Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

EstroPro Ingredients & Drug Interactions

by USANA

EstroPro label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking EstroPro against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

EstroPro is a dietary supplement by USANA with 3 active ingredients. Its ingredients are commonly taken for sore throat and cough, heartburn and stomach upset, mouth ulcers and digestive complaints.Based on those ingredients, 1,406 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Licorice Root Extract, Flaxseed Extract, Isoflavones. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against EstroPro by USANA

Ask about any prescription or over-the-counter medication and we check it for interactions with EstroPro by USANA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of EstroPro by USANA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

EstroPro contains three active ingredients. Licorice root extract has been studied for skin conditions like eczema and canker sores, where it shows possibly effective evidence.

Isoflavones (the active compound from kudzu) have been studied for alcohol use disorder with possibly effective evidence, though long-term safety data is limited. Flaxseed extract is possibly effective for high cholesterol, blood sugar control, breast pain, high blood pressure, and constipation.

The product also contains inactive ingredients — microcrystalline cellulose, modified starch, croscarmellose sodium, vegetable fatty acid, silicon dioxide, maltodextrin, sunflower lecithin, palm olein, and guar gum — which serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Support for women 40 and older.
  • We looked for evidence on: Menopausal symptoms, Postmenopausal conditions, Hot flashes, Hormone balance.
  • The closest evidence on file: Kudzu is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms (Natural Medicines).
  • Also on file: Kudzu is rated "Insufficient Reliable Evidence To Rate" for Postmenopausal conditions.
  • Also on file: Licorice is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms.

Licorice root is possibly effective for atopic dermatitis (eczema) and canker sores. There's insufficient reliable evidence to rate its use for Addison disease or asthma.

Isoflavones are possibly effective for alcohol use disorder, though long-term safety hasn't been well established; evidence for allergic rhinitis, angina, and back pain is insufficient. Flaxseed extract is possibly effective for high cholesterol, diabetes, breast pain, high blood pressure, and constipation.

If you're using EstroPro for one of these purposes, effectiveness varies by ingredient and condition — your pharmacist can help you weigh the evidence for your specific needs.

The evidence, ingredient by ingredient Licorice Kudzu Flaxseed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Licorice root is generally well tolerated in small food amounts, but the active compound glycyrrhizin can cause serious problems at high doses or with long-term use. Most common side effects are headache, nausea, and vomiting; rare serious effects are possible with overuse.

Licorice is unsafe in pregnancy due to links to harmful fetal effects, and there isn't enough safety data to recommend it while breastfeeding. Isoflavones are generally well tolerated short-term, but long-term safety isn't established; they should be avoided in pregnancy and breastfeeding due to insufficient safety data and possible hormone-like effects.

Flaxseed extract is usually well tolerated but commonly causes bloating, diarrhea, and gas — start with small amounts and drink plenty of water. Higher doses are more likely to cause digestive upset.

It's possibly unsafe in pregnancy because of hormone-like effects, and there isn't reliable safety information for breastfeeding.

Side effects, ingredient by ingredient Licorice Kudzu Flaxseed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Kudzu, Licorice, Flaxseed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,407 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking EstroPro, double-check these medication types: heart medications like digoxin (moderate interaction with licorice), blood thinners and antiplatelet drugs like warfarin or aspirin (moderate with both licorice and isoflavones, and flaxseed), estrogen therapy including birth control (moderate — both isoflavones and flaxseed may alter effects), diabetes medications (moderate with isoflavones and flaxseed, minor with isoflavones), loop diuretics or other water pills (moderate with licorice), methotrexate (moderate with isoflavones), tamoxifen (moderate with isoflavones), hepatotoxic drugs (moderate with isoflavones), antibiotics (moderate with flaxseed), and caffeine supplements or medications (moderate with isoflavones). Check each medication with the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

EstroPro may be worth considering if you're interested in evidence for eczema, high cholesterol, blood sugar control, or blood pressure — but only after checking your exact medications against the interaction tool below. If you take digoxin, warfarin, loop diuretics, diabetes pills, estrogen therapy, antibiotics, or blood thinners, talk with your pharmacist before starting.

Pregnant or breastfeeding? These ingredients aren't recommended — speak with your doctor first.

Your pharmacist can help you weigh the evidence and interactions for your specific situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about EstroPro, straight from the product label.

Brand USANA
Net contents 56 Tablet(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 322316
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Female (18 - 50 Years), Seniors/Mature (>50 Years) - Women ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for EstroPro by USANA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
56
IngredientAmount% DV
Licorice Root Extract30 mg--
Isoflavones24 mg--
Flaxseed Extract52.5 mg--

Other ingredients: Microcrystalline Cellulose, Starch, Modified, Croscarmellose Sodium, Vegetable Fatty Acid, Silicon Dioxide, Maltodextrin, Sunflower Lecithin, Palm Olein, Guar Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

For women 40 and older.

Precautions

Keep out of reach of children.

Do not take this product if you are pregnant, nursing, taking a prescription drug, have a gastrointestinal disorder, or other medical condition without first consulting your physician.

There is a safety seal under the cap. Do not use if the seal is broken or missing.

Contains: Soy.

Storage

Keep tablets in original container with the lid tightly closed between use. Store in a cool, dry place. Store below 25 degrees C.

Formulation

Laboratory tested. Quality guaranteed. Meets USP specification for uniformity, potency, and disintegration, where applicable.

Women's health support

Brand IP Statement(s)

Discard seal, empty & replace cap Plastic bottle how2recycle.info

Seals/Symbols

MWT Potency Guaranteed

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Women 40 and older take two (2) tablets daily, spaced evenly throughout the day.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

EstroPro by USANA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

EstroPro label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in EstroPro by USANA

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container56 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Licorice Root Extract

Interacts with
1,040 drugs
30 mg per serving Form: Glycyrrhiza glabra Root Extract

Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regu...

Licorice Root Extract monograph & interactions

Isoflavones

Interacts with
584 drugs
24 mg per serving Form: Red Clover, Soy Isoflavone

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Earl...

Isoflavones monograph & interactions

Flaxseed Extract

Interacts with
597 drugs
52.5 mg per serving Form: Linum usitatissimum

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and...

Flaxseed Extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Starch, Modified, Croscarmellose Sodium, Vegetable Fatty Acid, Silicon Dioxide, Maltodextrin, Sunflower Lecithin, Palm Olein, Guar Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

EstroPro by USANA Drug Interactions

Want to check YOUR meds against EstroPro?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,406Drugs
1,383 Moderate 23 Minor

Ingredients driving the most interactions

Licorice Root Extract 1,040
Flaxseed Extract 597
Isoflavones 584

Individual Drug Interactions

The ingredients in EstroPro interact with 1,406 drugs. Click any drug to see the details.

3 of the 3 ingredients in EstroPro interact with drugs. Each result below shows which ingredient is responsible. Licorice Root Extract Flaxseed Extract Isoflavones

Each ingredient & the kinds of drugs it affects

For each ingredient in EstroPro with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Licorice Root Extract18 drug types · 1,040 drugs

Antihypertensive Drugs

Theoretically, licorice might reduce the effects of antihypertensive drugs.
In human research, licorice increases blood pressure in a dose-dependent manner.

Likelihood Possible Evidence B
Cisplatin (Platinol-Aq)

Theoretically, licorice might reduce the effects of cisplatin.
In animal research, licorice diminished the therapeutic efficacy of cisplatin.

Likelihood Possible Evidence D
Corticosteroids

Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Case reports suggest that concomitant use of licorice and oral corticosteroids, such as hydrocortisone, can potentiate the duration of activity and increase blood levels of corticosteroids. Additionally, in one case report, a patient with neurogenic orthostatic hypertension stabilized on fludrocortisone 0.1 mg twice daily developed pseudohyperaldosteronism after recent consumption of large amounts of black licorice.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.
In vitro research shows that licorice extract and glabridin, a licorice constituent, inhibit CYP2B6 isoenzymes. Licorice extract from the species G. uralensis seems to inhibit CYP2B6 isoenzymes to a greater degree than G. glabra extract in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2B6; however, these interactions have not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
In vitro, licorice extracts from the species G. glabra and G. uralensis inhibit CYP2C19 isoenzymes in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C19; however, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
In vitro, licorice extract from the species G. glabra and G. uralensis inhibits CYP2C8 isoenzymes. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C8; however, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
There is conflicting evidence about the effect of licorice on CYP2C9 enzyme activity. In vitro research shows that extracts from the licorice species G. glabra and G. uralensis moderately inhibit CYP2C9 isoenzymes. However, evidence from an animal model shows that licorice extract from the species G. uralensis can induce hepatic CYP2C9 activity. Until more is known, licorice should be used cautiously in people taking CYP2C9 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Pharmacokinetic research shows that the licorice constituent glycyrrhizin, taken in a dosage of 150 mg orally twice daily for 14 days, modestly decreases the area under the concentration-time curve of midazolam by about 20%. Midazolam is a substrate of CYP3A4, suggesting that glycyrrhizin modestly induces CYP3A4 activity. Animal research also shows that licorice extract from the species G. uralensis induces CYP3A4 activity. However, licorice extract from G. glabra species appear to inhibit CYP3A4-induced metabolism of testosterone in vitro. It is thought that the G. glabra inhibits CYP3A4 due to its constituent glabridin, which is a moderate CYP3A4 inhibitor in vitro and not present in other licorice species. Until more is known, licorice should be used cautiously in people taking CYP3A4 substrates.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Theoretically, concomitant use of licorice with digoxin might increase the risk of cardiac toxicity.
Overuse or misuse of licorice with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of licorice with diuretic drugs might increase the risk of hypokalemia.
Overuse of licorice might compound diuretic-induced potassium loss. In one case report, a 72-year-old male with a past medical history of hypertension, type 2 diabetes, hyperlipidemia, arrhythmia, stroke, and hepatic dysfunction was hospitalized with severe hypokalemia and uncontrolled hypertension due to pseudohyperaldosteronism. This was thought to be provoked by concomitant daily consumption of a product containing 225 mg of glycyrrhizin, a constituent of licorice, and hydrochlorothiazide 12.5 mg for 1 month.

Likelihood Possible Evidence D
Estrogens

Theoretically, licorice might increase or decrease the effects of estrogen therapy.
Theoretically, licorice might interfere with estrogen therapy due to estrogenic and anti-estrogenic effects.

Likelihood Possible Evidence D
Loop Diuretics

Theoretically, loop diuretics might increase the mineralocorticoid effects of licorice.
Theoretically, loop diuretics might enhance the mineralocorticoid effects of licorice by inhibiting the enzyme that converts cortisol to cortisone; however, bumetanide (Bumex) does not appear to have this effect.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, licorice might decrease levels of midazolam.
In humans, the licorice constituent glycyrrhizin appears to moderately induce the metabolism of midazolam. This is likely due to induction of cytochrome P450 3A4 by licorice. Until more is known, licorice should be used cautiously in people taking midazolam.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
In vitro research shows that licorice can increase P-glycoprotein activity.

Likelihood Possible Evidence D
Paclitaxel (Abraxane, Onxol)

Theoretically, licorice might decrease plasma levels and clinical effects of paclitaxel.
Multiple doses of licorice taken concomitantly with paclitaxel might reduce the effectiveness of paclitaxel. Animal research shows that licorice 3 grams/kg given orally for 14 days before intravenous administration of paclitaxel decreases the exposure to paclitaxel and increases its clearance. Theoretically, this occurs because licorice induces cytochrome P450 3A4 enzymes, which metabolize paclitaxel. Notably, a single dose of licorice did not affect exposure or clearance of paclitaxel.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, licorice might decrease plasma levels and clinical effects of warfarin.
Licorice seems to increase metabolism and decrease levels of warfarin in animal models. This is likely due to induction of cytochrome P450 2C9 (CYP2C9) metabolism by licorice. Advise patients taking warfarin to avoid taking licorice.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that licorice induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, licorice might increase levels of methotrexate.
Animal research suggests that intravenous administration of glycyrrhizin, a licorice constituent, and high-dose methotrexate may delay methotrexate excretion and increase systemic exposure, leading to transient elevations in liver enzymes and total bilirubin. This interaction has not yet been reported in humans.

Likelihood Unlikely Evidence D
Licorice Root Extract full monograph & interactions

Flaxseed Extract5 drug types · 597 drugs

Antibiotic Drugs

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.

Likelihood Possible Evidence D
Flaxseed Extract full monograph & interactions

Isoflavones7 drug types · 584 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Kudzu isoflavones are reported to have antiplatelet activity.

Likelihood Possible Evidence D
Caffeine

Theoretically, taking kudzu with caffeine might increase levels of caffeine.
In healthy males injected with the kudzu constituent puerarin, caffeine clearance and metabolism is inhibited. This effect has been attributed to inhibition of cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if taking kudzu orally would have this same effect.

Likelihood Probable Evidence D
Estrogens

Theoretically, kudzu might alter the effects of estrogen therapy.
Some research suggests that kudzu has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
There is some concern that kudzu can adversely affect the liver.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, taking kudzu with methotrexate might increase the risk of methotrexate toxicity.
Preclinical research suggests that kudzu extract greatly reduces the elimination and increases the toxicity of methotrexate. Kudzu might inhibit organic anion transporters (OATs) that are responsible for hepatobiliary and renal excretion of anions, similar to the interaction between methotrexate and non-steroidal anti-inflammatory drugs (NSAIDs).

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, kudzu might interfere with tamoxifen activity.
Some research suggests that kudzu may have estrogenic effects.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Kudzu might lower blood glucose levels and have additive effects in patients treated with antidiabetic agents. The dose of diabetes medications might need to be adjusted.

Likelihood Unlikely Evidence D
Isoflavones full monograph & interactions
The maker

Brand information

Manufacturer and brand details for EstroPro, from the product label.

USANA

See all USANA products
Name
USANA Health Sciences, Inc.
Street Address
3838 W. Parkway Blvd.
City
Salt Lake City
State
Utah
ZipCode
84120
Pharmacist Counseling Corner

EstroPro by USANA: Common Questions

Does EstroPro by USANA interact with any medications?
Yes. Based on its ingredients, EstroPro has a known interaction with 1,406 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
EstroPro contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take EstroPro if I'm pregnant or breastfeeding?
Licorice is unsafe in pregnancy due to links with harmful fetal effects. Isoflavones and flaxseed should also be avoided in pregnancy because there isn't enough safety data and they may have hormone-like effects. For breastfeeding, licorice and isoflavones aren't recommended due to insufficient safety information, and flaxseed is also cautionary. Talk with your doctor or pharmacist before using this product if you're pregnant, planning to become pregnant, or breastfeeding.
What are the most common side effects of EstroPro?
Licorice can cause headache, nausea, and vomiting. Flaxseed commonly causes bloating, diarrhea, and gas — starting with small amounts and drinking plenty of water helps. Isoflavones may cause nausea, bloating, or dizziness, though these didn't occur more often than placebo in trials. If side effects bother you, stop and talk to your pharmacist.
Does EstroPro actually work?
The evidence varies by ingredient and what you're using it for. Licorice is possibly effective for eczema and canker sores. Isoflavones are possibly effective for alcohol use disorder. Flaxseed is possibly effective for high cholesterol, blood sugar, breast pain, blood pressure, and constipation. Talk to your pharmacist about whether the evidence matches your reason for considering this product.
Can I take EstroPro if I'm on birth control?
Both isoflavones and flaxseed may alter the effects of estrogen therapy, which includes most birth control pills. This could either enhance or reduce effectiveness. Talk to your doctor or pharmacist before starting EstroPro if you rely on hormonal birth control.
How much water should I drink with EstroPro?
Flaxseed in this product can cause bloating and gas. The facts recommend drinking plenty of water and starting with small amounts to reduce digestive side effects. There's no specific amount listed in the product information, so ask your pharmacist for guidance based on the dose you're taking.
Will EstroPro make my blood pressure drop too much?
Flaxseed can lower blood pressure, especially with regular use over 12 weeks. If you're already taking blood pressure medication, using EstroPro could cause your blood pressure to drop further than intended. Check with your pharmacist or doctor before taking it alongside antihypertensive drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

EstroPro label
Go deeper

The Full Monographs Behind EstroPro’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Licorice

Interacts with 1,040 drugs

Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regular licorice contains glycyrrhizin, whic...

Read the full Licorice monograph → Herb & supplement monograph

Kudzu

Interacts with 584 drugs

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Early research is promising for cutting back...

Read the full Kudzu monograph → Herb & supplement monograph

Flaxseed

Interacts with 597 drugs

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and may modestly lower cholesterol, but evid...

Read the full Flaxseed monograph →
Sources

Sources & How We Checked

EstroPro's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 150 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Licorice 92 references
  1. Farese RV Jr, Biglieri EG, Shackleton CH, et al. Licorice-induced hypermineralocorticoidism. N Engl J Med 1991;325:1223-7. PubMed
  2. Sigurjonsdottir HA, Ragnarsson J, Franzson L, Sigurdsson G. Is blood pressure commonly raised by moderate consumption of liquorice? J Hum Hypertens 1995;9:345-8.
  3. Armanini D, Lewicka S, Pratesi C, et al. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. J Endocrinol Invest 1996;19:624-9. PubMed
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See these in context on the Flaxseed monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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