SAM-e 200 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking SAM-e 200 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
SAM-e 200 mg is a dietary supplement by Wonder Laboratories with 1 active ingredient. Its ingredients are commonly taken for depression, osteoarthritis joint pain, liver conditions.Based on those ingredients, 189 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are S-Adenosylmethionine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against SAM-e 200 mg by Wonder Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with SAM-e 200 mg by Wonder Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of SAM-e 200 mg by Wonder Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: S-Adenosylmethionine (SAMe), a compound your body naturally makes that plays a role in mood regulation, joint health, and liver function. SAMe is the sole therapeutic ingredient here.
The tablet also contains several inactive ingredients—cellulose, mannitol, and others—that help hold it together and aid absorption, but they don't contribute to its effects.
Does it work?
Strong evidence
SAMe is likely effective for osteoarthritis, meaning the evidence supporting it for joint pain and stiffness is solid. For depression and cholestasis (a liver condition affecting bile flow), the evidence is less robust—it's rated possibly effective, so it may help some people but isn't as well established.
For Alzheimer disease and ADHD, there isn't enough reliable evidence yet to know whether it works.
How safe is it?
Well-documented data
SAMe is generally well tolerated in typical doses, though side effects become more common at higher doses. The most frequent ones are digestive—nausea, diarrhea, constipation, stomach upset, and flatulence—along with headache, dizziness, dry mouth, insomnia, and nervousness.
There's an important caution: SAMe can trigger mania in people with bipolar disorder, so if you have that condition, use it only under close medical supervision. Overall safety is not well established for all uses, so guidance from your healthcare provider is advised.
Meds to double-check
Moderate interaction found
Before taking SAMe, double-check with your doctor or pharmacist if you're on any serotonergic drugs—antidepressants, anti-anxiety medications, migraine treatments, or other medications that raise serotonin—because of the moderate risk of serotonin syndrome. Also confirm it's safe if you take levodopa for Parkinson disease, as SAMe may reduce how well it works.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
SAMe may be worth considering if you have osteoarthritis or depression and want to explore a natural option, but it's not right for everyone. Stay away from it if you take serotonin-raising antidepressants or levodopa without clearing it first with your doctor or pharmacist.
If you have bipolar disorder, talk with your healthcare provider before starting. Check your full medication list before you begin.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about SAM-e 200 mg, straight from the product label.
| Brand | Wonder Laboratories |
|---|---|
| Net contents | 60 Enteric Coated Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Dec 18, 2021 |
| DSLD ID | 262951 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for SAM-e 200 mg by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| S-Adenosylmethionine | 400 mg | -- |
Other ingredients: Cellulose, Mannitol, Glyceryl Behenate, Vegetable Magnesium Stearate, Silicon Dioxide, Sodium Starch Glycolate, Methacrylate Copolymers, Magnesium Silicate, Triethyl Citrate, Riboflavin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
All living things contain SAM-e (S-adenosylmethionine). The body makes SAM-e from the amino acid methionine. However, you may not be able to obtain sufficient methionine levels simply by ingesting food. In addition, because of age or other factors, levels of SAM-e can fluctuate or decline. Supplementation with SAM-e is the easiest way to increase intake. SAM-e is involved in over 36 biochemical reactions involving enzymatic transmethylation. The methylation process is the mechanism by which the body rids itself of potentially damaging compounds, synthesizes neurotransmitters, makes components of cartilage, regulates enzyme activity within the cell and maintains the flexibility of cell membranes. Science has been looking into this remarkable supplement and time after time clinical studies have drawn the same conclusions.
S-adenosylmethionine
Precautions
Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.
Caution: You should consult your physician before using SAM-e if you are taking MAO inhibitors. Like all supplements, SAM-e is not intended for use by children and you should consult your physician before using SAM-e if you are pregnant or nursing.
Like all supplements, SAM-e is not intended for use by children and you should consult your physician before using SAM-e if you are pregnant or nursing.
Discontinue use and consult your physician if gastrointestinal discomfort occurs.
Keep out of reach of children.
Formulation
A note about our enteric coating: SAM-e is enterically coated so that you receive optimal absorption. The enteric coating ensures that the breakdown of SAM-e occurs in the small intestine. Clinical trials indicate that absorption is more efficient in the small intestine rather than in the stomach. In addition, the enteric coating is designed to protect SAM-e from moisture. The lack of an enteric coating should not be harmful to the stomach, and there have been no reported cases to this effect. However, the enteric coating serves as a protective barrier so that SAM-e can be absorbed where it can provide you with the greatest benefits.
Promotes healthy joint function and comfort Boosts mood and emotional well-being Supports healthy liver function
Gluten free
Manufactured in an FDA Registered Facility using Good Manufacturing Practices (GMPs).
Suitable for vegetarians/vegans
Contains no wheat, soy, dairy, egg, fish/shellfish, peanuts/tree nuts.
Made in USA
SAM-e: Promotes healthy joint function and comfort Boosts mood and emotional well-being.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Reorder #2223
SAM-e discovered in Italy in 1952 and has been one of Europe's best kept secret for years. Through extensive testing, SAM-e has been shown to be well tolerated by most. But, perhaps the best news is that SAM-e has been found to be a safe, nontoxic supplement for nearly everyone in levels of up to 1,600 mg per day.
SAM-e is a revolutionary supplement. Because of its popularity and use, it has received widespread exposure in the press. Information has appeared in newspapers, magazines, on the internet, or simply through word of mouth. Whether you're a first time SAM-e user or have been a fan for years, you probably have some questions. Please see enclosed insert for more information.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, we recommend taking two (2) tablets daily, preferably on an empty stomach. In order to obtain maximum benefits, SAM-e should be taken at least 30 minutes prior to a meal.
Storage
Keep tightly closed. Store at room temperature: 59 degrees – 86 degrees F (15 degrees – 30 degrees C).
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
SAM-e 200 mg by Wonder Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in SAM-e 200 mg by Wonder Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.
S-Adenosylmethionine
Interacts with189 drugs
SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it ma...
S-Adenosylmethionine monograph & interactionsOther (inactive) ingredients: Cellulose, Mannitol, Glyceryl Behenate, Vegetable Magnesium Stearate, Silicon Dioxide, Sodium Starch Glycolate, Methacrylate Copolymers, Magnesium Silicate, Triethyl Citrate, Riboflavin. These complete the product’s ingredient list but are not active constituents.
SAM-e 200 mg by Wonder Laboratories Drug Interactions
HelloPharmacist Interaction Report
SAMe by Wonder Laboratories can interact with medications through its serotonergic effects and its impact on how your body processes levodopa.
The most serious concern is with serotonergic drugs—those that raise serotonin levels in your brain—where combining them with SAMe carries a moderate risk of serotonin syndrome, a potentially dangerous condition marked by agitation, confusion, rapid heart rate, and high blood pressure.
Read the full breakdown — every affected drug type, severity by severity
SAMe also interacts moderately with levodopa, a medication used to treat Parkinson disease. SAMe can reduce levodopa's effectiveness by altering how your body processes it, which could compromise symptom control.
Altogether, these interactions span 189 individual medications.
If you take any antidepressants, anti-anxiety medications, migraine drugs, or any other serotonin-raising medication, or if you're on levodopa for Parkinson disease, check your exact medications with the tool on this page before starting SAMe.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against SAM-e 200 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in SAM-e 200 mg interact with 189 drugs. Click any drug to see the details.
1 of the 1 ingredient in SAM-e 200 mg interact with drugs. Each result below shows which ingredient is responsible. S-Adenosylmethionine
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Meperidine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Almotriptan interactionAlosetronLotronex
How Alosetron interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Alosetron interactionAmitriptylineElavil
How Amitriptyline interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Amitriptyline, Perphenazine interactionAmoxapineAsendin
How Amoxapine interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Amoxapine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with SAM-e 200 mg — through 1 ingredient. Tap an ingredient for the detail:
S-adenosylmethionineSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosylmethionine + Aripiprazole interactionEach ingredient & the kinds of drugs it affects
For each ingredient in SAM-e 200 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
S-Adenosylmethionine
Levodopa
SAMe might reduce the effectiveness of levodopa.
SAMe methylates levodopa, which might reduce its effectiveness for treating Parkinson disease.
Serotonergic Drugs
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
SAMe has serotonergic effects. Theoretically, combining serotonergic drugs with SAMe might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. In one case report, SAMe 100 mg intramuscularly was given daily with clomipramine (Anafranil) 25 mg per day. When the clomipramine dose was increased to 75 mg per day the patient experienced serotonin syndrome about 48-72 hours later, requiring hospitalization.
Brand information
Manufacturer and brand details for SAM-e 200 mg, from the product label.
Wonder Laboratories
See all Wonder Laboratories products- Name
- Wonder Laboratories
- Street Address
- 115 S.C.T. Ct.
- City
- White House
- State
- TN
- ZipCode
- 37188
SAM-e 200 mg by Wonder Laboratories: Common Questions
Does SAM-e 200 mg by Wonder Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is SAMe safe during pregnancy or while breastfeeding?
What are the most common side effects?
Can SAMe help with depression?
What is SAMe and what does it do in the body?
Why is there a caution about bipolar disorder?
Does this product have any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if SAM-e 200 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind SAM-e 200 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
SAM-e 200 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Same 31 references
- Perna AF, Castaldo P, Ingrosso D, et al. Homocysteine, a new cardiovascular risk factor, is also a powerful uremic toxin. J Nephrol 1999;12:230-40.
- Mato JM, Camara J, Fernandez de Paz J, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-9. PubMed
- Iruela LM, Minguez L, Merino J, Monedero G. Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psychiatry 1993;150:522. PubMed
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