Interactions on record — worth a quick check against your medications. Based on 6 of 9 ingredients. Check your meds →
Dietary supplement

SBO Probiotics Women's Once Daily 25 Billion CFU Ingredients & Drug Interactions

by Ancient Nutrition

SBO Probiotics Women's Once Daily 25 Billion CFU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SBO Probiotics Women's Once Daily 25 Billion CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SBO Probiotics Women's Once Daily 25 Billion CFU is a dietary supplement by Ancient Nutrition with 9 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 1,532 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sage, Fermented, Amla, Fermented, Bacillus coagulans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SBO Probiotics Women's Once Daily 25 Billion CFU by Ancient Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with SBO Probiotics Women's Once Daily 25 Billion CFU by Ancient Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of SBO Probiotics Women's Once Daily 25 Billion CFU by Ancient Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “SBO Once Daily Blend” is a proprietary blend — the label gives one combined amount (245 mg) without saying how much of each component you get.
  • “Women's Support Blend” is a proprietary blend — the label gives one combined amount (370 mg) without saying how much of each component you get.

This product contains 9 ingredients total, including several active probiotic strains and botanicals. The spore-forming probiotics are Bacillus coagulans, Bacillus subtilis, and Bacillus clausii; the live yeast is Saccharomyces boulardii.

You also get fermented sage, turkey tail (a medicinal mushroom), chaste tree, and amla (Indian gooseberry), plus apple cider vinegar. The inactive ingredients are hypromellose (a capsule material), organic carnauba wax, and acacia gum.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune system health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation, Irritable bowel syndrome (IBS).

The evidence for this product's ingredients is mixed. Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome (IBS), though there isn't enough reliable evidence yet for antibiotic-associated diarrhea, athletic performance, cancer, or fatty liver disease.

Saccharomyces boulardii shows possibly effective evidence for several types of diarrhea—rotaviral, traveler's, and antibiotic-associated—as well as for clostridioides difficile and helicobacter pylori infections. Bacillus subtilis is possibly effective for antibiotic-associated diarrhea specifically.

Fermented sage is possibly effective for menopausal symptoms, high cholesterol, and cognitive function. Amla is possibly effective for acid reflux (GERD) and high cholesterol.

Apple cider vinegar, turkey tail, chaste tree, and Bacillus clausii lack established evidence in the data we hold.

The evidence, ingredient by ingredient Bacillus Coagulans Saccharomyces Boulardii Bacillus Subtilis Apple Cider Vinegar Sage Indian Gooseberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotics in this formula are generally well tolerated in healthy adults, but safety data varies by strain and product quality. There's a rare but serious concern: both Bacillus organisms and Saccharomyces can cause bloodstream infections (bacteremia or fungemia) in people who are critically ill, immunocompromised, have central venous catheters, or are very young preterm infants—though this is uncommon in healthy people with intact immune systems.

Gastrointestinal side effects like gas, cramps, nausea, and diarrhea have been reported rarely. Apple cider vinegar is fine in food amounts but can cause serious problems with long-term high doses, including low potassium levels and bone loss; topical application risks chemical burns.

Fermented sage is safe as a food or short-term tea but should not be used in medicinal amounts during pregnancy because of thujone content; during breastfeeding, avoid medicinal amounts since sage traditionally reduces milk supply. The effectiveness and safety data for this product's other ingredients are limited, so talk with your doctor before taking it.

Side effects, ingredient by ingredient Bacillus Coagulans Saccharomyces Boulardii Bacillus Subtilis Apple Cider Vinegar Sage Indian Gooseberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Saccharomyces Boulardii, Sage, Indian Gooseberry, Apple Cider Vinegar, Bacillus Coagulans, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications.
  • For scale: 1,533 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, antibiotics and the live Bacillus strains need to be separated (Moderate severity). Blood pressure medications, CNS depressants (sedatives), digoxin, insulin, diabetes drugs, estrogen-based hormone therapy, and any medication metabolized by your liver's CYP2D6, CYP2C19, CYP2C9, or CYP3A4 enzymes all interact with the fermented sage (Moderate).

Diuretics (water pills) and blood-thinning or antiplatelet drugs including aspirin and clopidogrel carry Moderate risks with the apple cider vinegar and amla. Antifungal drugs may reduce the live yeast's effectiveness (Minor).

Check your exact medications with your doctor or pharmacist before taking this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with certain types of diarrhea and constipation (especially the Saccharomyces and Bacillus strains), menopausal symptoms, cholesterol, and cognitive function, though the evidence is stronger for some uses than others. However, it carries multiple medication interactions—especially important to consider if you take antibiotics, diabetes drugs, blood pressure medications, blood thinners, or hormone therapy.

People who are critically ill or immunocompromised should avoid it. Before you start, bring the ingredient list to your doctor or pharmacist and review your medications against the interaction checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SBO Probiotics Women's Once Daily 25 Billion CFU, straight from the product label.

Brand Ancient Nutrition
Barcode (UPC) 816401025852
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 309192
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SBO Probiotics Women's Once Daily 25 Billion CFU by Ancient Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
816401025852
IngredientAmount% DV
Bacillus coagulans0 NP--
Saccharomyces boulardii0 NP--
Apple Cider Vinegar0 NP--
Bacillus subtilis0 NP--
Bacillus clausii0 NP--
Sage, Fermented0 NP--
Turkey Tail0 NP--
SBO Once Daily Blend245 mg--
Women's Support Blend370 mg--
Chaste Tree, Fermented0 NP--
Amla, Fermented0 NP--

Other ingredients: Hypromellose, organic Copernicia cerifera Wax, Acacia Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

SBOs (soil-based organisms) are shelf-stable bacteria that thrive in the gut. SBO Probiotics with prebiotics and postbiotics help promote digestive & immune system health. 25 Billion CFU At time of manufacture.

Formulation

Supports healthy digestion and reduces occasional bloating

Color and odor may vary from lot to lot.

FDA Statement of Identity

Whole Food Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1 capsule per day.

Precautions

Produced on equipment that also process peanuts, tree nuts, milk, soybean, wheat, sesame, shellfish, fish, egg.

Warning: If you are pregnant, nursing, allergic, have a medical condition, or taking any medications, consult a doctor before using this or any other dietary supplement.

Warning: If you are pregnant, nursing, allergic, have a medical condition, or taking any medications, consult a doctor before using this or any other dietary supplement.

Do not use if inner safety seal is broken or missing.

Keep out of reach of children.

Notice: Use this product as a food supplement only. Do not use for weight reduction.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Certified Carbon Neutral Product CarbonNeutral.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SBO Probiotics Women's Once Daily 25 Billion CFU by Ancient Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SBO Probiotics Women's Once Daily 25 Billion CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SBO Probiotics Women's Once Daily 25 Billion CFU by Ancient Nutrition

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

SBO Once Daily Blend

245 mg per serving

Women's Support Blend

370 mg per serving

Other (inactive) ingredients: Hypromellose, Organic Copernicia cerifera Wax, Acacia Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

SBO Probiotics Women's Once Daily 25 Billion CFU by Ancient Nutrition Drug Interactions

Want to check YOUR meds against SBO Probiotics Women's Once Daily 25 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,532Drugs
1,497 Moderate 35 Minor

Ingredients driving the most interactions

Sage, Fermented 1,296
Amla, Fermented 208
Bacillus coagulans 182
Bacillus subtilis 182
Apple Cider Vinegar 162

Individual Drug Interactions

The ingredients in SBO Probiotics Women's Once Daily 25 Billion CFU interact with 1,532 drugs. Click any drug to see the details.

6 of the 9 ingredients in SBO Probiotics Women's Once Daily 25 Billion CFU interact with drugs. Each result below shows which ingredient is responsible. Sage, Fermented Amla, Fermented Bacillus coagulans Bacillus subtilis Apple Cider Vinegar Saccharomyces boulardii

Each ingredient & the kinds of drugs it affects

For each ingredient in SBO Probiotics Women's Once Daily 25 Billion CFU with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sage, Fermented14 drug types · 1,296 drugs

Anticholinergic Drugs

Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Anticonvulsants

Theoretically, sage might interfere with the clinical effects of anticonvulsant drugs.
Some species of sage can cause convulsions when consumed in large quantities.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
In patients with polycystic ovary syndrome (PCOS) or inadequately controlled type 2 diabetes, common sage (Salvia officinalis) has demonstrated hypoglycemic activity. However, other clinical research in patients with inadequately controlled type 2 diabetes shows that common sage extract does not lower fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Animal research suggests that common sage (Salvia officinalis) can cause prolonged blood pressure reduction. However, clinical research suggests that Spanish sage (Salvia lavandulaefolia) can increase blood pressure in some people with hypertension. Until more is known, use with caution.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking sage might increase the sedative and adverse effects of benzodiazepines.
In vitro evidence suggests that certain components of common sage (Salvia officinalis) can bind to benzodiazepine receptors. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, sage might have additive effects when used with cholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Some constituents of sage have CNS depressant activity.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Animal research suggests that drinking common sage (Salvia officinalis) tea increases the expression of CYP2E1. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, sage might interfere with hormone therapy.
In vitro evidence suggests that geraniol, a constituent of Spanish sage (Salvia lavandulaefolia), exerts estrogenic activity. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
In vitro research suggests that common sage (Salvia officinalis) can inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Sage, Fermented full monograph & interactions

Amla, Fermented4 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking Indian gooseberry 500 mg along with clopidogrel 75 mg or ecosprin 75 mg, as a single dose or for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg or ecosprin 75 mg alone. Until more is known, use caution when taking Indian gooseberry in combination with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking Indian gooseberry fruit or fruit extract alone or in conjunction with antidiabetes medications can lower blood glucose levels. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Aspirin

Theoretically, Indian gooseberry may increase the risk of bleeding if used with aspirin; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with ecosprin 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus ecosprin 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with ecosprin 75 mg alone.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, Indian gooseberry may increase the risk of bleeding if used with clopidogrel; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with clopidogrel 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus clopidogrel 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg alone.

Likelihood Possible Evidence B
Amla, Fermented full monograph & interactions

Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans full monograph & interactions

Bacillus subtilis1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis full monograph & interactions

Apple Cider Vinegar4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar full monograph & interactions

Saccharomyces boulardii1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SBO Probiotics Women's Once Daily 25 Billion CFU, from the product label.

Ancient Nutrition

See all Ancient Nutrition products
Name
Ancient Nutrition, LLC
Street Address
3480 Summertown Hwy
City
Summertown
State
TN
ZipCode
38483
Web Address
www.AncientNutrition.com
Pharmacist Counseling Corner

SBO Probiotics Women's Once Daily 25 Billion CFU by Ancient Nutrition: Common Questions

Does SBO Probiotics Women's Once Daily 25 Billion CFU by Ancient Nutrition interact with any medications?
Yes. Based on its ingredients, SBO Probiotics Women's Once Daily 25 Billion CFU has a known interaction with 1,532 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SBO Probiotics Women's Once Daily 25 Billion CFU contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this if I'm pregnant or breastfeeding?
The fermented sage in this product should not be used in medicinal amounts during pregnancy because of its thujone content. During breastfeeding, medicinal amounts of sage are best avoided since it traditionally reduces milk supply. The safety of the other ingredients during pregnancy and lactation isn't established in the data we hold. Talk with your doctor or pharmacist before taking this product if you're pregnant or nursing.
Can I take this at the same time as my antibiotics?
No—the live Bacillus organisms (Bacillus coagulans and Bacillus subtilis) in this product can be killed by antibiotics, making the probiotics less effective. You'll need to space them apart. Ask your doctor or pharmacist how many hours apart they should be.
Will this help my IBS or constipation?
Bacillus coagulans is possibly effective for both IBS and constipation based on available evidence. However, evidence quality varies, and results differ from person to person. Talk with your doctor about whether it's a good fit for your situation.
What does the live yeast Saccharomyces boulardii do?
It's possibly effective for several kinds of diarrhea, including traveler's diarrhea, antibiotic-associated diarrhea, rotaviral diarrhea, and for infections like clostridioides difficile and helicobacter pylori. As a live organism, it's meant to help restore balance to your gut bacteria.
Who should avoid this product?
People who are critically ill, severely immunocompromised, have indwelling catheters, or are preterm infants should avoid probiotics like these due to the rare risk of bloodstream infection. If you're on antifungal medications or take multiple medications, check with your doctor or pharmacist first.
Are there any common side effects?
Most people tolerate it well. Rarely, you might experience gas, bloating, abdominal cramps, nausea, or diarrhea—especially when you first start. These usually settle down. Headache and musculoskeletal pain have been reported occasionally in trials.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SBO Probiotics Women's Once Daily 25 Billion CFU label
Go deeper

The Full Monographs Behind SBO Probiotics Women's Once Daily 25 Billion CFU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph → Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph → Herb & supplement monograph

Sage

Interacts with 1,296 drugs

Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some early research is encouraging for sore...

Read the full Sage monograph → Herb & supplement monograph

Indian Gooseberry

Interacts with 208 drugs

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some u...

Read the full Indian Gooseberry monograph →
Sources

Sources & How We Checked

SBO Probiotics Women's Once Daily 25 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 100 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
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See these in context on the Bacillus Coagulans monograph →

Saccharomyces Boulardii 26 references
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See these in context on the Saccharomyces Boulardii monograph →

Apple Cider Vinegar 11 references
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  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
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Bacillus Subtilis 10 references
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See these in context on the Bacillus Subtilis monograph →

Sage 27 references
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  13. Perry, N. S., Houghton, P. J., Sampson, J., Theobald, A. E., Hart, S., Lis-Balchin, M., Hoult, J. R., Evans, P., Jenner, P., Milligan, S., and Perry, E. K. In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's diseas
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  17. Kennedy, D. O., Pace, S., Haskell, C., Okello, E. J., Milne, A., and Scholey, A. B. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery. Neuropsychopharmacology 2006;31(4):84 PubMed
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  20. Hellum, B. H. and Nilsen, O. G. In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic Clin Pharmacol Toxicol. 2008;102(5):466-475.
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  24. Vandecasteele K, Ost P, Oosterlinck W, et al. Evaluation of the efficacy and safety of Salvia officinalis in controlling hot flashes in prostate cancer patients treated with androgen deprivation. Phytother Res. 2012;26(2):208-13.
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See these in context on the Sage monograph →

Indian Gooseberry 6 references
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  2. Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
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  4. Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
  5. Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
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See these in context on the Indian Gooseberry monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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