SharpMind Energy Ingredients & Drug Interactions
by Solaray
What is this page for?
First and foremost: checking SharpMind Energy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
SharpMind Energy is a dietary supplement by Solaray with 3 active ingredients. Its ingredients are commonly taken for fatigue and low energy, stress and coping (adaptogen), mental performance and focus.Based on those ingredients, 1,325 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhodiola root extract, Cordyceps Mushroom, Fermented. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against SharpMind Energy by Solaray
Ask about any prescription or over-the-counter medication and we check it for interactions with SharpMind Energy by Solaray — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of SharpMind Energy by Solaray
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
SharpMind Energy has 4 active ingredients. The main ones are rhodiola root extract (listed as a blend of its components) and fermented cordyceps mushroom, both traditionally used as adaptogens to support energy and mental clarity.
The product also contains rosavins and salidrosides — compounds naturally found in rhodiola — plus EnXtra, a proprietary ingredient. The capsule also contains inactive ingredients: cellulose, stearic acid, maltodextrin, and silica, which are fillers and binders that help hold the capsule together.
Does it work?
Not established
The evidence for most uses in this product isn't well established in our data. Cordyceps is rated possibly ineffective for athletic performance.
For cordyceps' other claimed uses — sexual dysfunction, heart rhythm problems (arrhythmia), asthma, lung cancer, and chronic obstructive pulmonary disease (COPD) — there's insufficient reliable evidence to rate whether it works. The effectiveness ratings for the rhodiola-derived ingredients aren't on file in our data.
How safe is it?
Well-documented data
Cordyceps is generally well tolerated when used for up to a year, though long-term safety data is limited and product quality varies. The most common side effects are mild — abdominal discomfort, constipation, or diarrhea — and may improve if you take it after eating.
Dry mouth and throat discomfort have also been reported but are uncommon. There is one case report of liver inflammation (hepatitis) possibly linked to a cordyceps-containing product, though it's unclear whether cordyceps was responsible or a contaminant.
The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe.
Meds to double-check
Moderate interaction found
If you take any blood thinners or antiplatelet medications (warfarin, aspirin, clopidogrel, or others), check with your doctor or pharmacist first — cordyceps may increase bleeding risk. Also clear it if you're on immunosuppressive drugs like cyclosporine or if you're using testosterone therapy.
No interactions are documented for the other ingredients we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
SharpMind Energy might appeal to you if you're looking for an adaptogenic energy support, but it's not your move if you take blood thinners, immunosuppressants, or testosterone therapy — cordyceps interacts with all three. Pregnant or breastfeeding?
The safety data recommends avoiding it. Talk it over with your own doctor or pharmacist before starting, especially if you're on any prescription medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about SharpMind Energy, straight from the product label.
| Brand | Solaray |
|---|---|
| Barcode (UPC) | 076280648065 |
| Net contents | 30 VegCap(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2023 |
| DSLD ID | 296352 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for SharpMind Energy by Solaray, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Rhodiola root extract | 100 mg | -- |
| Rosavins | 3 mg | -- |
| Salidrosides | 1 mg | -- |
| EnXtra | 300 mg | -- |
| Cordyceps Mushroom, Fermented | 100 mg | -- |
Other ingredients: Cellulose, Cellulose, Stearic Acid, Maltodextrin, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Solaray Est. 1973 A brighter way 1973
enXtra is a U.S. trademark of ENovate Biolife Pvt Ltd.
Formulation
Energy support Mental altertness
Lab Verified
Vegan
Caffeine free
FDA Statement of Identity
Dietary Supplement
General Statements
Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.
100% PCR Bottles
Precautions
Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.
Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Directions: Use only as directed. Take 1 VegCap daily with a meal or glass of water.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
SharpMind Energy by Solaray label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in SharpMind Energy by Solaray
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 VegCap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Rhodiola root extract
Interacts with1,271 drugs
Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...
Rhodiola root extract monograph & interactions- › Rosavins
- › Salidrosides
EnXtra
Cordyceps Mushroom, Fermented
Interacts with249 drugs
Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...
Cordyceps Mushroom, Fermented monograph & interactionsOther (inactive) ingredients: Cellulose, Cellulose, Stearic Acid, Maltodextrin, Silica. These complete the product’s ingredient list but are not active constituents.
SharpMind Energy by Solaray Drug Interactions
HelloPharmacist Interaction Report
SharpMind Energy by Solaray contains cordyceps mushroom, which has documented interactions with several medication types.
The most serious concern is with blood thinners and antiplatelet drugs (anticoagulants/antiplatelets) — cordyceps may theoretically increase bleeding risk, though this hasn't been reported in humans yet.
Read the full breakdown — every affected drug type, severity by severity
Cordyceps may also interfere with immune-suppressing medications (immunosuppressants), potentially lowering the dose needed for drugs like cyclosporine. There's also a theoretical additive effect if you're taking testosterone therapy, though the clinical importance of this is unclear.
We could not check three other ingredients in this product — rosavins, salidrosides, and EnXtra — because we hold no interaction data for them. Rhodiola root extract is a blend whose individual components are listed separately.
Altogether, these interactions span 249 individual medications.
Before you start SharpMind Energy, run your exact medications through the interaction checker on this page to see if any of yours are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against SharpMind Energy?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in SharpMind Energy interact with 1,325 drugs. Click any drug to see the details.
2 of the 3 ingredients in SharpMind Energy interact with drugs. Each result below shows which ingredient is responsible. Rhodiola root extract Cordyceps Mushroom, Fermented
Alteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mushroom, FermentedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mushroom, Fermented + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with SharpMind Energy — through 2 ingredients. Tap an ingredient for the detail:
Cordyceps Mushroom, FermentedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mushroom, Fermented + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionRhodiola Root ExtractCns Depressants Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Root Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mushroom, FermentedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mushroom, Fermented + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAlvimopanEntereg
How Alvimopan interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola Root Extract + Alvimopan interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola Root Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola Root Extract + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola Root Extract + Amiloride, Hydrochlorothiazide interactionAmitriptylineElavil
How Amitriptyline interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +3 Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Root Extract + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractCns Depressants, Antidepressant Drugs +3 Moderate
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola Root Extract + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +3 Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Root Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola Root Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola Root Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola Root Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola Root Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola Root Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola Root Extract + Ammonium Chloride interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
Read the full Rhodiola Root Extract + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola Root Extract + Amphotericin, Tetracycline interactionAmprenavirAgenerase
How Amprenavir interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola Root Extract + Amprenavir interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mushroom, FermentedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mushroom, Fermented + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with SharpMind Energy — through 2 ingredients. Tap an ingredient for the detail:
Cordyceps Mushroom, FermentedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mushroom, Fermented + Anagrelide interactionRhodiola Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola Root Extract + Anagrelide interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with SharpMind Energy — through 2 ingredients. Tap an ingredient for the detail:
Cordyceps Mushroom, FermentedImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mushroom, Fermented + Anifrolumab-fnia interactionRhodiola Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola Root Extract + Anifrolumab-fnia interactionAnisindioneMiradon
How Anisindione interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mushroom, FermentedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mushroom, Fermented + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractAntidiabetes Drugs, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola Root Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mushroom, FermentedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mushroom, Fermented + Antithrombin Iii interactionAntithymocyte GlobulinThymoglobulin
How Antithymocyte Globulin interacts with SharpMind Energy — through 2 ingredients. Tap an ingredient for the detail:
Cordyceps Mushroom, FermentedImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mushroom, Fermented + Antithymocyte Globulin interactionRhodiola Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola Root Extract + Antithymocyte Globulin interactionApixabanEliquis
How Apixaban interacts with SharpMind Energy — through 2 ingredients. Tap an ingredient for the detail:
Rhodiola Root ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola Root Extract + Apixaban interactionCordyceps Mushroom, FermentedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mushroom, Fermented + Apixaban interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola Root Extract + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with SharpMind Energy — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola Root ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola Root Extract + Apomorphine Hydrochloride interactionEach ingredient & the kinds of drugs it affects
For each ingredient in SharpMind Energy with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Rhodiola root extract
Antidiabetes Drugs
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.
Antihypertensive Drugs
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
Immunosuppressants
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.
Losartan (Cozaar)
Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
P-Glycoprotein Substrates
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.
Antidepressant Drugs
Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.
Cns Depressants
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.
Cordyceps Mushroom, Fermented
Anticoagulant/Antiplatelet Drugs
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.
Immunosuppressants
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.
Testosterone
Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.
Brand information
Manufacturer and brand details for SharpMind Energy, from the product label.
SharpMind Energy by Solaray: Common Questions
Does SharpMind Energy by Solaray interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take SharpMind Energy while pregnant or breastfeeding?
What are the most common side effects?
How long can I safely take this?
Does this actually improve athletic performance?
What's EnXtra?
Are there any fillers in this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if SharpMind Energy is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind SharpMind Energy’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Rhodiola
Interacts with 1,271 drugsRhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...
Read the full Rhodiola monograph → Herb & supplement monographCordyceps
Interacts with 249 drugsCordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...
Read the full Cordyceps monograph →Sources & How We Checked
SharpMind Energy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Rhodiola 13 references
- Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
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