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Dietary supplement

Siberian Rhubarb Extract 2500 mg Ingredients & Drug Interactions

by NusaPure

Siberian Rhubarb Extract 2500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Siberian Rhubarb Extract 2500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Siberian Rhubarb Extract 2500 mg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for constipation, digestive upset, menopausal symptoms.Based on those ingredients, 658 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Siberian Rhubarb Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Siberian Rhubarb Extract 2500 mg by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Siberian Rhubarb Extract 2500 mg by NusaPure — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Siberian Rhubarb Extract 2500 mg by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Siberian rhubarb root extract at 2,500 mg per capsule. Rhubarb is a plant with both food and medicinal uses — you may know it as the stalk in pies — but the root extract in supplements is a stimulant laxative, meaning it directly triggers your bowels to move.

The capsule also contains inactive ingredients (rice flour, cellulose, silica, and magnesium stearate), which are standard fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive support and bowel regularity.
  • We looked for evidence on: Constipation, Menopausal symptoms, Pancreatitis, Chronic kidney disease (CKD), Nonalcoholic fatty liver disease (NAFLD), Digestive health — and 3 related terms.
  • The strongest evidence on file: Rhubarb is rated "Possibly Effective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Rhubarb is rated "Possibly Effective" for Pancreatitis.
  • Also on file: Rhubarb is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Constipation, Chronic kidney disease (CKD).

The evidence for rhubarb root is limited depending on what you're using it for. It's rated possibly effective for pancreatitis (inflammation of the pancreas) and menopausal symptoms based on available studies.

For constipation, nonalcoholic fatty liver disease (NAFLD), appendicitis, and nasopharyngeal cancer, the evidence in our data is insufficient to rate whether it works — we can't tell you one way or the other.

The evidence, ingredient by ingredient Rhubarb

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rhubarb root is generally well tolerated in typical doses, but it does cause side effects in many people: cramping, diarrhea, gastrointestinal discomfort, nausea, and vomiting are common. In rare cases, anaphylaxis (a severe allergic reaction) has been reported.

The real concern is long-term use — chronic or excessive rhubarb can lead to potassium depletion, electrolyte loss, dehydration, kidney damage, and protein or blood in the urine. The safety data advises against medicinal rhubarb during pregnancy because it may stimulate the uterus, and against nursing because laxative compounds can pass into breast milk.

Don't use this supplement long-term without guidance.

Side effects, ingredient by ingredient Rhubarb

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rhubarb.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; heart-rhythm medications.
  • For scale: 659 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, run your medications through the checker below — especially if you take drugs that affect your kidneys or liver, blood thinners like warfarin, heart medications such as digoxin, corticosteroids, diuretics, cyclosporine (an immunosuppressant), or other laxatives. All carry moderate-risk interactions with rhubarb.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Rhubarb root extract is a stimulant laxative, not a general wellness supplement — it's for occasional bowel support, not daily use. If you take any medication for your heart, kidneys, liver, or blood pressure, or if you're on blood thinners or immunosuppressants, talk to your pharmacist before starting.

Pregnant or nursing? Skip it.

And if you're considering long-term use, check in with us first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Siberian Rhubarb Extract 2500 mg, straight from the product label.

Brand NusaPure
Barcode (UPC) X001WNFLG3
Net contents 200 Veg Cap(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 307393
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Siberian Rhubarb Extract 2500 mg by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
200
UPC/BARCODE
X001WNFLG3
IngredientAmount% DV
Siberian Rhubarb Root Extract250 mg--

Other ingredients: Rice Flour, Cellulose, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Siberian Rhubarb 10:1 ext 250mg

Siberian Rhubarb Extract 2500mg equivalent per serving

General Statements

New

Please recycle.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule daily, preferably with a meal. Read and follow directions carefully.

Precautions

Warning: For adults only.

Do not use if you have or develop diarrhea, loose stools, or abdominal pain because rhubarb root may worsen these conditions and be harmful to your health. Do not eat freshness packet. Keep in bottle.

Consult a physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.

Allergen information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool dry place after opening.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium quality Assembled in USA GMO free Made with Non-GMO ingredients Gluten free FDA Registered Facility

Manufactured in a cGMP inspected facility

Formulation

GMO free Made with Non-GMO ingredients Gluten free FDA Registered Facility

Assembled in USA Tested Supports normals nutritional supplementation Guaranteed quality, laboratory tested Made under strict GMP guidelines Max strength

Allergen information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.

Natural color variation may occur in this product.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Siberian Rhubarb Extract 2500 mg by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Siberian Rhubarb Extract 2500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Siberian Rhubarb Extract 2500 mg by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.

Siberian Rhubarb Root Extract

Interacts with
658 drugs
250 mg per serving Form: Rheum rhaponticum Root Extract

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal clai...

Siberian Rhubarb Root Extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Siberian Rhubarb Extract 2500 mg by NusaPure Drug Interactions

Want to check YOUR meds against Siberian Rhubarb Extract 2500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
658Drugs
658 Moderate

Ingredients driving the most interactions

Siberian Rhubarb Root Extract 658

Individual Drug Interactions

The ingredients in Siberian Rhubarb Extract 2500 mg interact with 658 drugs. Click any drug to see the details.

1 of the 1 ingredient in Siberian Rhubarb Extract 2500 mg interact with drugs. Each result below shows which ingredient is responsible. Siberian Rhubarb Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Siberian Rhubarb Extract 2500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Siberian Rhubarb Root Extract8 drug types · 658 drugs

Corticosteroids

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.

Likelihood Possible Evidence D
Nephrotoxic Drugs

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.

Likelihood Possible Evidence D
Siberian Rhubarb Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Siberian Rhubarb Extract 2500 mg, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central, LLC
Street Address
500 Westover Dr. #92909
City
Sanford
State
NC
ZipCode
27330
Pharmacist Counseling Corner

Siberian Rhubarb Extract 2500 mg by NusaPure: Common Questions

Does Siberian Rhubarb Extract 2500 mg by NusaPure interact with any medications?
Yes. Based on its ingredients, Siberian Rhubarb Extract 2500 mg has a known interaction with 658 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Siberian Rhubarb Extract 2500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or nursing?
No. The safety data advises against medicinal rhubarb during pregnancy — it may stimulate the uterus and bowels. While nursing, laxative compounds can pass into breast milk, so it's not recommended then either. Talk to your doctor or midwife about safer options.
What side effects should I expect?
The most common are cramping, diarrhea, gastrointestinal discomfort, nausea, and vomiting. Rare but serious: anaphylaxis (severe allergic reaction). If you use it long-term or take too much, you risk potassium depletion, dehydration, and kidney damage.
Can I use this long-term for constipation?
No. The safety notes specifically warn against long-term use — rhubarb root can cause cramping and electrolyte loss with chronic use. It's meant for occasional relief, not daily dosing. Talk to your pharmacist about better options if you have ongoing constipation.
Does this product actually work for what I want to use it for?
It depends. Rhubarb is rated possibly effective for pancreatitis and menopausal symptoms. For constipation, appendicitis, fatty liver disease, and nasopharyngeal cancer, the evidence in our data is too thin to say whether it works. Ask your pharmacist if it fits your specific need.
What's the difference between rhubarb stalk and rhubarb root in this supplement?
Rhubarb stalks are safe to eat as a food — think of it in pies or jams. The root extract here is medicinal and a laxative. It's much more potent and carries more risks, which is why we caution against long-term use and pregnancy.
Is it safe to combine this with other laxatives?
No. Combining rhubarb with other stimulant laxatives increases your risk of fluid and electrolyte loss and dehydration. Use only one laxative at a time, and talk to your pharmacist about which is best for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Siberian Rhubarb Extract 2500 mg label
Go deeper

The Full Monographs Behind Siberian Rhubarb Extract 2500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rhubarb

Interacts with 658 drugs

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...

Read the full Rhubarb monograph →
Sources

Sources & How We Checked

Siberian Rhubarb Extract 2500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rhubarb 20 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  6. Kwan TH, Tong MK, Leung KT, et al. Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones. Hong Kong Med J 2006;12:394-7.
  7. Fairbairn JW. The anthraquinone laxatives. Biological assay and its relation to chemical structure. Pharmacology 1976;14:48-61. PubMed
  8. Siegers, C. P., Hertzberg-Lottin, E., Otte, M., and Schneider, B. Anthranoid laxative abuse--a risk for colorectal cancer? Gut 1993;34(8):1099-1101. PubMed
  9. Fan, J. G. Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease: a multicenter clinical trial. Hepatobiliary.Pancreat.Dis.Int 2004;3(3):375-380.
  10. Yan, M., Zhang, L. Y., Sun, L. X., Jiang, Z. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. J Ethnopharmacol. 4-15-2006; PubMed
  11. Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. Chin Med J (Engl.) 1990;103(10):788-793.
  12. Mitsuma, T., Yokozawa, T., Oura, H., and Terasawa, K. [Rhubarb therapy in patients with chronic renal failure (Part 2)]. Nippon Jinzo Gakkai Shi 1987;29(2):195-207.
  13. Wu, C. X. [A preliminary study on the effect of a single Rheum officinale in heavy doses in the treatment of acute icteric hepatitis]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(2):88-89.
  14. Jiao, D. H. [Clinical research on the hemostatic effect of rhubarb on peptic ulcer with acute bleeding]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(10):597-600, 579.
  15. Jiao, D. H., Ma, Y. H., Chen, S. J., Liu, C. T., Shu, H. N., and Chu, C. M. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Pharmacology 1980;20 Suppl 1:128-130.
  16. Zhang, JH, Yao, XD, Song, Y, and et al. [Long-term treating effects of rhubarb and captopril in delaying the progression of renal failure]. Chinese Kidney Disease Journal 1993;9(4):197-201.
  17. Rehman H, Begum W, Anjum F, Tabasum H, Zahid S. Effect of rhubarb (Rheum emodi) in primary dysmenorrhoea: a single-blind randomized controlled trial. J Complement Integr Med. 2015 Mar;12(1):61-9.
  18. Yu CP, Lin HJ, Lin SP, Shia CS, Chang PH, Hou YC, Hsieh YW. Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A. Xenobiotica. 2016 Aug;46(8):677-82. PubMed
  19. Byeon JH, Kil JH, Ahn YC, Son CG. Systematic review of published data on herb induced liver injury. J Ethnopharmacol 2019;233:190-6. PubMed
  20. Zhao D, Feng SX, Zhang HJ, et al. Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale. Xenobiotica. 2021;51(8):916-925. PubMed

See these in context on the Rhubarb monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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