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Dietary supplement

Scutellaria Lat. Skullcap Ingredients & Drug Interactions

by Wise Woman Herbals

Scutellaria Lat. Skullcap label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Scutellaria Lat. Skullcap against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Scutellaria Lat. Skullcap is a dietary supplement by Wise Woman Herbals with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Scutellaria Lat. Skullcap by Wise Woman Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Scutellaria Lat. Skullcap by Wise Woman Herbals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Scutellaria Lat. Skullcap by Wise Woman Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (3 mL) without saying how much of each component you get.

This product contains one active ingredient: skullcap (Scutellaria lateriflora), a traditional herbal remedy. The liquid form also contains alcohol as an inactive ingredient to preserve and deliver the herb.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: anxiety stress and sleep support.
  • We looked for evidence on: Anxiety, Stress, Insomnia, nervous tension, relaxation, muscle tension.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence for skullcap is limited. Our data shows insufficient reliable evidence to rate its use for epilepsy, stress, stroke, spasticity, contact dermatitis, or premenstrual dysphoric disorder (PMDD).

While it has a long history in herbal medicine, clinical trials haven't yet established clear proof that it works for these conditions.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Safety data on skullcap is sparse, and product quality varies widely — use it with care if you choose to try it. Most common side effects from oral use are cognitive impairment, digestive upset, and sedation, especially at higher doses.

Do not use skullcap during pregnancy — there isn't enough safety data. Similarly, avoid it while breastfeeding because safety is unknown.

Talk with your doctor or pharmacist before taking it if you're pregnant, nursing, or have questions about whether it's right for you.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you use CNS depressants (Moderate severity) — that includes sedatives, sleeping pills, anxiety medications, and certain pain relievers. Skullcap can add to their drowsy, dizzying, or thinking-fog effects.

No interactions are documented in our data for other drug types, but that's not a guarantee none exist — run your full medication list through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap may appeal to you if you're drawn to traditional herbal remedies for relaxation or stress, but the clinical evidence isn't there yet to prove it works. Be especially cautious if you take any medication that makes you drowsy or slows your thinking — skullcap can add to those effects.

Because it's not well-studied and product quality varies, check in with your own doctor or pharmacist before you start, especially if you take other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Scutellaria Lat. Skullcap, straight from the product label.

Brand Wise Woman Herbals
Barcode (UPC) 748840014824
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 284914
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Scutellaria Lat. Skullcap by Wise Woman Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
20 Drop(s)
Maximum serving Sizes:
60 Drop(s)
Servings per container
20
UPC/BARCODE
748840014824
IngredientAmount% DV
Proprietary Blend3 mL--
Skullcap0 NP--

Other ingredients: Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Shake well. Add 20-60 drops to water, 1-4 times per day.

Formulation

The presence of particulate matter in this product is normal.

Precautions

Caution: Keep out of the reach of children.

General Statements

Botanical formula

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry area away from direct sunlight with the lid tightly sealed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Scutellaria Lat. Skullcap by Wise Woman Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Scutellaria Lat. Skullcap label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Scutellaria Lat. Skullcap by Wise Woman Herbals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size20 Drop(s) Dosage formLiquid Servings per container20 Amounts shown are per serving.

Proprietary Blend

3 mL per serving

Other (inactive) ingredients: Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Scutellaria Lat. Skullcap by Wise Woman Herbals Drug Interactions

Want to check YOUR meds against Scutellaria Lat. Skullcap?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Skullcap 248

Individual Drug Interactions

The ingredients in Scutellaria Lat. Skullcap interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Scutellaria Lat. Skullcap interact with drugs. Each result below shows which ingredient is responsible. Skullcap

Each ingredient & the kinds of drugs it affects

For each ingredient in Scutellaria Lat. Skullcap with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Scutellaria Lat. Skullcap, from the product label.

Wise Woman Herbals

See all Wise Woman Herbals products
Name
Wise Woman Herbals
City
Creswell
State
OR
ZipCode
97426
Phone Number
541.895.5152
Web Address
wisewomanherbals.com
Pharmacist Counseling Corner

Scutellaria Lat. Skullcap by Wise Woman Herbals: Common Questions

Does Scutellaria Lat. Skullcap by Wise Woman Herbals interact with any medications?
Yes. Based on its ingredients, Scutellaria Lat. Skullcap has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Scutellaria Lat. Skullcap contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take skullcap if I'm pregnant or breastfeeding?
No. Safety data is insufficient, so the advice is to avoid it during pregnancy and breastfeeding. Talk with your doctor or pharmacist about your situation before taking any skullcap product.
What are the side effects of skullcap?
The most common are cognitive impairment (trouble thinking clearly), mild digestive upset, and sedation — especially at higher doses. One person on a high dose reported vivid dreams, though it's unclear if skullcap caused it. Overall, adverse-effect data is limited.
Does skullcap work for stress or anxiety?
The evidence isn't established yet. Our data shows insufficient reliable evidence to rate skullcap for stress, so we can't say it's proven effective for that purpose.
Is this safe to take long-term?
Skullcap is often used short-term, but evidence on long-term safety is limited and product quality varies. Use it with care, and discuss long-term use with your doctor or pharmacist.
What's in this liquid besides the herb?
Skullcap is the active ingredient; alcohol is included as an inactive ingredient to preserve and deliver it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Scutellaria Lat. Skullcap is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Scutellaria Lat. Skullcap label
Go deeper

The Full Monographs Behind Scutellaria Lat. Skullcap’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Scutellaria Lat. Skullcap's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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