Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Serrapeptase 120,000 SPUs Ingredients & Drug Interactions

by Lake Avenue Nutrition

Serrapeptase 120,000 SPUs label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase 120,000 SPUs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase 120,000 SPUs is a dietary supplement by Lake Avenue Nutrition with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Serrapeptase 120,000 SPUs by Lake Avenue Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase 120,000 SPUs by Lake Avenue Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Serrapeptase 120,000 SPUs by Lake Avenue Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: serrapeptase, a proteolytic enzyme derived from the silkworm. Serrapeptase is supplied at 120,000 SPUs (serrapeptase protease units) per capsule.

The inactive ingredients are microcrystalline cellulose, organic rice hulls, hypromellose, pectin, and water — these are fillers, binders, and capsule materials that hold the formula together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy sinuses and immune function.
  • We looked for evidence on: Rhinosinusitis, Postoperative swelling, sinus congestion, mucus clearance.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Postoperative swelling.

The evidence on serrapeptase isn't yet established. For the conditions this product is typically marketed for — chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis — the data we hold shows insufficient reliable evidence to rate whether it actually works.

If you're considering this supplement for a specific condition, talk with your doctor or pharmacist about whether the current evidence supports its use for your situation.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated when taken short-term, though long-term safety hasn't been well studied. The most common side effects reported in trials are epigastric pain (discomfort in the upper abdomen), general gastrointestinal upset, and nausea — but these side effects appear to occur at about the same rate as placebo, so they may not be from the supplement itself.

A rare serious adverse effect, bullous pemphigoid (a blister-forming skin condition), has been reported. During pregnancy, there isn't enough safety data, so it's best avoided.

While breastfeeding, no reliable safety information exists — talk with your doctor or pharmacist before taking this supplement if you're nursing.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you're on any blood thinners or antiplatelet drugs — that's 122 medications across those categories. Serrapeptase can increase bleeding risk when combined with these medications.

If you're unsure whether your medication falls into one of these groups, use the search tool on this page or ask your pharmacist directly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase may be worth considering if you're interested in enzyme-based supplements and have talked with your healthcare provider, but the evidence for its effectiveness isn't established yet in our data. If you take blood thinners or antiplatelet medications, you need to check with your doctor or pharmacist first — the interaction risk is real.

During pregnancy or breastfeeding, the safety data isn't there, so discuss it with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase 120,000 SPUs, straight from the product label.

Brand Lake Avenue Nutrition
Barcode (UPC) 898220015719
Net contents 30 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 272703
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase 120,000 SPUs by Lake Avenue Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
898220015719
IngredientAmount% DV
Serrapeptase90 mg--

Other ingredients: Microcrystalline Cellulose, organic Rice hulls, Hypromellose, Pectin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily without food, or as recommended by a healthcare professional.

Formulation

Formulated without: GMOs or gluten.

Supports healthy sinuses & immune function

Not manufactured with egg, fish, shellfish, tree nuts, peanuts, wheat, or gluten.

Precautions

Warnings: Keep out of reach of children.

As with all dietary supplements, it is recommended to consult with a healthcare professional before adding something new to your health and wellness regimen. Sealed for your protection, do not use if seal is missing or broken.

Not manufactured with egg, fish, shellfish, tree nuts, peanuts, wheat, or gluten. Produced in a third-party cGMP facility that may process other products that contain these allergens or ingredients.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Proteolytic Enzyme

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase 120,000 SPUs by Lake Avenue Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase 120,000 SPUs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase 120,000 SPUs by Lake Avenue Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
90 mg per serving Form: Serratia

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Organic Rice hulls, Hypromellose, Pectin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase 120,000 SPUs by Lake Avenue Nutrition Drug Interactions

Want to check YOUR meds against Serrapeptase 120,000 SPUs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase 120,000 SPUs interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase 120,000 SPUs interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase 120,000 SPUs with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase 120,000 SPUs, from the product label.

Lake Avenue Nutrition

See all Lake Avenue Nutrition products
Name
Madre Labs, LLC
Street Address
301 N. Lake Ave., Ste. 500
City
Pasadena
State
CA
ZipCode
91101
Web Address
lakeavenuenutrition.com
Pharmacist Counseling Corner

Serrapeptase 120,000 SPUs by Lake Avenue Nutrition: Common Questions

Does Serrapeptase 120,000 SPUs by Lake Avenue Nutrition interact with any medications?
Yes. Based on its ingredients, Serrapeptase 120,000 SPUs has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase 120,000 SPUs contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take serrapeptase if I'm on aspirin or warfarin?
Not without checking with your doctor or pharmacist first. Serrapeptase can theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs like these. This is a Moderate-severity interaction, so your healthcare provider needs to know you're considering this supplement and can advise whether it's okay for you or if they need to monitor you.
What are the most common side effects?
The side effects reported most often are epigastric pain (upper belly discomfort), gastrointestinal upset, and nausea. However, these side effects appear to occur at the same rate as placebo in trials, so they may not actually be from the supplement. A rare serious side effect, a blister-forming skin condition, has been reported.
Is serrapeptase proven to work for back pain or asthma?
Not yet. For back pain, asthma, chronic bronchitis, atherosclerosis, and osteoporosis, the evidence we hold shows insufficient reliable evidence to rate whether serrapeptase actually works. Talk with your doctor if you're considering it for one of these conditions.
Is it safe to take long-term?
Serrapeptase is generally well tolerated short-term, but long-term safety hasn't been well studied. If you're thinking about taking this for weeks or months, check in with your doctor or pharmacist about what we know and don't know.
Can I take this while pregnant or breastfeeding?
Not based on the safety data available. During pregnancy, there isn't enough information to know whether it's safe, so it's best avoided. While breastfeeding, there's no reliable safety information either. Talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase 120,000 SPUs is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase 120,000 SPUs label
Go deeper

The Full Monographs Behind Serrapeptase 120,000 SPUs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase 120,000 SPUs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team