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Dietary supplement

Resveratrol Polygonum Cuspidatum 1000 mg Ingredients & Drug Interactions

by We Like Vitamins

Resveratrol Polygonum Cuspidatum 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Resveratrol Polygonum Cuspidatum 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Resveratrol Polygonum Cuspidatum 1000 mg is a dietary supplement by We Like Vitamins with 1 active ingredient. Its ingredients are commonly taken for source of resveratrol, heart and circulation support, inflammation.Based on those ingredients, 826 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Polygonum cuspidatum extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Resveratrol Polygonum Cuspidatum 1000 mg by We Like Vitamins

Ask about any prescription or over-the-counter medication and we check it for interactions with Resveratrol Polygonum Cuspidatum 1000 mg by We Like Vitamins — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Resveratrol Polygonum Cuspidatum 1000 mg by We Like Vitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: polygonum cuspidatum extract, a plant-derived source of resveratrol, standardized to 1000 mg per capsule. The capsule itself is filled with gelatin (the capsule shell) and rice powder as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hu Zhang's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports cardiovascular health and immune function.
  • We looked for evidence on: Unstable angina, Heart health, Circulation, Inflammation.
  • The closest evidence on file: Hu Zhang is rated "Insufficient Reliable Evidence To Rate" for Unstable angina (Natural Medicines).

The evidence for polygonum cuspidatum extract isn't established in the data we hold. The product is traditionally used for several conditions—hepatitis, rheumatoid arthritis, wound healing, gout, osteoarthritis, and unstable angina—but our data shows insufficient reliable evidence to rate how well it works for any of them.

If you're considering this for a specific health concern, talk it over with your doctor or pharmacist about what the current science actually supports.

The evidence, ingredient by ingredient Hu Zhang

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Human safety data for this supplement are limited. The emodin compound in polygonum cuspidatum may cause digestive upset.

The safety data advises against use during pregnancy, and there isn't enough safety information to use it while breastfeeding—talk with your doctor or pharmacist for personalized guidance if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Hu Zhang

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hu Zhang.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 827 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel), any medications broken down by liver enzymes CYP1A2, CYP2C19, CYP3A4, or CYP2E1, estrogen-based birth control or hormone replacement, or the seizure medication carbamazepine (Tegretol). These are all documented interaction categories.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

This product carries Moderate-severity interaction risks with blood thinners, liver-metabolized drugs, and hormone therapy, plus a Minor risk with the seizure medication carbamazepine. If you take any prescription medications, check them against this product's interactions before you start.

Anyone pregnant or breastfeeding should discuss it with their own doctor or pharmacist first, since safety data are sparse.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Resveratrol Polygonum Cuspidatum 1000 mg, straight from the product label.

Brand We Like Vitamins
Barcode (UPC) X0015CU1UR
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 259110
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Resveratrol Polygonum Cuspidatum 1000 mg by We Like Vitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
X0015CU1UR
IngredientAmount% DV
Polygonum cuspidatum extract1000 mg--

Other ingredients: Gelatin, Rice powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: For adults, take two (2) capsule daily, preferably with a meal or as directed by a healthcare professional. As a reminder, always discus all supplements with your health care provider.

Precautions

Warning: If you are pregnant, nursing, taking any medications, have or have had a health condition, or planning a medical procedure, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place. Avoid excessive heat or moisture.

Formulation

Helps to support cardiovascular health Helps to support immune function

Zero: Preservatives, artificial colors, artificial flavors, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch, or wheat.

FDA Statement of Identity

Dietary Supplement

General Statements

Vitamin Angels Proud supporter Every bottle counts Every item you purchase from us helps to provide life-changing vitamins to a mother or child in need. Thank You!

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Resveratrol Polygonum Cuspidatum 1000 mg by We Like Vitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Resveratrol Polygonum Cuspidatum 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Resveratrol Polygonum Cuspidatum 1000 mg by We Like Vitamins

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Polygonum cuspidatum extract

Interacts with
826 drugs
1000 mg per serving

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and ear...

Polygonum cuspidatum extract monograph & interactions

Other (inactive) ingredients: Gelatin, Rice powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Resveratrol Polygonum Cuspidatum 1000 mg by We Like Vitamins Drug Interactions

Want to check YOUR meds against Resveratrol Polygonum Cuspidatum 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
826Drugs
826 Moderate

Ingredients driving the most interactions

Polygonum cuspidatum extract 826

Individual Drug Interactions

The ingredients in Resveratrol Polygonum Cuspidatum 1000 mg interact with 826 drugs. Click any drug to see the details.

1 of the 1 ingredient in Resveratrol Polygonum Cuspidatum 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Polygonum cuspidatum extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Resveratrol Polygonum Cuspidatum 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Polygonum cuspidatum extract7 drug types · 826 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Hu zhang contains the constituent resveratrol. Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP1A2 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2E1 enzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP3A4 enzyme. However, a clinical study in adults with NAFLD found that adding resveratrol 3000 mg daily for 8 weeks did not necessitate dose adjustments to any established medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Estrogens

Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that hu zhang might have estrogenic activity.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, hu zhang might increase the effects and adverse effects of carbamazepine.
In animals, blood and tissue levels of carbamazepine were increased when given in combination with hu zhang. It is thought that increased levels of carbamazepine are due to cytochrome P450 3A4 (CYP3A4) inhibition. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Polygonum cuspidatum extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Resveratrol Polygonum Cuspidatum 1000 mg, from the product label.

We Like Vitamins

See all We Like Vitamins products
Name
We Like Vitamins
Street Address
7125 Headley St. #51
City
Ada
State
MI
ZipCode
49301
Web Address
welikevitamins.com
Pharmacist Counseling Corner

Resveratrol Polygonum Cuspidatum 1000 mg by We Like Vitamins: Common Questions

Does Resveratrol Polygonum Cuspidatum 1000 mg by We Like Vitamins interact with any medications?
Yes. Based on its ingredients, Resveratrol Polygonum Cuspidatum 1000 mg has a known interaction with 826 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Resveratrol Polygonum Cuspidatum 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is polygonum cuspidatum extract?
It's a plant extract that contains resveratrol, a compound traditionally used in herbal medicine. This product delivers 1000 mg of it per capsule.
Can I take this with blood thinners like warfarin?
No—not without checking with your doctor first. Resveratrol has antiplatelet effects, which means it may increase bleeding risk when combined with blood thinners or antiplatelet drugs like aspirin. Your doctor or pharmacist needs to weigh the risks for you personally.
Is this safe during pregnancy?
The safety data advise against use during pregnancy. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist before taking this product.
Can I take this if I'm breastfeeding?
There isn't enough safety information to use it while breastfeeding. Chat with your doctor or pharmacist to decide what's right for you and your baby.
Does this actually work for arthritis or gout?
The evidence isn't strong enough yet to say for sure. Our data show insufficient reliable evidence for rheumatoid arthritis, osteoarthritis, gout, and the other conditions listed, so we can't claim it works for them.
What are the side effects?
The main caution is digestive upset from emodin, a compound in polygonum cuspidatum. Beyond that, human safety data are limited, so other side effects aren't well documented.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Resveratrol Polygonum Cuspidatum 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Resveratrol Polygonum Cuspidatum 1000 mg label
Go deeper

The Full Monographs Behind Resveratrol Polygonum Cuspidatum 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hu Zhang

Interacts with 826 drugs

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for...

Read the full Hu Zhang monograph →
Sources

Sources & How We Checked

Resveratrol Polygonum Cuspidatum 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hu Zhang 19 references
  1. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  2. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  3. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  4. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  5. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  6. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  7. Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839-42. PubMed
  8. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  9. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  10. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  11. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  12. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  13. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  14. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  15. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  16. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  17. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  18. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  19. Chi YC, Lin SP, Hou YC. A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats. Toxicol Appl Pharmacol 2012;263(3):315-22. PubMed

See these in context on the Hu Zhang monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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