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Dietary supplement

Reishi Mushroom (Ganoderma) Extract Ingredients & Drug Interactions

by Herbadiet

Reishi Mushroom (Ganoderma) Extract label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Reishi Mushroom (Ganoderma) Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Reishi Mushroom (Ganoderma) Extract is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Mushroom extract powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Reishi Mushroom (Ganoderma) Extract by Herbadiet

Ask about any prescription or over-the-counter medication and we check it for interactions with Reishi Mushroom (Ganoderma) Extract by Herbadiet — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Reishi Mushroom (Ganoderma) Extract by Herbadiet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: reishi mushroom extract powder. Reishi is a medicinal fungus used traditionally to support general wellness.

There are no inactive ingredients listed for this formula.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Reishi Mushroom product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Reishi Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“promotes longevity”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence for reishi mushroom is limited. It's rated possibly ineffective for high cholesterol (hyperlipidemia).

For altitude sickness, Alzheimer disease, and athletic performance, we don't have enough reliable evidence to say whether it works. If you're considering reishi for one of these uses, talk with your doctor or pharmacist about whether the current evidence supports it for your situation.

The evidence, ingredient by ingredient Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Reishi mushroom is generally well tolerated in the short term, but how safe it is over months or years hasn't been well studied. The most common side effects from oral use are dizziness, dry mouth, itching, nausea, rash, and stomach upset.

Rarely, it can cause insomnia or headache. Some people may also experience respiratory allergy to reishi spores, with sore throat or runny nose.

There isn't enough safety data to use reishi during pregnancy or while breastfeeding. If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Reishi Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Reishi Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before starting if you take blood thinners (anticoagulants or antiplatelet drugs) — reishi may increase bleeding risk at higher doses. Also flag blood pressure medications, because reishi can lower blood pressure further.

Finally, if you're on diabetes medications, reishi's blood-sugar effects may combine with them, though the evidence is inconsistent.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Reishi mushroom may be worth considering if you're interested in general wellness support and you're not on blood pressure, blood-thinning, or diabetes medications. If you do take any of those drugs—or any prescription medication—check with your pharmacist or doctor first, because the dose and your individual health matter.

Long-term safety hasn't been established, so this is best used short-term unless you're under professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Reishi Mushroom (Ganoderma) Extract, straight from the product label.

Brand Herbadiet
Net contents 0 Not Present
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244386
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Reishi Mushroom (Ganoderma) Extract by Herbadiet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
1000 mg
IngredientAmount% DV
Reishi Mushroom extract powder500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Promotes Longevity

Free of fillers, binders, artificial ingredients, dairy, soy, wheat, gluten, yeast

V Vegan

Ethically Sourced Scientifically Tested Premium Grade Ingredients

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take up to 1000 mg, or as directed by your physician

Precautions

Keep out of reach of children.

Warning: Pregnant or lactating women should consult your physician before use.

Storage

Store in a dry, cool & dark.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Batch No. ARK-P68

Formula

Standardized Extract Powder Derived from Ganoderma Lucidum

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Reishi Mushroom (Ganoderma) Extract by Herbadiet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Reishi Mushroom (Ganoderma) Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Reishi Mushroom (Ganoderma) Extract by Herbadiet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Amounts shown are per serving.

Reishi Mushroom extract powder

Interacts with
375 drugs
500 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom extract powder monograph & interactions
Interaction report

Reishi Mushroom (Ganoderma) Extract by Herbadiet Drug Interactions

Want to check YOUR meds against Reishi Mushroom (Ganoderma) Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Reishi Mushroom extract powder 375

Individual Drug Interactions

The ingredients in Reishi Mushroom (Ganoderma) Extract interact with 375 drugs. Click any drug to see the details.

1 of the 1 ingredient in Reishi Mushroom (Ganoderma) Extract interact with drugs. Each result below shows which ingredient is responsible. Reishi Mushroom extract powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Reishi Mushroom (Ganoderma) Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi Mushroom extract powder3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom extract powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Reishi Mushroom (Ganoderma) Extract, from the product label.

Herbadiet

See all Herbadiet products
Name
Arkure Health Care
Street Address
11, Sector - 14
City
Rohtak
State
Haryana
ZipCode
124001
Web Address
www.herbadiet.in
Pharmacist Counseling Corner

Reishi Mushroom (Ganoderma) Extract by Herbadiet: Common Questions

Does Reishi Mushroom (Ganoderma) Extract by Herbadiet interact with any medications?
Yes. Based on its ingredients, Reishi Mushroom (Ganoderma) Extract has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Reishi Mushroom (Ganoderma) Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does reishi mushroom do?
Reishi is a medicinal fungus used traditionally for general wellness support. It may have some effects on blood pressure and blood sugar, though the evidence varies from person to person. We don't have reliable evidence that it works for high cholesterol, altitude sickness, Alzheimer disease, or athletic performance.
What are the most common side effects?
The most frequent side effects from taking reishi by mouth are dizziness, dry mouth, itching, nausea, rash, and stomach upset. Some people also report sore throat or runny nose if they're sensitive to reishi spores.
Is this safe to take long-term?
Reishi is generally well tolerated in the short term, but we don't have good data on long-term safety. If you're thinking of taking it regularly for months or longer, talk with your doctor or pharmacist to make sure it's right for you.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data to recommend reishi during pregnancy or while breastfeeding. If you're in either situation, talk with your doctor or pharmacist before starting.
Will this affect my blood pressure medication?
Yes—reishi may lower blood pressure on its own, so taking it with blood pressure drugs could drop your pressure too much and cause dizziness or weakness. Check with your doctor or pharmacist before using both.
I'm on a blood thinner. Can I take this?
At higher doses, reishi may increase bleeding risk. At lower doses (around 1.5 grams daily), it doesn't seem to affect clotting, but higher doses do. Talk with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Reishi Mushroom (Ganoderma) Extract label
Go deeper

The Full Monographs Behind Reishi Mushroom (Ganoderma) Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

Reishi Mushroom (Ganoderma) Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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