Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Relax+ Ultimate Calm Ingredients & Drug Interactions

by Natrol

Relax+ Ultimate Calm label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Relax+ Ultimate Calm against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Relax+ Ultimate Calm is a dietary supplement by Natrol with 4 active ingredients. Its ingredients are commonly taken for low mood or depression, anxiety and stress, sleep problems.Based on those ingredients, 1,376 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril, L-Theanine, 5-Hydroxytryptophan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Relax+ Ultimate Calm by Natrol

Ask about any prescription or over-the-counter medication and we check it for interactions with Relax+ Ultimate Calm by Natrol — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Relax+ Ultimate Calm by Natrol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Relax+ Ultimate Calm contains four active ingredients. 5-Hydroxytryptophan (5-HTP) is an amino acid precursor to serotonin, the brain chemical involved in mood regulation.

L-Theanine is an amino acid found in tea that may support relaxation and cognitive function. Lemon Balm Aerial Parts Extract comes from the lemon balm plant and is used traditionally for calming effects.

Sensoril is a branded ashwagandha extract, an adaptogenic herb used for stress and sleep support. The product also contains inactive ingredients—hypromellose, maltodextrin, magnesium stearate, and silicon dioxide—which serve as capsule material and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: reduces stress and supports relaxed calm mood.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Panic disorder, Emotional balance, Nervousness, Restlessness.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety.

Evidence for these ingredients is mixed. 5-HTP is rated Possibly Effective for depression, though evidence is limited.

L-Theanine is Possibly Effective for cognitive function support, but its effects on anxiety and age-related cognitive decline have Insufficient Reliable Evidence. Lemon Balm is Possibly Effective for cold sores and stress-related mood support.

Ashwagandha (Sensoril) is Possibly Effective for insomnia, anxiety, stress, and generalized anxiety disorder. For other conditions listed—Alzheimer's disease, panic disorder, OCD, bipolar disorder—the evidence is insufficient or the ingredient is rated Possibly Ineffective, meaning the data we hold does not establish benefit.

The evidence, ingredient by ingredient 5-htp Theanine Lemon Balm Ashwagandha

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of these ingredients is generally well tolerated in healthy adults, though long-term safety data are limited. 5-HTP commonly causes gastrointestinal side effects—nausea, vomiting, abdominal pain, diarrhea, anorexia—typically dose-dependent and sometimes easing with continued use; it also causes drowsiness, headache, dizziness, and insomnia.

Rare serious effects include aggression, hallucinations, and mania. L-Theanine may cause headaches, drowsiness, and increased dream activity.

Lemon Balm commonly causes dizziness and sedation. Ashwagandha typically causes diarrhea, nausea, and vomiting at high doses, and drowsiness; rare serious cases include acute liver failure and hepatitis.

Pregnancy: the data advises against 5-HTP and ashwagandha during pregnancy; lemon balm safety is insufficient unless your doctor advises otherwise; L-theanine safety is insufficient—talk to your doctor. Breastfeeding: avoid 5-HTP and ashwagandha due to insufficient safety data; use lemon balm and L-theanine only with caution and your doctor's input.

Side effects, ingredient by ingredient 5-htp Theanine Lemon Balm Ashwagandha

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lemon Balm, 5-htp, Ashwagandha, Theanine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,377 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Relax+ Ultimate Calm, double-check the following medication types with your pharmacist: serotonergic drugs (antidepressants, certain migraine and pain medications), CNS depressants (sleep aids, sedatives, opioids, anti-anxiety drugs), blood pressure medications, diabetes drugs, thyroid hormones, benzodiazepines, immunosuppressants, and hepatotoxic drugs (medications that stress the liver). Additionally, carbidopa (Lodosyn) for Parkinson's disease and medications metabolized by the liver enzyme CYP1A2 warrant review.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to people looking for natural stress and sleep support, but it's essential to check it against your medications first—especially if you take antidepressants, blood pressure drugs, sleep aids, diabetes medications, or thyroid hormones. Talk with your pharmacist or doctor before starting, particularly if you're pregnant, breastfeeding, or have liver or thyroid conditions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Relax+ Ultimate Calm, straight from the product label.

Brand Natrol
Barcode (UPC) 047469074135
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 332300
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Relax+ Ultimate Calm by Natrol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
047469074135
IngredientAmount% DV
5-Hydroxytryptophan100 mg--
L-Theanine200 mg--
Lemon Balm Aerial Parts Extract3 mg--
Sensoril125 mg--

Other ingredients: Hypromellose, Maltodextrin, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Natrol Relax + Ultimate Calm will help you get on your way to a better day: Reduces occasional stress Supports a relaxed mood Feel calm Feel balanced

100% drug free

Reduces occasional stress & tension Helps you feel calm & balanced

No: milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, sesame

Precautions

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reactions occur, discontinue use.

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reactions occur, discontinue use. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Mood + Stress

Formula

Ashwagandha, 5-HTP and L-Theanine

Sensoril

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Adults, take 1 capsule daily with or without food.

Brand IP Statement(s)

Sensoril is a registered trademark of Natreon, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Relax+ Ultimate Calm by Natrol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Relax+ Ultimate Calm label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Relax+ Ultimate Calm by Natrol

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

5-Hydroxytryptophan

Interacts with
398 drugs
100 mg per serving Form: Griffonia simplicifolia

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...

5-Hydroxytryptophan monograph & interactions

L-Theanine

Interacts with
565 drugs
200 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Lemon Balm Aerial Parts Extract

Interacts with
264 drugs
3 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm Aerial Parts Extract monograph & interactions

Sensoril

Interacts with
1,372 drugs
125 mg per serving Form: Ashwagandha Leaf, Root Extract

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Sensoril monograph & interactions

Other (inactive) ingredients: Hypromellose, Maltodextrin, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Relax+ Ultimate Calm by Natrol Drug Interactions

Want to check YOUR meds against Relax+ Ultimate Calm?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,376Drugs
1,044 Moderate 332 Minor

Ingredients driving the most interactions

Sensoril 1,372
L-Theanine 565
5-Hydroxytryptophan 398
Lemon Balm Aerial Parts Extract 264

Individual Drug Interactions

The ingredients in Relax+ Ultimate Calm interact with 1,376 drugs. Click any drug to see the details.

4 of the 4 ingredients in Relax+ Ultimate Calm interact with drugs. Each result below shows which ingredient is responsible. Sensoril L-Theanine 5-Hydroxytryptophan Lemon Balm Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Relax+ Ultimate Calm with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

5-Hydroxytryptophan3 drug types · 398 drugs

Carbidopa (Lodosyn)

Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.

Likelihood Possible Evidence D
5-Hydroxytryptophan full monograph & interactions

Lemon Balm Aerial Parts Extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Relax+ Ultimate Calm, from the product label.

Natrol

See all Natrol products
Name
Natrol LLC
City
Sherman Oaks
State
CA
ZipCode
91403
Phone Number
1-800-262-8765
Web Address
www.natrol.com
Pharmacist Counseling Corner

Relax+ Ultimate Calm by Natrol: Common Questions

Does Relax+ Ultimate Calm by Natrol interact with any medications?
Yes. Based on its ingredients, Relax+ Ultimate Calm has a known interaction with 1,376 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Relax+ Ultimate Calm contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does 5-HTP do, and why is it in this product?
5-HTP is an amino acid your body uses to make serotonin, a brain chemical linked to mood and calm. It's included here for its possibly effective role in supporting mood and relaxation. However, because it raises serotonin levels, it can interact with antidepressants and other serotonergic drugs.
Can I take this if I'm on an antidepressant?
Not without checking first. 5-HTP in this product interacts Moderately with serotonergic drugs like SSRIs and SNRIs—the most common antidepressants. Combining them risks serotonin syndrome. Talk to your pharmacist or doctor before starting; they may need to adjust your plan.
Will this make me drowsy?
Possibly. All four active ingredients—5-HTP, L-Theanine, Lemon Balm, and Ashwagandha—have been associated with drowsiness, and three of them interact with other sedating medications by adding to their effect. If you take sleep aids or anti-anxiety drugs, the drowsiness may be stronger.
Is this safe during pregnancy?
No. The safety data advise against 5-HTP and ashwagandha during pregnancy. L-Theanine and Lemon Balm have insufficient safety information—don't assume they're okay. Talk to your doctor before using any of these during pregnancy.
What's the difference between ashwagandha in this product and plain ashwagandha supplements?
This product uses Sensoril, a branded ashwagandha extract. It's the same plant and carries the same interactions and safety profile as other ashwagandha supplements—same benefits, same precautions.
Can I take this with my thyroid medication?
Possibly, but check with your pharmacist first. Ashwagandha may increase thyroid hormone effects and has been linked to hyperthyroidism in case reports. Lemon Balm may interfere with thyroid hormone therapy. Your doctor may need to monitor your thyroid levels if you start this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Relax+ Ultimate Calm label
Go deeper

The Full Monographs Behind Relax+ Ultimate Calm’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

5-htp

Interacts with 398 drugs

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early research is promising, but the overall evide...

Read the full 5-htp monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph →
Sources

Sources & How We Checked

Relax+ Ultimate Calm's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 82 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

5-htp 32 references
  1. Birdsall TC. 5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor. Altern Med Rev 1998;3:271-80.
  2. Michelson D, Page SW, Casey R, et al. An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan. J Rheumatol 1994;21:2261-5.
  3. Cangiano C, Ceci F, Cancino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7. PubMed
  4. U.S. Food and Drug Administration. Impurities confirmed in dietary supplement 5-hydroxy-L-tryptophan. FDA Talk Paper, August 31, 1998; T98-48.
  5. Sternberg EM, Van Woert MH, Young SN, et al. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med 1980;303:782-7. PubMed
  6. Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991;24:53-81.
  7. Ribeiro CA. L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. Headache 2000;40:451-6.
  8. U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
  9. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  10. Johnson KL, Klarskov K, Benson LM, et al. Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. J Rheumatol 1999;26:2714-7.
  11. Takahashi S, Kondo H, Kato N. Effect of l-5-hydroxytryptophan on brain monoamine metabolism and evaluation of its clinical effect in depressed patients. J Psychiatr Res 1975;12:177-87. PubMed
  12. Iovieno, N., Dalton, E. D., Fava, M., and Mischoulon, D. Second-tier natural antidepressants: review and critique. J Affect.Disord. 2011;130(3):343-357. PubMed
  13. den Boer JA, Westenberg HG. Behavioral, neuroendocrine, and biochemical effects of 5-hydroxytryptophan administration in panic disorder. Psychiatry Res 1990;31:267-78. PubMed
  14. Jangid P, Malik P, Singh P, Sharma M, Gulia AK. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode. Asian J Psychiatr 2013;6:29-34. PubMed
  15. Ceci F, Cangiano C, Cairella M, et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J Neural Transm 1989;76:109-17. PubMed
  16. Angst J, Woggon B, Schoepf J. The treatment of depression with L-5-hydroxytryptophan versus imipramine. Results of two open and one double-blind study. Arch Psychiatr Nervenkr 1977;224:175-86. DOI
  17. Titus F, Dávalos A, Alom J, Codina A. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. Eur Neurol 1986;25:327-9. PubMed
  18. De Benedittis G, Massei R. Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytryptophan vs. placebo. J Neurosurg Sci 1985;29:239-48.
  19. Van Woert, M. H., Rosenbaum, D., Howieson, J., and Bowers, M. B., Jr. Long-term therapy of myoclonus and other neurologic disorders with L-5- hydroxytryptophan and carbidopa. N Engl J Med 1-13-1977;296(2):70-75. PubMed
  20. Wyatt, R. J., Vaughan, T., Galanter, M., Kaplan, J., and Green, R. Behavioral changes of chronic schizophrenic patients given L-5- hydroxytryptophan. Science 9-22-1972;177(54):1124-1126. PubMed
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Ashwagandha 32 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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