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Dietary supplement

Sceletium Tortuosum II 300 mg Ingredients & Drug Interactions

by HBC Protocols

Sceletium Tortuosum II 300 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sceletium Tortuosum II 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sceletium Tortuosum II 300 mg is a dietary supplement by HBC Protocols with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, low mood, mental focus and cognition.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sceletium tortuosum powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sceletium Tortuosum II 300 mg by HBC Protocols

Ask about any prescription or over-the-counter medication and we check it for interactions with Sceletium Tortuosum II 300 mg by HBC Protocols — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sceletium Tortuosum II 300 mg by HBC Protocols

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: sceletium tortuosum powder at 300 mg per capsule. Sceletium is a succulent plant traditionally used in South Africa; the powder here is the whole plant material.

The capsule also holds inactive ingredients—rice powder, magnesium stearate, silicon dioxide, and maltodextrin—which are fillers and binders that help deliver the active ingredient.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: mood and anxiety support.
  • We looked for evidence on: Anxiety, Depression, Stress, mood elevation, emotional wellness.
  • The closest evidence on file: Sceletium is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Sceletium is rated "Insufficient Reliable Evidence To Rate" for Depression, Stress.

The evidence for what sceletium does isn't established in the data we hold. We don't have reliable evidence to rate it for anxiety, depression, stress, alcohol use disorder, athletic performance, or weight management.

That doesn't mean it doesn't work; it means the clinical studies so far haven't been robust enough to say one way or the other.

The evidence, ingredient by ingredient Sceletium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sceletium appears generally well tolerated in small studies, but we don't know much about its safety over the long haul. The most common side effects reported from oral use are anxiety, headache, insomnia, irritability, and nausea.

There are also anecdotal reports of headache, depression, and listlessness from chewing it, and at higher doses it may cause euphoric effects or raise blood pressure. It's not recommended during pregnancy or while breastfeeding—there isn't enough safety data either way.

Side effects, ingredient by ingredient Sceletium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sceletium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Sceletium Tortuosum II, double-check any CNS depressants you take—that's sedatives, sleep aids, anti-anxiety medications, opioid pain relievers, and some antihistamines. Combining them with this supplement could boost drowsiness.

Use the medication search tool on this page to confirm your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement is worth considering if you're interested in sceletium for stress or mood and you don't take CNS depressants—but the evidence for what it actually does isn't solid yet. If you take any sedatives, sleep aids, or other brain-slowing medications, check with your pharmacist or doctor before adding this.

The long-term safety picture is still unclear, so talk it over with your own healthcare provider to decide if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sceletium Tortuosum II 300 mg, straight from the product label.

Brand HBC Protocols
Barcode (UPC) 678940750264
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 74986
Product type Botanical
Supplement form Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sceletium Tortuosum II 300 mg by HBC Protocols, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
678940750264
IngredientAmount% DV
Sceletium tortuosum powder300 mg--

Other ingredients: Rice powder, Magnesium Stearate, Silicon Dioxide, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no sugar, starch, yeast, artificial colors, preservatives or dairy products.

Precautions

Keep out of the reach of children.

Not to be taken by pregnant women or those using MAO inhibitors.

People taking psychiatric, anti-anxiety or anti-depressant medication should discuss the concomitant use of Sceletium tortuosum-containing products with their healthcare professional.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Dosage: Minimum one capsule per day.

General Statements

Sceletium tortuosum has been demonstrated to be clinically effective in human studies. Sceletium has a self-affirmed GRAS (generally recognized as safe) status.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sceletium Tortuosum II 300 mg by HBC Protocols label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sceletium Tortuosum II 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sceletium Tortuosum II 300 mg by HBC Protocols

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Sceletium tortuosum powder

Interacts with
248 drugs
300 mg per serving

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, s...

Sceletium tortuosum powder monograph & interactions

Other (inactive) ingredients: Rice powder, Magnesium Stearate, Silicon Dioxide, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sceletium Tortuosum II 300 mg by HBC Protocols Drug Interactions

Want to check YOUR meds against Sceletium Tortuosum II 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Sceletium tortuosum powder 248

Individual Drug Interactions

The ingredients in Sceletium Tortuosum II 300 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sceletium Tortuosum II 300 mg interact with drugs. Each result below shows which ingredient is responsible. Sceletium tortuosum powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Sceletium Tortuosum II 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sceletium tortuosum powder1 drug type · 248 drugs

Cns Depressants

Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.
Some evidence suggests that sceletium has sedative properties.

Likelihood Possible Evidence D
Sceletium tortuosum powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sceletium Tortuosum II 300 mg, from the product label.

HBC Protocols

See all HBC Protocols products
Name
HBC Protocols, Inc
Street Address
P.O. Box 712445
City
Los Angeles
State
CA
ZipCode
90071
Phone Number
888.497.3742
Web Address
www.hbcprotocols.com
Pharmacist Counseling Corner

Sceletium Tortuosum II 300 mg by HBC Protocols: Common Questions

Does Sceletium Tortuosum II 300 mg by HBC Protocols interact with any medications?
Yes. Based on its ingredients, Sceletium Tortuosum II 300 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sceletium Tortuosum II 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does sceletium actually do?
We don't have reliable evidence yet to say whether sceletium helps with anxiety, depression, stress, or the other conditions it's marketed for. The science isn't there to rate it one way or the other.
Is it safe to take while I'm pregnant or breastfeeding?
No—there isn't enough safety data, so it's best avoided in pregnancy and while breastfeeding. Talk with your doctor or pharmacist about what's right for you during this time.
What side effects should I watch for?
The most common ones reported are anxiety, headache, insomnia, irritability, and nausea. Anecdotal reports also mention depression, listlessness, and a rise in blood pressure. Safety data are limited overall, so watch how you feel and report anything unusual to your pharmacist.
Why does this product interact with so many medications if it's just one herb?
CNS depressants is a broad drug category—it includes sleep aids, sedatives, anti-anxiety medications, opioids, and some antihistamines. The 248 figure is the total number of individual medications across all those types that could theoretically interact with sceletium.
Is it safe to take long-term?
We don't have good long-term safety data, so caution is advised if you're thinking of using it regularly. Stick with your doctor or pharmacist about how long it's okay for you to take it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sceletium Tortuosum II 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sceletium Tortuosum II 300 mg label
Go deeper

The Full Monographs Behind Sceletium Tortuosum II 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sceletium

Interacts with 248 drugs

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, so its benefits are not well proven. Talk...

Read the full Sceletium monograph →
Sources

Sources & How We Checked

Sceletium Tortuosum II 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sceletium 3 references
  1. Smith MT, Crouch NR, Gericke N, Hirst M. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. J Ethnopharmacol 1996;50:119-30. PubMed
  2. Meyer GMJ, Wink CSD, Zapp J, Maurer HH. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum
  3. Gericke J, Lekhooa M, Steyn SF, Viljoen AM, Harvey BH. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat. J Ethnopharmacol. 2022 Feb 10;284:114550. do PubMed

See these in context on the Sceletium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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