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Dietary supplement

Serrapeptase 20,000 SPU Ingredients & Drug Interactions

by BIOVEA

Serrapeptase 20,000 SPU label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase 20,000 SPU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase 20,000 SPU is a dietary supplement by BIOVEA with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase 20,000 SPU by BIOVEA

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase 20,000 SPU by BIOVEA — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Serrapeptase 20,000 SPU by BIOVEA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: serrapeptase, a proteolytic enzyme (a protein-digesting enzyme) derived from the digestive system of silkworm larvae. It's included at a strength of 20,000 SPU (serrapeptidase units).

The capsule also holds several inactive ingredients — rice flour, hypromellose (a capsule coating), gellan gum, magnesium stearate, and silicon dioxide — that serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Support inflammation and swelling reduction.
  • We looked for evidence on: Postoperative swelling, Back pain, Carpal tunnel syndrome, Osteoarthritis, Rheumatoid arthritis (RA), Fibromyalgia — and 4 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Back pain, Carpal tunnel syndrome, Fibromyalgia, Osteoarthritis, and more.

The evidence for serrapeptase isn't established in the data we hold. Studies don't yet provide reliable evidence to support its use for chronic bronchitis, asthma, atherosclerosis, back pain, or osteoporosis.

That doesn't mean it doesn't work — it means we don't have strong trial data backing those uses yet.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase appears to be well tolerated in the short term. The most common side effects reported are stomach pain, gastrointestinal upset, and nausea, though these occur at about the same rate as placebo in trials.

A rare serious side effect — bullous pemphigoid (a blistering skin condition) — has been reported but is uncommon. Long-term safety hasn't been well studied, so caution is warranted with extended use.

For pregnancy, the safety data advises against it. For breastfeeding, there's not enough reliable safety information, so it's best avoided.

If you're pregnant or nursing and thinking about serrapeptase, talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start serrapeptase, double-check with your pharmacist if you're on any blood thinners or antiplatelet drugs — aspirin, warfarin, clopidogrel, and similar medications. The risk is a Moderate increase in bruising and bleeding if you combine them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase is generally well tolerated short-term if you're not on blood thinners or antiplatelet medications. If you take aspirin, warfarin, or any drug that affects clotting, check with your pharmacist first.

The evidence for its effectiveness in the conditions it's marketed for isn't yet reliable. Long-term safety is understudied, so this is best used short-term and under guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase 20,000 SPU, straight from the product label.

Brand BIOVEA
Barcode (UPC) 818423024004
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 303232
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase 20,000 SPU by BIOVEA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
45
UPC/BARCODE
818423024004
IngredientAmount% DV
Serrapeptase0 NP--

Other ingredients: Rice Flour, Hypromellose, Gellan Gum, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

GMP Compliant

Formulation

Vegan

Gluten free Non-GMO

Premium Quality Guaranteed Since 2001. BIOVEA is committed to product quality to support you and your family's wellness goals. Because we feel so strongly about the quality, potency and purity of our product, we 100% guarantee your satisfaction with every purchase.

Guaranteed premium quality

Suggested/Recommended/Usage/Directions

Suggested daily intake: Take 2 capsules twice daily as needed on an empty stomach with at least 8 oz of water.

Precautions

Warning: Do not take if you are pregnant, may become pregnant, or breastfeeding, or if you suffer from any gastrointestinal disorders such as ulcers. Consult your healthcare professional before taking this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin, warfarin (coumadin), or aspirin.

Discontinue use if nausea, diarrhea, or other intestinal discomfort occurs.

Keep out of reach of children.

Do not use this product if the safety seal on the bottle is broken.

Storage

Store in a cool, dry place.

Formula

Serrapeptase 20,000 SPU per capsule

FDA Statement of Identity

Dietary Supplement

General Statements

Enzyme

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase 20,000 SPU by BIOVEA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase 20,000 SPU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase 20,000 SPU by BIOVEA

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
0 NP per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Rice Flour, Hypromellose, Gellan Gum, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase 20,000 SPU by BIOVEA Drug Interactions

Want to check YOUR meds against Serrapeptase 20,000 SPU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase 20,000 SPU interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase 20,000 SPU interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase 20,000 SPU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase 20,000 SPU, from the product label.

BIOVEA

See all BIOVEA products
Name
BIOVEA
Street Address
9160 E. Bahia Dr.
City
Scottsdale
State
AZ
ZipCode
85260
Web Address
www.biovea.com
Pharmacist Counseling Corner

Serrapeptase 20,000 SPU by BIOVEA: Common Questions

Does Serrapeptase 20,000 SPU by BIOVEA interact with any medications?
Yes. Based on its ingredients, Serrapeptase 20,000 SPU has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase 20,000 SPU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does serrapeptase do?
Serrapeptase is an enzyme that breaks down proteins. Lab research shows it has fibrinolytic activity — meaning it can break down fibrin, a protein in blood clots — which is why it's studied for various conditions. However, we don't have reliable evidence yet that it works for chronic bronchitis, asthma, atherosclerosis, back pain, or osteoporosis.
Is serrapeptase safe to take long-term?
Short-term use appears well tolerated. Long-term safety hasn't been well studied, so caution is advised if you're thinking about taking it for extended periods. Talk to your pharmacist about how long is appropriate for your situation.
What are the side effects?
The most common side effects are stomach pain, gastrointestinal upset, and nausea — though these happen at about the same rate as placebo in trials. A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported but is uncommon.
Can I take this while pregnant or breastfeeding?
No — the safety data advises against serrapeptase in pregnancy. For breastfeeding, there isn't enough reliable safety information, so it's best avoided. If you're pregnant or nursing and considering it, talk with your doctor or pharmacist first.
What's in the capsule besides the active ingredient?
The capsule contains rice flour, hypromellose, gellan gum, magnesium stearate, and silicon dioxide. These are inactive ingredients that help form and stabilize the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase 20,000 SPU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase 20,000 SPU label
Go deeper

The Full Monographs Behind Serrapeptase 20,000 SPU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase 20,000 SPU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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