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Dietary supplement

SBO Probiotic 50 Billion CFU Ingredients & Drug Interactions

by Amen

SBO Probiotic 50 Billion CFU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SBO Probiotic 50 Billion CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SBO Probiotic 50 Billion CFU is a dietary supplement by Amen with 7 active ingredients. Its ingredients are commonly taken for stress and anxiety, blood sugar support, respiratory complaints.Based on those ingredients, 2,223 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Acacia Fiber, Fermented, Jerusalem Artichoke, Fermented, Holy Basil, Fermented. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SBO Probiotic 50 Billion CFU by Amen

Ask about any prescription or over-the-counter medication and we check it for interactions with SBO Probiotic 50 Billion CFU by Amen — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of SBO Probiotic 50 Billion CFU by Amen

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.
  • “Prebiotic Blend” is a proprietary blend — the label gives one combined amount (440 mg) without saying how much of each component you get.
  • “Probiotic Blend” is a proprietary blend — the label gives one combined amount (143 mg) without saying how much of each component you get.

This probiotic contains 12 active ingredients, including multiple strains of beneficial bacteria and yeast: Lactobacillus plantarum, Lactobacillus paracasei, Bacillus coagulans, Bacillus subtilis, Bacillus clausii, and Saccharomyces boulardii. It also includes fermented botanicals—Holy Basil, Broccoli, Astragalus, Jerusalem Artichoke, and Turkey Tail—plus Acacia Fiber, which acts as a prebiotic (food for the beneficial bacteria).

The capsule itself contains hypromellose, an inert capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Bacillus Subtilis) (Natural Medicines).
  • On file: Colorectal cancer — rated "Possibly Effective" (Broccoli) (Natural Medicines).
  • On file: Constipation — rated "Possibly Effective" (Bacillus Coagulans) (Natural Medicines).
  • On file: Dyspepsia — rated "Possibly Effective" (Artichoke) (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Saccharomyces Boulardii) (Natural Medicines).

The probiotic strains show varied evidence for different uses. Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome (IBS), though evidence for antibiotic-associated diarrhea, athletic performance, cancer support, and fatty liver disease is insufficient.

Bacillus subtilis is possibly effective for antibiotic-associated diarrhea but has insufficient evidence for athletic performance, cirrhosis, constipation, eczema, and diabetes. Saccharomyces boulardii—a beneficial yeast—is possibly effective for rotaviral diarrhea, travelers' diarrhea, antibiotic-associated diarrhea, a serious intestinal condition called necrotizing enterocolitis, C. difficile infection, and H. pylori.

The fermented botanicals (Holy Basil, Broccoli, Astragalus, and Jerusalem Artichoke) lack established evidence for most of their traditional uses in our data.

The evidence, ingredient by ingredient Holy Basil Broccoli Astragalus Artichoke Gum Arabic Lactobacillus Acidophilus Bacillus Coagulans Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotic strains are generally well tolerated in healthy adults, though safety data and product quality vary widely. B. coagulans and B. subtilis carry a caution: in critically ill or severely immunocompromised patients—including those on central venous catheters, preterm infants, or those with intact immune systems but indwelling medical devices—rare cases of blood infection (bacteremia) and life-threatening infection (sepsis) have been reported.

Similarly, S. boulardii is generally safe for healthy adults but should be avoided by critically ill or immunocompromised patients due to rare reports of yeast blood infection. B. subtilis has rarely caused headache or diarrhea in trials.

Holy Basil most commonly causes loose stools and nausea; the facts note it is possibly unsafe in pregnancy and should be avoided while breastfeeding due to insufficient safety data. Broccoli extract is likely safe in pregnancy but may cause loose stools, diarrhea, abdominal pain, and cramping, especially at high doses.

Astragalus should be avoided in pregnancy and breastfeeding. Jerusalem Artichoke should be avoided during pregnancy and breastfeeding; orally it may cause abdominal pain, diarrhea, flatulence, and nausea.

Acacia Fiber commonly causes abdominal bloating, flatulence, and nausea; these often subside within 2 weeks. Not enough reliable safety data exist for most ingredients overall, so talk with your doctor before using this product.

Side effects, ingredient by ingredient Holy Basil Broccoli Astragalus Artichoke Gum Arabic Lactobacillus Acidophilus Bacillus Coagulans Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 8 of the 8 matched ingredients can interact with medications — Gum Arabic, Saccharomyces Boulardii, Artichoke, Astragalus, Holy Basil, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 2,224 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use antibiotics—B. coagulans and B. subtilis may lose effectiveness, so space them 2 hours apart. Blood thinners (anticoagulants or antiplatelets) need review due to Holy Basil's potential to increase bleeding risk.

Diabetes medications should be discussed because Holy Basil, Astragalus, and Jerusalem Artichoke may increase low blood sugar risk. Antifungals, immunosuppressants, lithium, and liver-metabolized drugs (especially CYP1A2, CYP2A6, CYP2C19, and CYP2B6 substrates) also warrant a conversation with your healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you have recurring digestive issues like IBS or antibiotic-associated diarrhea and a healthy immune system, this probiotic may be worth exploring—especially for the Saccharomyces boulardii and Bacillus strains. However, do not use this product if you're critically ill, severely immunocompromised, or have central lines or indwelling catheters, due to rare risk of serious infection.

Before starting, check your exact medications with your doctor or pharmacist, especially antibiotics, blood thinners, diabetes drugs, antifungals, and any liver-metabolized medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SBO Probiotic 50 Billion CFU, straight from the product label.

Brand Amen
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298407
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SBO Probiotic 50 Billion CFU by Amen, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
L. plantarum0 NP--
Prebiotic Blend440 mg--
Probiotic Blend143 mg--
L. paracasei0 NP--
B. coagulans0 NP--
B. subtilis0 NP--
B. clausii0 NP--
S. boulardii0 NP--
Holy Basil, Fermented0 NP--
Broccoli, Fermented0 NP--
Astragalus, Fermented0 NP--
Jerusalem Artichoke, Fermented0 NP--
Acacia Fiber, Fermented0 NP--
Turkey Tail, Fermented0 NP--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Good Manufacturing Practice cGMP Certified Lab Tested

Formulation

Made with NON GMO Ingredients

Advanced Nutrition

Contains No Added: Milk, tree nuts, wheat, peanuts, soy.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.

Brand IP Statement(s)

Copyright Codeage LLC. All rights reserved.

DRcaps hypermellose capsules DRcaps & logo are trademarks of Lonza or its affiliates.

Precautions

Made on equipment that also processes milk, eggs, fish, tree nuts and soy.

CAUTION: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Please use caution if you have allergies or sensitivities to any of the listed ingredients.

Do not use if product has been opened or tampered with in any way. Keep out of reach of children and pets.

Keep out of reach of children and pets.

Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SBO Probiotic 50 Billion CFU by Amen label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SBO Probiotic 50 Billion CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SBO Probiotic 50 Billion CFU by Amen

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Prebiotic Blend

440 mg per serving

Probiotic Blend

Interacts with
182 drugs
143 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

SBO Probiotic 50 Billion CFU by Amen Drug Interactions

Want to check YOUR meds against SBO Probiotic 50 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,223Drugs
2,216 Moderate 7 Minor

Ingredients driving the most interactions

Acacia Fiber, Fermented 2,022
Jerusalem Artichoke, Fermented 363
Holy Basil, Fermented 212
Astragalus, Fermented 208
Broccoli, Fermented 187

Individual Drug Interactions

The ingredients in SBO Probiotic 50 Billion CFU interact with 2,223 drugs. Click any drug to see the details.

6 of the 7 ingredients in SBO Probiotic 50 Billion CFU interact with drugs. Each result below shows which ingredient is responsible. Acacia Fiber, Fermented Jerusalem Artichoke, Fermented Holy Basil, Fermented Astragalus, Fermented Broccoli, Fermented Probiotic Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in SBO Probiotic 50 Billion CFU with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Acacia Fiber, Fermented2 drug types · 2,022 drugs

Amoxicillin (Amoxil, Trimox)

Gum arabic can reduce the absorption of amoxicillin.
A small study in healthy volunteers shows that taking amoxicillin and gum arabic concurrently significantly reduces the absorption of amoxicillin. Separate doses of amoxicillin from gum arabic by at least 2 hours.

Likelihood Probable Evidence B
Oral Drugs

Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Gum arabic has been used as a suspending osmotic agent in drug formulations. It might improve bioavailability of water-insoluble drugs like naproxen, but reduce absorption of polar drugs like amoxicillin. To avoid changes in absorption, take gum arabic 30-60 minutes after oral medications.

Likelihood Possible Evidence B
Acacia Fiber, Fermented full monograph & interactions

Jerusalem Artichoke, Fermented4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Jerusalem Artichoke, Fermented full monograph & interactions

Holy Basil, Fermented3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Holy Basil, Fermented full monograph & interactions

Astragalus, Fermented4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus, Fermented full monograph & interactions

Broccoli, Fermented2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli, Fermented full monograph & interactions

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SBO Probiotic 50 Billion CFU, from the product label.

Amen

See all Amen products
Name
Codeage LLC
Street Address
449 S. Beverly Dr.
City
Beverly Hills
State
CA
ZipCode
90212
Web Address
www.amennutrition.com
Pharmacist Counseling Corner

SBO Probiotic 50 Billion CFU by Amen: Common Questions

Does SBO Probiotic 50 Billion CFU by Amen interact with any medications?
Yes. Based on its ingredients, SBO Probiotic 50 Billion CFU has a known interaction with 2,223 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SBO Probiotic 50 Billion CFU contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
Not at the same time. The Bacillus coagulans and Bacillus subtilis in this product are live organisms, and antibiotics can kill them, making the probiotic less effective. Separate your antibiotic dose from this probiotic by at least 2 hours. Talk to your pharmacist about the best timing for your specific antibiotic.
Does this have any fillers or unnecessary ingredients?
The capsule itself is made from hypromellose, an inert material. The rest of the 12 ingredients are active—probiotics and fermented botanicals. If you're sensitive to any of them, check the full ingredient list and discuss it with your pharmacist.
Is this safe to take while pregnant?
The probiotic bacteria themselves aren't rated for pregnancy, so there isn't enough data to say. Holy Basil is possibly unsafe and should be avoided, Broccoli is likely safe, and Astragalus and Jerusalem Artichoke should be avoided. Talk with your doctor or midwife before taking this product during pregnancy.
Can this help with IBS?
Bacillus coagulans in this product is possibly effective for IBS based on available evidence. However, evidence quality varies, so results aren't guaranteed. If you want to try it, give it time and monitor how you feel; talk to your doctor about whether it's right for your situation.
What's the difference between the probiotic strains in here?
Each strain has different possible uses. Bacillus coagulans and subtilis may help with constipation and antibiotic-related diarrhea. Saccharomyces boulardii is a yeast that's possibly effective for travelers' diarrhea, C. difficile infection, and several other types of diarrhea. They work differently, which is why combining them may offer broader support.
Will this cause side effects?
Most people tolerate it well. The most common effects are loose stools, nausea, abdominal bloating, and flatulence—these often fade within a couple of weeks. Rare reports include allergic reactions, especially to the Acacia Fiber or Broccoli if you're sensitive to related plants. Start with a small dose to see how you respond.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SBO Probiotic 50 Billion CFU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SBO Probiotic 50 Billion CFU label
Go deeper

The Full Monographs Behind SBO Probiotic 50 Billion CFU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Holy Basil

Interacts with 212 drugs

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...

Read the full Holy Basil monograph → Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph → Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph → Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph → Herb & supplement monograph

Gum Arabic

Interacts with 2,022 drugs

Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplement for digestive health and as a prebiotic. Early s...

Read the full Gum Arabic monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph →
Sources

Sources & How We Checked

SBO Probiotic 50 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 121 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
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Bacillus Coagulans 20 references
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See these in context on the Bacillus Coagulans monograph →

Bacillus Subtilis 10 references
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Saccharomyces Boulardii 26 references
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Holy Basil 8 references
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See these in context on the Holy Basil monograph →

Broccoli 5 references
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See these in context on the Broccoli monograph →

Astragalus 13 references
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  9. Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
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Artichoke 16 references
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Gum Arabic 8 references
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