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Dietary supplement

Riboflavin (Vitamin B2) Ingredients & Drug Interactions

by BulkSupplements.com

Riboflavin (Vitamin B2) label
See full label image
Powder Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Riboflavin (Vitamin B2) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Riboflavin (Vitamin B2) is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Riboflavin (Vitamin B2) by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Riboflavin (Vitamin B2) by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Riboflavin (Vitamin B2) by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: riboflavin, also called vitamin B2. It's a B vitamin your body uses to turn food into energy and to support your eyes, nerves, and skin.

The powder form lets you measure your own dose. There are no inactive ingredients listed for this product.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Riboflavin product and its label doesn't state a use — see Riboflavin's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't hold effectiveness data for riboflavin in the facts provided for this product. If you'd like to know how well it works for a specific health goal, talk with your pharmacist or doctor—they can point you to the research on vitamin B2 and what dose might help you.

The evidence, ingredient by ingredient Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is very well tolerated. Your body removes any excess through your urine, so it's hard to overdose on it.

The most common side effects are dose-related nausea and bright yellow urine at higher doses. Rarely, some people report diarrhea or increased urination at high doses.

Riboflavin is considered likely safe during pregnancy and while breastfeeding, and your body actually needs it at both times. That said, before taking a high-dose supplement during pregnancy or breastfeeding, check with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on a tetracycline antibiotic (such as doxycycline, tetracycline, or minocycline). Lab data suggests riboflavin may reduce how well these antibiotics work, though human studies haven't confirmed it yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Riboflavin is a straightforward, well-tolerated B vitamin useful if you want to top up your intake. If you're on a tetracycline antibiotic, check with your pharmacist or doctor before starting it—timing matters.

For anyone else, this is a low-concern supplement, though it's wise to run your exact medications through the interaction checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Riboflavin (Vitamin B2), straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000HUJKC3
Net contents 50 Gram(s); 1.76 Ounce(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 254285
Product type Vitamin
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Riboflavin (Vitamin B2) by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
50 mg
Maximum serving Sizes:
50 mg
Servings per container
1000
UPC/BARCODE
X000HUJKC3
IngredientAmount% DV
Riboflavin50 mg3846%

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 50 mg once daily, or as directed by a physician. Use an accurate milligram scale to measure.

Storage

Store in a dry, cool, dark place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Riboflavin (Vitamin B2) by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Riboflavin (Vitamin B2) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Riboflavin (Vitamin B2) by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size50 mg Dosage formPowder Servings per container1000 Amounts shown are per serving.

Riboflavin

Interacts with
20 drugs
50 mg per serving Form: Vitamin B2

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Riboflavin (Vitamin B2) by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Riboflavin (Vitamin B2)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Riboflavin 20

Individual Drug Interactions

The ingredients in Riboflavin (Vitamin B2) interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in Riboflavin (Vitamin B2) interact with drugs. Each result below shows which ingredient is responsible. Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in Riboflavin (Vitamin B2) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Riboflavin (Vitamin B2), from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
bulksupplements.com
Pharmacist Counseling Corner

Riboflavin (Vitamin B2) by BulkSupplements.com: Common Questions

Does Riboflavin (Vitamin B2) by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Riboflavin (Vitamin B2) has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Riboflavin (Vitamin B2) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take riboflavin while pregnant or breastfeeding?
Yes, riboflavin is considered likely safe during pregnancy and breastfeeding, and your body actually needs it at both times. If you're thinking about a high-dose supplement, though, check with your doctor or pharmacist first to make sure the dose is right for you.
What are the side effects of riboflavin?
Riboflavin is generally well tolerated. At higher doses, you might notice nausea or bright yellow urine. Rarely, some people report diarrhea or increased urination. These effects are dose-related, so they often go away if you lower your dose.
Why does riboflavin turn my urine yellow?
Riboflavin is yellow, and when you take more than your body needs, the excess passes into your urine, turning it bright yellow. This is harmless and normal—it just means you're excreting the extra vitamin.
Is this powder safe for long-term use?
Yes, riboflavin is very safe over time. Your body removes excess through your urine, so there's no accumulation risk. That said, if you're on any medications, use the interaction checker on this page to be sure.
How much riboflavin do I need?
We don't have effectiveness data in our facts for this product, so I can't tell you the right dose for your goal. Your doctor or a registered dietitian can recommend an amount based on your diet and what you're trying to achieve.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Riboflavin (Vitamin B2) is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Riboflavin (Vitamin B2) label
Go deeper

The Full Monographs Behind Riboflavin (Vitamin B2)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

Riboflavin (Vitamin B2)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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