Tri-Fiber Complex Ingredients & Drug Interactions
by Herbadiet
What is this page for?
First and foremost: checking Tri-Fiber Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Tri-Fiber Complex is a dietary supplement by Herbadiet with 3 active ingredients. Its ingredients are commonly taken for constipation relief, diarrhea and loose stools, high cholesterol.Based on those ingredients, 2,031 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Psyllium, Apple Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Tri-Fiber Complex by Herbadiet
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Tri-Fiber Complex by Herbadiet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Tri-Fiber Complex contains 3 active ingredients: oat bran, organic psyllium, and apple pectin. All three are soluble and insoluble fibers that work in the digestive tract to add bulk and moisture to stool.
The product is enclosed in a vegetable cellulose capsule.
Does it work?
Strong evidence
Psyllium is effective for constipation and likely effective for high cholesterol and heart disease prevention. Apple pectin is possibly effective for high cholesterol, though the evidence is less robust.
We don't have established effectiveness data on oat bran from the product information we hold. The combination is intended to support digestive regularity and cholesterol management, though individual results vary.
How safe is it?
Well-documented data
Psyllium and pectin are generally well tolerated when taken with plenty of water. The most common side effects are mild — abdominal pain, gas, diarrhea, nausea, or cramping.
Rarely, bowel obstruction or esophageal obstruction can occur with psyllium, and allergic reactions (including anaphylaxis in sensitive people) are possible with either ingredient. Both are rated likely safe in pregnancy and lactation, though concentrated pectin supplements haven't been extensively studied in pregnancy — check with your doctor if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before starting Tri-Fiber Complex, check with your doctor or pharmacist if you take metformin, lithium, carbamazepine, olanzapine, lovastatin, tetracycline antibiotics, digoxin, or birth control containing ethinyl estradiol. Psyllium and pectin can reduce how much of these drugs your body absorbs, so spacing doses 30–60 minutes apart is important.
No interactions are documented for oat bran.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is a straightforward fiber blend best suited for people looking to support digestive health and manage cholesterol naturally. If you take metformin, lithium, a seizure or heart medication, or a statin, check your exact drugs with the tool on this page and talk it over with your doctor or pharmacist — timing matters.
Take it with a full glass of water and space it away from other medications as directed.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Tri-Fiber Complex, straight from the product label.
| Brand | Herbadiet |
|---|---|
| Barcode (UPC) | 880364694868 |
| Net contents | 60 V-Cap(s) |
| Market status | On market |
| Date entered into DSLD | Dec 18, 2021 |
| DSLD ID | 258229 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Tri-Fiber Complex by Herbadiet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Oat Bran | 710 mg | -- |
| organic Psyllium | 750 mg | -- |
| Apple Pectin | 40 mg | -- |
Other ingredients: Vegetable Cellulose Shell
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
A good daily supply of dietary fiber is crucial for cardiovascular health and for maintaining normal bowel function. Unfortunately, most of us don't get enough fiber in our regular diet. That's where Tri-Fiber Complex can help. This formula makes it easy to get the fiber you need every day by combining psyllium, oat bran and apple pectin in convenient capsules.
With Psyllium Husk, Oat Bran & Apple Pectin
Formulation
Promotes healthy digestion Helps with occasional constipation Supports bowel regularity
Natural color variation may occur in this product
100% natural Digestive health support
Non-GMO
Suitable for vegetarians and vegans
Free Of preservatives, binders, gluten, artificial ingredients, dairy, soy, wheat, yeast
Every batch 3rd party lab tested
FDA Disclaimer Statement
These statements have not been evaluated by FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Do not use if seal under the cap is broken or missing. Dietary supplement shouldn't be used as a substitute for a varied diet
Caution: If you are pregnant, breast feeding, or taking medications, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Not for medicinal use
Storage
Store in cool, dry place
Seals/Symbols
fssai Lic. No.: 20817018000147 Vcaps Plus GMP Good Manufacturing Practice Quality Product
General Statements
1% for the planet
License Number: 10018064001315
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions for Use: Take 3 capsules twice a day with full glass of water or as directed by your physician.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Tri-Fiber Complex by Herbadiet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Tri-Fiber Complex by Herbadiet
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Oat Bran
Organic Psyllium
Interacts with2,025 drugs
Blond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements. It can help with both...
Organic Psyllium monograph & interactionsApple Pectin
Interacts with23 drugs
Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...
Apple Pectin monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose Shell. These complete the product’s ingredient list but are not active constituents.
Tri-Fiber Complex by Herbadiet Drug Interactions
HelloPharmacist Interaction Report
Tri-Fiber Complex by Herbadiet interacts with medications through its psyllium and pectin content.
The most serious documented interaction is Moderate severity: psyllium may reduce metformin absorption, which could affect blood sugar control in people taking this diabetes medication. Spacing the two at least 30–60 minutes apart can help.
Read the full breakdown — every affected drug type, severity by severity
Psyllium also has Moderate interactions with lithium (a mood stabilizer), carbamazepine (a seizure medication), and olanzapine (an antipsychotic) — each through reduced drug absorption. Pectin carries Moderate interactions with lovastatin (a cholesterol drug), tetracycline antibiotics, and digoxin (a heart medication), again by limiting how much your body absorbs.
Psyllium and pectin also have Minor interactions with other oral medications and with ethinyl estradiol (birth control). The variable effects mean spacing doses — psyllium or pectin 30–60 minutes after your other drugs — is your best safeguard.
Altogether, these interactions span 2,032 individual medications.
We could not check oat bran for interactions. Before you start Tri-Fiber Complex, run your exact medications through the search tool on this page, and talk with your doctor or pharmacist about the best timing.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Tri-Fiber Complex?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Tri-Fiber Complex interact with 2,031 drugs. Click any drug to see the details.
2 of the 3 ingredients in Tri-Fiber Complex interact with drugs. Each result below shows which ingredient is responsible. organic Psyllium Apple Pectin
Alogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Alogliptin, Metformin interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Tri-Fiber Complex — through 2 ingredients. Tap an ingredient for the detail:
Apple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Amphotericin, Tetracycline interactionOrganic PsylliumOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Amphotericin, Tetracycline interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with Tri-Fiber Complex — through 2 ingredients. Tap an ingredient for the detail:
Apple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionOrganic PsylliumOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Organic Psyllium + Canagliflozin, Metformin Hydrochloride interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumCarbamazepine (tegretol), Oral Drugs Moderate
Interaction Summary
Theoretically, blond psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Read the full Organic Psyllium + Carbamazepine interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Tri-Fiber Complex — through 2 ingredients. Tap an ingredient for the detail:
Apple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Chlortetracycline interactionOrganic PsylliumOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Chlortetracycline interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Dapagliflozin Propanediol, Metformin interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDemeclocyclineDeclomycin
How Demeclocycline interacts with Tri-Fiber Complex — through 2 ingredients. Tap an ingredient for the detail:
Apple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Demeclocycline interactionOrganic PsylliumOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Demeclocycline interactionDigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Tri-Fiber Complex — through 2 ingredients. Tap an ingredient for the detail:
Apple PectinDigoxin (lanoxin) Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
Read the full Apple Pectin + Digoxin interactionOrganic PsylliumOral Drugs, Digoxin (lanoxin) Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Digoxin interactionDoripenemDoribax
How Doripenem interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Apple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Doripenem interactionDoxycyclineDoryx, Doxy, Doxy-D, Doxycin, Doxycycline Injection, Doxylin +6 more
How Doxycycline interacts with Tri-Fiber Complex — through 2 ingredients. Tap an ingredient for the detail:
Apple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Doxycycline interactionOrganic PsylliumOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Doxycycline interactionDoxycycline HyclateActiclate, Acticlate Cap, Lymepak
How Doxycycline Hyclate interacts with Tri-Fiber Complex — through 2 ingredients. Tap an ingredient for the detail:
Apple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Doxycycline Hyclate interactionOrganic PsylliumOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Doxycycline Hyclate interactionDoxycycline MonohydrateErfacea
How Doxycycline Monohydrate interacts with Tri-Fiber Complex — through 2 ingredients. Tap an ingredient for the detail:
Apple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Doxycycline Monohydrate interactionOrganic PsylliumOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Doxycycline Monohydrate interactionDoxycylineDoxychel
How Doxycyline interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Apple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Doxycyline interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Organic Psyllium + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Organic Psyllium + Empagliflozin, Metformin Hydrochloride interactionEravacyclineXerava
How Eravacycline interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Apple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Eravacycline interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Ertugliflozin, Metformin Hydrochloride interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Organic Psyllium + Glipizide, Metformin interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Glyburide, Metformin interactionLinagliptin, Metformin HydrochlorideJentadueto XR
How Linagliptin, Metformin Hydrochloride interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Linagliptin, Metformin Hydrochloride interactionLithium Carbonate (prescription Drug)Eskalith, Lithium Carbonate
How Lithium Carbonate (prescription Drug) interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Lithium Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Lithium Carbonate (prescription Drug) interactionLovastatinAltocor, Mevacor
How Lovastatin interacts with Tri-Fiber Complex — through 2 ingredients. Tap an ingredient for the detail:
Apple PectinLovastatin (mevacor) Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Read the full Apple Pectin + Lovastatin interactionOrganic PsylliumOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Lovastatin interactionMetforminGlucophage, Metformin
How Metformin interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Organic Psyllium + Metformin interactionMetformin HydrochlorideRiomet ER
How Metformin Hydrochloride interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Metformin Hydrochloride interactionMetformin, LinagliptinJentadueto
How Metformin, Linagliptin interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Organic Psyllium + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
How Metformin, Rosiglitazone interacts with Tri-Fiber Complex — through 1 ingredient. Tap an ingredient for the detail:
Organic PsylliumMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Organic Psyllium + Metformin, Rosiglitazone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Tri-Fiber Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Psyllium
Carbamazepine (Tegretol)
Theoretically, blond psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Blond psyllium might reduce carbamazepine absorption and serum levels. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug.
Lithium
Theoretically, taking blond psyllium at the same time as lithium might reduce lithium absorption.
The fiber in blond psyllium might decrease the absorption of lithium. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped.
Metformin (Glucophage)
Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Concurrent use of blond psyllium with metformin slows and increases metformin absorption. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking blond psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in blond psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was taken concomitantly with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking blond psyllium at the same time as digoxin might reduce digoxin absorption.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking blond psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. However, this is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Conversely, case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin.
Apple Pectin
Digoxin (Lanoxin)
Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.
Lovastatin (Mevacor)
Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.
Tetracycline Antibiotics
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.
Brand information
Manufacturer and brand details for Tri-Fiber Complex, from the product label.
Herbadiet
See all Herbadiet products- Name
- Arkure Health Care
- City
- Haryana
- State
- India
- Web Address
- www.herbadiet.in
Tri-Fiber Complex by Herbadiet: Common Questions
Does Tri-Fiber Complex by Herbadiet interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this fiber supplement affect my birth control?
What are the most common side effects?
Is this safe if I'm pregnant or breastfeeding?
Does fiber help with high cholesterol?
How much water should I drink with this?
Can this cause bowel obstruction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Tri-Fiber Complex is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Tri-Fiber Complex’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Blond Psyllium
Interacts with 2,025 drugsBlond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements. It can help with both constipation and diarrhea and may modest...
Read the full Blond Psyllium monograph → Herb & supplement monographPectin
Interacts with 23 drugsPectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...
Read the full Pectin monograph →Sources & How We Checked
Tri-Fiber Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 39 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Blond Psyllium 28 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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