Interactions on record — worth a quick check against your medications. Based on 5 of 13 ingredients. Check your meds →
Dietary supplement

RNA-DNA Plus Ingredients & Drug Interactions

by Nutri-West

RNA-DNA Plus label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking RNA-DNA Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

RNA-DNA Plus is a dietary supplement by Nutri-West with 13 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 862 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Niacin, Vitamin B6, Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against RNA-DNA Plus by Nutri-West

Ask about any prescription or over-the-counter medication and we check it for interactions with RNA-DNA Plus by Nutri-West — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of RNA-DNA Plus by Nutri-West

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 12 of its 13 active ingredients.

RNA-DNA Plus contains 13 ingredients, including the amino acid L-glutamine, the B vitamins niacin and vitamin B6, choline (a nutrient related to B vitamins), manganese (a trace mineral), and DL-methionine (another amino acid). It also includes tissue concentrates derived from parotid gland, adrenal, and trachea, plus RNA and DNA as actives.

The product contains no inactive fillers or binders listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sideroblastic anemia — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Manganese deficiency — rated "Effective" (Manganese) (Natural Medicines).
  • On file: Sickle cell disease — rated "Effective" (Glutamine) (Natural Medicines).
  • On file: Vitamin B6 deficiency — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Pyridoxine-dependent epilepsy — rated "Effective" (Vitamin B6) (Natural Medicines).

The evidence for this product's ingredients is mixed. L-glutamine is effective for sickle cell disease and possibly effective for recovery after surgery and for wasting related to HIV/AIDS.

Niacin is effective for pellagra (a deficiency disease) and possibly effective for dyslipidemia in HIV/AIDS and metabolic syndrome. Vitamin B6 is effective for certain anemias and B6 deficiency itself, and possibly effective for pregnancy-related nausea.

Choline, manganese, and the tissue concentrates have insufficient evidence or have not been established for most claimed uses in the data we hold. The RNA and DNA components have no effectiveness ratings on file.

The evidence, ingredient by ingredient Glutamine Niacin Vitamin B6 Choline Manganese

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is likely safe during pregnancy and lactation, though high supplement doses should be taken only under doctor supervision, and people with kidney or liver disease should use it only with medical oversight. It commonly causes belching, bloating, constipation, nausea, and diarrhea; at very high doses (10–30 grams daily), gastrointestinal effects are more frequent.

Niacin in normal dietary amounts is well tolerated, but high-dose supplements cause flushing in up to 70% of users and can harm the liver—especially sustained-release forms. Niacin is likely safe in pregnancy when used as prescribed, but high-dose supplements should be avoided.

Vitamin B6 is safe at normal levels but can cause nerve damage (sensory neuropathy) at very high daily doses or over long periods; it is likely safe in pregnancy at recommended doses but possibly unsafe at high levels. Choline is likely safe during pregnancy and lactation but can cause fishy body odor, nausea, vomiting, diarrhea, and other GI effects at doses above 3.5 grams daily.

Manganese is safe in food amounts but poses a rare risk of Parkinson-like symptoms and liver damage at high doses; the lactation data shows mixed ratings. We have no safety information on file for DL-methionine, vitamin B1, parotid, adrenal concentrate, RNA, DNA, or trachea concentrate.

Side effects, ingredient by ingredient Glutamine Niacin Vitamin B6 Choline Manganese

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Manganese, Choline, Glutamine, Niacin, Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; Parkinson's medications.
  • For scale: 863 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking RNA-DNA Plus, double-check these medication types with your pharmacist or doctor: diabetes drugs (niacin raises blood sugar), antihypertensive medications (niacin and vitamin B6 may lower blood pressure further), seizure medications like phenobarbital and phenytoin (vitamin B6 at high doses may reduce their effect), blood thinners and antiplatelet drugs (niacin may increase bleeding risk), cholesterol-lowering statins (rare risk of muscle breakdown with niacin), antipsychotic drugs (manganese and vitamin B6 may interact), quinolone and tetracycline antibiotics (manganese may reduce their absorption), gout drugs like allopurinol and probenecid (niacin may interfere), bile acid sequestrants (space doses 4–6 hours apart from niacin), liver-toxic drugs (niacin adds risk), amiodarone (vitamin B6 may worsen photosensitivity), and levodopa (unless you also take carbidopa). No interactions are documented for the ingredients we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

RNA-DNA Plus is a multi-ingredient supplement with some ingredients backed by evidence (L-glutamine for sickle cell, niacin for deficiency) and others with unclear efficacy. If you take diabetes medications, blood pressure drugs, seizure medications, antipsychotics, statins, blood thinners, gout treatments, or antibiotics, you'll want to check your specific medications before starting this.

Talk with your own doctor or pharmacist about whether this product makes sense for you and your health plan.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about RNA-DNA Plus, straight from the product label.

Brand Nutri-West
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Dec 24, 2013
DSLD ID 28235
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for RNA-DNA Plus by Nutri-West, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
L-Glutamine25 mg--
Niacin5 mg25%
Vitamin B65 mg250%
DL-Methionine50 mg--
Choline10 mg--
Vitamin B12 mg165%
Parotid1 mg--
Adrenal concentrate10 mg--
Other ingredients:0 NP--
Manganese5 mg250%
RNA160 mg--
DNA30 mg--
Trachea Concentrate10 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no starch, salt, sugar, corn, yest, milk, soy, or preservatives.

Precautions

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT OUTER SEAL DO NOT USE IF BROKEN.

Formula

All glandulars are bovine source.

General

Product # 1160

General Statements

FOR DISTRIBUTION BY HEALTH CARE PROFESSIONALS ONLY.

"When You Want The Best"

8803 MFG07/2009

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for Use: One tablet daily or as directed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

RNA-DNA Plus by Nutri-West label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

RNA-DNA Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in RNA-DNA Plus by Nutri-West

These are the 13 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
25 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Niacin

Interacts with
727 drugs
5 mg per serving

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Vitamin B6

Interacts with
210 drugs
5 mg per serving

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

DL-Methionine

50 mg per serving

Choline

Interacts with
16 drugs
10 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Vitamin B1

2 mg per serving

Parotid

1 mg per serving

Adrenal concentrate

10 mg per serving

Other ingredients:

0 NP per serving

Manganese

Interacts with
83 drugs
5 mg per serving Form: {manganese} sulfate

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

RNA

160 mg per serving

DNA

30 mg per serving

Trachea Concentrate

10 mg per serving
Interaction report

RNA-DNA Plus by Nutri-West Drug Interactions

Want to check YOUR meds against RNA-DNA Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
862Drugs
846 Moderate 16 Minor

Ingredients driving the most interactions

Niacin 727
Vitamin B6 210
Manganese 83
L-Glutamine 50
Choline 16

Individual Drug Interactions

The ingredients in RNA-DNA Plus interact with 862 drugs. Click any drug to see the details.

5 of the 13 ingredients in RNA-DNA Plus interact with drugs. Each result below shows which ingredient is responsible. Niacin Vitamin B6 Manganese L-Glutamine Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in RNA-DNA Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Niacin full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for RNA-DNA Plus, from the product label.

Nutri-West

See all Nutri-West products
Phone Number
1-307-358-5066
Pharmacist Counseling Corner

RNA-DNA Plus by Nutri-West: Common Questions

Does RNA-DNA Plus by Nutri-West interact with any medications?
Yes. Based on its ingredients, RNA-DNA Plus has a known interaction with 862 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
RNA-DNA Plus contains 13 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is RNA-DNA Plus safe to take while I'm pregnant?
L-glutamine and niacin are rated likely safe during pregnancy at appropriate doses, and choline is also likely safe. Vitamin B6 is likely safe at recommended levels but possibly unsafe at high doses. However, high-dose niacin supplements should be avoided unless prescribed, and you should discuss any supplement with your doctor—especially one this complex—to make sure it's right for your individual pregnancy.
What side effects should I expect from this product?
The most common side effects come from L-glutamine (belching, bloating, constipation, nausea, diarrhea) and niacin (flushing affecting up to 70% of users, gastrointestinal upset, and headache). Vitamin B6 can cause headache, nausea, and heartburn at lower doses, while choline at high doses may cause fishy body odor, nausea, and diarrhea. These effects are usually mild, but if you notice nerve symptoms (tingling or numbness, especially from vitamin B6) or signs of liver problems, stop and talk to your doctor.
Can this product help with my symptoms?
That depends on what you're dealing with. L-glutamine has solid evidence for sickle cell disease and may help after surgery or with certain types of wasting. Niacin works for pellagra and may help with cholesterol issues in HIV/AIDS. Vitamin B6 is proven for certain anemias and B6 deficiency. The other ingredients—tissue concentrates, RNA, DNA, and choline—don't have established benefits for most uses in the data we hold, so talk with your doctor about what this product can realistically do for you.
Is it safe to take this with blood pressure medication?
Both niacin and vitamin B6 at higher doses may lower blood pressure, so combining them with blood pressure drugs could cause your pressure to drop too far. Before you start this product, check with your doctor or pharmacist to make sure it won't interfere with your treatment.
What's in this product, exactly?
RNA-DNA Plus has 13 ingredients: two amino acids (L-glutamine and DL-methionine), three B vitamins (niacin, vitamin B6, and vitamin B1), choline, manganese, and tissue concentrates from your parotid gland, adrenal gland, and trachea, plus RNA and DNA itself. There are no fillers or other inactive ingredients listed.
Will this interact with my diabetes medicine?
Yes—niacin can raise blood glucose and may reduce how well your diabetes drugs work, which is a real concern if you're managing your blood sugar. Before you take this, talk with your doctor or pharmacist to see if it's safe for you and whether your medication dose might need adjustment.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

RNA-DNA Plus label
Go deeper

The Full Monographs Behind RNA-DNA Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph →
Sources

Sources & How We Checked

RNA-DNA Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 144 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
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Niacin 66 references
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Vitamin B6 32 references
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Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
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See these in context on the Choline monograph →

Manganese 21 references
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  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
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