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Dietary supplement

Serrapeptase 40,000 SPUs Ingredients & Drug Interactions

by Lake Avenue Nutrition

Serrapeptase 40,000 SPUs label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase 40,000 SPUs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase 40,000 SPUs is a dietary supplement by Lake Avenue Nutrition with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase 40,000 SPUs by Lake Avenue Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase 40,000 SPUs by Lake Avenue Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Serrapeptase 40,000 SPUs by Lake Avenue Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: serrapeptase, a protease enzyme (a protein-digesting enzyme) sourced from the silkworm. The capsule also holds inactive ingredients—microcrystalline cellulose, modified cellulose, rice husk, and silicon dioxide—which serve as fillers and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports healthy sinuses and immune function.
  • We looked for evidence on: Rhinosinusitis, Sinus congestion, Mucus clearance, Respiratory health.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis (Natural Medicines).

The evidence for serrapeptase isn't established in our data. It carries a rating of insufficient reliable evidence to rate for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis.

That means research so far hasn't been robust enough to draw firm conclusions about whether it works for these conditions.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase appears to be well tolerated in the short term. The most common side effects reported are epigastric pain (pain in the upper belly), gastrointestinal upset, and nausea—though in trials these occurred at about the same rate as placebo.

A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported. Long-term safety isn't well studied.

During pregnancy, there isn't enough safety data; the facts advise against it. While breastfeeding, reliable safety information is lacking, so it's best avoided.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners and antiplatelet medications (such as warfarin, aspirin, clopidogrel, and others) carry a Moderate interaction risk with serrapeptase. Check your exact medications with your pharmacist or doctor before taking this product to make sure it's safe alongside what you're already on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase is generally well tolerated short-term, but long-term safety isn't established and evidence for its claimed uses is insufficient. If you take blood thinners or antiplatelet drugs, check your specific medications with your pharmacist or doctor before starting this supplement.

Anyone pregnant or breastfeeding should discuss it with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase 40,000 SPUs, straight from the product label.

Brand Lake Avenue Nutrition
Barcode (UPC) 898220015733
Net contents 30 Veggie Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299376
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase 40,000 SPUs by Lake Avenue Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
898220015733
IngredientAmount% DV
Serrapeptase30 mg--

Other ingredients: Microcrystalline Cellulose, Modified Cellulose, Rice Husk, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule daily without food, or as recommended by a healthcare professional.

Formulation

Formulated Without: GMOs or Gluten.

Supports Healthy Sinuses & Immune Function

Not manufactured with egg, fish, shellfish, tree nuts, peanuts, wheat, sesame, or gluten.

Precautions

Warnings: Keep out of reach of children.

As with all dietary supplements, it is recommended to consult with a healthcare professional before adding something new to your health and wellness regimen. Sealed for your protection, do not use if seal is missing or broken.

Not manufactured with egg, fish, shellfish, tree nuts, peanuts, wheat, sesame, or gluten. Produced in a third-party cGMP facility that may process other products that contain these allergens or ingredients.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statement has not ben evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Lake Avenue Nutrition is a registered trademark of Madre Labs, LLC

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase 40,000 SPUs by Lake Avenue Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase 40,000 SPUs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase 40,000 SPUs by Lake Avenue Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
30 mg per serving Form: Serratia sp.

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Modified Cellulose, Rice Husk, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase 40,000 SPUs by Lake Avenue Nutrition Drug Interactions

Want to check YOUR meds against Serrapeptase 40,000 SPUs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase 40,000 SPUs interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase 40,000 SPUs interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase 40,000 SPUs with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase 40,000 SPUs, from the product label.

Lake Avenue Nutrition

See all Lake Avenue Nutrition products
Name
Madre Labs, LLC
Street Address
301 N. Lake Ave., Ste. 500
City
Pasadena
State
CA
ZipCode
91101
Web Address
lakeavenuenutrition.com
Pharmacist Counseling Corner

Serrapeptase 40,000 SPUs by Lake Avenue Nutrition: Common Questions

Does Serrapeptase 40,000 SPUs by Lake Avenue Nutrition interact with any medications?
Yes. Based on its ingredients, Serrapeptase 40,000 SPUs has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase 40,000 SPUs contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is serrapeptase, and what is it supposed to do?
Serrapeptase is a protease enzyme—a protein-digesting enzyme sourced from silkworms. It's claimed to help with conditions like chronic bronchitis, asthma, back pain, and atherosclerosis, but the research evidence so far isn't strong enough to confirm it works for any of these.
Can I take this if I'm on a blood thinner like warfarin or aspirin?
Don't start this without checking first. Serrapeptase may increase bleeding and bruising risk when combined with blood thinners or antiplatelet drugs. Talk with your pharmacist or doctor about your specific medications before taking it.
What side effects might I experience?
Most commonly, people report epigastric pain (upper belly pain), stomach upset, and nausea—though in studies these occurred about as often as they did with placebo. Rarely, a serious blistering skin condition called bullous pemphigoid has been reported.
Is it safe to take long-term?
Short-term use appears generally well tolerated, but long-term safety hasn't been well studied. If you're thinking about taking it for weeks or months, discuss that with your doctor or pharmacist.
Can I take this while pregnant or breastfeeding?
No. There isn't enough safety data during pregnancy, so it's best avoided. While breastfeeding, reliable safety information is lacking as well. Talk with your doctor or pharmacist about your options if you're pregnant, planning pregnancy, or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase 40,000 SPUs is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase 40,000 SPUs label
Go deeper

The Full Monographs Behind Serrapeptase 40,000 SPUs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase 40,000 SPUs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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