Seasonal Pollen Protection Ingredients & Drug Interactions
by Hawaii Pharm
What is this page for?
First and foremost: checking Seasonal Pollen Protection against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Seasonal Pollen Protection is a dietary supplement by Hawaii Pharm with 2 active ingredients. Its ingredients are commonly taken for enlarged prostate (bph) symptoms, seasonal allergies, joint pain and arthritis.Based on those ingredients, 285 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astragalus Root Extract, Dry, Stinging Nettle Leaf Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Seasonal Pollen Protection by Hawaii Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Seasonal Pollen Protection by Hawaii Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Seasonal Pollen Protection by Hawaii Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Seasonal Pollen Protection contains 2 active ingredients: stinging nettle leaf extract and astragalus root extract, both in dry form. The product also holds a proprietary extract blend—we've listed its components separately below.
These herbs are mixed into a liquid base with alcohol, water, and glycerin as inactive ingredients.
Does it work?
Not established
The evidence for what this product can do is limited. Stinging nettle is possibly effective for diabetes, but we don't have reliable evidence it works for hay fever, anemia, asthma, benign prostatic hyperplasia (enlarged prostate), or gingivitis.
Astragalus shows insufficient evidence for hay fever, anemia, asthma, angina, and other conditions the product might be promoted for. In short, the data we hold doesn't establish that this blend works for seasonal allergies or the conditions it may target.
How safe is it?
Well-documented data
Stinging nettle is generally well tolerated when taken by mouth, though some people report constipation or diarrhea. Rare cases of liver injury have been reported with products containing stinging nettle, usually in combination with other herbs.
Because stinging nettle may affect the uterus and isn't proven safe during breastfeeding, the safety data advises against it during pregnancy and lactation—talk with your doctor or pharmacist before using it if you're pregnant or nursing. Astragalus is generally well tolerated short-term in healthy adults, though dizziness and rash have been reported rarely.
Like stinging nettle, astragalus lacks reliable safety data in pregnancy and breastfeeding, so it's best avoided until you've checked with your doctor or pharmacist.
Meds to double-check
Moderate interaction found
If you take warfarin or another blood thinner, diuretics (water pills), lithium, antidiabetes drugs, immunosuppressants, or cyclophosphamide, check with your doctor or pharmacist before adding this product. All of these carry moderate interaction risks with one or both of the active ingredients here.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product may appeal to people looking for herbal support for seasonal allergies, but the evidence that it works isn't established in our data. The bigger concern is its interactions with blood thinners, diabetes medications, diuretics, lithium, and immune-suppressing drugs—all common prescriptions.
If you take any of those or other regular medications, check your exact drug names against the interaction tool on this page before you start, and talk it over with your doctor or pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Seasonal Pollen Protection, straight from the product label.
| Brand | Hawaii Pharm |
|---|---|
| Barcode (UPC) | 840253663313 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2023 |
| DSLD ID | 301857 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Seasonal Pollen Protection by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Blend | 983 mg | -- |
| Stinging Nettle Leaf Extract, Dry | 0 NP | -- |
| Astragalus Root Extract, Dry | 0 NP | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Hawaii Pharm Herbal Extract Highest quality since 2008
Suggested/Recommended/Usage/Directions
Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.
Precautions
Warning: We recommend to seek expert medical advice before taking.
Do not use if you are allergic to any ingredients.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.
Keep out of the reach of children!
Storage
Store in a cool dry place.
Seals/Symbols
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Organic Alcohol Based USA Made in United States of America
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Made in USA, Hawaii
Only natural ingredients Purity is laboratory tested and verified
All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives
Not tested on animals
Organic Alcohol Based
FDA Statement of Identity
Herbal Supplement
Formula
Organic Alcohol Based
General Statements
Scan this QR-code to get 15% discount on your next purchase. Limited time deal.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Seasonal Pollen Protection by Hawaii Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Seasonal Pollen Protection by Hawaii Pharm
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Seasonal Pollen Protection by Hawaii Pharm Drug Interactions
HelloPharmacist Interaction Report
Seasonal Pollen Protection by Hawaii Pharm contains stinging nettle and astragalus, both of which interact with medications.
The most serious concern involves stinging nettle's effects on blood thinner medications: stinging nettle is high in vitamin K, which may reduce how well warfarin (Coumadin) works to prevent clots.
Read the full breakdown — every affected drug type, severity by severity
Stinging nettle also moderately interacts with antidiabetes drugs—it may lower blood sugar on its own, so combining it with diabetes medication could push your levels too low. It similarly affects diuretics (water pills) and lithium, a mood stabilizer: stinging nettle's diuretic properties might reduce how your body clears lithium, raising its levels and risk of side effects.
Astragalus carries its own moderate interactions. It may interfere with immunosuppressants (drugs that calm an overactive immune system) and cyclophosphamide (a chemotherapy agent) because it seems to boost immune function.
Like stinging nettle, astragalus can lower blood sugar and might reduce lithium clearance through diuretic effects.
Altogether, these interactions span 285 individual medications. Before you start this product, run your exact prescriptions through the interaction checker on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Seasonal Pollen Protection?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Seasonal Pollen Protection interact with 285 drugs. Click any drug to see the details.
2 of the 2 ingredients in Seasonal Pollen Protection interact with drugs. Each result below shows which ingredient is responsible. Astragalus Root Extract, Dry Stinging Nettle Leaf Extract, Dry
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Seasonal Pollen Protection — through 2 ingredients. Tap an ingredient for the detail:
Astragalus Root Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus Root Extract, Dry + Acarbose interactionStinging Nettle Leaf Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Stinging Nettle Leaf Extract, Dry + Acarbose interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Stinging Nettle Leaf Extract, DryDiuretic Drugs Moderate
Interaction Summary
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Stinging Nettle Leaf Extract, Dry + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Stinging Nettle Leaf Extract, DryDiuretic Drugs Moderate
Interaction Summary
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Stinging Nettle Leaf Extract, Dry + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Stinging Nettle Leaf Extract, DryDiuretic Drugs Moderate
Interaction Summary
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Stinging Nettle Leaf Extract, Dry + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Seasonal Pollen Protection — through 2 ingredients. Tap an ingredient for the detail:
Stinging Nettle Leaf Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Stinging Nettle Leaf Extract, Dry + Acetohexamide interactionAstragalus Root Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus Root Extract, Dry + Acetohexamide interactionAdalimumabHumira
How Adalimumab interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Seasonal Pollen Protection — through 2 ingredients. Tap an ingredient for the detail:
Astragalus Root Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus Root Extract, Dry + Albiglutide interactionStinging Nettle Leaf Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Stinging Nettle Leaf Extract, Dry + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Alemtuzumab interactionAlogliptinNesina
How Alogliptin interacts with Seasonal Pollen Protection — through 2 ingredients. Tap an ingredient for the detail:
Stinging Nettle Leaf Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Stinging Nettle Leaf Extract, Dry + Alogliptin interactionAstragalus Root Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus Root Extract, Dry + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Seasonal Pollen Protection — through 2 ingredients. Tap an ingredient for the detail:
Astragalus Root Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus Root Extract, Dry + Alogliptin, Metformin interactionStinging Nettle Leaf Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Stinging Nettle Leaf Extract, Dry + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Seasonal Pollen Protection — through 2 ingredients. Tap an ingredient for the detail:
Stinging Nettle Leaf Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Stinging Nettle Leaf Extract, Dry + Alogliptin, Pioglitazone interactionAstragalus Root Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus Root Extract, Dry + Alogliptin, Pioglitazone interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Stinging Nettle Leaf Extract, DryDiuretic Drugs Moderate
Interaction Summary
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Stinging Nettle Leaf Extract, Dry + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Stinging Nettle Leaf Extract, DryDiuretic Drugs Moderate
Interaction Summary
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Stinging Nettle Leaf Extract, Dry + Ammonium Chloride interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Anifrolumab-fnia interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Seasonal Pollen Protection — through 2 ingredients. Tap an ingredient for the detail:
Astragalus Root Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus Root Extract, Dry + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionStinging Nettle Leaf Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Stinging Nettle Leaf Extract, Dry + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithymocyte GlobulinThymoglobulin
How Antithymocyte Globulin interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Antithymocyte Globulin interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Stinging Nettle Leaf Extract, DryDiuretic Drugs Moderate
Interaction Summary
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Stinging Nettle Leaf Extract, Dry + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Stinging Nettle Leaf Extract, DryDiuretic Drugs Moderate
Interaction Summary
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Stinging Nettle Leaf Extract, Dry + Atenolol, Chlorthalidone interactionAtezolizumabTecentriq
How Atezolizumab interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Atezolizumab interactionAzamuneImmunoprin
How Azamune interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Azamune interactionAzathioprineAzamune, Imuran
How Azathioprine interacts with Seasonal Pollen Protection — through 1 ingredient. Tap an ingredient for the detail:
Astragalus Root Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus Root Extract, Dry + Azathioprine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Seasonal Pollen Protection with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Astragalus Root Extract, Dry
Antidiabetes Drugs
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.
Cyclophosphamide
Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.
Immunosuppressants
Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.
Lithium
Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.
Stinging Nettle Leaf Extract, Dry
Antidiabetes Drugs
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.
Diuretic Drugs
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.
Lithium
Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.
Warfarin (Coumadin)
There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.
Brand information
Manufacturer and brand details for Seasonal Pollen Protection, from the product label.
Hawaii Pharm
See all Hawaii Pharm products- Name
- Hawaii Pharm LLC
- Street Address
- 510 Sumner St. Ste. 613
- City
- Honolulu
- State
- HI
- ZipCode
- 96817
- Phone Number
- 888-854-2924
- Web Address
- www.hawaiipharm.com
Seasonal Pollen Protection by Hawaii Pharm: Common Questions
Does Seasonal Pollen Protection by Hawaii Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
Does this actually help with hay fever or seasonal allergies?
What side effects might I have?
Is this safe to take long-term?
What is astragalus used for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Seasonal Pollen Protection is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Seasonal Pollen Protection’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Stinging Nettle
Interacts with 164 drugsStinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...
Read the full Stinging Nettle monograph → Herb & supplement monographAstragalus
Interacts with 208 drugsAstragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...
Read the full Astragalus monograph →Sources & How We Checked
Seasonal Pollen Protection's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Stinging Nettle 23 references
- Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 1990;56:44-7.
- Vontobel HP, Herzog R, Rutishauser G, Kres H. [Results of a double-blind study on the effectiveness of ERU (extractum radicis Urticae) capsules in conservative treatment of benign prostatic hyperplasia]. (Abstract). Urologe A 1985;24:49-51.
- Randall C, Randall H, Dobbs F, et al. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 2000;93:305-9. PubMed
- Caliskaner Z, Karaayvaz M, Ozturk S. Misuse of a herb: stinging nettle (Urtica urens) induced severe tongue oedema. Complement Ther Med 2004;12:57-8. PubMed
- Krzeski, T., Kazon, M., Borkowski, A., Witeska, A., and Kuczera, J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther 1993;15(6):1011-1020.
- Randall, C., Meethan, K., Randall, H., and Dobbs, F. Nettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapy. Complement Ther Med 1999;7(3):126-131. PubMed
- Tahri, A., Yamani, S., Legssyer, A., Aziz, M., Mekhfi, H., Bnouham, M., and Ziyyat, A. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol 2000;73(1-2):95-100. PubMed
- Sahin, M., Yilmaz, H., Gursoy, A., Demirel, A. N., Tutuncu, N. B., and Guvener, N. D. Gynaecomastia in a man and hyperoestrogenism in a woman due to ingestion of nettle (Urtica dioica). N.Z.Med.J. 2007;120(1265):U2803.
- Randall, C., Dickens, A., White, A., Sanders, H., Fox, M., and Campbell, J. Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther.Med. 2008;16(2):66-72. PubMed
- Rayburn, K., Fleischbein, E., Song, J., Allen, B., Kundert, M., Leiter, C., and Bush, T. Stinging nettle cream for osteoarthritis. Altern.Ther.Health Med. 2009;15(4):60-61.
- Oliver, F., Amon, E. U., Breathnach, A., Francis, D. M., Sarathchandra, P., Black, A. K., and Greaves, M. W. Contact urticaria due to the common stinging nettle (Urtica dioica)-- histological, ultrastructural and pharmacological studies. Clin Exp Dermato PubMed
- Kulze, A. and Greaves, M. Contact urticaria caused by stinging nettles. Br.J Dermatol. 1988;119(2):269-270. PubMed
- Patten G. Medicinal plant review: Urtica. Aust J Med Herbalism 1993;5(1):5-13.
- Maor D, Little M. Skin contact with a stinging tree requiring intensive care unit admission. Contact Dermatitis. 2017 Nov;77(5):335-37. PubMed
- Easton L, Vaid S, Nagel AK, Venci JV, Fortuna RJ. Stinging Nettle (Urtica dioica): An Unusual Case of Galactorrhea. Am J Case Rep 2021;22:e933999. PubMed
- Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
- Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed
Astragalus 13 references
- Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
- Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.
- Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.
- Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..
- Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.
- Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.
- Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):18 PubMed
- Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest PubMed
- Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
- Hong KF, Liu PY, Zhang W, Gui DK, Xu YH. The Efficacy and Safety of Astragalus as an Adjuvant Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Integr Complement Med 2023. PubMed
- Chan KW, Kwong ASK, Tsui PN, et al. Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial. Phytomedicine 2024;130:155457. PubMed
- Han X, Yu T, Chen X, Du Z, Yu M, Xiong J. Effect of Astragalus membranaceus on left ventricular remodeling in HFrEF: a systematic review and meta-analysis. Front Pharmacol 2024;15:1345797. PubMed
- Jing P, Hongzheng H, Zhenqi WU, Meijuan Z, Zuojing LI, Gang C. Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials. J Tradit Chin Med 2024;44(2):
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC