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Dietary supplement

Resveratrol 1000 mg Ingredients & Drug Interactions

by Oomph Naturals

Resveratrol 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Resveratrol 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Resveratrol 1000 mg is a dietary supplement by Oomph Naturals with 1 active ingredient. Its ingredients are commonly taken for source of resveratrol, heart and circulation support, inflammation.Based on those ingredients, 828 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Polygonum cuspidatum Rhizome, Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Resveratrol 1000 mg by Oomph Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Resveratrol 1000 mg by Oomph Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Resveratrol 1000 mg by Oomph Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Polygonum cuspidatum Rhizome Root Extract, the plant source of resveratrol. The extract is provided in gelatin capsules with rice powder as an inactive filler.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hu Zhang product and its label doesn't state a use — see Hu Zhang's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The data we hold shows insufficient reliable evidence to rate hu zhang for any of the conditions listed—hepatitis, rheumatoid arthritis, wound healing, gout, osteoarthritis, and unstable angina. That means studies haven't yet established whether it works for these uses.

If you're considering it for a specific health concern, that's worth discussing with your doctor to see what the broader research literature shows.

The evidence, ingredient by ingredient Hu Zhang

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Safety data in humans is limited. The product's emodin content may cause digestive upset in some people.

The safety information we have advises against use during pregnancy because some of hu zhang's compounds may affect the uterus or bowel. Similarly, there isn't enough safety data to recommend it while breastfeeding.

If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Hu Zhang

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hu Zhang.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 829 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any medications metabolized by liver enzymes CYP1A2, CYP2C19, CYP3A4, or CYP2E1 (the product's resveratrol may raise their levels). Also flag blood thinners or antiplatelet drugs like warfarin or aspirin, estrogen-based medications including birth control and hormone replacement therapy, and carbamazepine (Tegretol).

Use the medication checker on this page to search your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

This product has a moderate interaction profile because its single ingredient affects how your body handles a large number of medications. If you take prescription drugs—especially for seizures, blood clotting, hormones, or anything metabolized by the liver—you'll want to clear it with your doctor or pharmacist first.

The effectiveness evidence we hold is limited, so weigh the interaction risk against what you're hoping to gain.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Resveratrol 1000 mg, straight from the product label.

Brand Oomph Naturals
Barcode (UPC) B0BR9197HD
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 314044
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Resveratrol 1000 mg by Oomph Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Quick Release Capsule(s)
Maximum serving Sizes:
2 Quick Release Capsule(s)
Servings per container
45
UPC/BARCODE
B0BR9197HD
IngredientAmount% DV
Polygonum cuspidatum Rhizome, Root Extract1000 mg--

Other ingredients: Gelatin, Rice, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

New

OomphNaturals Unlease your oomph!

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement take two (2) capsules once a day with a meal or as directed by your healthcare practitioner.

Precautions

Caution: Do not exceed recommended dose

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition, should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition, should consult a physician before using this or any dietary supplement. Keep out of reach of children. Not intended for use by persons under the age of 18.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Formulated in the USA American Product Good manufacturing practice GMP Certified Ethically Sourced

Formulation

Dairy free Non-GMO Gluten free Gluten free, non-GMO, dairy free

Heart support Made under strict GMP guidelines

Contains no: Artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium soy, sugar, gluten, starch or wheat.

FDA Statement of Identity

Dietary Supplement

Formula

Resveratrol, 1000 mg polyphenol, Support heart health Resveratrol 1000 mg per serving

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Resveratrol 1000 mg by Oomph Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Resveratrol 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Resveratrol 1000 mg by Oomph Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Quick Release Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Polygonum cuspidatum Rhizome, Root Extract

Interacts with
828 drugs
1000 mg per serving Form: Polygonum cuspidatum Rhizome Extract, Polygonum cuspidatum Root Extract

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and ear...

Polygonum cuspidatum Rhizome, Root Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Rice, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Resveratrol 1000 mg by Oomph Naturals Drug Interactions

Want to check YOUR meds against Resveratrol 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
828Drugs
828 Moderate

Ingredients driving the most interactions

Polygonum cuspidatum Rhizome, Root Extract 828

Individual Drug Interactions

The ingredients in Resveratrol 1000 mg interact with 828 drugs. Click any drug to see the details.

1 of the 1 ingredient in Resveratrol 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Polygonum cuspidatum Rhizome, Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Resveratrol 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Polygonum cuspidatum Rhizome, Root Extract7 drug types · 828 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Hu zhang contains the constituent resveratrol. Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP1A2 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2E1 enzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP3A4 enzyme. However, a clinical study in adults with NAFLD found that adding resveratrol 3000 mg daily for 8 weeks did not necessitate dose adjustments to any established medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Estrogens

Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that hu zhang might have estrogenic activity.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, hu zhang might increase the effects and adverse effects of carbamazepine.
In animals, blood and tissue levels of carbamazepine were increased when given in combination with hu zhang. It is thought that increased levels of carbamazepine are due to cytochrome P450 3A4 (CYP3A4) inhibition. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Polygonum cuspidatum Rhizome, Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Resveratrol 1000 mg, from the product label.

Oomph Naturals

See all Oomph Naturals products
Name
Oomph Naturals
Street Address
380 Jelliff Ave
City
Newark
State
NJ
ZipCode
07108
Phone Number
(855) 686-6674
Pharmacist Counseling Corner

Resveratrol 1000 mg by Oomph Naturals: Common Questions

Does Resveratrol 1000 mg by Oomph Naturals interact with any medications?
Yes. Based on its ingredients, Resveratrol 1000 mg has a known interaction with 828 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Resveratrol 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is hu zhang and where does the resveratrol come from?
Hu zhang is the rhizome (underground stem) and root of Polygonum cuspidatum, a plant used in traditional medicine. Resveratrol is a natural compound found in the plant. This product delivers the extract in a gelatin capsule with rice powder.
Could this supplement make my blood thinner medications less effective or cause bleeding?
Actually, the opposite concern: hu zhang's resveratrol may have antiplatelet effects, meaning it could theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs like aspirin or warfarin. That's why it's important to check with your doctor or pharmacist before starting it if you take any of those medications.
Is it safe to take this if I'm on birth control or hormone replacement?
Lab studies suggest hu zhang has estrogenic activity and might interfere with how estrogen medications work. The interaction is rated Moderate, so before you add this product, run it by your doctor or pharmacist—they can weigh the risk for your specific situation.
Can this cause stomach upset?
The product's emodin content may cause digestive upset in some people, though specific side effect frequencies aren't documented in our data. If you have a sensitive stomach, start cautiously and watch for any changes.
Is this safe during pregnancy or breastfeeding?
No. The safety data advises against it in pregnancy because hu zhang compounds may affect the uterus, and there isn't enough safety information to recommend use while breastfeeding. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing.
Does this product actually work for arthritis, gout, or wound healing?
We don't have enough reliable evidence to say. The data shows insufficient evidence to rate hu zhang for any of those uses, so the science hasn't yet established whether it helps. Your doctor can point you to what the broader research shows for your specific condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Resveratrol 1000 mg label
Go deeper

The Full Monographs Behind Resveratrol 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hu Zhang

Interacts with 828 drugs

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for...

Read the full Hu Zhang monograph →
Sources

Sources & How We Checked

Resveratrol 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hu Zhang 19 references
  1. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  2. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  3. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  4. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  5. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  6. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  7. Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839-42. PubMed
  8. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  9. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  10. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  11. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  12. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  13. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  14. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  15. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  16. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  17. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  18. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  19. Chi YC, Lin SP, Hou YC. A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats. Toxicol Appl Pharmacol 2012;263(3):315-22. PubMed

See these in context on the Hu Zhang monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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