Interactions on record — worth a quick check against your medications. Based on 2 of 8 ingredients. Check your meds →
Dietary supplement

Revolution Abdominal Cuts Green Ingredients & Drug Interactions

by Corr-Jensen Labs

Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Revolution Abdominal Cuts Green is a dietary supplement by Corr-Jensen Labs with 8 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 941 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Grape seed Oil, Vitamin E. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Revolution Abdominal Cuts Green by Corr-Jensen Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend (Combination)” is a proprietary blend — the label gives one combined amount (1,645 mg) without saying how much of each component you get.

This softgel contains 8 ingredients, most of which are oils and plant extracts. The active ingredients we have data on are vitamin E and grape seed oil (from organic grape seed).

Vitamin E is a fat-soluble vitamin and antioxidant; grape seed extract is rich in plant compounds called proanthocyanidins. The product also includes alpha-linolenic acid, gamma-linolenic acid, sesame seed oil, safflower oil, and conjugated linolenic acid — all fatty acids or oils — plus organic wakame, a type of seaweed.

The inactive ingredients are bee's wax, gelatin, glycerin, and sodium copper chlorophyllins, which serve as the capsule shell and preservation aids.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: weight loss support and heart health.
  • We looked for evidence on: Cardiovascular disease (CVD), Hypercholesterolemia, Hypertension, Atherosclerosis, Angina, Congestive heart failure (CHF) — and 4 related terms.
  • The closest evidence on file: Vitamin E is rated "Possibly Ineffective" for Angina (Natural Medicines).
  • Also on file: Vitamin E is rated "Possibly Ineffective" for Atherosclerosis, Congestive heart failure (CHF).
  • Also on file: Vitamin E is rated "Likely Ineffective" for Cardiovascular disease (CVD).

The evidence for vitamin E applies mainly to deficiency states — it's effective for treating vitamin E deficiency itself and for a rare genetic condition called ataxia with vitamin E deficiency (AVED). For other uses, the data shows only possibly effective ratings: Alzheimer disease, beta-thalassemia, and glucose-6-phosphate dehydrogenase (G6PD) deficiency, plus intracranial hemorrhage.

We hold no effectiveness data for the abdominal or weight-related claims this product's name suggests. Grape seed extract shows possibly ineffective evidence for weight loss (obesity) and allergic rhinitis (hay fever).

It is possibly effective for chronic venous insufficiency (CVI), a condition affecting blood flow in the legs. No effectiveness ratings are established in our data for the other ingredients in this product.

The evidence, ingredient by ingredient Vitamin E Grape

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E from food and normal dietary amounts is safe, but high-dose long-term supplements carry caution — they may raise the risk of bleeding and other harms. Rare serious side effects include bleeding, hemorrhagic stroke, and cardiovascular problems.

There's also concern that high doses might increase hemorrhagic stroke risk, though studies conflict on this. High doses increase bleeding risk especially if you have a vitamin K deficiency or take blood thinners or antiplatelet drugs.

Grape seed extract appears generally well tolerated, with the most common side effects being abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, and nausea. Rare serious effects include anaphylaxis to grape skin.

For pregnancy, concentrated grape supplements are not well studied and should be avoided — food grapes and prenatal vitamins are fine. For breastfeeding, regular grape food is acceptable, but concentrated grape supplements lack safety data and high-dose vitamin E supplements should be checked with your doctor first.

Side effects, ingredient by ingredient Vitamin E Grape

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Grape, Vitamin E.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 942 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use blood thinners (anticoagulants) like warfarin, or antiplatelet drugs — vitamin E and grape seed oil may increase bleeding risk. Also check if you take cancer chemotherapy drugs (alkylating agents or antitumor antibiotics), cyclosporine, or medications processed through the liver (especially CYP3A4, CYP2D6, or CYP2E1 substrates).

Niacin and midazolam are also affected. You can search your specific medications on this page to see the details.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're considering this product, keep in mind the evidence is strongest for vitamin E's role in correcting deficiency, not for the weight or abdominal claims the name implies. The real concern is interactions — particularly with blood thinners, liver-metabolized drugs, and cancer chemotherapy.

If you take any prescription medications or have bleeding concerns, talk it over with your pharmacist or doctor before starting, and don't stop any blood thinner or other medication without their guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Revolution Abdominal Cuts Green, straight from the product label.

Brand Corr-Jensen Labs
Barcode (UPC) 632964500120
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 2290
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Revolution Abdominal Cuts Green by Corr-Jensen Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
60
UPC/BARCODE
632964500120
IngredientAmount% DV
Vitamin E0 NP25%
Alpha-Linolenic Acid0 NP--
Proprietary Blend (Combination)1645 mg--
Gamma-Linolenic Acid0 NP--
organic Sesame seed Oil0 NP--
organic Safflower Oil0 NP--
Conjugated Linolenic Acid0 NP--
organic Wakame0 NP--
organic Grape seed Oil0 NP--

Other ingredients: Bee's Wax, Gelatin, Glycerin, Sodium Copper Chlorophyllins

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietry supplement for adults, take 1 serving (2 softgels) one to three times daily, preferably with a meal.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Warning: DO NOT USE IF PREGNANT OR NURSING.

Consult a physician or licensed qualified health care professional before using this product if you have, or have a family hisotry of any medical condition, or if you are using any other dieatry supplement, prescription drug including but not limited to anti-coagulant, anti-diabetic and/or antihypertensive agents, or over-the-counter drug.

DO NOT EXCEED RECOMMENDED DOSE ANYTIME.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure of prevent disease.

General Statements

midsection formula made with organic ingredients

STIMULANT FREE FAT BURNER WITH OMEGA 3-6-9*

TONE MIDSECTION STOMACH HIPS THIGHS BUTT*

WEIGHT LOSS SUPPORT AND HEART HEALTH*

Formulation

made with organic ingredients

FDA Statement of Identity

DIETARY SUPPLEMENT

See for yourself

Revolution Abdominal Cuts Green by Corr-Jensen Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Revolution Abdominal Cuts Green by Corr-Jensen Labs

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend (Combination)

1645 mg per serving
  • Vitamin E
  • › Alpha-Linolenic Acid
  • › Gamma-Linolenic Acid
  • › Organic Sesame seed Oil
  • › Organic Safflower Oil
  • › Conjugated Linolenic Acid
  • › Organic Wakame
  • Organic Grape seed Oil

Other (inactive) ingredients: Bee's Wax, Gelatin, Glycerin, Sodium Copper Chlorophyllins. These complete the product’s ingredient list but are not active constituents.

Interaction report

Revolution Abdominal Cuts Green by Corr-Jensen Labs Drug Interactions

Want to check YOUR meds against Revolution Abdominal Cuts Green?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
941Drugs
898 Moderate 43 Minor

Ingredients driving the most interactions

Vitamin E 764

Each ingredient & the kinds of drugs it affects

For each ingredient in Revolution Abdominal Cuts Green with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Grape seed Oil9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
The maker

Brand information

Manufacturer and brand details for Revolution Abdominal Cuts Green, from the product label.

Corr-Jensen Labs

See all Corr-Jensen Labs products
Name
Corr-Jensen Labs
Street Address
6341 S. Troy Circle Suite E
City
Centennial
State
CO
ZipCode
80111
Pharmacist Counseling Corner

Revolution Abdominal Cuts Green by Corr-Jensen Labs: Common Questions

Does Revolution Abdominal Cuts Green by Corr-Jensen Labs interact with any medications?
Yes. Based on its ingredients, Revolution Abdominal Cuts Green has a known interaction with 941 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Revolution Abdominal Cuts Green contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this while pregnant?
The safety data on vitamin E is uncertain during pregnancy — normal food amounts are fine, but high-dose supplements should not be taken unless your doctor directs it. Grape seed extracts are not well studied in pregnancy, so concentrated supplements should be avoided. Talk with your doctor or midwife before starting any new supplement during pregnancy for personalized advice.
Can I take this while breastfeeding?
Regular food amounts of grapes are fine, and vitamin E from prenatal vitamins and food is appropriate. However, high-dose vitamin E supplements need a check-in with your doctor first. For grape seed extract, we don't have enough safety data on concentrated supplements during breastfeeding, so ask your doctor or pharmacist whether it's right for you.
What is grape seed extract supposed to do?
Grape seed extract is possibly effective for chronic venous insufficiency (CVI), a condition where blood doesn't flow well through the veins in your legs. The evidence for weight loss or allergies is possibly ineffective based on the data we hold.
What kind of side effects might I experience?
Most common mild side effects from grape seed extract include abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, and nausea. High-dose vitamin E can cause bleeding, and rare serious effects from grape extracts include anaphylaxis. Stop and contact your doctor or pharmacist if you notice unusual bruising, bleeding, or signs of an allergic reaction.
Why is this product called 'Abdominal Cuts' if the evidence doesn't support that?
The name reflects marketing claims, but we have no effectiveness data in our records showing that the ingredients in this product work for weight loss or abdominal fat. What we do have evidence for — like vitamin E's role in deficiency and grape seed extract's possible benefit for leg blood flow — is different from what the name suggests. Talk with your doctor about realistic expectations.
Does this have any fillers or inactive ingredients I should know about?
Yes — the inactive ingredients are bee's wax, gelatin, glycerin, and sodium copper chlorophyllins. These are the capsule shell and preservatives. If you have allergies to gelatin or beeswax, check the label or contact the manufacturer.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Revolution Abdominal Cuts Green label
Sources

Sources & How We Checked

Revolution Abdominal Cuts Green's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 98 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
  17. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  18. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  19. Liu M, Wallmon A, Olsson-Mortlock C, et al. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am J Clin Nutr 2003;77:700-6. PubMed
  20. Sokol RJ, Johnson KE, Karrer FM, et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991;338:212-4.. PubMed
  21. Stein JH, Carlsson CM, Papcke-Benson K, et al. The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia. J Am Coll Cardiol 2001;38:1806-13.. PubMed
  22. Carlsson CM, Papcke-Benson K, Carnes M, et al. Health-related quality of life and long-term therapy with pravastatin and tocopherol (vitamin E) in older adults. Drugs Aging 2002;19:793-805. . PubMed
  23. Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
  24. Schrogie JJ. Coagulopathy and fat-soluble vitamins (letter). JAMA 1975;232:19. DOI
  25. Celestini A, Pulcinelli FM, Pignatelli P, et al. Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets. Haematologica 2002;87:420-6.
  26. Stampfer MJ, Jakubowski JA, Faigel D, et al. Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels. Am J Clin Nutr 1988;47:700-6. PubMed
  27. Jandak J, Steiner M, Richardson PD. Alpha-tocopherol, an effective inhibitor of platelet adhesion. Blood 1989;73:141-9. DOI
  28. Freedman JE, Farhat JH, Loscalzo J, Keaney JF. Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 1996;94:2434-40. PubMed
  29. Steiner M. Vitamin E, a modifier of platelet function: rationale and use in cardiovascular and cerebrovascular disease. Nutr Rev 1999;57:306-9. PubMed
  30. Brodkin RH, Bleiberg J. Sensitivity to topically applied vitamin E. Arch Dermatol 1965;92:76-7. DOI
  31. Booth SL, Golly I, Sacheck JM, et al. Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status. Am J Clin Nutr 2004;80:143-8. PubMed
  32. Miller ER 3rd, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:60520-53. PubMed
  33. Lonn E, Bosch J, Yusuf S, et al. HOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005;293:1338-47. PubMed
  34. Landes N, Pfluger P, Kluth D, et al. Vitamin E activates gene expression via the pregnane X receptor. Biochem Pharmacol 2003;65:269-73. . PubMed
  35. Brigelius-Flohe R. Vitamin E and drug metabolism. Biochem Biophys Res Commun 2003;305:737-40. PubMed
  36. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  37. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
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See these in context on the Grape monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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