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Dietary supplement

Psyllium Husk Ingredients & Drug Interactions

by Bixa Botanical

Psyllium Husk label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Psyllium Husk against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Psyllium Husk is a dietary supplement by Bixa Botanical with 1 active ingredient. Its ingredients are commonly taken for constipation relief, diarrhea and loose stools, high cholesterol.Based on those ingredients, 2,025 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Plantago ovata powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Psyllium Husk by Bixa Botanical

Ask about any prescription or over-the-counter medication and we check it for interactions with Psyllium Husk by Bixa Botanical — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Psyllium Husk by Bixa Botanical

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Bixa Botanical's Psyllium Husk is a single-ingredient product: blond psyllium powder (Plantago ovata). There are no inactive ingredients or fillers listed.

Psyllium is a soluble fiber derived from psyllium seeds; it absorbs water in your digestive tract and adds bulk to your stool.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: promotes safe natural laxation.
  • We looked for evidence on: Constipation, Diarrhea, Fecal incontinence, Hemorrhoids, Irritable bowel syndrome (IBS), Crohn disease — and 3 related terms.
  • The strongest evidence on file: Blond Psyllium is rated "Effective" for Constipation (Natural Medicines).
  • Also on file: Blond Psyllium is rated "Possibly Effective" for Diarrhea, Hemorrhoids, Irritable bowel syndrome (IBS).
  • Also on file: Blond Psyllium is rated "Insufficient Reliable Evidence To Rate" for Crohn disease, Ulcerative colitis, Fecal incontinence.

The evidence supports psyllium for constipation — it's rated Effective for relieving it. For cholesterol and heart disease, the data shows it's Likely Effective; psyllium can help lower LDL (bad) cholesterol and support cardiovascular health when used regularly.

The evidence, ingredient by ingredient Blond Psyllium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Psyllium is generally well tolerated when you drink plenty of water with it. The most common side effects are mild — bloating, gas, abdominal discomfort, nausea, or diarrhea — especially when you first start.

Rarely, bowel or esophageal obstruction can occur, and a small number of people develop allergic reactions (sneezing, itching, rash, or in serious cases wheezing, swelling, or anaphylaxis), particularly with repeated or occupational exposure. Backache has also been reported.

For pregnancy and lactation, the safety data rates psyllium as Likely Safe, but talk with your doctor or pharmacist before starting it during pregnancy or while breastfeeding to make sure it's right for your situation.

Side effects, ingredient by ingredient Blond Psyllium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Blond Psyllium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2,026 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this psyllium product, double-check with your doctor or pharmacist if you're on metformin, lithium, carbamazepine, or olanzapine — all ranked Moderate concern. If you take birth control pills, digoxin, or any other oral medications, spacing this product 30–60 minutes after your dose can help protect absorption, but it's worth confirming the exact timing with your pharmacist to be safe.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Psyllium is a solid choice if you're dealing with constipation or want to support your cholesterol and heart health — the evidence backs it. The main catch is that it can interfere with how your body absorbs several medications, especially metformin, lithium, carbamazepine, and olanzapine.

If you take any prescription drugs, check them against the interaction tool on this page and talk with your doctor or pharmacist before you start, to figure out the right timing or whether you need adjustments.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Psyllium Husk, straight from the product label.

Brand Bixa Botanical
Barcode (UPC) 8904289001142
Net contents 454 Gram(s); 16 Ounce(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229719
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Psyllium Husk by Bixa Botanical, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
3 Gram(s)
Servings per container
151
UPC/BARCODE
8904289001142
IngredientAmount% DV
Plantago ovata powder3 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: One - two teaspoon with 1 glass warm water daily at night or as directed by your health practitioner.

Brand IP Statement(s)

Trademark of Bixa Botanical INC, USA

Formula

Seed husk powder

K LBD (Kosher)

Formulation

Promotes safe & natural laxation

Vegan

Non GMO

FDA Statement of Identity

Herbal Food Supplement

FDA Disclaimer Statement

Disclaimer: These statements have not been evaluated by the Food and Drug Administration and this product is a herbal food supplement and not intended to diagnose, treat, cure or prevent a disease.

Precautions

Warning: This product is not intended for use by those with serious medical condition or pregnant or lactating women.

Consult your physician before use.

Do not use if seal is broken.

Keep out of reach of children.

Storage

Store in a cool and dry place.

General Statements

Product of India

Over 140 years of quality trust

More than a company, Bixa Botanical is a dream - to share the collective knowledge of five generations of a family with the world; secrets of Herbal Healing that have been painstakingly accumulated over the last 140 years. Over 500 varieties of herbs are exclusively cleaned, processed and packed-in the company's ultra-modern in-house facilities.

Mfg. Lic. No : MP25D/14/318

Seals/Symbols

Good manufacturing practices GMP Certified K LBD (Kosher)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Psyllium Husk by Bixa Botanical label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Psyllium Husk label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Psyllium Husk by Bixa Botanical

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container151 Amounts shown are per serving.

Plantago ovata powder

Interacts with
2,025 drugs
3 Gram(s) per serving

Blond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements. It can help with both...

Plantago ovata powder monograph & interactions
Interaction report

Psyllium Husk by Bixa Botanical Drug Interactions

Want to check YOUR meds against Psyllium Husk?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,025Drugs
23 Moderate 2,002 Minor

Ingredients driving the most interactions

Plantago ovata powder 2,025

Individual Drug Interactions

The ingredients in Psyllium Husk interact with 2,025 drugs. Click any drug to see the details.

1 of the 1 ingredient in Psyllium Husk interact with drugs. Each result below shows which ingredient is responsible. Plantago ovata powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Psyllium Husk with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Plantago ovata powder7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, blond psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Blond psyllium might reduce carbamazepine absorption and serum levels. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug.

Likelihood Probable Evidence D
Lithium

Theoretically, taking blond psyllium at the same time as lithium might reduce lithium absorption.
The fiber in blond psyllium might decrease the absorption of lithium. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Concurrent use of blond psyllium with metformin slows and increases metformin absorption. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking blond psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in blond psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was taken concomitantly with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking blond psyllium at the same time as digoxin might reduce digoxin absorption.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking blond psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. However, this is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Conversely, case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin.

Likelihood Possible Evidence B
Plantago ovata powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Psyllium Husk, from the product label.

Bixa Botanical

See all Bixa Botanical products
Name
Bixa Botanical
Street Address
80-83, Long Lane
City
London
ZipCode
ECIA9ET
Web Address
www.bixabotanical.com
Pharmacist Counseling Corner

Psyllium Husk by Bixa Botanical: Common Questions

Does Psyllium Husk by Bixa Botanical interact with any medications?
Yes. Based on its ingredients, Psyllium Husk has a known interaction with 2,025 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Psyllium Husk contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take psyllium at the same time as my metformin?
No — psyllium slows and increases how much metformin your body absorbs, which can boost both its benefits and side effects. Take psyllium at least 30–60 minutes after your metformin to avoid this. Check with your doctor or pharmacist on the exact timing that works for your schedule.
Will this interfere with my lithium medication?
Psyllium's fiber may reduce how much lithium your body absorbs, which can lower its effectiveness. This is serious because lithium levels need to stay in a narrow range. Before starting psyllium, talk with your doctor about whether it's safe for you and how to monitor it.
What are the most common side effects?
Mild digestive effects are most likely — bloating, gas, abdominal pain, nausea, or diarrhea — especially when you first start. Make sure you drink plenty of water; that helps a lot. Rare but serious effects include bowel obstruction and allergic reactions, so stop and seek care if you have severe pain, trouble swallowing, or signs of allergy like swelling or difficulty breathing.
Is psyllium safe to use during pregnancy or while breastfeeding?
The safety data rates it as Likely Safe in pregnancy and lactation, but you should still check with your doctor or pharmacist first. They know your full health picture and can confirm it's the right choice for you right now.
Will this lower my cholesterol?
The evidence shows psyllium is Likely Effective for lowering cholesterol and supporting heart health, but it works best as part of a broader approach — diet, exercise, and any medications your doctor recommends. Don't rely on it as a replacement for prescribed cholesterol medications.
How much water should I drink with psyllium?
The facts we hold don't specify an exact amount, but psyllium works by absorbing water, so drink plenty with each dose — at least a full glass — and stay hydrated throughout the day. Ask your doctor or pharmacist for a personalized recommendation based on your health and diet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Psyllium Husk label
Go deeper

The Full Monographs Behind Psyllium Husk’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blond Psyllium

Interacts with 2,025 drugs

Blond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements. It can help with both constipation and diarrhea and may modest...

Read the full Blond Psyllium monograph →
Sources

Sources & How We Checked

Psyllium Husk's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blond Psyllium 28 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Agha FP, Nostrant TT, Fiddian-Green RG. Giant colonic bezoar: a medication bezoar due to psyllium seed husks. Am J Gastroenterol 1984;79:319-21.
  7. Anderson JW, Allgood LD, Lawrence A, et al. Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. Am J Clin Nutr 2000;71:472-9. PubMed
  8. Suhonen R, Kantola I, Bjorksten F. Anaphylactic shock due to ingestion of psyllium laxative. Allergy 1983;38:363-5. PubMed
  9. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  10. Freeman GL. Psyllium hypersensitivity. Ann Allergy 1994;73:490-2.
  11. Morgan MS, Arlian LG, Vyszenski-Moher DL, et al. English plantain and psyllium: lack of cross-allergenicity by crossed immunoelectrophoresis. Ann Allergy Asthma Immunol 1995;75:351-9.
  12. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  13. Schneider RP. Perdiem causes esophageal impaction and bezoars. South Med J 1989;82:1449-50. PubMed
  14. Shulman LM, Minagar A, Weiner WJ. Perdiem causing esophageal obstruction in Parkinson's disease. Neurology 1999;52:670-1. PubMed
  15. James JM, Cooke SK, Barnett A, Sampson HA. Anaphylactic reactions to a psyllium-containing cereal. J Allergy Clin Immunol 1991;88:402-8.. PubMed
  16. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  17. Schaller DR. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1073. DOI
  18. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  19. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  20. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  21. Bernedo N, García M, Gastaminza G, et al. Allergy to laxative compound (Plantago ovata seed) among health care professionals. J Investig Allergol Clin Immunol 2008;18(3):181-9.
  22. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  23. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  24. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  25. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  26. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
  27. Shin S, Kim JH, Mun YH, Chung HS. Acute esophageal obstruction after ingestion of psyllium seed husk powder: A case report. World J Clin Cases 2022;10(7):2336-2340. PubMed
  28. Tominaga Y, Hirayama I, Nonaka M, Yano T, Ishii M. Intestinal obstruction caused by consuming diet food containing psyllium. Acute Med Surg 2023;10(1):e846. PubMed

See these in context on the Blond Psyllium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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