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Dietary supplement

Serrapeptase Ingredients & Drug Interactions

by BioAnue

Serrapeptase label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase is a dietary supplement by BioAnue with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase by BioAnue

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase by BioAnue — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Serrapeptase by BioAnue

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

BioAnue Serrapeptase is a single-ingredient product: the protease enzyme serrapeptase, delivered in a gelatin capsule. Serrapeptase is a proteolytic enzyme — meaning it breaks down proteins — originally isolated from the silkworm gut.

It works by digesting fibrin and other proteins in the body.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Serrapeptase product and its label doesn't state a use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The data we hold rates serrapeptase as having insufficient reliable evidence for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis. That means the studies so far haven't been robust enough to say whether it works for these uses.

If you're considering it for one of these conditions, that's a conversation to have with your doctor about whether the evidence is compelling enough for your situation.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in the short term. The most common side effects reported are epigastric pain (discomfort in the upper abdomen), gastrointestinal upset, and nausea — though these occur at about the same rate as placebo in trials, suggesting they may not be directly caused by the supplement.

A rare serious side effect (bullous pemphigoid, a blistering skin condition) has been reported. Long-term safety hasn't been well studied, so we don't have a lot of data on what happens if you take it for months or years.

During pregnancy, there isn't enough safety data, so it's best avoided. The same goes for breastfeeding — no reliable safety information is available.

If you're pregnant or nursing and interested in serrapeptase, talk it over with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start serrapeptase, check with your doctor or pharmacist if you take any blood thinners (anticoagulants) or antiplatelet medications — that's the one Moderate-severity interaction category our data covers. These include prescription drugs like warfarin and clopidogrel, as well as over-the-counter aspirin.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase may be worth considering if you're looking to support fibrin breakdown, but the evidence for common uses like bronchitis or back pain isn't established yet. If you take any blood thinner or anticlotting medication, this product needs a green light from your doctor or pharmacist first.

Long-term safety data is thin, so this is a short-term option to discuss with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase, straight from the product label.

Brand BioAnue
Net contents 10 Capsule(s); 350 mg
Market status On market
Date entered into DSLD Nov 25, 2013
DSLD ID 27391
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase by BioAnue, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
10
IngredientAmount% DV
Serrapeptase350 mg--

Other ingredients: Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Your Edge - Your New Beginning

Suggested/Recommended/Usage/Directions

Usage: As a dietary supplement consume 1 to 6 capsules per day, or as directed by a health care professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase by BioAnue label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase by BioAnue

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container10 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
350 mg per serving Form: Bombyx mori

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase by BioAnue Drug Interactions

Want to check YOUR meds against Serrapeptase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase, from the product label.

BioAnue

See all BioAnue products
Name
BioAnue Laboratories Inc.
Street Address
P.O. Box 1056, 123 Wood Tech Dr.
City
Rochelle
State
GA
ZipCode
31079
Pharmacist Counseling Corner

Serrapeptase by BioAnue: Common Questions

Does Serrapeptase by BioAnue interact with any medications?
Yes. Based on its ingredients, Serrapeptase has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take serrapeptase if I'm on aspirin or warfarin?
Not without checking with your doctor or pharmacist first. Serrapeptase has fibrinolytic activity (it breaks down clotting proteins), and combining it with blood thinners or antiplatelet drugs may raise your bleeding and bruising risk. Your own healthcare provider needs to weigh whether the benefit is worth that potential risk in your case.
What are the side effects?
The most common ones are epigastric pain (upper-belly discomfort), upset stomach, and nausea. Interestingly, these occur at about the same rate as placebo in studies, so they may not be caused by serrapeptase itself. A rare serious side effect — bullous pemphigoid, a blistering skin condition — has been reported.
Is serrapeptase proven to work for back pain or arthritis?
We hold insufficient reliable evidence to rate it for back pain and osteoporosis. The studies haven't been solid enough yet to say whether it works. If you're thinking about it for these conditions, your doctor can help you decide whether the current evidence feels convincing enough.
Is it safe to take long-term?
Long-term safety hasn't been well studied, so we don't have much data on what happens if you take it for months or years. It's generally tolerated in the short term, but that's the scope of the evidence.
Can I take it while pregnant or breastfeeding?
No — there isn't enough safety data for pregnancy, so it's best avoided. The same applies to breastfeeding. Talk with your doctor or pharmacist if you're pregnant, nursing, or planning to become pregnant.
What exactly does serrapeptase do?
It's a protease enzyme — a protein-digesting enzyme originally found in silkworm gut. It has fibrinolytic activity, meaning it breaks down fibrin and other proteins involved in clotting and inflammation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase label
Go deeper

The Full Monographs Behind Serrapeptase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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