baker's Yeast extract 136
Zinc 67

Individual Drug Interactions

The ingredients in Proglucamune interact with 765 drugs. Click any drug to see the details.

4 of the 4 ingredients in Proglucamune interact with drugs. Each result below shows which ingredient is responsible. Reishi mushroom mycelium powder Shiitake mushroom mycelium powder Baker's Yeast extract Zinc

Each ingredient & the kinds of drugs it affects

For each ingredient in Proglucamune with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi mushroom mycelium powder3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi mushroom mycelium powder full monograph & interactions

Shiitake mushroom mycelium powder2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake mushroom mycelium powder full monograph & interactions

Baker's Yeast extract4 drug types · 136 drugs

Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking brewer's yeast with MAOIs might increase the risk of hypertension.
Brewer's yeast contains tyramine. Taking brewer's yeast with MAOIs might increase the risk for hypertensive crisis.

Likelihood Likely Evidence D
Antidiabetes Drugs

Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking chromium-containing brewer's yeast can decrease levels of blood glucose in diabetic patients being treated with antidiabetes drugs.

Likelihood Possible Evidence B
Lithium

Theoretically, taking brewer's yeast with lithium might cause additive effects and side effects.
Some brewer's yeast products contains lithium.

Likelihood Possible Evidence D
Antifungals

Theoretically, taking antifungals with some brewer's yeast products might decrease the effectiveness of brewer's yeast.
Some brewer's yeast products contain live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Baker's Yeast extract full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Proglucamune, from the product label.

Usana

Name
USANA Health Sciences, Inc.
Street Address
3838 W. Parkway Blvd.
City
Salt Lake City
State
Utah
ZipCode
84120
Pharmacist Counseling Corner

Proglucamune by Usana: Common Questions

Does Proglucamune by Usana interact with any medications?
Yes. Based on its ingredients, Proglucamune has a known interaction with 765 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Proglucamune contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does zinc do in this product?
Zinc supports your immune system and is proven to help with zinc deficiency. It may also help with acne and certain other conditions, though the evidence for those is less solid. The safe upper limit is 40 mg daily for adults — going much higher can cause stomach upset and, over time, copper deficiency.
Can I take this if I'm pregnant or breastfeeding?
Zinc is likely safe during pregnancy and breastfeeding in normal amounts. However, reishi mushroom should be avoided during pregnancy and breastfeeding — there's not enough safety data. Baker's yeast and shiitake mushroom haven't been well studied in pregnancy and breastfeeding at supplement doses. Talk with your doctor or pharmacist for personalized advice before starting.
What side effects might I notice?
Zinc can cause nausea, stomach cramps, diarrhea, and a metallic taste, especially at higher doses. Baker's yeast commonly causes gas and bloating. Reishi may cause dizziness, dry mouth, nausea, or a rash. Shiitake can cause abdominal discomfort, bloating, or diarrhea. Most of these are mild and dose-related.
Does this really work for boosting immunity?
The evidence for zinc supporting immune function is solid, especially if you're deficient. For the mushroom and yeast ingredients, the studies show mostly insufficient or unclear results — we don't have strong proof they boost immunity in the way the product suggests.
Is there anything else I should know about the ingredients?
Baker's yeast contains tyramine, a compound that can be risky if you're on certain older antidepressants. Reishi and shiitake are generally safe when eaten as food, but concentrated supplements — especially raw mushrooms — can cause allergic reactions in some people, including skin rashes or respiratory symptoms.
What are the inactive ingredients, and do they matter?
The product contains microcrystalline cellulose, modified cellulose, vegetable fatty acid, maltodextrin, croscarmellose sodium, silicon dioxide, vanilla extract, organic sunflower lecithin, organic palm olein, and organic guar gum. These are binders, fillers, and flow agents that help form the tablet — they're not considered active, though if you have sensitivities to any of them, that's worth knowing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Proglucamune label
Go deeper

The Full Monographs Behind Proglucamune’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Brewer's Yeast

Interacts with 136 drugs

Brewer's yeast is a nutrient-rich fungus that provides B vitamins, protein, and minerals, and a related yeast product (S. boulardii) is used for some types of diarrhea. Most other health cla...

Read the full Brewer's Yeast monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph →
Sources

Sources & How We Checked

Proglucamune's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 178 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zinc 88 references
  1. Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
  2. Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
  3. Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
  4. Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
  5. Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
  6. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
  7. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
  8. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
  9. Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, et al. Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents. J Am Coll Nutr 1993;12:26-30. PubMed
  10. Fosmire GJ. Zinc toxicity. Am J Clin Nutr 1990;51:225-7.
  11. Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. 1995 update. Drug Saf 1995;12:314-33. PubMed
  12. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  13. Seelig MS. Auto-immune complications of D-penicillamine - A possible result of zinc and magnesium depletion and of pyridoxine inactivation. J Am Coll Nutr 1982;1:207-14. PubMed
  14. Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 1976;11:45-54.. PubMed
  15. Hirt M, Nobel S, Barron E. Zinc nasal gel for the treatment of common cold symptoms: A double-blind, placebo-controlled trial. Ear Nose Throat J 2000;79:778-82.. DOI
  16. Simkin PA. Oral zinc sulphate in rheumatoid arthritis. Lancet 1976;2:539-42. PubMed
  17. Wray D. A double-blind trial of systemic zinc sulfate in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1982;53:469-72. PubMed
  18. Douglas RM, Miles HB, Moore BW, et al. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother 1987;31:1263-5. PubMed
  19. Lagiou P, Wuu J, Trichopoulou A, et al. Diet and benign prostatic hyperplasia: a study in Greece. Urology 1999;54:284-90. PubMed
  20. Ewing CI, Gibbs AC, Ashcroft C, David TJ. Failure of oral zinc supplementation in atopic eczema. Eur J Clin Nutr 1991;45:507-10.
  21. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  22. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS report no. 8. Arch Oph
  23. Greenberg JE, Lynn M, Kirsner RS, et al. Mucocutaneous pigmented macule as a result of zinc deposition. J Cutan Pathol 2002;29:613-5. PubMed
  24. Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7:49-56.
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