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Dietary supplement

Serrapeptase 120,000 SPUs Ingredients & Drug Interactions

by Lake Avenue Nutrition

Serrapeptase 120,000 SPUs label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase 120,000 SPUs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase 120,000 SPUs is a dietary supplement by Lake Avenue Nutrition with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase 120,000 SPUs by Lake Avenue Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase 120,000 SPUs by Lake Avenue Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Serrapeptase 120,000 SPUs by Lake Avenue Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: serrapeptase, a protein-digesting enzyme at a dose of 120,000 SPUs (serrapeptase units). The remaining ingredients are inert capsule materials and fillers—microcrystalline cellulose, organic rice, hypromellose, pectin, and water—that serve no therapeutic role.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy sinuses and immune function.
  • We looked for evidence on: Rhinosinusitis, Postoperative swelling, Laryngitis, Pharyngitis, Otitis media, Chronic bronchitis — and 4 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Asthma, Otitis media, Pharyngitis, Rhinosinusitis, and more.

The evidence we hold rates serrapeptase as having insufficient reliable evidence for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis. That means the science hasn't yet established whether it works for any of these conditions.

If you're considering it for a specific health reason, talk with your doctor about whether the current evidence supports its use for your situation.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in the short term, though long-term safety hasn't been well studied. The most common side effects reported—epigastric pain (upper stomach discomfort), gastrointestinal upset, and nausea—occur at rates similar to placebo in trials.

Rarely, serious reactions like bullous pemphigoid (a blistering skin condition) have been reported. There isn't enough safety data to know whether serrapeptase is safe in pregnancy or while breastfeeding—the facts advise against both.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners and antiplatelet drugs (like warfarin, aspirin, and clopidogrel) are the main concern—serrapeptase may increase bleeding and bruising risk with these medications. If you take any anticoagulant or antiplatelet agent, confirm with your doctor or pharmacist that it's safe to add this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase may be worth considering if you're looking for a natural enzyme supplement, but the evidence for its effectiveness isn't established yet for the conditions it's marketed for. The biggest caution is with blood thinners and antiplatelet medications, where there's a documented interaction risk.

Before you start it, especially if you take any blood-thinning medication, check with your doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase 120,000 SPUs, straight from the product label.

Brand Lake Avenue Nutrition
Barcode (UPC) 898220015726
Net contents 180 Veggie Capsule(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 274425
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase 120,000 SPUs by Lake Avenue Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
898220015726
IngredientAmount% DV
Serrapeptase90 mg--

Other ingredients: Microcrystalline Cellulose, organic Rice, Hypromellose, Pectin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily without food, or as recommended by a healthcare professional.

Formulation

Formulated without: GMOs or gluten.

Supports healthy sinuses & immune function

Not manufactured with egg, fish, shellfish, tree nuts, peanuts, wheat, or gluten.

Precautions

Warnings: Keep out of reach of children.

As with all dietary supplements, it is recommended to consult with a healthcare professional before adding something new to your health and wellness regimen. Sealed for your protection, do not use if seal is missing or broken.

Not manufactured with egg, fish, shellfish, tree nuts, peanuts, wheat, or gluten. Produced in a third-party cGMP facility that may process other products that contain these allergens or ingredients.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Proteolytic Enzyme

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Lake Avenue Nutrition is a registered trademark of Madre Labs, LLC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase 120,000 SPUs by Lake Avenue Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase 120,000 SPUs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase 120,000 SPUs by Lake Avenue Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
90 mg per serving Form: Serratia

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Organic Rice, Hypromellose, Pectin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase 120,000 SPUs by Lake Avenue Nutrition Drug Interactions

Want to check YOUR meds against Serrapeptase 120,000 SPUs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase 120,000 SPUs interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase 120,000 SPUs interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase 120,000 SPUs with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase 120,000 SPUs, from the product label.

Lake Avenue Nutrition

See all Lake Avenue Nutrition products
Name
Madre Labs, LLC
Street Address
301 N. Lake Ave., Ste. 500
City
Pasadena
State
CA
ZipCode
91101
Web Address
lakeavenuenutrition.com
Pharmacist Counseling Corner

Serrapeptase 120,000 SPUs by Lake Avenue Nutrition: Common Questions

Does Serrapeptase 120,000 SPUs by Lake Avenue Nutrition interact with any medications?
Yes. Based on its ingredients, Serrapeptase 120,000 SPUs has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase 120,000 SPUs contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the most common side effects?
Upper stomach pain, general gastrointestinal upset, and nausea are reported most often—though in clinical trials they happened at the same rate as placebo. Most people tolerate it well in the short term.
Is serrapeptase safe to take long-term?
It's generally well tolerated in the short term, but we don't have good long-term safety data. If you're thinking of taking it regularly for months or years, talk with your doctor about what we do and don't know.
Can I take this while pregnant or breastfeeding?
The safety data isn't adequate for either—the facts advise against both pregnancy and breastfeeding. Talk with your doctor or pharmacist before use if you're pregnant, trying to conceive, or nursing.
Does serrapeptase actually work for the conditions it's marketed for?
We hold insufficient reliable evidence for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis. That means the science hasn't yet proven whether it works for any of these. Ask your doctor whether the current evidence supports using it for your specific condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase 120,000 SPUs is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase 120,000 SPUs label
Go deeper

The Full Monographs Behind Serrapeptase 120,000 SPUs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase 120,000 SPUs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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