Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Riboflavin Ingredients & Drug Interactions

by Gematria

Riboflavin label
See full label image
Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Riboflavin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Riboflavin is a dietary supplement by Gematria with 1 active ingredient. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Riboflavin by Gematria

Ask about any prescription or over-the-counter medication and we check it for interactions with Riboflavin by Gematria — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Riboflavin by Gematria

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Gematria Riboflavin is a single-ingredient supplement delivering vitamin B2 (also called riboflavin), a B vitamin your body uses for energy and cell growth. The capsule itself is the only other component — a kosher-certified capsule material with no added fillers or binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: carbohydrate metabolism and cellular energy production.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The product facts we hold don't include effectiveness ratings for riboflavin, so we can't tell you from our data how well it works or what conditions it may help. If you're considering it for a specific health reason, that's a good question to ask your doctor or pharmacist.

The evidence, ingredient by ingredient Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is very well tolerated overall — your body clears any excess through urine. The most common side effects are mild: dose-related nausea and bright yellow urine at higher doses.

Rarely, diarrhea or increased urination have been reported. Riboflavin is needed during pregnancy and breastfeeding and is considered safe at standard recommended amounts.

If you're pregnant, nursing, or planning to take a high-dose supplement, check with your provider first to make sure the dose is right for you.

Side effects, ingredient by ingredient Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take tetracycline antibiotics (such as doxycycline or minocycline) for a bacterial infection, check with your doctor or pharmacist before starting this product. Lab evidence suggests riboflavin may reduce how well these antibiotics work, though this hasn't been proven in humans — it's still worth confirming with your prescriber.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gematria Riboflavin is a straightforward, single-ingredient B vitamin that's very safe for most people at normal doses. The main thing to watch for is whether you're on a tetracycline antibiotic — if you are, run it by your doctor or pharmacist before adding this.

Otherwise, this is a low-risk supplement to discuss with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Riboflavin, straight from the product label.

Brand Gematria
Barcode (UPC) 689980140304
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Dec 23, 2011
DSLD ID 3198
Product type Vitamin
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Riboflavin by Gematria, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
689980140304
IngredientAmount% DV
Vitamin B2400 mg25000%

Other ingredients: Kosher Certified Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Vitamin B2 or riboflavin is important for carbohydrate metabolism and for energy production at the cellular level. It is most effective when taken on a regular, daily basis.

Gematria Products

B-Vitamin support formula

Made in U.S.A.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule daily.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of reach of children.

Leave desiccants in the bottle. Keep bottle tightly closed.

Storage

Keep dry and cool.

FDA Statement of Identity

Laser Energized Dietary Supplement

Brand IP Statement(s)

Our laser energizing process is protected by world wide patent #WO09722022A1. Other patents pending.

2004 Gematria Products, Inc. All Rights Reserved

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Riboflavin by Gematria label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Riboflavin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Riboflavin by Gematria

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Vitamin B2

Interacts with
20 drugs
400 mg per serving Form: Riboflavin

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Vitamin B2 monograph & interactions

Other (inactive) ingredients: Kosher Certified Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Riboflavin by Gematria Drug Interactions

Want to check YOUR meds against Riboflavin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Vitamin B2 20

Individual Drug Interactions

The ingredients in Riboflavin interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in Riboflavin interact with drugs. Each result below shows which ingredient is responsible. Vitamin B2

Each ingredient & the kinds of drugs it affects

For each ingredient in Riboflavin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B21 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Vitamin B2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Riboflavin, from the product label.

Gematria

See all Gematria products
Name
Gematria Products, Inc.
Street Address
2075 Corte del Nogal Suite A
City
Carlsbad
State
CA
ZipCode
92009
Phone Number
760-931-8563
Pharmacist Counseling Corner

Riboflavin by Gematria: Common Questions

Does Riboflavin by Gematria interact with any medications?
Yes. Based on its ingredients, Riboflavin has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Riboflavin contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take riboflavin if I'm pregnant or breastfeeding?
Riboflavin is needed during pregnancy and while breastfeeding, and it's considered safe at recommended amounts. If you're thinking of taking a high-dose supplement, check with your doctor or pharmacist first to confirm the dose is right for you.
What are the side effects of riboflavin?
Riboflavin is generally well tolerated. At higher doses, you might notice nausea or bright yellow urine — both dose-related and harmless. Diarrhea and increased urination are rare but have been reported.
Will riboflavin turn my urine yellow?
Yes — at higher doses, bright yellow urine is normal and expected. It's harmless; your body is simply excreting the excess riboflavin.
Is this safe to take long-term?
Riboflavin is very safe; your body removes excess through urine, so it doesn't accumulate. Long-term use at normal doses is considered safe.
Does riboflavin work for energy?
The facts we hold don't include effectiveness ratings for riboflavin, so we can't tell you from our data whether or how well it works for energy or other purposes — ask your doctor or pharmacist about that.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Riboflavin is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Riboflavin label
Go deeper

The Full Monographs Behind Riboflavin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

Riboflavin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team